Letter: sprue ‐like enteropathy associated with angiotensin II receptor blockers other than olmesartan
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: M. Zanelli, A. Negro, R. Santi, A. Bisagni, M. Ragazzi, S. Ascani, L. De Marco Tags: LETTER TO THE EDITOR Source Type: research

Letter: clinical response to pioglitazone in nonalcoholic steatohepatitis [NASH] treatment —use of pharmacokinetic surrogate
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: N. R. Srinivas Tags: LETTER TO THE EDITOR Source Type: research

Letter: Mendelian randomisation to investigate moderate alcohol consumption in nonalcoholic fatty liver disease; modest effects need large numbers —authors' reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: S. Sookoian, C. J. Pirola Tags: LETTER TO THE EDITOR Source Type: research

Letter: Mendelian randomisation to investigate moderate alcohol consumption in nonalcoholic fatty liver disease; modest effects need large numbers
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: C. A. Parisinos Tags: LETTER TO THE EDITOR Source Type: research

Editorial: migration studies to determine risk and cause of inflammatory bowel disease —authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: Oriana M. Damas, Seth J. Schwartz, Maria T. Abreu Tags: INVITED EDITORIAL Source Type: research

Editorial: migration studies to determine risk and cause of inflammatory bowel disease
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: M. E. Kuenzig, E. I. Benchimol Tags: INVITED EDITORIAL Source Type: research

Editorial: different tests for different drugs in Crohn ’s disease, or different tests for different people? Authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: M. G. Ward, P. M. Irving Tags: INVITED EDITORIAL Source Type: research

Editorial: different tests for different drugs in Crohn ’s disease, or different tests for different people?
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: C. H. Seow, R. Panaccione Tags: INVITED EDITORIAL Source Type: research

Editorial: mesalazine to prevent recurrent acute diverticulitis —the final nail in the coffin. Authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: W. Kruis, R. Greinwald Tags: INVITED EDITORIAL Source Type: research

Editorial: mesalazine to prevent recurrent acute diverticulitis —the final nail in the coffin
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: D. J. Gracie, A. C. Ford Tags: INVITED EDITORIAL Source Type: research

Editorial: liver transplantation in patients with non ‐alcoholic fatty liver disease and obesity—authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: M. Barone, M. T. Viggiani, G. Losurdo, M. Principi, G. Leandro, A. Di Leo Tags: INVITED EDITORIAL Source Type: research

Editorial: liver transplantation in patients with non ‐alcoholic fatty liver disease and obesity
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: S. A. Townsend, P. N. Newsome Tags: INVITED EDITORIAL Source Type: research

Editorial: changing nature of paediatric IBD —new insights from Irish data. Author's reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: S. Hussey Tags: INVITED EDITORIAL Source Type: research

Editorial: changing nature of paediatric IBD —new insights from Irish data
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 14, 2017 Category: Drugs & Pharmacology Authors: A. E. Wiskin, B. K. Sandhu Tags: INVITED EDITORIAL Source Type: research

Tenofovir disoproxil fumarate significantly decreases serum lipoprotein levels compared with entecavir nucleos(t)ide analogue therapy in chronic hepatitis B carriers
Summary BackgroundTenofovir disoproxil fumarate (TDF) and entecavir (ETV) are first‐line treatments for chronic hepatitis B (CHB). Studies suggest lipid lowering effect of TDF in human immunodeficiency virus positive (HIV+) individuals, but the effect on lipids and cardiovascular disease (CVD) risk in CHB is unknown. AimTo compare TDF vs ETV effects on lipid levels in CHB. MethodsIn this retrospective cohort study, data on serum lipids and CVD risk factors at baseline and ~1 year on TDF or ETV were collected from CHB carriers. We used propensity score matched models to assess the effect on total cholesterol (TC), LD...
Source: Alimentary Pharmacology and Therapeutics - July 13, 2017 Category: Drugs & Pharmacology Authors: A. A. Shaheen, M. AlMattooq, S. Yazdanfar, K. W. Burak, M. G. Swain, S. E. Congly, M. A. Borman, S. S. Lee, R. P. Myers, C. S. Coffin Tags: ORIGINAL ARTICLE Source Type: research

Performance characteristics of serum C4 and FGF19 measurements to exclude the diagnosis of bile acid diarrhoea in IBS ‐diarrhoea and functional diarrhoea
ConclusionsAmong 101 patents with IBS‐D, fasting FGF19 and C4 levels had good specificity and negative predictive value, suggesting utility as screening tests to exclude bile acid diarrhoea. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 10, 2017 Category: Drugs & Pharmacology Authors: P. Vijayvargiya, M. Camilleri, P. Carlson, A. Lueke, J. O'Neill, D. Burton, I. Busciglio, L. Donato Tags: ORIGINAL ARTICLE Source Type: research

