A realistic aneurysm clipping simulation combining 3D-printed and placenta-based models —how I do it
ConclusionOur neurovascular surgical station bridges the gap between existing training models, offering affordability, ecological considerations, and minimal ethical concerns. It empowers neurosurgery residents to refine their skills in handling both emergencies and elective cases under close-to-real surgical conditions, with the potential for independent practice and senior supervision. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 9, 2024 Category: Neurosurgery Source Type: research
A novel repair strategy using knotless squeeze anchors for lumbar disc herniation with endplate junction lesions under biportal endoscopic spinal surgery
ConclusionThe procedure is a simple, safe, and feasible knotless suturing technique for the treatment of LDH with AF-EP junction lesions. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 9, 2024 Category: Neurosurgery Source Type: research
Perifocal edema is a risk factor for preoperative seizures in patients with meningioma WHO grade 2 and 3
ConclusionsPreoperative seizures were frequently encountered in about every third patient with meningioma WHO grade 2 or 3. Patients presenting with peritumoral edema on preoperative imaging are at particular risk for developing tumor-related seizures. Tumor resection was highly effective in achieving seizure freedom. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 6, 2024 Category: Neurosurgery Source Type: research
Treatment modalities and outcomes of granular cell tumors and spindle cell oncocytomas of the pituitary gland: an analysis of two national cancer databases
ConclusionSCOs and GCTs are rare pituitary tumors, and their management entails particular challenges. Gross total resection is often not possible, and adjuvant radiation might be employed following subtotal resection. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 5, 2024 Category: Neurosurgery Source Type: research
Refining the predictive value of preoperative apparent diffusion coefficient (ADC) by whole-tumor analysis for facial nerve outcomes in vestibular schwannomas
ConclusionsWhole-tumor histogram yielded a robust regression tree analysis that defined three ADC groups with significantly different facial nerve outcomes. This likely reflects tumor heterogeneity better than solid-tumor ROI sampling. Whole-tumor ADC warrants further study as a useful radiographic biomarker in patients with vestibular schwannoma who are considering surgical resection. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 5, 2024 Category: Neurosurgery Source Type: research
Treatment modalities and outcomes of granular cell tumors and spindle cell oncocytomas of the pituitary gland: an analysis of two national cancer databases
ConclusionSCOs and GCTs are rare pituitary tumors, and their management entails particular challenges. Gross total resection is often not possible, and adjuvant radiation might be employed following subtotal resection. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 5, 2024 Category: Neurosurgery Source Type: research
Refining the predictive value of preoperative apparent diffusion coefficient (ADC) by whole-tumor analysis for facial nerve outcomes in vestibular schwannomas
ConclusionsWhole-tumor histogram yielded a robust regression tree analysis that defined three ADC groups with significantly different facial nerve outcomes. This likely reflects tumor heterogeneity better than solid-tumor ROI sampling. Whole-tumor ADC warrants further study as a useful radiographic biomarker in patients with vestibular schwannoma who are considering surgical resection. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 5, 2024 Category: Neurosurgery Source Type: research
Cognition and health-related quality of life in long-term survivors of high-grade glioma: an interactive perspective from patient and caregiver
ConclusionsIn long-term HGG survivors maintained HRQoL seems possible even when cognition is impaired in a large variety at the individual level. A tailored approach is therefore recommended to investigate the cognitive impairments and HRQoL in patients and the need for patient and caregiver support. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 3, 2024 Category: Neurosurgery Source Type: research
The diagnostic yield of inferior petrosal sinus sampling in Cushing syndrome in the era of ovine CRH shortage
ConclusionsWith the current drug shortages in Europe, ACTH measurements without oCRH stimulation in IPSS cannot be recommended. Thus, we call for desmopressin or the commercially available human CRH as a potential alternative in the confirmation of ACTH excess by IPSS in equivocal MRI findings. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 3, 2024 Category: Neurosurgery Source Type: research
Venous thromboembolism chemical prophylaxis after skull base surgery
ConclusionPostoperative chemoprophylaxis represents a relatively safe strategy in patients undergoing skull base surgery. We advocate a personalised approach to chemoprophylaxis and recommend it on postoperative days 1 or 2 when indicated. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 3, 2024 Category: Neurosurgery Source Type: research
Cognition and health-related quality of life in long-term survivors of high-grade glioma: an interactive perspective from patient and caregiver
ConclusionsIn long-term HGG survivors maintained HRQoL seems possible even when cognition is impaired in a large variety at the individual level. A tailored approach is therefore recommended to investigate the cognitive impairments and HRQoL in patients and the need for patient and caregiver support. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 3, 2024 Category: Neurosurgery Source Type: research
The diagnostic yield of inferior petrosal sinus sampling in Cushing syndrome in the era of ovine CRH shortage
ConclusionsWith the current drug shortages in Europe, ACTH measurements without oCRH stimulation in IPSS cannot be recommended. Thus, we call for desmopressin or the commercially available human CRH as a potential alternative in the confirmation of ACTH excess by IPSS in equivocal MRI findings. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 3, 2024 Category: Neurosurgery Source Type: research
Venous thromboembolism chemical prophylaxis after skull base surgery
ConclusionPostoperative chemoprophylaxis represents a relatively safe strategy in patients undergoing skull base surgery. We advocate a personalised approach to chemoprophylaxis and recommend it on postoperative days 1 or 2 when indicated. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 3, 2024 Category: Neurosurgery Source Type: research
Beyond fluorescence-guided resection: 5-ALA-based glioblastoma therapies
AbstractGlioblastoma is the most common primary malignant brain tumor. Despite advances in multimodal concepts over the last decades, prognosis remains poor. Treatment of patients with glioblastoma remains a considerable challenge due to the infiltrative nature of the tumor, rapid growth rates, and tumor heterogeneity. Standard therapy consists of maximally safe microsurgical resection followed by adjuvant radio- and chemotherapy with temozolomide. In recent years, local therapies have been extensively investigated in experimental as well as translational levels. External stimuli-responsive therapies such as Photodynamic T...
Source: Acta Neurochirurgica - April 2, 2024 Category: Neurosurgery Source Type: research
