Brain atrophy in primary age-related tauopathy is linked to transactive response DNA-binding protein of 43 kDa
DiscussionTDP-43 is associated with greater brain atrophy in PART. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 3, 2019 Category: Geriatrics Source Type: research

Inflammatory biomarkers in Alzheimer's disease plasma
DiscussionPlasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 30, 2019 Category: Geriatrics Source Type: research

Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials
DiscussionReducing participant burden, while ensuring that technological tools are suitable for older individuals, maintaining face-to-face contacts, and taking into account participant characteristics may increase adherence in future trials. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 30, 2019 Category: Geriatrics Source Type: research

Mitigating stigma of Alzheimer's disease dementia among Chinese Americans
Publication date: Available online 25 April 2019Source: Alzheimer's & DementiaAuthor(s): Benjamin K.P. Woo, Siubak Chung, Gina Woo, Jamie O.P. Chung (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 26, 2019 Category: Geriatrics Source Type: research

Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations
Publication date: Available online 25 April 2019Source: Alzheimer's & DementiaAuthor(s): Michael J. Thrippleton, Walter H. Backes, Steven Sourbron, Michael Ingrisch, Matthias J.P. van Osch, Martin Dichgans, Franz Fazekas, Stefan Ropele, Richard Frayne, Robert J. van Oostenbrugge, Eric E. Smith, Joanna M. WardlawAbstractCerebral small vessel disease (cSVD) comprises pathological processes of the small vessels in the brain that may manifest clinically as stroke, cognitive impairment, dementia, or gait disturbance. It is generally accepted that endothelial dysfunction, including blood-brain barrier (BBB) failure, is pivotal i...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 26, 2019 Category: Geriatrics Source Type: research

A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment
DiscussionA dose of 30 g/day of kMCT taken for 6 months bypasses a significant part of the brain glucose deficit and improves several cognitive outcomes in MCI. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 23, 2019 Category: Geriatrics Source Type: research

Aaron Klug and the study of Alzheimer's disease
Publication date: Available online 19 April 2019Source: Alzheimer's & DementiaAuthor(s): Michel Goedert (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 20, 2019 Category: Geriatrics Source Type: research

Dementia: Paradigm shifting into high gear
Publication date: Available online 9 April 2019Source: Alzheimer's & DementiaAuthor(s): Vladimir HachinskiAbstractRedressing the rising threat of dementia demands not only an increase, but a diversification of efforts. We need new approaches, trials, and partners. We cannot afford to continue to only round up the usual suspects, β amyloid, and tau and try to stop them with a single drug “silver bullet”. Dementia of late onset is not a disease, but an amalgam of interactive pathologies on the shifting background of aging, requiring multimodal targeting. Cerebrovascular diseases coexist and coact with all major neurodeg...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 10, 2019 Category: Geriatrics Source Type: research

Erratum to “Validation of a simple severity scale for assessing ARIA-E” [Alzheimer’s & Dementia 2017;13:P253-4.]
Publication date: Available online 9 April 2019Source: Alzheimer's & DementiaAuthor(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 10, 2019 Category: Geriatrics Source Type: research

Targeting Alzheimer's Disease in the Preclinical Stage
Publication date: April 2019Source: Alzheimer's & Dementia, Volume 15, Issue 4Author(s): Eric McDade, Ann Marie Hake, Lisa J. Bain, Maria Carrillo (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 9, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: April 2019Source: Alzheimer's & Dementia, Volume 15, Issue 4Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 9, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: April 2019Source: Alzheimer's & Dementia, Volume 15, Issue 4Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 9, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: April 2019Source: Alzheimer's & Dementia, Volume 15, Issue 4Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 9, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: April 2019Source: Alzheimer's & Dementia, Volume 15, Issue 4Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 9, 2019 Category: Geriatrics Source Type: research

Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study
DiscussionAll four CSF biomarkers increase with age, but this effect deviates in AD for t-tau and p-tau. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - April 7, 2019 Category: Geriatrics Source Type: research