Effectiveness of 8 ‐ or 12‐weeks of ledipasvir and sofosbuvir in real‐world treatment‐naïve, genotype 1 hepatitis C infected patients
Summary BackgroundTreatment of genotype 1 hepatitis C virus (HCV) infection with combination direct acting anti‐virals is associated with very high rates of sustained virological response (SVR). Daily combination of ledipasvir and sofosbuvir for 12 weeks is approved for the treatment of genotype 1 HCV patients, though noncirrhotic patients who are naïve to treatment with a baseline HCV RNA
Source: Alimentary Pharmacology and Therapeutics - July 10, 2017 Category: Drugs & Pharmacology Authors: M. P. Curry, E. B. Tapper, B. Bacon, D. Dieterich, S. L. Flamm, L. Guest, K. V. Kowdley, Y. Lee, S. Milligan, N. Tsai, Z. Younossi, N. H. Afdhal Tags: ORIGINAL ARTICLE Source Type: research

Review article: new treatments in non ‐alcoholic fatty liver disease
ConclusionsRising demand and an improved understanding of NASH pathophysiology has led to a surge in development of new therapies. Tailoring pharmacotherapy to the dominant pathogenic pathway in a given patient along with use of combination therapy is likely to represent the future direction in treatment of patients with NASH. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 5, 2017 Category: Drugs & Pharmacology Authors: S. A. Townsend, P. N. Newsome Tags: REVIEW ARTICLE Source Type: research

Letter: functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohort —methodological issues to avoid misinterpretation. Authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: L. Wauters, S. Nightingale, M. Jones, N. J. Talley, M. M. Walker Tags: LETTERS TO THE EDITORS Source Type: research

Letter: functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohort —methodological issues to avoid misinterpretation
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: S. Safiri, E. Ayubi Tags: LETTERS TO THE EDITORS Source Type: research

Letter: bias in clinical trials of the symptomatic effects of the low FODMAP diet for irritable bowel syndrome —getting the facts right. Authors' reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: L. R. Krogsgaard, M. Lyngesen, P. Bytzer Tags: LETTERS TO THE EDITORS Source Type: research

Letter: bias in clinical trials of the symptomatic effects of the low FODMAP diet for irritable bowel syndrome —getting the facts right
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: P. R. Gibson, E. P. Halmos, J. G. Muir Tags: LETTERS TO THE EDITORS Source Type: research

Letter: autoimmune hepatitis —drug‐induced liver injury must always be excluded. Authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: H. Gr ønbæk, H. J. Møller, H. Vistrup Tags: LETTERS TO THE EDITORS Source Type: research

Letter: autoimmune hepatitis —drug‐induced liver injury must always be excluded
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: X. Fan, T. Wang, L. Yang Tags: LETTERS TO THE EDITORS Source Type: research

Letter: complications of percutaneous liver biopsy with Klatskin needles —methodological issues. Authors’ Reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: V. Takyar, C. Koh Tags: LETTERS TO THE EDITORS Source Type: research

Letter: complications of percutaneous liver biopsy with Klatskin needles —methodological issues
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: E. Ayubi, M. J. M. Sullman, S. Safiri Tags: LETTERS TO THE EDITORS Source Type: research

Editorial: hepatitis C direct acting antiviral agents and the kidney —authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: R. Maan, J. J. Feld, A. Duarte ‐Rojo Tags: INVITED EDITORIALS Source Type: research

Editorial: hepatitis C direct acting anti ‐viral agents and the kidney
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: T. Hussaini, E. M. Yoshida Tags: INVITED EDITORIALS Source Type: research

Editorial: new insights into the relationship between the intestine and non ‐alcoholic fatty liver—is “fatty gut” involved in disease progression?
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: L. Valenti, S. Romeo Tags: INVITED EDITORIALS Source Type: research

Editorial: the risk of cancer in patients with gastric intestinal metaplasia —Authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: R. Pittayanon, A. Barkun Tags: INVITED EDITORIALS Source Type: research

Editorial: the risk of cancer in patients with gastric intestinal metaplasia
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: Ernst J. Kuipers Tags: INVITED EDITORIALS Source Type: research

Editorial: gut selective immunosuppression —is it a double edged sword? Authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: W. A. Bye, V. Jairath, S. P. L. Travis Tags: INVITED EDITORIALS Source Type: research

