Alzheimer's and Dementia: The Journal of the Alzheimer's Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease
DiscussionEarly abnormalities in CSF tTau, pTau, SNAP-25, VILIP-1, and YKL-40 suggest that synaptic damage, neuronal injury, and neuroinflammation begin shortly after the commencement of brain amyloid accumulation. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 5, 2019 Category: Geriatrics Source Type: research

Brain arterial dilatation and the risk of Alzheimer's disease
DiscussionUnderstanding the pathophysiology of the association between AD and brain arterial dilatation may reveal new clues to the vascular contributions to AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 1, 2019 Category: Geriatrics Source Type: research

Parkinsonism in MCI or mild Alzheimer's disease
Publication date: Available online 1 March 2019Source: Alzheimer's & DementiaAuthor(s): Kurt A. Jellinger (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 1, 2019 Category: Geriatrics Source Type: research

MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study
DiscussionPreliminary evidence suggests that protective effects of the MIND diet are geographically generalizable. Additional prospective studies are needed in diverse samples to determine the relative effects of the MIND and the Mediterranean diets against cognitive decline. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 28, 2019 Category: Geriatrics Source Type: research

Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline
Publication date: Available online 26 February 2019Source: Alzheimer's & DementiaAuthor(s): Feng Zhang, Rujia Zhong, Song Li, Zhenfa Fu, Renfei Wang, Tianxiao Wang, Zhili Huang, Weidong LeAbstractObjectiveThe present work aims to evaluate the significance of sleep disturbance and electroencephalogram (EEG) alteration in the early stage of Alzheimer's disease (AD).Background and RationaleSleep disturbance is common in patients with AD. It is not known if it can occur at the early stage of AD and if EEG recording may help identify the early sign of the disease.Historical EvolutionSleep disturbance in AD has generally been co...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 26, 2019 Category: Geriatrics Source Type: research

Incidence of dementia after age 90 in a multiracial cohort
DiscussionPatterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 20, 2019 Category: Geriatrics Source Type: research

Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort
DiscussionDespite a smaller sample size, Hispanics demonstrated longer disease duration with Alzheimer's disease, but not greater lifespan. Neuropathologic differences across ethnoracial groups supported differences in tau pathology distribution and coexisting hippocampal sclerosis, which may impact biomarker studies. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 18, 2019 Category: Geriatrics Source Type: research

Hospitalization, surgery, and incident dementia
DiscussionWe confirm hospitalization as a risk factor for dementia, with repeated hospitalizations a more important risk factor than surgery. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 16, 2019 Category: Geriatrics Source Type: research

Staging biomarkers in preclinical autosomal dominant Alzheimer's disease by estimated years to symptom onset
DiscussionDuration of each preclinical stage can be estimated in ADAD, facilitating better planning of prevention trials with the EYO cutoffs under the recently released FDA guidance. The generalization of these results to sporadic AD warrants further investigation. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 15, 2019 Category: Geriatrics Source Type: research

GeneMatch: A novel recruitment registry using at-home APOE genotyping to enhance referrals to Alzheimer's prevention studies
DiscussionGeneMatch, the first trial-independent research enrollment program designed to recruit and refer cognitively healthy adults to AD prevention studies based in part on APOE test results, provides a novel mechanism to accelerate prescreening and enrollment for AD prevention trials. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 13, 2019 Category: Geriatrics Source Type: research

Clinical and cortical decline in the aphasic variant of Alzheimer's disease
DiscussionPreferential language network neurodegeneration is present in PPA irrespective of amyloid status. Clinical and anatomical progression appears to differ for PPA due to Alzheimer's disease versus non–Alzheimer's disease neuropathology, a distinction that may help to inform prognosis and the design of intervention trials. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 12, 2019 Category: Geriatrics Source Type: research

Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)
We report a family with a novel variant in PSEN1.MethodsWe performed clinical and genetic evaluation of 93 related individuals from a Colombian admixed population. 31 individuals had whole-genome sequencing.ResultsGenetic analysis revealed a missense variant in PSEN1 (NM_000021.3: c.1247T>C p.Ile416Thr), which originated on an African haplotype and segregated with AD logarithm of the odds score of 6. Their clinical phenotype is similar to sporadic AD except for earlier age at onset: the mean age at onset for mild cognitive impairment was 47.6 years (standard deviation 5.83) and for dementia 51.6 years (standard deviation...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 11, 2019 Category: Geriatrics Source Type: research

Erratum to “Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies” [Alzheimer’s & Dementia 2018;14:707-22.]
Publication date: February 2019Source: Alzheimer's & Dementia, Volume 15, Issue 2Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 6, 2019 Category: Geriatrics Source Type: research

Erratum to “Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults” [Alzheimer's & Dementia 2018;14:1640-50.]
Publication date: February 2019Source: Alzheimer's & Dementia, Volume 15, Issue 2Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 6, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: February 2019Source: Alzheimer's & Dementia, Volume 15, Issue 2Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - February 6, 2019 Category: Geriatrics Source Type: research