Penetrating orbitocranial injury.
PENETRATING ORBITOCRANIAL INJURY. Acta Clin Croat. 2018 Dec;57(4):792-796 Authors: Klančnik M, Ivanišević P, Lupi-Ferandin S, Sučić A, Ledenko V, Lešin M, Krnić Martinić M, Kuščić-Juretić L Abstract - A case of a 37-year-old female patient is presented. The patient was admitted to the Surgical Emergency Unit after accidental fall on a metal rod when she had sustained stab injury of the right orbit with penetration into the right frontal brain lobe. Multi-slice computed tomography (MSCT) showed penetrating injury and fracture of the right orbital roof without eyeball damage...
Source: Acta Clinica Croatica - June 8, 2019 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Spinal dumbbell epidural hemangioma: two stage/same sitting/same position posterior microsurgical and transthoracic endoscopic resection - case report and review of the literature.
We describe a dumbbell spinal tumor (epidural cavernous hemangioma) resected by a 2-stage single-sitting combined approach. We also conduct a substantial literature review of the subject. We present a case of a 78-year-old male who was found to have a homogeneously enhancing, dumbbell-shaped, intraspinal, extradural tumor mass extending into the left chest cavity. The tumor was resected with a single-sitting 2-stage posterior technique: a microsurgical approach, followed by endoscopic resection via a thoracoscopic approach. There are several reports in the literature on the combined approach for dumbbell tumors of the spin...
Source: Acta Clinica Croatica - June 8, 2019 Category: General Medicine Tags: Acta Clin Croat Source Type: research

History of Urology at the Sestre Milosrdnice University Hospital Center.
Authors: Ružić B, Katušić J, Spajić B, Reljić A, Popović A, Štimac G, Tomašković I, Šoipi Š, Justinić D, Grubišić I, Tomić M, Knežević M, Svaguša I, Pezelj I, Nikles S, Pirša M, Vrhovec B Abstract The history of Croatian urology clearly shows its affiliation to the medical and civilizational circle of the Western world. The Department of Urology at the Sestre milosrdnice University Hospital Center is the oldest urology institution in the Republic of Croatia. The Department was established in 1894, when the new Sestre milosrdnice Hospital was open i...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

20 Years of the Reference Center for Prostate Tumors of the Ministry Of Health at the Department of Urology in Sestre Milosrdnice University Hospital Center.
Authors: Tomašković I, Nikles S, Pezelj I, Tomić M, Svaguša I, Pirša M, Justinić D, Grubišić I, Knežević M, Vrhovec B, Popović A, Reljić A, Spajić B, Katušić J, Ružić B Abstract The Department of Urology at the Sestre milosrdnice University Hospital Center is the oldest urological institution in the Republic of Croatia and this part of Europe. Today, the Department is a modern tertiary healthcare institution, where the most complex methods of urological practice are performed using modern medical devices and highly sophisticated technology. In 2011, our urology special...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Epidemiology of Prostate Cancer in Croatia - Situation and Perspectives.
Authors: Reljić A, Čukelj P, Tomašković I, Ružić B, Šekerija M Abstract Prostate cancer represents a significant public health burden in Croatia, as well as in other developed countries. The aim of this paper was to present the current epidemiological situation in Croatia in comparison to other similar countries, using basic indicators such as incidence, mortality, prevalence and survival, and to discuss future possibilities in this field. The incidence of prostate cancer in Croatia has been rapidly increasing since the mid-nineties; recent data indicates that the trend is levelling off. Mortalit...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Role of Multiparametric Magnetic Resonance Imaging in Prostate Cancer Assessment.
