Advanced Heart Failure Therapies and Cardiorenal Syndrome
Publication date: September 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 5Author(s): Jennifer A. Cowger, Ryhm RadjefHeart failure (HF) is extremely prevalent and for those with end-stage (stage D) disease, 1-year survival is only 25-50%. Several studies have captured the mortality impact of kidney disease on patients with HF, and measures of kidney function are a component of many HF risk stratification scores. The management of advanced HF complicated by cardiorenal syndrome (CRS) is challenging, and irreversible kidney failure often limits patient candidacy for advanced HF therapies, such as transplan...
Source: Advances in Chronic Kidney Disease - October 9, 2018 Category: Urology & Nephrology Source Type: research
Working Toward an Improved Understanding of Chronic Cardiorenal Syndrome Type 4
Publication date: September 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 5Author(s): Daniel Edmonston, Jessica D. Morris, John P. MiddletonChronic diseases of the heart and of the kidneys commonly coexist in individuals. Certainly combined and persistent heart and kidney failure can arise from a common pathologic insult, for example, as a consequence of poorly controlled hypertension or of severe diffuse arterial disease. However, strong evidence is emerging to suggest that cross talk exists between the heart and the kidney. Independent processes are set in motion when kidney function is chronically dim...
Source: Advances in Chronic Kidney Disease - October 9, 2018 Category: Urology & Nephrology Source Type: research
Masthead
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
Editorial Board
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
Table of Contents
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
It Is Really Time for Ammonium Measurement
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Kalani L. Raphael, Jerry Yee (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
Renal Tubular Acidosis and the Nephrology Teaching Paradigm
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Daniel Batlle, Jose Arruda (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
Hypokalemic Distal Renal Tubular Acidosis
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Patricia G. Vallés, Daniel BatlleDistal renal tubular acidosis (DRTA) is defined as hyperchloremic, non-anion gap metabolic acidosis with impaired urinary acid excretion in the presence of a normal or moderately reduced glomerular filtration rate. Failure in urinary acid excretion results from reduced H+ secretion by intercalated cells in the distal nephron. This results in decreased excretion of NH4+ and other acids collectively referred as titratable acids while urine pH is typically above 5.5 in the face of systemic acid...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
Hyperkalemic Forms of Renal Tubular Acidosis: Clinical and Pathophysiological Aspects
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Daniel Batlle, Jose ArrudaIn contrast to distal type I or classic renal tubular acidosis (RTA) that is associated with hypokalemia, hyperkalemic forms of RTA also occur usually in the setting of mild-to-moderate CKD. Two pathogenic types of hyperkalemic metabolic acidosis are frequently encountered in adults with underlying CKD. One type, which corresponds to some extent to the animal model of selective aldosterone deficiency (SAD) created experimentally by adrenalectomy and glucocorticoid replacement, is manifested in human...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
Renal Tubular Acidosis: H+/Base and Ammonia Transport Abnormalities and Clinical Syndromes
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Ira KurtzRenal tubular acidosis (RTA) represents a group of diseases characterized by (1) a normal anion gap metabolic acidosis; (2) abnormalities in renal HCO3− absorption or new renal HCO3− generation; (3) changes in renal NH4+, Ca2+, K+, and H2O homeostasis; and (4) extrarenal manifestations that provide etiologic diagnostic clues. The focus of this review is to give a general overview of the pathogenesis of the various clinical syndromes causing RTA with a particular emphasis on type I (hypokalemic distal RTA) and ty...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
Clinical Approach to Proximal Renal Tubular Acidosis in Children
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Gal Finer, Daniel LandauProximal renal tubular acidosis (pRTA) is an inherited or acquired clinical syndrome in which there is a decreased bicarbonate reclamation in the proximal tubule resulting in normal anion gap hyperchloremic metabolic acidosis. In children, pRTA may be isolated but is often associated with a general proximal tubular dysfunction known as Fanconi syndrome which frequently heralds an underlying systemic disorder from which it arises. When accompanied by Fanconi syndrome, pRTA is characterized by additiona...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
Pseudo-Renal Tubular Acidosis: Conditions Mimicking Renal Tubular Acidosis
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Junior Uduman, Jerry YeeHyperchloremic metabolic acidosis, particularly renal tubular acidosis, can pose diagnostic challenges. The laboratory phenotype of a low total carbon dioxide content, normal anion gap, and hyperchloremia may be misconstrued as hypobicarbonatemia from renal tubular acidosis. Several disorders can mimic renal tubular acidosis, and these must be appropriately diagnosed to prevent inadvertent and inappropriate application of alkali therapy. Key physiologic principles and limitations in the assessment of ...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
Incomplete Distal Renal Tubular Acidosis and Kidney Stones
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Daniel G. Fuster, Orson W. MoeRenal tubular acidosis (RTA) is comprised of a diverse group of congenital or acquired diseases with the common denominator of defective renal acid excretion with protean manifestation, but in adults, recurrent kidney stones and nephrocalcinosis are mainly found in presentation. Calcium phosphate (CaP) stones and nephrocalcinosis are frequently encountered in distal hypokalemic RTA type I. Alkaline urinary pH, hypocitraturia, and, less frequently, hypercalciuria are the tripartite lithogenic fac...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research
Masthead
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research
Editorial Board
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research
