Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex
AbstractIdentification and characterisation of novel targets for treatment is a priority in the field of psychiatry.FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a subset of psychiatric patients, with potential to be leveraged as a therapeutic target for these individuals. While it is widely reported thatFKBP5/FKBP51 mRNA/protein (FKBP5/1) expression is impacted by psychiatric disease state, risk genotype and age, it is not known in which cell types and sub-anatomical areas of the human brain this occurs. This knowledge is critical to propelFKBP5/1-targeted treatment development. Here, we perfo...
Source: Acta Neuropathologica - February 2, 2023 Category: Neurology Source Type: research

Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 2, 2023 Category: Neurology Source Type: research

Loss of p16 expression is a sensitive marker of CDKN2A homozygous deletion in malignant meningiomas
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - February 1, 2023 Category: Neurology Source Type: research

Archival wild-type poliovirus 1 infected central nervous system tissues of the pre-vaccination era in Switzerland reveal a distinct virus genotype
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - January 31, 2023 Category: Neurology Source Type: research