Authors: Tomašković I, Knežević M, Pezelj I, Bolanča Čulo K, Novosel L, Nikles S, Tomić M, Justinić D, Ninčević J, Pirša M, Ružić B Abstract Multiparametric magnetic resonance is assuming an increasingly important role in the diagnosis, initial assessment and monitoring of patients with prostate cancer. This paper offers a more complex insight into the application of magnetic resonance imaging with prostate cancer, with a current literature overview. The focus is on the problem of initial prostate cancer evaluation which strongly affects further decision-making and therapeutic interventions...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Diagnostic Value of Cognitive-Registration Multiparametric Magnetic Resonance Guided Biopsy for the Detection of Prostate Cancer after Initial Negative Biopsy.
Authors: Tomašković I, Pezelj I, Bolanča Čulo K, Novosel L, Nikles S, Tomić M, Reljić A, Katušić J, Knežević M, Pirša M, Kruslin B, Ulamec M, Ružić B Abstract The aim of this prospective clinical study was to determine the detection rate of prostate cancers by multiparametric magnetic resonance and transrectal ultrasound (mpMRI-TRUS) cognitive fusion biopsies in patients with a previously negative TRUS-guided biopsy. Between 1 October 2016 and 1 July 2017, in 101 consecutive patients with elevated antigen (PSA) and/or positive digital rectal examination and after a negative first TRUS...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Cost-Benefit Analysis of the Introduction of Mp-Mri Guided Biopsies in Croatia.
The objective of this study was to determine differential expression of TFF1, TFF2 and TFF3 genes and proteins in breast tumor subtypes. In addition, we investigated the correlation between TFF genes within tumor subgroups, and TFF genes with clinical and pathologic characteristics of the tumor. Study group included 122 patients with surgically removed breast tumors. Samples were investigated using qRT-PCR and immunohistochemistry. TFF1 and TFF3 genes and proteins were expressed in breast tumors, while the levels of TFF2 gene and protein expression were very low or undetectable. TFF1 was significantly more expressed in ben...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Histopathological Outcomes after Radical Prostatectomy for Prostate Cancer Based On a New Grading System.
Authors: Spajić B, Nikles S, Grubišić I, Knežević M, Shoipi S, Ulamec M, Štimac G, Tomašković I, Ružić B Abstract One of the main reasons for the introduction of a new grading system was Gleason sum 7, which differed significantly in the prognosis of the disease depending on the primary Gleason. The aim of this study was to compare grade group 2 and grade group 3, and the impact of cancer percentages in final pathology reports after radical prostatectomy on the occurrence of T3 stage of the disease after radical prostatectomy of clinically localized prostate cancer. The study covered 365...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Expression of LMO2 in Prostate Carcinoma and Adjacent Prostatic Parenchyma.
Authors: Krušlin B, Vučić M, Mašić S, Kruljac I, Lež C, Ružić B, Spajić B, Ulamec M Abstract LMO2 (LIM domain only) is a member of transcription factor family of proteins characterized by their cysteine-rich, zinc-binding LIM domains. Its expression in prostate cancer cells, as well as in adjacent stroma, is described in a study in a cohort of 83 patients treated with radical prostatectomy for clinically localized prostate adenocarcinoma. Authors found that LMO2 overexpression in prostate cancer was strongly associated with features indicative of worse prognosis (higher preoperative PSA, higher...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Unfavorable Clinicopathological Features in Radical Prostatectomy Patients Who Were Spared Pelvic Lymphadenectomy.
Authors: Tomašković I, Nikles S, Tomić M, Pezelj I, Svaguša I, Pirša M, Ružić B Abstract Pelvic lymph node dissection (PLND) during radical prostatectomy (RP) is the most accurate staging modality for lymph node assessment in patients with prostate cancer. It is recommended in all patients with intermediate or high-risk disease undergoing radical prostatectomy. The goal of our study was to assess unfavorable clinicopathological characteristics in patients with omitted lymphadenectomy (PLND) during radical prostatectomy based on the nomogram proposed by Briganti and colleagues. In 2011, 200 ...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Prostatic Artery Embolization as a New Option in the Treatment of Lower Urinary Tract Symptoms in Benign Prostatic Hyperplasia - Current Evidence.
