Alzheimer's and Dementia: The Journal of the Alzheimer's Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype
DiscussionEstimates of AD disease duration become more accurate if age, sex, setting, APOE, and cerebrospinal fluid tau are taken into account. This will be relevant for clinical practice and trial design. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 2, 2019 Category: Geriatrics Source Type: research

Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging
DiscussionWe empirically identified three neuropsychological subtypes of MCI that share some features with MCI subtypes identified in the Alzheimer's Disease Neuroimaging Initiative. The fourth subtype with SCI in the Mayo Clinic Study of Aging differed from the fourth cluster-derived normal group in Alzheimer's Disease Neuroimaging Initiative and could represent a group to target with early interventions. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 23, 2019 Category: Geriatrics Source Type: research

Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease
DiscussionFor the first time, we demonstrated that the pleiotropic biological effect of the APOE ε4 allele impacts the dynamic trajectory of the DMN during aging. Dynamic functional biomarkers may become useful surrogate outcomes for the development of preclinical targeted therapeutic interventions. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 19, 2019 Category: Geriatrics Source Type: research

Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease
DiscussionOur results encourage an independent validation cohort study to confirm the indication that the plasma Aβ1–40/Aβ1–42 ratio, assessed via Simoa, may improve future standard of care and clinical trial design. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 19, 2019 Category: Geriatrics Source Type: research

Comparison of 18F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL® approaches: Validation against histopathology
DiscussionQuantification of 18F-florbetaben positron emission tomography scans using magnetic resonance–based and magnetic resonance–less CapAIBL® approaches showed high agreement, establishing a pathology-based threshold in CL. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 15, 2019 Category: Geriatrics Source Type: research

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint
We examined associations between cognition, clinical functioning, and magnetic resonance imaging volumes.ResultsNIH-EXAMINER scores detected baseline and differences in slopes between carriers and noncarriers, even in carriers with a baseline Clinical Dementia Rating scale plus NACC FTLD Module = 0. NIH-EXAMINER declines were associated with worsening clinical symptoms and brain volume loss.DiscussionThe NIH-EXAMINER is sensitive to cognitive changes in presymptomatic familial FTLD and is a promising surrogate endpoint. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 12, 2019 Category: Geriatrics Source Type: research

AAIC Satellite Symposium explores Alzheimer's disease research in South Asia
Publication date: May 2019Source: Alzheimer's & Dementia, Volume 15, Issue 5Author(s): Vijayalakshmi Ravindranath, Naren Rao, Lisa J. Bain, Heather M. Snyder, Maria C. Carrillo (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 9, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: May 2019Source: Alzheimer's & Dementia, Volume 15, Issue 5Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 9, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: May 2019Source: Alzheimer's & Dementia, Volume 15, Issue 5Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 9, 2019 Category: Geriatrics Source Type: research

Subscriber information
Publication date: May 2019Source: Alzheimer's & Dementia, Volume 15, Issue 5Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 9, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: May 2019Source: Alzheimer's & Dementia, Volume 15, Issue 5Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 9, 2019 Category: Geriatrics Source Type: research

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.ResultsEight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, gl...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 9, 2019 Category: Geriatrics Source Type: research

The MOPEAD project: Advancing patient engagement for the detection of “hidden” undiagnosed cases of Alzheimer's disease in the community
This article describes the design of the Models of Patient Engagement for Alzheimer's Disease project, an ongoing EU-funded public-private multinational initiative that will compare four innovative patient engagement strategies across five European countries regarding their ability to identify individuals with prodromal AD and mild AD dementia, which are “hidden” in their communities and traditionally not found in the typical memory clinic setting. The strategies include an online AD citizen science platform, an open house initiative at the memory clinics, and patient engagement at primary care and diabetologist clinic...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 8, 2019 Category: Geriatrics Source Type: research

Erratum to “Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice” [Alzheimer’s & Dementia 2016;12:1273-87.]
Publication date: Available online 4 May 2019Source: Alzheimer's & DementiaAuthor(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 5, 2019 Category: Geriatrics Source Type: research

Urate and risk of Alzheimer's disease and vascular dementia: A population-based study
We examined whether sU (determined in 1968–1969 and 1992–1994) is associated with risk of late-life dementia.ResultsDuring 44 years of follow-up, a higher sU (per standard deviation of 76.5 μmol/L) was associated with lower risk for dementia (n = 320; hazard ratio [HR] 0.81; confidence interval [CI] 0.72–0.91), Alzheimer's disease (n = 152; HR 0.78; CI 0.66–0.91), and vascular dementia (n = 52; HR 0.66; CI 0.47–0.94).DiscussionOur findings support the hypothesis that sU has a protective role in the development of dementia, regardless of dementia subtype. This may have important implications in the treatme...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - May 3, 2019 Category: Geriatrics Source Type: research