Translating animal research from the laboratory to the neonatal clinical arena requires great caution
(Source: Acta Paediatrica)
Source: Acta Paediatrica - November 6, 2017 Category: Pediatrics Authors: Po ‐Yin Cheung Tags: Editorial Source Type: research

Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants
Acta Paediatrica,Volume 107, Issue 4, Page 605-610, April 2018. (Source: Acta Paediatrica)
Source: Acta Paediatrica - November 4, 2017 Category: Pediatrics Source Type: research

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Acta Paediatrica,Volume 107, Issue 4, Page 605-610, April 2018. (Source: Acta Paediatrica)
Source: Acta Paediatrica - November 4, 2017 Category: Pediatrics Source Type: research

Uniform national guidelines do not prevent wide variations in the clinical application of phototherapy for neonatal jaundice
ConclusionThere were considerable variations in phototherapy practices among Norwegian NICUs. In particular, the significant variations in duration need to be addressed.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - November 1, 2017 Category: Pediatrics Authors: Khalaf Mreihil, Britt Nakstad, Hans J ørgen Stensvold, Jūratė Šaltytė Benth, Thor Willy Ruud Hansen, , Tags: Regular Article Source Type: research

Effects of fetal growth restriction and preterm birth on cardiac morphology and function during infancy
Abstract AimTo investigate the effects of fetal growth restriction (FGR) and prematurity on cardiac morphology and function in infancy. We hypothesized that FGR and prematurity would both alter cardiac development. MethodsCardiac morphology and function were evaluated in 24 preterm FGR infants (p‐FGR) and 23 preterm and 19 term appropriately‐grown‐for‐gestational‐age infants (p‐AGA and t‐AGA, respectively) by conventional echocardiography and Tissue Doppler Imaging. p‐FGR and p‐AGA infants were studied on postnatal Day One and all groups were studied at one and six months post‐term age. Resultsp‐FGR i...
Source: Acta Paediatrica - November 1, 2017 Category: Pediatrics Authors: Emily Cohen, Christie Whatley, Flora Y Wong, Euan M Wallace, Joanne C Mockler, Alexsandria Odoi, Samantha Hollis, Rosemary S C Horne, Stephanie R Yiallourou Tags: Regular Article Source Type: research

A possible way to assess tidal exhaled nitric oxide in neonates and infants treated with nasal continuous positive airway pressure
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - November 1, 2017 Category: Pediatrics Authors: Birgitte Johanne Schmidt, Pauline Schibler Reim, Ole Find Pedersen, Per Albertsen, Gorm Greisen, Inger Merete J ørgensen Tags: A Different View Source Type: research

The self ‐reported quality of life of Lithuanian children with asthma was comparable to Western populations
ConclusionThe overall level and major determinants of QoL in children with asthma in Lithuania were comparable with Western populations.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - November 1, 2017 Category: Pediatrics Authors: Vaida Taminskiene, Egle Vaitkaitiene, Algirdas Valiulis, Steve Turner, Adamos Hadjipanayis, Rimantas Stukas, Arunas Valiulis Tags: Regular Article Source Type: research

National study shows that abusive head trauma mortality in Sweden was at least 10 times lower than in other Western countries
ConclusionThe risk of unreported fatal AHT in Sweden was low and there may have been cases misdiagnosed as AHT. The at least 10 times lower incidence than has been reported from other Western countries, raises the question if previously reported higher incidences of fatal AHT have been exaggerated.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - November 1, 2017 Category: Pediatrics Authors: Jacob Andersson, Ingemar Thiblin Tags: Regular Article Source Type: research

Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants
Abstract AimSymptomatic patent ductus arteriosus may lead to serious complications in extremely preterm and extremely low birth weight infants and is often resistant to medication. We evaluated early intravenous paracetamol for pain prevention during respiratory therapy, in an attempt to understand the ductal treatment of such infants. MethodsOur cohort were 295 extremely preterm or extremely low birth weight infants, born at less than 28 weeks or 1,000g, respectively, who were treated in the neonatal intensive care unit of Oulu University Hospital from 2002‐2015, before and after intravenous paracetamol was introduced i...
Source: Acta Paediatrica - November 1, 2017 Category: Pediatrics Authors: S Juuj ärvi, T Saarela, M Hallman, O Aikio Tags: Regular Article Source Type: research