Authors: Novosel L, Pezelj I, Tomašković I, Zadravec D, Ružić B Abstract Prostatic artery embolization is a minimally invasive endovascular treatment that improves lower urinary tract symptoms in men with benign prostatic hyperplasia. Although further randomized studies and long-term evidence is still needed for this method to be fully incorporated into treatment guidelines for benign prostatic hyperplasia, current studies show that this method can be an effective and safe alternative in patients with a significantly enlarged prostate gland who are not good surgical candidates. Therefore, we present the t...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Incidental Prostate Cancer in Patients Treated for Benign Prostate Hyperplasia in the Period of 21 Years.
Authors: Pirša M, Pezelj I, Knežević M, Spajić B, Tomašković I, Reljić A, Ružić B Abstract The aim of this study was to determine the incidence of incidental prostate cancer and its clinical significance among patients who underwent transurethral prostate resection or transvesical adenomectomy for benign prostate hyperplasia at the Department of Urology in Sestre milosrdnice University Hospital Center from January 1997 to December 2017. A total of 277/4,372 (6.34%) patients from our cohort were diagnosed with incidental prostate cancer (mean age 74.5 years). Due to incomplete data, 12 patents w...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Transobturator Advance ® Sling Suspension for the Treatment of Postprostatectomy Stress Urinary Incontinence.
We report our results with the AdVance® sling for the management of postoperative SUI. The evaluation was conducted on 47 patients with AdVance® implant for SUI in our institution (November 2010 - June 2017). Measurements included age, etiology of SUI, duration of SUI, follow-up and pad use per day (PPD) pre- and postoperatively. Patients were classified as cured if they used no pads or 1 PPD for security reasons, or as improved if 1-2 PPDs were used and if there was a 50% reduction in pad use per day postoperatively. In our series we observed a reduction of mean PPD of 5.1 (2-8) to 1.7 (0-4) postoperatively. After...
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Paneth Cell-Like Component in Prostate Cancer - Case Report.
We report a case of a 54 year-old patient with prostatic adenocarcinoma showing Paneth cell-like neuroendocrine differentiation. PMID: 30457254 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - November 22, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Zygomatic Air Cell Defect - Magnetic Resonance Imaging of the Temporomandibular Joint Compared with Panoramic Radiographs.
Authors: Zadravec D, Badel T, Smoljan M, Čimić S, Katavić N, Savić Pavičin I Abstract The aim of the study was to analyze zygomatic air cell defect (ZACD) incidence using magnetic resonance imaging (MRI) and validity of panoramic radiograph as a comparative method of ZACD diagnostics. The connection between ZACD incidence, age, left/right temporomandibular joint (TMJ) and comorbidity with diagnosis of TMJ disorder was analyzed. Panoramic radiographs and MRIs of 140 TMJs of 70 consecutive patients with previously confirmed TMJ diagnosis were compared in the study. A grading system (4-point scale from '0' for ab...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Measuring Healthcare Quality - Paradigm of Medqual.
Authors: Musa-Juroš K, Mijoč J, Horvat J, Ilakovac V, Marković S, Racz A Abstract Medical activity is assumed to be service activity the effects of which can be measured. The SERVQUAL scale was used as a starting point for our research, which resulted in a new, adopted scale called MEDQUAL. The MEDQUAL scale aims to measure the quality of healthcare provided by medical staff of one hospital department instead of the overall quality of hospital services or parts of services on which medical staff in one department has no influence. The study was conducted in a clinical hospital department in Croatia and inc...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Effect of Different Visual Impairment Levels on the Quality of Life in Glaucoma Patients.
