Advances in Pharmacological Sciences 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Efficacy of Aloe vera, Ananas comosus, and Sansevieria masoniana Cream on the Skin Wound Infected with MRSA.
Authors: Prakoso YA, Setiyo Rini C, Wirjaatmadja R
Abstract
The tropical area has a lot of herbal medicines such as Aloe vera (AV), Ananas comosus (AC), and Sansevieria masoniana (SM). All the three have a unique potential effect as an antibacterial and wound-healing promoter. The aim of this study is to explore the role of AV, AC, and SM on the skin wound infected with methicillin-resistant Staphylococcus aureus (MRSA). Forty-five adult female Sprague Dawley rats weighing 250-300 grams were divided into 5 groups. All the groups were exposed to two round full-thickness punch biopsy and infected with MRSA. ...
Source: Advances in Pharmacological Sciences - June 2, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Studies on the Dual Cytotoxicity and Antioxidant Properties of Berberis vulgaris Extracts and Its Main Constituent Berberine.
Authors: El Khalki L, Tilaoui M, Jaafari A, Ait Mouse H, Zyad A
Abstract
The present study attempts to investigate the cytotoxic activity of ethanol and ethyl acetate extracts of the Moroccan Berberis vulgaris and its major component berberine, together with exploring their antioxidant properties. It also consists of studying the combination effect of berberine and S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide (NO) donor, against the human breast adenocarcinoma cell line (MCF-7). Using the MTT assay, we report a differential cytotoxic effect of ethanol and ethyl acetate extracts since the ethanol ...
Source: Advances in Pharmacological Sciences - May 30, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One.
This study was conducted according to OECD 423 guidelines in female mice and revealed that these compounds are nontoxic. We then assessed the psychotropic effects of our products on the central nervous system (CNS). The results obtained show that 4-phenyl-1,5-benzodiazepin-2-one has no sedative effect at therapeutic doses of 100 and 200 mg/kg. On the other hand, its long-chain derivatives possess them. Moreover, all these products have no cataleptic and hypnotic effects at the doses studied. But at 100 mg/kg, these compounds all have the ability to significantly prolong the hypnotic effect of thiopental sodium.
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Source: Advances in Pharmacological Sciences - May 30, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Antibacterial and Antioxidant Compounds from the Flower Extracts of Vernonia amygdalina.
Authors: Habtamu A, Melaku Y
Abstract
Vernonia amygdalina is traditionally used in Ethiopia to treat various diseases. This prompted us to isolate bioactive compounds from the flowers of this plant. The CHCl3 extract after silica gel column chromatography has led to the isolation of two compounds identified as tricosane (1) and vernolide (2), while the acetone extract furnished isorhamnetin (3) and luteolin (4). The acetone extract and isorhamnetin significantly scavenged the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical by 91.6 and 94%, respectively. It was also shown that the acetone extract and isorhamne...
Source: Advances in Pharmacological Sciences - May 16, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery.
In conclusion, downregulation of TP receptors in the renal artery smooth muscle cells occurs mainly via the NF-κB signaling pathway.
PMID: 28775740 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - August 6, 2017 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Chemical Composition and Cytotoxic and Antibacterial Activities of the Essential Oil of Aloysia citriodora Palau Grown in Morocco.
Authors: Oukerrou MA, Tilaoui M, Mouse HA, Leouifoudi I, Jaafari A, Zyad A
Abstract
The aim of this work is to investigate the in vitro cytotoxic and antibacterial effects of the essential oils of Aloysia citriodora Palau, harvested in different regions of Morocco. The chemical profile was established using gas chromatography-mass spectrometry analysis. The cytotoxic activity against P815, MCF7, and VERO cell lines as well as the normal human peripheral blood mononuclear cells (PBMCs) was evaluated using the MTT assay. Standard, ATCC, strains of bacteria (Escherichia coli, Staphylococcus aureus, and Pseudo...
Source: Advances in Pharmacological Sciences - July 13, 2017 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats.
Conclusion. These results indicated that P. granatum flower extract promoted wound healing in rats and could be used for managing burn injuries.
PMID: 28203250 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - February 18, 2017 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats.
In conclusion, the initial drug-induced subclinical liver injury, its spontaneous healing, and the associated adaptive immune response have been demonstrated.
PMID: 27990159 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - December 20, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K(+) Channel as Antinociceptive Mechanism.
Authors: Sharmin Ani N, Chakraborty S, Moniruzzaman M
Abstract
Murraya koenigii L. is a perennial shrub, belonging to the family Rutaceae. Traditionally, the leaves of this plant are extensively used in treatment of a wide range of diseases and disorders including pain and inflammation. Although researchers have revealed the antinociceptive effects of this plant's leaves during past few years, the mechanisms underlying these effects are still unknown. Therefore, the present study evaluated some antinociceptive mechanisms of the methanolic extract of M. koenigii (MEMK) leaves along with its antinociceptive ...
Source: Advances in Pharmacological Sciences - November 5, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Thrombus Degradation by Fibrinolytic Enzyme of Stenotrophomonas sp. Originated from Indonesian Soybean-Based Fermented Food on Wistar Rats.
Conclusions. Oral treatment of enzyme from Stenotrophomonas sp. of Indonesian fermented food was capable of degrading thrombus induced in Wistar rats.
PMID: 27635131 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - September 18, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties.
Conclusion. The present study demonstrated that copper, cobalt, and zinc complexes possess higher antinociceptive, anxiolytic, CNS depressant, and hypoglycemic properties than the parent ligand.
PMID: 27478435 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - August 3, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
MDMA Impairs Response to Water Intake in Healthy Volunteers.
Authors: Baggott MJ, Garrison KJ, Coyle JR, Galloway GP, Barnes AJ, Huestis MA, Mendelson JE
Abstract
Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies. In Study 1, healthy drug-experienced volunteers received MDMA or placebo alone and in combination with the alpha-1 adrenergic inverse agonist prazosin, used as a positive control to release antidiuretic hormone (ADH). In Study 2, volunteers received MDMA or placebo followed by standardized water intake. MDMA lowered serum sodium but di...
Source: Advances in Pharmacological Sciences - July 13, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
A Review on Medicinal Properties of Orientin.
Authors: Lam KY, Ling AP, Koh RY, Wong YP, Say YH
Abstract
Medicinal plants continue to play an important role in modern medications and healthcare as consumers generally believe that most of them cause fewer or milder adverse effects than the conventional modern medicines. In order to use the plants as a source of medicinal agents, the bioactive compounds are usually extracted from plants. Therefore, the extraction of bioactive compounds from medicinal plants is a crucial step in producing plant-derived drugs. One of the bioactive compounds isolable from medicinal plants, orientin, is often used in variou...
Source: Advances in Pharmacological Sciences - June 16, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Radical-Scavenging Activity and Ferric Reducing Ability of Juniperus thurifera (L.), J. oxycedrus (L.), J. phoenicea (L.) and Tetraclinis articulata (L.).
Conclusion. These results suggest that the aqueous extracts of Juniperus thurifera, Juniperus oxycedrus, Juniperus phoenicea, and Tetraclinis articulata can constitute a promising new source of natural compounds with antioxidants ability.
PMID: 27293428 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - June 15, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Review of Anti-Inflammatory Herbal Medicines.
Authors: Ghasemian M, Owlia S, Owlia MB
Abstract
Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies. Curcuma longa, Zingiber officinale, Rosmarinus officinalis, Borago officinalis, evening primrose, and Devil's claw are some of the introd...
Source: Advances in Pharmacological Sciences - June 3, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