Oxygen, weight gain, IGF ‐1 and ROP: not a straight‐forward equation
Acta Paediatrica, EarlyView. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 30, 2017 Category: Pediatrics Source Type: research

High ‐sensitivity C‐reactive protein concentration in young adults in the Helsinki Study of Very Low Birth Weight Adults
Acta Paediatrica, EarlyView. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 30, 2017 Category: Pediatrics Source Type: research

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Acta Paediatrica, Ahead of Print. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 30, 2017 Category: Pediatrics Source Type: research

Antenatal magnesium for preterm delivery reduces risk of cerebral palsy among surviving very preterm infants
(Source: Acta Paediatrica)
Source: Acta Paediatrica - October 30, 2017 Category: Pediatrics Authors: Megan E. Paulsen, Robert M. Dietz Tags: EBNEO Commentary Source Type: research

Oxygen, weight gain, IGF ‐1 and ROP: not a straight‐forward equation
(Source: Acta Paediatrica)
Source: Acta Paediatrica - October 30, 2017 Category: Pediatrics Authors: Brian A. Darlow, Gil Binenbaum Tags: Editorial Source Type: research

An epidemic of meningococcal disease in children in North Norway in the 1970s and 1980s was dominated by a hypervirulent group B strain
ConclusionThe B:15:P1.7,6 strain was more prevalent during the Norwegian epidemic of invasive meningococcal disease, but had a significantly lower mortality rate. The phenotype distribution was more heterogeneous after 1990. The dominant serogroup was B.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 28, 2017 Category: Pediatrics Authors: Kine Nordheim, Ingunn Holmefoss Hovland, Bj ørn Erik Kristiansen, Per Ivar Kaaresen, Trond Flaegstad Tags: Regular Article Source Type: research

Interpretation of pyuria in children with urinary tract infection
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 28, 2017 Category: Pediatrics Authors: M Kenosi, L whitla, N Khan, E Carty, D Coghlan, M Nadeem Tags: Brief Report Source Type: research

Performance of risk stratification criteria in the management of febrile young infants younger than three months of age
Abstract AimWe evaluated the diagnosis, risk stratification and management of febrile infants under three months of age who presented to an Israeli pediatric emergency room (ER). MethodsThis retrospective study enrolled all febrile infants examined in the pediatric ER of Soroka Medical Center during 2010‐2013. The patients were classified into low‐risk and high‐risk subgroups and compared by age and ethnicity. ResultsOverall, 2,251 febrile infants (60.5% of Bedouin and 34.4% of Jewish ethnicity) were enrolled. Hospitalisation rates were higher among Bedouin versus Jewish infants (55% vs. 39.8%, p
Source: Acta Paediatrica - October 28, 2017 Category: Pediatrics Authors: Yekaterina Belov, Eugene Leibovitz, Alina Vodonos, Guy Hazan, Eduard Ling, Rimma Melamed Tags: Regular Article Source Type: research

Norepinephrine infusion improves haemodynamics in the preterm infants during septic shock
ConclusionNorepinephrine therapy could be considered to improve blood pressure and urine output during neonatal septic shock in preterm infants. Further studies are needed to prove the efficacy and safety of norepinephrine infusion in neonates. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 26, 2017 Category: Pediatrics Authors: MY Rizk, A Lapointe, F Lefebvre, KJ Barrington Tags: Regular Article Source Type: research

A Serratia marcescens outbreak in a neonatal intensive care unit was successfully managed by rapid hospital hygiene interventions and screening
ConclusionA Serratia marcescens outbreak caused significant morbidity in neonates and one death. Rapid hospital hygiene interventions and patient screening effectively contained the outbreak.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 25, 2017 Category: Pediatrics Authors: Emilia Åttman, Päivi Korhonen, Outi Tammela, Risto Vuento, Janne Aittoniemi, Jaana Syrjänen, Erja Mattila, Monica Österblad, Reetta Huttunen Tags: Regular Article Source Type: research

Communication between healthcare professionals and parents is a key factor in involving parents in neonatal intensive care
(Source: Acta Paediatrica)
Source: Acta Paediatrica - October 25, 2017 Category: Pediatrics Authors: Sari Ahlqvist ‐Björkroth Tags: Editorial Source Type: research