Authors: Runjić T, Novak Lauš K, Vatavuk Z Abstract The aim of this study was to assess the effect of different visual impairment levels on difference in the subjective quality of life estimation. We included 150 patients with glaucoma whose best-corrected visual acuity in the better-seeing eye was 0.5 and less. All of them were in advanced stage of the disease, with visual field defect worse than 12 dB in mean defect, when measured with the Octopus Visual Field Analyzer. In order to assess the quality of life, we used the Impact of Vision Impairment questionnaire. Additionally, we used General Information ...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Expression of Nedd9 in Transbronchial Biopsies of Lung Adenocarcinoma.
Authors: Ostojić J, Brčić L, Hrabač P, Seiwerth S Abstract Lung cancer as the major cause of cancer mortality worldwide includes several histologic subtypes evolving from numerous genetic and epigenetic changes emerging in alveolar, bronchiolar and bronchial epithelium. The majority of cases are diagnosed in advanced stage (i.e. stages IIIB and IV), often with scanty amount of tissue in transbronchial biopsies or cytology specimens. The aim of the present study was to investigate the expression of the scaffolding protein neural precursor cell expressed, developmentally downregulated 9 (NEDD9) in small biopsies ...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Patient, Healthcare System and Total Delay in Tuberculosis Diagnosis and Treatment Among Serbian Population.
Authors: Stjepanović M, Škodrić-Trifunović V, Radisavljević-Pavlović S, Roksandić-Milenković M, Milin-Lazović J, Babić U, Mašković J, Buha I, Stojković-Lalošević M, Stojković M, Mihailović-Vučinić V Abstract Currently, topical are studies that examine different reasons for delay of tuberculosis (TB) diagnosis and its impact on disease prognosis. The aim was to examine three time periods associated with treatment delay: patient related, health system related and total delay. This retrospective-prospective study included 100 consecutive patients hospitalized at Department of Pulmo...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Differential Expression of TFF Genes and Proteins in Breast Tumors.
The objective of this study was to determine differential expression of TFF1, TFF2 and TFF3 genes and proteins in breast tumor subtypes. In addition, we investigated the correlation between TFF genes within tumor subgroups, and TFF genes with clinical and pathologic characteristics of the tumor. Study group included 122 patients with surgically removed breast tumors. Samples were investigated using qRT-PCR and immunohistochemistry. TFF1 and TFF3 genes and proteins were expressed in breast tumors, while the levels of TFF2 gene and protein expression were very low or undetectable. TFF1 was significantly more expressed in ben...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Cytotoxicity and Genotoxicity of Resin Based Dental Materials in Human Lymphocytes In Vitro.
In conclusion, under the conditions of this in vitro study, cured conventional composites did not show cytotoxic or genotoxic effect, which is important for clinical application of these materials, whereas uncured forms exhibited certain level of cytotoxicity and genotoxicity, mainly because of monomers in their composition. PMID: 30431720 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Morphological Characteristics and Frequency of Accessory Right Hepatic Veins - Evaluation with Computed Tomography.
Authors: Mišič J, Popović P, Hribernik M, Starc A, Dahmane R Abstract In the liver, there are many vascular variants, which are important in liver surgery, the presence of accessory right hepatic veins (aRHVs) in particular. Th eir frequency, number and diameter vary considerably. Detailed imaging diagnostics with computed tomography (CT) should be undertaken before surgery. Th e aim of our study was to examine the characteristics of aRHVs and their demographic correlations. Th e study included data on 188 patients that underwent CT examination of the abdomen with contrast media, 103 men (54.8%) men and 85...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Albi Score as a Predictor of Survival in Patients with Compensated Cirrhosis Resected for Hepatocellular Carcinoma: Exploratory Evaluation in Relationship to Palbi and Meld Liver Function Scores.
In conclusion, ALBI score demonstrated significant predictive capabilities for survival in patients with compensated cirrhosis resected for hepatocellular carcinoma. PMID: 30431722 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Flow Changes in Orbital Vessels Detected with Color Doppler Ultrasound in Patients with Early Dysthyroid Optic Neuropathy.
