Letter: extensive intestinal metaplasia is associated with the presence of incomplete intestinal metaplasia subtype and could be an easier marker for high risk of gastric cancer Authors' reply
This article is linked to Pittayanon et al and Quach and Hiyama papers. To view these articles visit https://doi.org/10.1111/apt.14082 and https://doi.org/10.1111/apt.14553. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: R. Pittayanon, A. Barkun Tags: LETTER TO THE EDITORS Source Type: research

Letter: extensive intestinal metaplasia is associated with the presence of incomplete intestinal metaplasia subtype and could be an easier marker for high risk of gastric cancer
This article is linked to Pittayanon et al and Pittayanon and Barkun papers. To view these articles visit https://doi.org/10.1111/apt.14082 and https://doi.org/10.1111/apt.14555. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: D. T. Quach, T. Hiyama Tags: LETTER TO THE EDITORS Source Type: research

Letter: predicting azathioprine ‐associated pancreatitis in IBD—phenotype or genotype? Authors' reply
This article is linked to Wilson et al and Teich et al papers. To view these articles visit https://doi.org/10.1111/apt.14483 and https://doi.org/10.1111/apt.14562. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: A. Wilson, L. E. Jansen, R. V. Rose, J. C. Gregor, T. Ponich, N. Chande, R. Khanna, B. Yan, V. Jairath, N. Khanna, M. Sey, M. Beaton, K. McIntosh, W. A. Teft, R. B. Kim Tags: LETTER TO THE EDITORS Source Type: research

Letter: predicting azathioprine ‐associated pancreatitis in IBD—phenotype or genotype?
This article is linked to Wilson et al papers. To view these articles visit https://doi.org/10.1111/apt.14483 and https://doi.org/10.1111/apt.14562. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: N. Teich, T. Bruns, A. Stallmach Tags: LETTER TO THE EDITORS Source Type: research

Letter: the addition of an immunosuppressant in patients with unsatisfactory response to vedolizumab —Authors' reply
This article is linked to Strik et al and Macaluso et al papers. To view these articles visit https://doi.org/10.1111/apt.13994 and https://doi.org/10.1111/apt.14541. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: A. S. Strik, G. R. D'Haens Tags: LETTER TO THE EDITORS Source Type: research

Letter: the addition of an immunosuppressant in patients with unsatisfactory response to vedolizumab
This article is linked to Strik et al and Strik and D'Haens papers. To view these articles visit https://doi.org/10.1111/apt.13994 and https://doi.org/10.1111/apt.14570. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: F. S. Macaluso, R. Orlando, S. Renna, C. Sapienza, M. Ventimiglia, G. Rizzuto, M. Cottone, A. Orlando Tags: LETTER TO THE EDITORS Source Type: research

Editorial: weight change, liver histology and the metabolic effects of obeticholic acid in NASH
This article is linked to Hameed et al paper. To view this article visit https://doi.org/10.1111/apt.14492. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: M. Eslam, J. George Tags: INVITED EDITORIAL Source Type: research

Editorial: NAFLD in Asia —clinical associations with advanced disease become clearer. Authors' reply
This article is linked to Chan et al and Hardy and McPherson papers. To view these articles visit https://doi.org/10.1111/apt.14506 and https://doi.org/10.1111/apt.14557. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: W. ‐K. Chan, Y. Y. Dan, V. W.‐S. Wong, Tags: INVITED EDITORIAL Source Type: research

Editorial: NAFLD in Asia —clinical associations with advanced disease become clearer
This article is linked to Chan et al papers. To view these articles visit https://doi.org/10.1111/apt.14506 and https://doi.org/10.1111/apt.14572. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: T. Hardy, S. McPherson Tags: INVITED EDITORIAL Source Type: research

Editorial: older ‐onset inflammatory bowel disease—is it time to start looking beyond a number?
This article is linked to Mañosa et al paper. To view this paper visit https://doi.org/10.1111/apt.14494. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: S. Taleban Tags: INVITED EDITORIAL Source Type: research

Editorial: ulcerative colitis submucosal fibrosis and inflammation: more than just strictures
This article is linked to Gordon et al paper. To view this article visit https://doi.org/10.1111/apt.14526. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: F. Magro, H. T. Sousa Tags: INVITED EDITORIAL Source Type: research