Near ‐infrared spectroscopy is a promising noninvasive technique for monitoring the effects of feeding regimens on the cerebral and splanchnic regions
Abstract AimThe effects of different milk and, or, administration regimens on cerebro‐splanchnic perfusion are still a matter of debate. We investigated the effects of the bolus administration of breast milk or formula on cerebro‐splanchnic oximetry, function and perfusion, assessed by near‐infrared spectroscopy (NIRS). MethodsThis observational study of 30 infants fed with breast (n = 15) or formula (n = 15) milk, and matched for gestational age and birth weight, was carried out in the neonatal intensive care unit of the C Arrigo Children's Hospital, Alessandria, Italy, a tertiary‐level referra...
Source: Acta Paediatrica - October 24, 2017 Category: Pediatrics Authors: Alice Grometto, Benedetta Pizzo, Maria Chiara Strozzi, Francesca Gazzolo, Diego Gazzolo Tags: Regular Article Source Type: research

Neonatal Eating Outcome Assessment: Tool Development and Inter ‐rater Reliability
ConclusionThe “total” score had good to excellent reliability. Fleiss’ Kappa scores for all 18 scorable items ranged from slight agreement to moderate agreement. Items with lowest Kappa scores were revised, and additional feedback from therapists engaged in reliability testing was incorporated, resulting in final version 5.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 23, 2017 Category: Pediatrics Authors: Roberta Pineda, Rachel Harris, Felicia Foci, Jessica Roussin, Michael Wallendorf Tags: Regular Article Source Type: research

What we do in neonatal analgesia overshadows how we do it
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 23, 2017 Category: Pediatrics Authors: Carlo V Bellieni, Giuseppe Buonocore Tags: A Different View Source Type: research

Skin ‐to‐skin hospital transfers are physiologically sound and empower parents
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 23, 2017 Category: Pediatrics Authors: Mattias Kjellberg Tags: Short Commentary Source Type: research

Systematic review found that there was moderate evidence that vaccinating healthcare workers prevented pertussis in infants
ConclusionThere was moderate evidence that tetanus–diphtheria acellular pertussis vaccinations for healthcare workers were effective in preventing pertussis in all age groups and specifically in infants. The results must be interpreted with caution due to the low quality and heterogeneity of the studies.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 21, 2017 Category: Pediatrics Authors: A. van den Hoogen, J.M. Duijn, L.G.M. Bode, D.C. Vijlbrief, L. de Hooge, H.D.L. Ockhuijsen Tags: Review Article Source Type: research

Longitudinal study showed that the quality of life of Finnish adolescents with cerebral palsy continued to be relatively good
ConclusionWe showed that QoL was relatively good in childhood and adolescence. The Finnish version of the CP QOL‐Teen questionnaire was an appropriate clinical tool for assessing QoL.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 20, 2017 Category: Pediatrics Authors: Sanna B öling, Tarja Varho, Leena Haataja Tags: Regular Article Source Type: research

Teamwork and conflicts in paediatric end ‐of‐life care
(Source: Acta Paediatrica)
Source: Acta Paediatrica - October 18, 2017 Category: Pediatrics Authors: A.A. Eduard Verhagen Tags: Editorial Source Type: research

The early signs of reading difficulties at school can start with foetal growth restriction
(Source: Acta Paediatrica)
Source: Acta Paediatrica - October 18, 2017 Category: Pediatrics Authors: Tzipi Horowitz ‐Kraus Tags: Editorial Source Type: research

IMPACT ‐III is a valid and reliable questionnaire for assessing health‐related quality of life in Swedish children with inflammatory bowel disease
ConclusionThe Swedish version of the IMPACT‐III questionnaire was valid and reliable, but the shorter, four‐factor version is quicker and may be more convenient in clinical settings.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 15, 2017 Category: Pediatrics Authors: C Uggla, V Lindh, T Lind, M Lindkvist Tags: Regular Article Source Type: research

