Lateral medullary vascular compression manifesting as paroxysmal hypertension
We present the case of a patient affected by episodes of severe paroxysmal hypertension, some episodes associated with vago-glossopharyngeal neuralgia. Classical secondary forms of hypertension were excluded. Imaging revealed a neurovascular conflict between the posterior inferior cerebellar artery (PICA) and the ventrolateral medulla at the level of the root entry zone of the ninth and tenth cranial nerves (CN IX-X REZ). A MVD of a conflict between the PICA and the RVLM and adjacent CN IX-X REZ was performed, resulting in reduction of the frequency and severity of the episodes. Brain MRI should be performed in cases of pa...
Source: Acta Neurochirurgica - March 15, 2024 Category: Neurosurgery Source Type: research
Multiple surgical resections for progressive IDH wildtype glioblastoma —is it beneficial?
ConclusionsThis study demonstrates potential prolongation of survival for rGB patients undergoing repeat resection, without significant increase in complication rates with repeat resections. Achieving a more complete repeat resection improved survival. Moreover, the use of intraoperative imaging adjuncts can maximise tumour resection, whilst minimising the risk of neurological deficit. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 15, 2024 Category: Neurosurgery Source Type: research
Pretreatment with a dual antiplatelet and anticoagulant (APAC) reduces ischemia –reperfusion injury in a mouse model of temporary middle cerebral artery occlusion—implications for neurovascular procedures
ConclusionsPretreatment with APAC or UFH was safe and effective in reducing brain injury in a model of cerebral ischemia induced by transient middle cerebral artery occlusion. Further studies on the use of APAC to limit ischemic injury during temporary occlusion in neurovascular procedures are indicated. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 15, 2024 Category: Neurosurgery Source Type: research
Taking the knife to neurodegeneration: a review of surgical gene therapy delivery to the CNS
AbstractGene supplementation and editing for neurodegenerative disorders has emerged in recent years as the understanding of the genetic mechanisms underlying several neurodegenerative disorders increases. The most common medium to deliver genetic material to cells is via viral vectors; and with respect to the central nervous system, adeno-associated viral (AAV) vectors are a popular choice. The most successful example of AAV-based gene therapy for neurodegenerative disorders is Zolgensma © which is a transformative intravenous therapy given to babies with spinal muscular atrophy. However, the field has stalled in achievi...
Source: Acta Neurochirurgica - March 14, 2024 Category: Neurosurgery Source Type: research
Alexis retractor efficacy in transthoracic thoracoscopically assisted discectomy for thoracic disc herniations
ConclusionUse of the flexible and intuitive Alexis retractor maximises operative exposure and is an effective adjunct when performing complex transthoracic approaches for thoracic disc herniations. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 13, 2024 Category: Neurosurgery Source Type: research
The association between head injury and facial fracture treatment: an observational study of hospitalized bicyclists from a level 1 trauma centre
ConclusionBicyclists with more severe head injuries had increased odds for midface fractures and surgical correction of orbital fractures. During trauma triage, the head and the face should be considered as one unit. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 12, 2024 Category: Neurosurgery Source Type: research
Cisternal nicardipine for prevention of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a comparative retrospective cohort study
ConclusionAdministration of intrathecal nicardipine for moderate to severe CV reduces the rate of DCI and improved long-term functional outcomes in patients with high modified Fisher grade aSAH. This study also showed a relative benefit of cisternal over intraventricular nicardipine, thereby reducing the number of angioplasties performed in the post-treatment phase. However, these preliminary results should be confirmed with future prospective studies. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 12, 2024 Category: Neurosurgery Source Type: research
Biportal endoscopic transforaminal thoracic interbody fusion for the treatment of thoracic myelopathy
ConclusionBiportal endoscopic transforaminal thoracic interbody fusion can be a feasible technique for treating thoracic spondylotic myelopathy at the thoracolumbar junction levels. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 12, 2024 Category: Neurosurgery Source Type: research
Direct superior sagittal sinus puncture via a surgical burr hole for curative embolization of the complex transverse-sigmoid sinus dural arteriovenous fistula: How I do it
ConclusionThe direct puncture of the superior sagittal sinus is a safe and effective method for treating complex dAVFs. This approach grants access to the fistula channel which facilitates curative embolization. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 12, 2024 Category: Neurosurgery Source Type: research
The association between head injury and facial fracture treatment: an observational study of hospitalized bicyclists from a level 1 trauma centre
ConclusionBicyclists with more severe head injuries had increased odds for midface fractures and surgical correction of orbital fractures. During trauma triage, the head and the face should be considered as one unit. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 12, 2024 Category: Neurosurgery Source Type: research
Cisternal nicardipine for prevention of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a comparative retrospective cohort study
ConclusionAdministration of intrathecal nicardipine for moderate to severe CV reduces the rate of DCI and improved long-term functional outcomes in patients with high modified Fisher grade aSAH. This study also showed a relative benefit of cisternal over intraventricular nicardipine, thereby reducing the number of angioplasties performed in the post-treatment phase. However, these preliminary results should be confirmed with future prospective studies. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 12, 2024 Category: Neurosurgery Source Type: research
Biportal endoscopic transforaminal thoracic interbody fusion for the treatment of thoracic myelopathy
ConclusionBiportal endoscopic transforaminal thoracic interbody fusion can be a feasible technique for treating thoracic spondylotic myelopathy at the thoracolumbar junction levels. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 12, 2024 Category: Neurosurgery Source Type: research
Direct superior sagittal sinus puncture via a surgical burr hole for curative embolization of the complex transverse-sigmoid sinus dural arteriovenous fistula: How I do it
ConclusionThe direct puncture of the superior sagittal sinus is a safe and effective method for treating complex dAVFs. This approach grants access to the fistula channel which facilitates curative embolization. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 12, 2024 Category: Neurosurgery Source Type: research
