Muscarinic Receptor Stimulation Does Not Inhibit Voltage-dependent Ca < sup > 2+ < /sup > Channels in Rat Adrenal Medullary Chromaffin Cells
Acta Histochem Cytochem. 2023 Aug 30;56(4):67-75. doi: 10.1267/ahc.23-00042. Epub 2023 Aug 23.ABSTRACTAdrenal medullary chromaffin (AMC) and sympathetic ganglion cells are derived from the neural crest and show a similar developmental path. Thus, these two cell types have many common properties in membrane excitability and signaling. However, AMC cells function as endocrine cells while sympathetic ganglion cells are neurons. In rat sympathetic ganglion cells, muscarinic M1 and M4 receptors mediate excitation and inhibition via suppression of M-type K+ channels and suppression of voltage-dependent Ca2+ channels, respectivel...
Source: Acta Histochemica - September 8, 2023 Category: Biochemistry Authors: Keita Harada Masumi Inoue Source Type: research
Immunolocalization of Cytoplasmic ER in ER-negative Breast Carcinoma as a Potent Favorable Prognostic Predictor
Acta Histochem Cytochem. 2023 Aug 30;56(4):59-66. doi: 10.1267/ahc.23-00016. Epub 2023 Aug 23.ABSTRACTIt is known that estrogen receptor (ER) has extranuclear signaling functions in addition to classical genomic pathway, and estrogenic actions have been reported in ER-negative breast carcinoma cells. However, significance of cytoplasmic-ER immunoreactivity has not been reported in ER-negative breast carcinoma tissues. We immunolocalized cytoplasmic ER in 155 ER-negative breast carcinoma tissues and evaluated its clinicopathological significance including the prognosis. As a comparative cohort set, we also used 142 ER-posit...
Source: Acta Histochemica - September 8, 2023 Category: Biochemistry Authors: Akiko Ebata Takashi Suzuki Narumi Shoji-Harada Yohei Hamanaka Minoru Miyashita Erina Iwabuchi Kiyoshi Takagi Yasuhiro Miki Hiroshi Tada Takanori Ishida Source Type: research
Muscarinic Receptor Stimulation Does Not Inhibit Voltage-dependent Ca < sup > 2+ < /sup > Channels in Rat Adrenal Medullary Chromaffin Cells
Acta Histochem Cytochem. 2023 Aug 30;56(4):67-75. doi: 10.1267/ahc.23-00042. Epub 2023 Aug 23.ABSTRACTAdrenal medullary chromaffin (AMC) and sympathetic ganglion cells are derived from the neural crest and show a similar developmental path. Thus, these two cell types have many common properties in membrane excitability and signaling. However, AMC cells function as endocrine cells while sympathetic ganglion cells are neurons. In rat sympathetic ganglion cells, muscarinic M1 and M4 receptors mediate excitation and inhibition via suppression of M-type K+ channels and suppression of voltage-dependent Ca2+ channels, respectivel...
Source: Acta Histochemica - September 8, 2023 Category: Biochemistry Authors: Keita Harada Masumi Inoue Source Type: research
Immunolocalization of Cytoplasmic ER in ER-negative Breast Carcinoma as a Potent Favorable Prognostic Predictor
Acta Histochem Cytochem. 2023 Aug 30;56(4):59-66. doi: 10.1267/ahc.23-00016. Epub 2023 Aug 23.ABSTRACTIt is known that estrogen receptor (ER) has extranuclear signaling functions in addition to classical genomic pathway, and estrogenic actions have been reported in ER-negative breast carcinoma cells. However, significance of cytoplasmic-ER immunoreactivity has not been reported in ER-negative breast carcinoma tissues. We immunolocalized cytoplasmic ER in 155 ER-negative breast carcinoma tissues and evaluated its clinicopathological significance including the prognosis. As a comparative cohort set, we also used 142 ER-posit...
Source: Acta Histochemica - September 8, 2023 Category: Biochemistry Authors: Akiko Ebata Takashi Suzuki Narumi Shoji-Harada Yohei Hamanaka Minoru Miyashita Erina Iwabuchi Kiyoshi Takagi Yasuhiro Miki Hiroshi Tada Takanori Ishida Source Type: research
Muscarinic Receptor Stimulation Does Not Inhibit Voltage-dependent Ca < sup > 2+ < /sup > Channels in Rat Adrenal Medullary Chromaffin Cells
Acta Histochem Cytochem. 2023 Aug 30;56(4):67-75. doi: 10.1267/ahc.23-00042. Epub 2023 Aug 23.ABSTRACTAdrenal medullary chromaffin (AMC) and sympathetic ganglion cells are derived from the neural crest and show a similar developmental path. Thus, these two cell types have many common properties in membrane excitability and signaling. However, AMC cells function as endocrine cells while sympathetic ganglion cells are neurons. In rat sympathetic ganglion cells, muscarinic M1 and M4 receptors mediate excitation and inhibition via suppression of M-type K+ channels and suppression of voltage-dependent Ca2+ channels, respectivel...
Source: Acta Histochemica - September 8, 2023 Category: Biochemistry Authors: Keita Harada Masumi Inoue Source Type: research