Functional variants in intercellular adhesion molecule ‐1 and toll‐like receptor‐4 genes are more frequent in children with febrile urinary tract infection with renal parenchymal involvement
ConclusionFunctional variants in intercellular adhesion molecule‐1 and toll‐like receptor‐4 genes were increasingly common in children with febrile UTIs with renal parenchymal involvement, but the ICAM‐1 Glu469Lys (1462A/G) association was less evident. TLR4 Asp299Gly might independently increase renal parenchymal infection rather than renal scarring.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 13, 2017 Category: Pediatrics Authors: Almontaser Hussein, Khaled Saad, Eman Askar, Asmaa M. Zahran, Hekma Farghaly, Kotb Metwalley, Ahmad A Elderwy Tags: Regular Article Source Type: research

Elevated serum adipsin may predict unsuccessful treatment for cows' milk allergy but other biomarkers do not
ConclusionNone of the 15 allergy, immunology or inflammatory markers were useful in predicting the outcome of OIT. Preliminary evidence was found that high serum adipsin after the six‐month escalation phase of OIT might predict unsuccessful outcome.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 13, 2017 Category: Pediatrics Authors: Susanna Salmivesi, Marita Paassilta, Heini Huhtala, Riina Nieminen, Eeva Moilanen, Matti Korppi Tags: Regular Article Source Type: research

Nutritional support in paediatric Crohn's disease: outcome at 12 months
Abstract AimPaediatric Crohn's disease (CD) is associated with growth delay and poor nutritional status. Maintenance enteral nutrition (MEN) supplementation is a potential adjunct to improve growth/prolong remission. MethodsNewly diagnosed CD patients were identified. Anthropometry, treatments and outcomes were collected for 12 months following diagnosis. Data are presented as medians. ResultsA total of 102 patients were identified (age = 13 years, 76% male), 58 (57%) completed exclusive enteral nutrition (EEN) as induction therapy, and 77 (75%) entered clinical remission. Following induction, 58 (57%) of all patients cont...
Source: Acta Paediatrica - October 13, 2017 Category: Pediatrics Authors: J Gavin, JJ Ashton, N Heather, LV Marino, RM Beattie Tags: Regular Article Source Type: research

Music exposure and maturation of late preterm sleep –wake cycles: a randomised crossover trial
ConclusionMusic exposure elicits an increasing PCA pattern in AS and fewer interruptions in QS. Music may benefit sleep in late preterm infants. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 11, 2017 Category: Pediatrics Authors: Adia Stokes, Alexander G. Agthe, Dina El Metwally Tags: Regular Article Source Type: research

Serum levels of omentin ‐1 are increased after weight loss and are particularly associated with increases in obese children with metabolic syndrome
ConclusionSerum omentin‐1 was regulated by weight and seemed to be associated with children's metabolic disorders. A six‐month lifestyle intervention significantly increased serum omentin‐1 levels. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 10, 2017 Category: Pediatrics Authors: Meizhen Zhang, Xinrui Tan, Chunyan Yin, Li Wang, Yingchun Tie, Yanfeng Xiao Tags: Regular Article Source Type: research

Return of neonatal CPAP resistance – the Medijet device family examined using in vitro flow simulations
ConclusionThe main mechanism of CPAP generation for the disposable Medijet generator was resistance. The Medijet device family showed increasing resistance with each design generation. The high resistance of the Medijet disposable generator could be of great value when examining the clinical importance of pressure stability. Our results suggest that this device should be used cautiously in patients where pressure‐stable CPAP is believed to be clinically important. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 10, 2017 Category: Pediatrics Authors: Markus Falk, Snorri Donaldsson, Baldvin Jonsson, Thomas Drevhammar Tags: Regular Article Source Type: research

Highlights in this issue
(Source: Acta Paediatrica)
Source: Acta Paediatrica - October 10, 2017 Category: Pediatrics Authors: Anna K äll, Hugo Lagercrantz Tags: Highlights in this issue Source Type: research

Issue Information
(Source: Acta Paediatrica)
Source: Acta Paediatrica - October 10, 2017 Category: Pediatrics Tags: Issue Information Source Type: research

Extremely prematurely born adolescents self ‐report of anxiety symptoms, and the mothers' reports on their offspring
ConclusionsSelf‐reports did not clearly indicate more anxiety in the preterm group, although confidence intervals supported a possible twofold increase. Mother‐ and self‐reports correlated only for the preterm group, which may indicate increased sensitivity for their children's symptoms. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 10, 2017 Category: Pediatrics Authors: M J S ømhovd, B H Esbjørn, B M Hansen, G Greisen Tags: Regular Article Source Type: research