Editorial: clinical trials in IBD —how much of a difference is enough?
This article is linked to Olivera et al paper. To view this article visit https://doi.org/10.1111/apt.14514. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Authors: M. P. Sparrow Tags: INVITED EDITORIAL Source Type: research

Issue Information
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 7, 2018 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Proton pump inhibitor use and risk of hip fractures among community ‐dwelling persons with Alzheimer's disease—a nested case‐control study
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1135-1142, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 6, 2018 Category: Drugs & Pharmacology Source Type: research

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Alimentary Pharmacology&Therapeutics, Ahead of Print. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 6, 2018 Category: Drugs & Pharmacology Source Type: research

The adverse effects of interferon ‐free regimens in 149 816 chronic hepatitis C treated Egyptian patients
Alimentary Pharmacology&Therapeutics, EarlyView. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 5, 2018 Category: Drugs & Pharmacology Source Type: research

Faecal calprotectin effectively excludes inflammatory bowel disease in 789 symptomatic young adults with/without alarm symptoms: a prospective UK primary care cohort study
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1103-1116, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 5, 2018 Category: Drugs & Pharmacology Source Type: research

Systematic review: adrenal insufficiency secondary to swallowed topical corticosteroids in eosinophilic oesophagitis
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1071-1078, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 5, 2018 Category: Drugs & Pharmacology Source Type: research

The adverse effects of interferon ‐free regimens in 149 816 chronic hepatitis C treated Egyptian patients
Alimentary Pharmacology&Therapeutics, EarlyView. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 5, 2018 Category: Drugs & Pharmacology Source Type: research

Faecal calprotectin effectively excludes inflammatory bowel disease in 789 symptomatic young adults with/without alarm symptoms: a prospective UK primary care cohort study
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1103-1116, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 5, 2018 Category: Drugs & Pharmacology Source Type: research

Systematic review: adrenal insufficiency secondary to swallowed topical corticosteroids in eosinophilic oesophagitis
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1071-1078, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 5, 2018 Category: Drugs & Pharmacology Source Type: research

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Alimentary Pharmacology&Therapeutics, Ahead of Print. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 5, 2018 Category: Drugs & Pharmacology Source Type: research

Faecal calprotectin effectively excludes inflammatory bowel disease in 789 symptomatic young adults with/without alarm symptoms: a prospective UK primary care cohort study
ConclusionsCalprotectin testing of young adults with suspected IBD in primary care accurately distinguishes IBD from functional gut disorder, even in patients with gastrointestinal alarm symptoms and reduces secondary care referrals and diagnostic healthcare costs. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 5, 2018 Category: Drugs & Pharmacology Authors: G. J. Walker, L. Moore, N. Heerasing, P. Hendy, M. H. Perry, T. J. McDonald, T. Debenham, R. Bethune, C. Bewshea, C. Hyde, G. A. Heap, A. Singh, C. Calvert, N. A. Kennedy, J. R. Goodhand, T. Ahmad Tags: ORIGINAL ARTICLE Source Type: research

Systematic review: adrenal insufficiency secondary to swallowed topical corticosteroids in eosinophilic oesophagitis
ConclusionTopical corticosteroids were associated with adrenal insufficiency in a minority of patients. Most cases came from uncontrolled observational studies, with widely varying definitions of adrenal insufficiency. Longer follow‐up and larger controlled studies are needed to quantify the risk of adrenal insufficiency with maintenance topical corticosteroid therapy in EoE. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 5, 2018 Category: Drugs & Pharmacology Authors: H. Philpott, M. K. Dougherty, C. C. Reed, M. Caldwell, D. Kirk, D. J. Torpy, E. S. Dellon Tags: SYSTEMATIC REVIEW Source Type: research

Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1170-1180, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 2, 2018 Category: Drugs & Pharmacology Source Type: research

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Alimentary Pharmacology&Therapeutics, Ahead of Print. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 2, 2018 Category: Drugs & Pharmacology Source Type: research

