The niche matters: origin, function and fate of CNS-associated macrophages during health and disease
AbstractThere are several cellular and acellular structural barriers associated with the brain interfaces, which include the dura, the leptomeninges, the perivascular space and the choroid plexus epithelium. Each structure is enriched by distinct myeloid populations, which mainly originate from erythromyeloid precursors (EMP) in the embryonic yolk sac and seed the CNS during embryogenesis. However, depending on the precise microanatomical environment, resident myeloid cells differ in their marker profile, turnover and the extent to which they can be replenished by blood-derived cells. While some EMP-derived cells seed the ...
Source: Acta Neuropathologica - February 12, 2024 Category: Neurology Source Type: research
Macrophages and endothelial cells in the neurovascular unit
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 12, 2024 Category: Neurology Source Type: research
Pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion. Scientific commentary on ‘Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics’
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 10, 2024 Category: Neurology Source Type: research
Reply: pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 10, 2024 Category: Neurology Source Type: research
Pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion. Scientific commentary on ‘Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics’
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 10, 2024 Category: Neurology Source Type: research
Reply: pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 10, 2024 Category: Neurology Source Type: research
“RYR1 and the cerebellum”: scientific commentary on “Defective Cerebellar Ryanodine Receptor Type 1 and Endoplasmic Reticulum Calcium ‘Leak’ in Tremor Pathophysiology”
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 7, 2024 Category: Neurology Source Type: research
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer ’s disease
AbstractSynapse loss correlates with cognitive decline in Alzheimer ’s disease, and soluble oligomeric amyloid beta (Aβ) is implicated in synaptic dysfunction and loss. An important knowledge gap is the lack of understanding of how Aβ leads to synapse degeneration. In particular, there has been difficulty in determining whether there is a synaptic receptor that binds Aβ and mediates toxicity. While many candidates have been observed in model systems, their relevance to human AD brain remains unknown. This is in part due to methodological limitations preventing visualization of Aβ binding at individual synapses. To ov...
Source: Acta Neuropathologica - February 6, 2024 Category: Neurology Source Type: research
New insights into neuropathology and pathogenesis of autoimmune glial fibrillary acidic protein meningoencephalomyelitis
AbstractAnti-glial fibrillary acidic protein (GFAP) meningoencephalomyelitis (autoimmune GFAP astrocytopathy) is a new autoimmune central nervous system (CNS) disease diagnosable by the presence of anti-GFAP autoantibodies in the cerebrospinal fluid and presents as meningoencephalomyelitis in the majority of patients. Only few neuropathological reports are available and little is known about the pathogenic mechanisms. We performed a histopathological study of two autopsies and nine CNS biopsies of patients with anti-GFAP autoantibodies and found predominantly a lymphocytic and in one autopsy case a granulomatous inflammato...
Source: Acta Neuropathologica - February 3, 2024 Category: Neurology Source Type: research
Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains
We examined whether TDP-43 regulated cryptic exons accumulate in the hippocampus of neuropathologically confirmed LATE-NC cases. We found that several cryptic RNAs are robustly expressed in LATE-NC cases with or without comorbid ADNC and correlate with pT DP-43 abundance; however, the accumulation of cryptic RNAs is more robust in LATE-NC with comorbid ADNC. Additionally, cryptic RNAs can robustly distinguish LATE-NC from healthy controls and AD cases. These findings expand our current understanding and provide novel potential biomarkers for LATE pat hogenesis. (Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 3, 2024 Category: Neurology Source Type: research
Scientific commentary on: “Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies”
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 3, 2024 Category: Neurology Source Type: research
New insights into neuropathology and pathogenesis of autoimmune glial fibrillary acidic protein meningoencephalomyelitis
AbstractAnti-glial fibrillary acidic protein (GFAP) meningoencephalomyelitis (autoimmune GFAP astrocytopathy) is a new autoimmune central nervous system (CNS) disease diagnosable by the presence of anti-GFAP autoantibodies in the cerebrospinal fluid and presents as meningoencephalomyelitis in the majority of patients. Only few neuropathological reports are available and little is known about the pathogenic mechanisms. We performed a histopathological study of two autopsies and nine CNS biopsies of patients with anti-GFAP autoantibodies and found predominantly a lymphocytic and in one autopsy case a granulomatous inflammato...
Source: Acta Neuropathologica - February 3, 2024 Category: Neurology Source Type: research
Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains
We examined whether TDP-43 regulated cryptic exons accumulate in the hippocampus of neuropathologically confirmed LATE-NC cases. We found that several cryptic RNAs are robustly expressed in LATE-NC cases with or without comorbid ADNC and correlate with pT DP-43 abundance; however, the accumulation of cryptic RNAs is more robust in LATE-NC with comorbid ADNC. Additionally, cryptic RNAs can robustly distinguish LATE-NC from healthy controls and AD cases. These findings expand our current understanding and provide novel potential biomarkers for LATE pat hogenesis. (Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 3, 2024 Category: Neurology Source Type: research