Authors: Lešin M, Rogošić V, Vanjaka Rogošić L, Barišić I, Pelčić G Abstract Thyroid-associated orbitopathy (TAO) is a common manifestation of Graves' disease. The aim of the study was to assess the six percent of patients with TAO that develop dysthyroid optic neuropathy (DON), which is the most serious complication of TAO. As DON can cause perma-nent damage, it is essential to detect DON early when visual loss is still reversible. Color Doppler ultrasound is a noninvasive diagnostic method, which may be useful in early detection of DON. Thirty-six patients with confirmed Graves' d...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience.
Authors: Jelušić M, Kronja M, Frković M, Sršen S, Huljev Frković S, Štekić Novački K Abstract Macrophage activation syndrome (MAS) is a potentially fatal complication of systemic juvenile idiopathic arthritis (sJIA), caused by exaggerated but ineffective immune response. The aim of the study was to compare the capacity of the HLH-2004 guidelines with the capacity of the MAS guidelines from 2005, and with the new set of classification criteria from 2016 in diagnosing MAS complicating sJIA. The study included 35 children aged 1-18 diagnosed with sJIA according to ILAR criteria and treated at...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The Efficacy of Low-Level Laser Therapy in Burning Mouth Syndrome - A Pilot Study.
Authors: Sikora M, Včev A, Siber S, Vučićević Boras V, Rotim Ž, Matijević M Abstract The aim of this clinical study was to compare low-level laser therapy (LLLT) switched on and switched off in the treatment of burning mouth syndrome (BMS). BMS is a debilitating condition for patients and highly demanding for physicians, characterized by burning symptoms in the oral cavity. Despite extensive research, so far only cognitive behavioral therapy and clonazepam have been proven successful for its treatment in randomized controlled trials. Forty-four patients with BMS were randomly assigned to the study laser group...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Correlation Between Salivary Biochemical Stress Indicators and Psychological Indicators.
Authors: Crnković D, Peco M, Gelo J Abstract Saliva is a complex body fluid that has various functions in the oral cavity. Central nervous system has the most important role in regulating salivation. Saliva as a sample is suitable for simplicity of sampling and because it contains analytes in the free active form. Stress is a condition in which the internal (psychophysical) balance of the body is disturbed. It activates the hypothalamic-pituitary axis, so salivary cortisol is a free cortisol indicator that correlates well with its serum value and reflects the free fraction that is biologically active. At the same ...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Intravitreal Injection of Perfluoropropane is More Efficacious than Sulfur Hexafluoride In Releasing Vitreomacular Traction.
Authors: Čokl N, Globočnik Petrovič M Abstract The aim was to compare the efficacy of a single intravitreal injection of perfluoropropane (C3F8) and sulfur hexafluoride (SF6) in releasing vitreomacular traction (VMT). This prospective study included two groups of patients with symptomatic VMT confirmed by spectral-domain optical coherence tomography (SD-OCT). Patients from both groups received a single intravitreal injection of expansile gas. One group (29 eyes) received 0.3 mL of 100% C3F8, and the other group (28 eyes) received 0.3 mL of 100% SF6. Eyes without VMT release one month after SF6 injection were sec...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Reliability of Ultrasound Measurement of Muscle Thickness in Patients with Supraspinatus Tendon Pathology.
In conclusion, supraspinatus muscle thickness measurement by US is a reliable method for muscle atrophy evaluation and strongly correlates with other acknowledged methods. PMID: 30431728 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Differential Diagnosis of Cheilitis - How to Classify Cheilitis?
Authors: Lugović-Mihić L, Pilipović K, Crnarić I, Šitum M, Duvančić T Abstract Although cheilitis as a term describing lip inflammation has been identified and recognized for a long time, until now there have been no clear recommendations for its work-up and classification. The disease may appear as an isolated condition or as part of certain systemic diseases/conditions (such as anemia due to vitamin B12 or iron deficiency) or local infections (e.g., herpes and oral candidiasis). Cheilitis can also be a symptom of a contact reaction to an irritant or allergen, or may be provoked by sun exposure (actin...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Multiple Sclerosis: New Aspects of Immunopathogenesis.