Proton pump inhibitor use and risk of hip fractures among community ‐dwelling persons with Alzheimer's disease—a nested case‐control study
Summary BackgroundHip fractures are a major health concern among older persons with Alzheimer's disease, who usually use many concomitant drugs for several diseases. Evidence of the association between proton pump inhibitor use and risk of hip fracture is contradictory. AimTo investigate whether the long‐term use of proton pump inhibitor is associated with risk of hip fractures among community‐dwelling persons with Alzheimer's disease. MethodsIn this nested case‐control study, the nationwide MEDALZ data were utilised. Community‐dwelling persons with Alzheimer's disease who encountered incident hip fracture (N ...
Source: Alimentary Pharmacology and Therapeutics - March 1, 2018 Category: Drugs & Pharmacology Authors: S. Torvinen ‐Kiiskinen, A.‐M. Tolppanen, M. Koponen, A. Tanskanen, J. Tiihonen, S. Hartikainen, H. Taipale Tags: ORIGINAL ARTICLE Source Type: research

The adverse effects of interferon ‐free regimens in 149 816 chronic hepatitis C treated Egyptian patients
Summary BackgroundInterferon‐free regimens are associated with high sustained virological response; however, associated adverse effects have yet to be fully reported. AimTo evaluate the adverse effects associated with the different direct‐acting antiviral drug (DAA) regimens in Egyptian patients. MethodsThis multicenter retrospective study included all adverse effects during and after treatment with DAA regimens of 149 816 chronic hepatitis C treated Egyptian patients. Patients received sofosbuvir (SOF)/ribavirin (RBV) (n = 21 835), SOF/simeprevir (n = 24 215) SOF/daclatasvir (DCV) (n ...
Source: Alimentary Pharmacology and Therapeutics - March 1, 2018 Category: Drugs & Pharmacology Authors: D. Attia, K. El Saeed, W. Elakel, T. Elbaz, A. Omar, A. Yosry, M.  H. Elsayed, M. El Raziky, M. Anees, W. Doss, Y. El Shazly, H. Wedemeyer, G. Esmat Tags: ORIGINAL ARTICLE Source Type: research

Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes
ConclusionTreatment withdrawal in Caucasian chronic hepatitis B patients after nucleos(t)ide analogue‐induced HBeAg seroconversion results in viral relapses in more than half of patients with potential fatal outcomes. These real‐world data further lend support to preferentially continue NA treatment after HBeAg seroconversion until HBsAg loss. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 1, 2018 Category: Drugs & Pharmacology Authors: S. Van Hees, S. Bourgeois, H. Van Vlierberghe, T. Serst é, S. Francque, P. Michielsen, D. Sprengers, H. Reynaert, J. Henrion, S. Negrin Dastis, J. Delwaide, L. Lasser, J. Decaestecker, H. Orlent, F. Janssens, G. Robaeys, I. Colle, P. Stärkel, C. Moreno, Tags: ORIGINAL ARTICLE Source Type: research

Predictors of failure to detect early hepatocellular carcinoma in patients with chronic hepatitis B who received regular surveillance
ConclusionsIn CHB patients undergoing regular surveillance with ultrasonography and alpha‐foetoprotein (AFP) analysis every 6 months, the HCC detection failure rate was not high (0.8% per person; 0.1% per test). However, careful attention should be paid in patients with advanced liver fibrosis (clinical cirrhosis or LS value>11.7 kPa), high AFP levels, or diabetes mellitus, who are prone to surveillance failure. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 1, 2018 Category: Drugs & Pharmacology Authors: Y. E. Chon, K. S. Jung, M. ‐J. Kim, J.‐Y. Choi, C. An, J. Y. Park, S. H. Ahn, B. K. Kim, S. U. Kim, H. Park, S. K. Hwang, K. S. Rim, K.‐H. Han, D. Y. Kim Tags: ORIGINAL ARTICLE Source Type: research

Quantification of the duodenal eosinophil content in adults: a necessary step for an evidence ‐based diagnosis of duodenal eosinophilia
ConclusionsThis study suggests that in this diverse US population, a cut‐off count of 20 eos/hpf would be useful to separate patients with normal from those with elevated duodenal eosinophilic infiltrations. The clinical implications of duodenal eosinophilia, particularly when it is not an expression of eosinophilic gastroenteritis, remain to be established. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 28, 2018 Category: Drugs & Pharmacology Authors: R. M. Genta, A. Sonnenberg, K. Turner Tags: ORIGINAL ARTICLE Source Type: research

Predictors of failure to detect early hepatocellular carcinoma in patients with chronic hepatitis B who received regular surveillance
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1201-1212, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 28, 2018 Category: Drugs & Pharmacology Source Type: research