Editorial: gut selective immunosuppression —is it a double edged sword?
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: J. Sheridan, G. A. Doherty Tags: INVITED EDITORIALS Source Type: research

Editorial: volatile organic compounds in breath for monitoring IBD —longitudinal studies are essential. Authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: A. Smolinska, F. J. Schooten Tags: INVITED EDITORIALS Source Type: research

Editorial: volatile organic compounds in breath for monitoring IBD —longitudinal studies are essential
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 4, 2017 Category: Drugs & Pharmacology Authors: H. R. T. Williams, T. R. Orchard Tags: INVITED EDITORIALS Source Type: research

Mixture model analysis identifies irritable bowel syndrome subgroups characterised by specific profiles of gastrointestinal, extraintestinal somatic and psychological symptoms
ConclusionsThis model‐based subgrouping of IBS partly supports the distinction of subgroups based on bowel habits, but additionally distinguishes subgroups with or without co‐morbid extraintestinal somatic and psychological symptoms. The resulting groups show specific profiles of symptom combinations. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 1, 2017 Category: Drugs & Pharmacology Authors: A. Polster, L. Van Oudenhove, M. Jones, L. Öhman, H. Törnblom, M. Simrén Tags: ORIGINAL ARTICLE Source Type: research

The outcome of ulcerative colitis patients undergoing pouch surgery is determined by pre ‐surgical factors
ConclusionsMost patients with UC undergoing pouch surgery will develop pouchitis. Patients operated for nonrefractory indications have a more favourable outcome. These results may contribute to pre‐ and post‐surgical decision‐making. The findings imply that the processes determining UC severity may be similar to that causing pouchitis. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 30, 2017 Category: Drugs & Pharmacology Authors: H. Yanai, S. Ben ‐Shachar, L. Mlynarsky, L. Godny, M. Leshno, H. Tulchinsky, I. Dotan Tags: ORIGINAL ARTICLE Source Type: research

Randomised clinical trial: sofosbuvir and ledipasvir in patients with transfusion ‐dependent thalassaemia and HCV genotype 1 or 4 infection
ConclusionsIn conclusion, SOF/LDV for 12 weeks provides simple, highly effective and safe Peg‐IFN/RBV‐free treatment for HCV GT1/4 thalassaemia patients. EUDRACT number 2015‐002401‐1. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 29, 2017 Category: Drugs & Pharmacology Authors: A. Mangia, R. Sarli, R. Gamberini, A. Piga, G. Cenderello, V. Piazzolla, R. Santoro, V. Caruso, A. Quarta, R. Ganga, M. Copetti, G. Forni Tags: RANDOMISED CLINICAL TRIAL Source Type: research

Review article: dyssynergic defaecation and biofeedback therapy in the pathophysiology and management of functional constipation
ConclusionsDyssynergic defaecation is a common clinical condition in patients with chronic constipation not responding to conservative management. Biofeedback therapy appears to be a safe, successful treatment with sustained results for patients with dyssynergic defaecation. Further studies are required to standardise the diagnosis of dyssynergic defaecation in addition to employing systematic protocols for biofeedback therapy. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 29, 2017 Category: Drugs & Pharmacology Authors: G. R. Skardoon, A. J. Khera, A. V. Emmanuel, R. E. Burgell Tags: REVIEW ARTICLE Source Type: research

Systematic review with meta ‐analysis: the efficacy of probiotics in inflammatory bowel disease
ConclusionsVSL#3 may be effective in inducing remission in active UC. Probiotics may be as effective as 5‐ASAs in preventing relapse of quiescent UC. The efficacy of probiotics in CD remains uncertain, and more evidence from RCTs is required before their utility is known. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 27, 2017 Category: Drugs & Pharmacology Authors: Y. Derwa, D. J. Gracie, P. J. Hamlin, A. C. Ford Tags: SYSTEMATIC REVIEW WITH META ‐ANALYSIS Source Type: research

The development of a magnetic resonance imaging index for fistulising Crohn's disease
ConclusionsAlthough “almost perfect” intra‐rater reliability was observed for the assessment of MRI images for fistulising CD using the Van Assche index, inter‐rater reliability was considerably lower. Our modification of this index should result in a more optimal instrument. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 27, 2017 Category: Drugs & Pharmacology Authors: M. A. Samaan, C. A. J. Puylaert, B. G. Levesque, G. Y. Zou, L. Stitt, S. A. Taylor, L. M. Shackelton, M. K. Vandervoort, R. Khanna, C. Santillan, J. Rimola, P. Hindryckx, C. Y. Nio, W. J. Sandborn, G. D'Haens, B. G. Feagan, V. Jairath, J. Stoker Tags: ORIGINAL ARTICLE Source Type: research