Authors: Lazibat I, Rubinić Majdak M, Županić S Abstract Multiple sclerosis (MS) is a multicomponent disease characterized by inflammation, neurodegeneration, and cancellation of the central nervous system recovery mechanisms. The cause of MS is still unknown, but it is undeniable that genetic, environmental and immune factors are involved in the etiopathogenesis of this complex and heterogeneous disease. From the aspect of immunopathogenesis, until recently the opinion prevailed that autoreactive T lymphocytes played a major role, the activation of which is a key step in MS. The knowledge of the effector and re...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

T-Cell Large Granular Lymphocytic Leukemia - Case Reports.
Authors: Kojić Katović S, Vasilj A, Rinčić G Abstract T-cell large granular lymphocytic leukemia (T-LGLL) is an uncommon but probably underdiagnosed disease caused by clonal proliferation of large granular lymphocytes. Diagnosis is typically based on the high number of morphologically characteristic lymphoid cells and finding of an abnormal immunophenotype by flow cytometry. Because of its relatively indolent clinical behavior, observation is often an appropriate therapy. Here we present a case of a 53-year-old male admitted to the hospital because of abdominal pain. Blood examination revealed mild mycrocitic a...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Brachial Plexus Schwannoma - Case Report and Literature Review.
We present a case of a 49-year-old female patient with a slow growing painless mass in the right supraclavicular region that was diagnosed as schwannoma and operated at our department. The case is described to remind that in case of supraclavicular tumors, differential diagnosis should take brachial plexus tumors, i.e. schwannomas, in consideration. Extra caution is also required on fine needle aspiration procedures or biopsies of schwannomas due to the possible iatrogenic injury of the nerve and adjacent structures. On operative treatment of schwannoma, complete tumor resection should be achieved while preserving the nerv...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

An Unusual Case of Papillary Thyroid Carcinoma Iodine-131 Avid Metastasis to the Adrenal Gland.
Authors: Blažeković I, Jukić T, Granić R, Punda M, Franceschi M Abstract Papillary thyroid carcinoma (PTC) is considered one of the most favorable tumors, indolent, with rare distant dissemination. Lungs and bones are the most common metastatic sites. Unusual sites of PTC distant metastases are extremely rare. Brain, liver, skin, kidney, pancreas, and adrenal gland PTC metastases have been sporadically reported in the literature. An 86-year-old female patient underwent total thyroidectomy and neck dissection due to PTC. Postoperative whole body iodine-131 scintigraphy with I-131 SPECT/CT of the abdomen revealed...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Lateral Inverted Osteochondral Fracture of the Talus: Case Reports and Review of the Literature.
We describe two LIFT cases referred from other institutions after unsuccessful conservative treatment of OLT. They presented with pain, swelling and tenderness over the anterolateral aspect of the right ankle. We recognized the LIFT lesion on the magnetic resonance imaging scans in patient 2, while in patient 1 the orientation of the fragment was recognized upon direct visualization during operative treatment. Both patients underwent arthroscopic procedure. Due to articular cartilage damage and insufficiency of the adjacent bone of the fragment, both patients were treated with excision fol-lowed by microfracture. Treatment...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Recommendations for Perioperative Management of Patients with Cardiac Implantable Electronic Devices.
Authors: Pavlović N, Manola Š, Vražić H, Vučić M, Brusich S, Radeljić V, Zeljković I, Matasić R, Anić A, Benko I, Gavranović Ž, Zlatić Glogoški M Abstract Four thousand cardiac implantable electronic devices (CIED) are implanted yearly in Croatia with constant increase. General anesthesia and surgery carry some specific risk for the patients with implanted CIEDs. Since most of the surgical procedures are performed in institutions without reprogramming devices available, or in the periods when they are unavailable, these guidelines aim to standardize the protocol for perioperative managemen...