Norepinephrine infusion improves hemodynamics in the preterm infants during septic shock
ConclusionNorepinephrine therapy could be considered to improve blood pressure and urine output during neonatal septic shock in preterm infants. Further studies are needed to prove the efficacy and safety of norepinephrine infusion in neonates.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 9, 2017 Category: Pediatrics Authors: M. Y Rizk, A Lapointe, F Lefebvre, KJ Barrington Tags: Regular Article Source Type: research

Children in out ‐of‐home care are at high risk of somatic, dental and mental ill health
ConclusionThis study found high levels of wide‐ranging health issues. Despite national Swedish guidelines and policies, only 6% of the children in out‐of‐home care were referred by social workers for a CNIF health assessment.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 7, 2017 Category: Pediatrics Authors: L S Randsalu, L Laurell Tags: Original Article Source Type: research

Failing to meet relative humidity targets for incubated neonates causes higher heat loss and metabolic costs in the first week of life
Acta Paediatrica, EarlyView. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 5, 2017 Category: Pediatrics Source Type: research

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Acta Paediatrica, Ahead of Print. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 5, 2017 Category: Pediatrics Source Type: research

Preterm infants with necrotising enterocolitis demonstrate an unbalanced gut microbiota
ConclusionThe NEC infants were poorly colonised with no more than seven species, and the controls had a more diversified and balanced gut microbiota. Understanding NEC aetiology better could lead to more effective prophylactic interventions and a reduced incidence. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 5, 2017 Category: Pediatrics Authors: Tarek Itani, Carole Ayoub Moubareck, Imad Melki, Clotilde Rousseau, Ir ène Mangin, Marie‐José Butel, Dolla Karam‐Sarkis Tags: Regular Article Source Type: research

Sex and maturity status affected the validity of a submaximal cycle test in  adolescents
ConclusionThe EB test was reasonably valid in adolescents, seemed to be related to sex and maturity status, and our findings support its use. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 5, 2017 Category: Pediatrics Authors: Frida Bj örkman, Andrea Eggers, Adam Stenman, Tony Bohman, Björn Ekblom, Örjan Ekblom Tags: Regular Article Source Type: research

Serum complement factor 5a levels are associated with non ‐alcoholic fatty liver IL‐6 disease in obese children
ConclusionSerum C5a was elevated in obese children, especially in those with NAFLD and it may be proposed as a novel marker to predict advanced disease.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 5, 2017 Category: Pediatrics Authors: Wei Hu, Min Wang, Chunyan Yin, Shuangshaung Li, Yuesheng Liu, Yanfeng Xiao Tags: Regular Article Source Type: research

Severe obesity is a limitation for the use of body mass index standard deviation scores in children and adolescents
ConclusionsOur findings suggest that it may be more appropriate to use the percentage above a particular BMI cut‐off, such as the percentage above IOTF‐25, than the IOTF, WHO and BGS BMI‐SDS in paediatric patients with severe obesity.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 1, 2017 Category: Pediatrics Authors: P étur B. Júlíusson, Mathieu Roelants, Beate Benestad, Samira Lekhal, Yngvild Danielsen, Jøran Hjelmesæth, Jens K Hertel Tags: Regular Article Source Type: research

High Blood Pressure in the Young: Why Should We Care?
ConclusionChildhood hypertension warrants action to prevent adult cardiovascular disease.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 1, 2017 Category: Pediatrics Authors: Joseph T Flynn Tags: Original Article Source Type: research

The distance between the delivery room and neonatal intensive care unit had no impact on the respiratory management of preterm infants at birth
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 1, 2017 Category: Pediatrics Authors: Daniele Trevisanuto, Francesca Rech Morassutti, Nicoletta Doglioni, Cristina Contessotto Avil és, Alfonso Galderisi, Francesco Cavallin Tags: Brief Report Source Type: research

Challenging intra ‐institutional moral complicity
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 1, 2017 Category: Pediatrics Authors: Patrick J. Marmion Tags: Letter Source Type: research