Carvedilol for reducing portal pressure in primary prophylaxis of variceal bleeding: a dose ‐response study
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1162-1169, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 28, 2018 Category: Drugs & Pharmacology Source Type: research

Predictors of failure to detect early hepatocellular carcinoma in patients with chronic hepatitis B who received regular surveillance
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1201-1212, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 28, 2018 Category: Drugs & Pharmacology Source Type: research

Carvedilol for reducing portal pressure in primary prophylaxis of variceal bleeding: a dose ‐response study
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1162-1169, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 28, 2018 Category: Drugs & Pharmacology Source Type: research

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Alimentary Pharmacology&Therapeutics, Ahead of Print. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 28, 2018 Category: Drugs & Pharmacology Source Type: research

Carvedilol for reducing portal pressure in primary prophylaxis of variceal bleeding: a dose ‐response study
Summary BackgroundSequential measurements of hepatic venous pressure gradient (HVPG) are used to assess the haemodynamic response to nonselective betablockers (NSBBs) in patients with portal hypertension. AimsTo assess the rates of HVPG response to different doses of carvedilol. MethodsConsecutive patients with cirrhosis undergoing HVPG‐guided carvedilol therapy for primary prophylaxis of variceal bleeding between 08/2010 and 05/2015 were retrospectively included. After baseline HVPG measurement, carvedilol 6.25 mg/d was administered and HVPG response (HVPG‐decrease ≥20% or to ≤12 mm Hg) was assessed af...
Source: Alimentary Pharmacology and Therapeutics - February 28, 2018 Category: Drugs & Pharmacology Authors: R. Schwarzer, D. Kivaranovic, R. Paternostro, M. Mandorfer, T. Reiberger, M. Trauner, M. Peck ‐Radosavljevic, A. Ferlitsch Tags: ORIGINAL ARTICLE Source Type: research

Quantification of the duodenal eosinophil content in adults: a necessary step for an evidence ‐based diagnosis of duodenal eosinophilia
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1143-1150, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 27, 2018 Category: Drugs & Pharmacology Source Type: research

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Alimentary Pharmacology&Therapeutics, Ahead of Print. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 27, 2018 Category: Drugs & Pharmacology Source Type: research

An expert consensus for the management of chronic hepatitis B in Asian Americans
Summary BackgroundHepatitis B virus (HBV) infection is common with major clinical consequences. In Asian Americans, the HBsAg carrier rate ranges from 2% to 16% which approximates the rates from their countries of origin. Similarly, HBV is the most important cause of cirrhosis, hepatocellular carcinoma (HCC) and liver related deaths in HBsAg positive Asians worldwide. AimTo generate recommendations for the management of Asian Americans infected with HBV. MethodsThese guidelines are based on relevant data derived from medical reports on HBV from Asian countries as well as from studies in the HBsAg positive Asian Americans. ...
Source: Alimentary Pharmacology and Therapeutics - February 26, 2018 Category: Drugs & Pharmacology Authors: M. J. Tong, C. Q. Pan, S. ‐H. B. Han, D. S.‐K. Lu, S. Raman, K.‐Q. Hu, J. K. Lim, H. W. Hann, A. D. Min Tags: ORIGINAL ARTICLE Source Type: research

An expert consensus for the management of chronic hepatitis B in Asian Americans
Alimentary Pharmacology&Therapeutics,Volume 47, Issue 8, Page 1181-1200, April 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 26, 2018 Category: Drugs & Pharmacology Source Type: research

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Alimentary Pharmacology&Therapeutics, Ahead of Print. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 26, 2018 Category: Drugs & Pharmacology Source Type: research

Low risk of hepatotoxicity from rifampicin when used for cholestatic pruritus: a cross ‐disease cohort study
ConclusionsGiven the efficacy of rifampicin for an important sub‐group of those with cholestatic pruritus, adult patients, including those with jaundice, can be counselled that 95% of prescriptions are safe, and where hepatitis occurs, including at long latency, drug cessation appears effective. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 22, 2018 Category: Drugs & Pharmacology Authors: G. J. Webb, S. R. Rahman, C. Levy, G. M. Hirschfield Tags: ORIGINAL ARTICLE Source Type: research