Source: Acta Clinica Croatica - November 17, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The Impact of Comorbidity on Rehabilitation Outcome after Ischemic Stroke.
Authors: Simić-Panić D, Bošković K, Milićević M, Rabi Žikić T, Cvjetković Bošnjak M, Tomašević-Todorović S, Jovićević M Abstract Comorbidity decreases survival but it still remains unknown to what extent functional recovery after ischemic stroke is affected. The aim of this research was to determine the prevalence of the most common comorbidities in patients with ischemic stroke and to examine their predictive value on the functional status and recovery. In order to obtain relevant information for this research, we conducted a prospective study over a two-year period. It included pa...
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Do We Pay Enough Attention to Neuropathic Pain in Knee Osteoarthritis Patients?
In conclusion, knee osteoarthritis patients with neuropathic pain component were experiencing higher levels of pain, implicating poorer pain control with common analgesics. Recognizing these patients as a distinct subgroup would allow clinicians to improve their treatment by using unconventional analgesics with central activity. PMID: 30256007 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Cardiovascular Risk Assessed by Reynolds Risk Score in Relation to Waist Circumference in Apparently Healthy Middle-Aged Population in Montenegro.
Authors: Klisić A, Kavarić N, Bjelaković B, Jovanović M, Zvrko E, Stanišić V, Ninić A, Šćepanović A Abstract Reynolds Risk Score (RRS) is regarded as a good screening tool for cardiovascular disease (CVD) risk. Since CVD is the leading cause of death in Montenegro, we aimed to assess the risk of CVD as assessed by RRS and to examine its association with cardiometabolic parameters in apparently healthy middle-aged population. In addition, we aimed to test whether obesity had an independent influence on RRS. A total of 132 participants (mean age 56.2±6.73 years, 69% females) were included...
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Lower Extremity Injuries in Novice Runners: Incidence, Types, Time Patterns, Sociodemographic and Motivational Risk Factors in a Prospective Cohort Study.
Authors: Vlahek P, Matijević V Abstract The aim was to determine types and incidence of running-related lower extremity injuries and identify sociodemographic and motivational risk factors in novice runners attending an eight-month running school. Between January 2011 and October 2014, 349 novice runners were included. Sociodemographic, anthropometric, and data on running motivation and self-perceived health and fitness were collected. Subjects were screened for lower extremity injuries at regular three-month intervals. The cohort mean age was 35.46±7.31 years, and 271 (79.5%) were female. There were 173 (4...
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Anxiety During Pregnancy and Postpartum: Course, Predictors and Comorbidity with Postpartum Depression.
Authors: Nakić Radoš S, Tadinac M, Herman R Abstract Previous findings on peripartum anxiety are inconsistent in respect to the prevalence and course of peripartum anxiety with comorbidity of depression. Our aim was threefold: (1) to examine the course of elevated anxiety during pregnancy, immediately after childbirth, and six weeks postpartum; (2) to establish comorbidity of postpartum anxiety and postpartum depression (PPD); and (3) to examine predictors of anxiety 6 weeks postpartum. A sample of women (N=272) who were below the cut-off score for clinical depression during pregnancy were assessed in the t...
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Female Sexual Function and Dysfunction: A Cross-National Prevalence Study in Slovenia.
Authors: Starc A, Jukić T, Poljšak B, Dahmane R Abstract The purpose of the current study was to evaluate the prevalence of female sexual dysfunction in Slovenia. We aimed to explore the prevalence itself, comparison among demographic groups and potential correlations. Data were collected based on the validated standardized Female Sexual Function Index (FSFI) (N=605). Most participants had sexual intercourse with one partner (n=523), and the majority of sexual relationships were heterosexual (n=584). University educated subjects had the highest claims of arousal, followed by those with master/doctoral degre...
