Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship
Publication date: Available online 11 April 2019Source: Advances in Biological RegulationAuthor(s): Meena Jhanwar-Uniya, John V. Wainwright, Avinash L. Mohan, Michael E. Tobias, Raj Murali, Chirag D. Gandhi, Meic H. SchmidtAbstractActivation of Mechanistic target of rapamycin (mTOR) signaling plays a crucial role in tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical PI3K/Akt/mTOR signaling cascade is commonly upregulated due to loss of the tumor suppressorm PTEN, a phosphatase that acts antagonistically to the kinase (PI3K) in conversion of PIP2 to PIP3. mTOR forms two multiprotein complexes,...
Source: Advances in Biological Regulation - April 13, 2019 Category: Biology Source Type: research
Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction
Publication date: Available online 6 April 2019Source: Advances in Biological RegulationAuthor(s): Rhîan Gaenor Jacobsen, Fatemeh Mazloumi Gavgani, Amanda J. Edson, Marianne Goris, Altanchimeg Altankhuyag, Aurélia E. LewisAbstractBiomolecular interactions between proteins and polyphosphoinositides are essential in the regulation of the vast majority of cellular processes. Consequently, alteration of these interactions is implicated in the development of many diseases. Polyphosphoinositides (PPIns) are phosphorylated derivatives of phosphatidylinositol and consist of seven species with different phosphate combinations. PP...
Source: Advances in Biological Regulation - April 7, 2019 Category: Biology Source Type: research
Effects of the MDM-2 inhibitor Nutlin-3a on PDAC cells containing and lacking WT-TP53 on sensitivity to chemotherapy, signal transduction inhibitors and nutraceuticals
Publication date: Available online 15 March 2019Source: Advances in Biological RegulationAuthor(s): Saverio Candido, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Matilde Y. Follo, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Paolo Lombardi, Weifeng Mao, Giuseppe Montalto, Melchiorre Cervello, Dariusz Rakus, Agnieska Gizak, Heng-Liang Lin, Massimo LibraAbstractMutations at the TP53 gene are readily detected (approximately 50–75%) in pancreatic ductal adenocarcinoma (PDAC) patients. TP53 was previously thought to be a diffi...
Source: Advances in Biological Regulation - March 16, 2019 Category: Biology Source Type: research
Fructose-1,6-bisphosphatase: From a glucose metabolism enzyme to multifaceted regulator of a cell fate
Publication date: Available online 9 March 2019Source: Advances in Biological RegulationAuthor(s): Agnieszka Gizak, Przemyslaw Duda, Janusz Wisniewski, Dariusz RakusAbstractFructose-1,6-bisphosphatase (FBPase) is one of the ancient, evolutionarily conserved enzymes of carbohydrate metabolism. It has been described for a first time in 1943, however, for the next half a century mostly kinetic and structural parameters of animal FBPases have been studied. Discovery of ubiquitous expression of the muscle isozyme of FBPase, thus far considered to merely regulate glycogen synthesis from carbohydrate precursors, and its nuclear l...
Source: Advances in Biological Regulation - March 9, 2019 Category: Biology Source Type: research
Pancreatic cancer tumorspheres are cancer stem-like cells with increased chemoresistance and reduced metabolic potential
Publication date: Available online 23 February 2019Source: Advances in Biological RegulationAuthor(s): Alice Domenichini, Jeanne S. Edmands, Aleksandra Adamska, Romana-Rea Begicevic, Silvano Paternoster, Marco FalascaAbstractCancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attract interest as a therapeutic target. In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. Here we investigated the characteristi...
Source: Advances in Biological Regulation - February 23, 2019 Category: Biology Source Type: research
Editorial Board
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 23, 2019 Category: Biology Source Type: research
Foreword
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 23, 2019 Category: Biology Source Type: research
Acknowledgments
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 23, 2019 Category: Biology Source Type: research
List of Participants
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 23, 2019 Category: Biology Source Type: research
Group Photo
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 23, 2019 Category: Biology Source Type: research
Key to Photograph of Participants
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 23, 2019 Category: Biology Source Type: research
Flimsy overlay to Group photo
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 23, 2019 Category: Biology Source Type: research
Carlo M. Croce Special Symp Lect ABR Vol.71
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 23, 2019 Category: Biology Source Type: research
Crosstalk between Ras and inositol phosphate signaling revealed by lithium action on inositol monophosphatase in Schizophyllum commune
In this study, a crosstalk between Ras signaling and inositol phosphate signaling by inositol monophosphatase (IMPase) is revealed. Constitutively active Ras1 leads to the repression of IMPase transcription and lithium action on IMPase activity is compensated by the induction of IMPase at transcriptome level. Astonishingly, in S. commune lithium induces a considerable shift to inositol phosphate metabolism leading to a massive increase in the level of higher phosphorylated inositol species up to the inositol pyrophosphates. The lithium induced metabolic changes are not observable in a constitutively active Ras1 mutant. In ...
Source: Advances in Biological Regulation - January 3, 2019 Category: Biology Source Type: research
A novel role for DGATs in cancer
Publication date: Available online 13 December 2018Source: Advances in Biological RegulationAuthor(s): María José Hernández-Corbacho, Lina M. Obeid (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - December 14, 2018 Category: Biology Source Type: research
