AJP: Heart and Circulatory Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction
In conclusion, our data provide the evidence that impaired cardiac BCAA catabolism directly contributes to post-MI cardiac dysfunction and remodeling. Moreover, improving cardiac BCAA catabolic defects may be a promising therapeutic strategy against post-MI HF. (Source: AJP: Heart and Circulatory Physiology)
Source: AJP: Heart and Circulatory Physiology - October 31, 2016 Category: Cardiology Authors: Wang, W., Zhang, F., Xia, Y., Zhao, S., Yan, W., Wang, H., Lee, Y., Li, C., Zhang, L., Lian, K., Gao, E., Cheng, H., Tao, L. Tags: Integrative Cardiovascular Physiology and Pathophysiology Source Type: research

Cardiac neural crest ablation results in early endocardial cushion and hemodynamic flow abnormalities
In this study, using a CNCC-ablated quail model, we contribute quantitative phenotyping of CNCC ablation-related CHDs and investigate abnormal early cardiac function, which potentially contributes to late-stage CHDs. Optical coherence tomography was used to assay early- and late-stage embryos and hearts. In CNCC-ablated embryos at four-chambered heart stages, great vessel diameter and left atrioventricular valve leaflet volumes are reduced. Earlier, at cardiac looping stages, CNCC-ablated embryos exhibit abnormally twisted bodies, abnormal blood flow waveforms, increased retrograde flow percentage, and abnormal cardiac cus...
Source: AJP: Heart and Circulatory Physiology - October 31, 2016 Category: Cardiology Authors: Ma, P., Gu, S., Karunamuni, G. H., Jenkins, M. W., Watanabe, M., Rollins, A. M. Tags: Integrative Cardiovascular Physiology and Pathophysiology Source Type: research

Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors
Histone deacetylase (HDAC) inhibitors are small molecule anticancer therapeutics that exhibit limiting cardiotoxicities including QT interval prolongation and life-threatening cardiac arrhythmias. Because the molecular mechanisms for HDAC inhibitor-induced cardiotoxicity are poorly understood, we performed whole cell patch voltage-clamp experiments to measure cardiac sodium currents (INa) from wild-type neonatal mouse ventricular or human-induced pluripotent stem cell-derived cardiomyocytes treated with trichostatin A (TSA), vorinostat (VOR), or romidepsin (FK228). All three pan-HDAC inhibitors dose dependently decreased p...
Source: AJP: Heart and Circulatory Physiology - October 31, 2016 Category: Cardiology Authors: Xu, Q., Patel, D., Zhang, X., Veenstra, R. D. Tags: Cardiac Excitation and Contraction Source Type: research

Pathways for insulin access to the brain: the role of the microvascular endothelial cell
Insulin affects multiple important central nervous system (CNS) functions including memory and appetite, yet the pathway(s) by which insulin reaches brain interstitial fluid (bISF) has not been clarified. Recent studies demonstrate that to reach bISF, subarachnoid cerebrospinal fluid (CSF) courses through the Virchow-Robin space (VRS) which sheaths penetrating pial vessels down to the capillary level. Whether insulin predominantly enters the VRS and bISF by local transport through the blood-brain barrier, or by being secreted into the CSF by the choroid plexus, is unknown. We injected 125I-TyrA14-insulin or regular insulin...
Source: AJP: Heart and Circulatory Physiology - October 31, 2016 Category: Cardiology Authors: Meijer, R. I., Gray, S. M., Aylor, K. W., Barrett, E. J. Tags: Call for Papers: Small Vessels Big Problems Source Type: research

Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: Pathomechanisms, perspectives, and therapeutic implications
Traumatic brain injury (TBI) is a major health problem worldwide. In addition to its high mortality (35–40%), survivors are left with cognitive, behavioral, and communicative disabilities. While little can be done to reverse initial primary brain damage caused by trauma, the secondary injury of cerebral tissue due to cerebromicrovascular alterations and dysregulation of cerebral blood flow (CBF) is potentially preventable. This review focuses on functional, cellular, and molecular changes of autoregulatory function of CBF (with special focus on cerebrovascular myogenic response) that occur in cerebral circulation aft...
Source: AJP: Heart and Circulatory Physiology - October 31, 2016 Category: Cardiology Authors: Toth, P., Szarka, N., Farkas, E., Ezer, E., Czeiter, E., Amrein, K., Ungvari, Z., Hartings, J. A., Buki, A., Koller, A. Tags: Call for Papers: Small Vessels Big Problems Source Type: research