Systematic review: health ‐related quality of life in children and adults with eosinophilic oesophagitis—instruments for measurement and determinant factors
ConclusionsHRQoL is a relevant outcome that should be considered in clinical practice and research of EoE. Further validation studies in several languages and populations are required to support the use of disease‐specific HRQoL measures. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 22, 2017 Category: Drugs & Pharmacology Authors: A. J. Lucendo, L. Arias ‐González, J. Molina‐Infante, Á. Arias Tags: SYSTEMATIC REVIEW Source Type: research

No evidence of hepatitis B virus reactivation in patients with resolved infection treated with direct ‐acting antivirals for hepatitis C in a large real‐world cohort
Summary BackgroundHepatitis B virus (HBV) reactivation has been observed following interferon (IFN)‐based treatment in HBV/hepatitis C virus (HCV) co‐infected patients. Recent reports suggest that reactivation may also occur in both hepatitis B surface antigen (HBsAg)‐positive and HBsAg‐negative patients during HCV treatment with direct‐acting antivirals (DAAs). AimTo investigate the rate of patients with HBV reactivation during IFN‐based and IFN‐free HCV treatment in a large real‐world cohort. MethodsA total of 848 patients with chronic hepatitis C were treated with different combinations of DAAs. Among pa...
Source: Alimentary Pharmacology and Therapeutics - June 19, 2017 Category: Drugs & Pharmacology Authors: V. T. M ücke, M. M. Mücke, K.‐H. Peiffer, N. Weiler, T. M. Welzel, C. Sarrazin, S. Zeuzem, A. Berger, J. Vermehren Tags: ORIGINAL ARTICLE Source Type: research

Lack of immunogenicity of hydrolysed wheat flour in patients with coeliac disease after a short ‐term oral challenge
Summary BackgroundA gluten‐free diet is currently the only reliable therapeutic strategy that is approved for coeliac disease (CD). For many patients, however, compliance remains inadequate. AimTo investigate the immunogenicity of wheat flour that was pre‐treated with selected lactobacilli and fungal proteases (hydrolysed wheat gluten) in coeliac patients. MethodsThe immunogenicity of hydrolysed wheat gluten was evaluated both in vitro in intestinal T cell lines (TCLs) and in vivo in treated CD patients after a short‐term gluten challenge. Twenty treated CD patients were enrolled and equally randomised into two group...
Source: Alimentary Pharmacology and Therapeutics - June 19, 2017 Category: Drugs & Pharmacology Authors: R. Mandile, S. Picascia, C. Parrella, A. Camarca, M. Gobbetti, L. Greco, R. Troncone, C. Gianfrani, R. Auricchio Tags: ORIGINAL ARTICLE Source Type: research

Letter: anti ‐TNF dose de‐escalation in Crohn's disease—a case‐by‐case decision
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 15, 2017 Category: Drugs & Pharmacology Authors: N. Imperatore, A. Testa, N. Caporaso, A. Rispo Tags: LETTERS TO THE EDITORS Source Type: research

Letter: HBV/HCV coinfection in the era of direct ‐acting antivirals
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 15, 2017 Category: Drugs & Pharmacology Authors: C. ‐S. Hsu, P.‐C. Wang, C.‐H. Li, H. H. Lin Tags: LETTERS TO THE EDITORS Source Type: research

Letter: the efficacy of oltipraz in patients with non ‐alcoholic fatty liver disease has not been confirmed—authors’ reply
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 15, 2017 Category: Drugs & Pharmacology Authors: W. Kim, Y. J. Kim Tags: LETTERS TO THE EDITORS Source Type: research

Letter: the efficacy of oltipraz in patients with non ‐alcoholic fatty liver disease has not been confirmed
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 15, 2017 Category: Drugs & Pharmacology Authors: S. Y. Wang, J. Lin Tags: LETTERS TO THE EDITORS Source Type: research

Letter: the influence of direct acting agents for hepatitis C, on hepatitis B reactivation
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 15, 2017 Category: Drugs & Pharmacology Authors: C. ‐C. Wang, J.‐H. Kao Tags: LETTERS TO THE EDITORS Source Type: research

Editorial: food for thought —the low‐FODMAP diet and IBS in perspective
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 15, 2017 Category: Drugs & Pharmacology Authors: E. M. M. Quigley Tags: INVITED EDITORIALS Source Type: research