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Treatment of Elderly Patients with Chronic Hepatitis C: A Retrospective Cohort Study.
In conclusion, selected elderly patients can achieve comparable SVR rates as younger patients, but with a higher rate of side effects. Since complications of HCV infection occur more frequently in elderly patients, they should be given priority for antiviral therapy. PMID: 30256012 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Association Between Interleukin-10 Gene (-1082g/A) Polymorphism and Type 2 Diabetes, Diabetes-Related Traits, and Microvascular Complications in the Croatian Population.
Authors: Canecki-Varžić S, Prpić-Križevac I, Mihaljević S, Bilić-Ćurčić I, Alkhamis T, Wagner J, Škrlec I, Barbić J Abstract Interleukin (IL)-10 is an anti-inflammatory cytokine, and a decrease in its secretion is associated with obesity, metabolic syndrome and type 2 diabetes. However, it has not been established whether the intensity of the immune response during diabetes-associated chronic inflammation affects the development and/or progression of type 2 diabetes and its microvascular complications. The aim of this study was to investigate the role of single nucleotide polymorphism (SNP)-1082G/A...
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Allergic Diseases and Atopy Among Schoolchildren in Eastern Croatia.
Authors: Aberle N, Kljaić Bukvić B, Blekić M, Vučković M, Bardak D, Gudelj A, Čančarević G, Franić M Abstract A cross-sectional study was carried out in Brod-Posavina County, Croatia, to assess the prevalence of allergic diseases and atopy, as well as to investigate the possible etiologic factors for asthma, allergic rhinitis and eczema in childhood. The study included 1687 schoolchildren aged 10-11 years. Data were collected using standardized International Study of Asthma and Allergies in Childhood (ISAAC) Phase II written questionnaire. Skin prick tests were performed to provide an objective measure of ...
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Presence of Helicobacter Pylori in the Stomach and Laryngeal Mucosal Linings in Patients with Laryngeal Cancer.
In conclusion, H. pylori was found in the area of laryngeal carcinoma, and its migration appeared likely to occur both upwards (from the stomach to the mouth) and downwards (from the oral cavity to the stomach). PMID: 30256015 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The Role of Pai-1 Gene 4g/5g Polymorphism and Diagnostic Value of Biomarkers in Allergic and Non-Allergic Asthma Phenotype.
Authors: Lampalo M, Jukić I, Bingulac-Popović J, Safić H, Ferara N, Popović-Grle S Abstract Asthma is a chronic inflammatory disease that is characterized by reversible obstruction of airways, bronchial hyper-reactivity and airway remodeling. The etiology of asthma is multifactorial, with inheritance playing an important role. The aim of our study was to investigate the importance of biomarkers of asthma and the role of plasminogen activator inhibitor-1 (PAI-1) gene as a genetic factor that could be involved in the pathogenesis of asthma. The research was conducted at Jordanovac University Department for Lung D...
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Distribution of Stroke Risk Factors in Eastern Croatia.
Authors: Rostohar Bijelić B, Petek M, Kadojić M, Bijelić N, Kadojić D Abstract The aim of this study was to determine the distribution of risk factors according to age, gender, subtypes and recurrence of stroke in eastern Croatia. The study included 250 acute stroke patients admitted to University Department of Neurology, Osijek University Hospital Centre in 2011. Patients were grouped according to age, gender, subtypes and recurrence of stroke. The study showed significant differences in the distribution of cigarette smoking, diabetes, cardiomyopathy and hyperuricemia according to patient age. According to gen...
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Globus Pharyngeus: A Symptom of Increased Thyroid or Laryngopharyngeal Reflux?
Authors: Penović S, Roje Ž, Brdar D, Gračan S, Bubić A, Vela J, Punda A Abstract The aim of this study was to investigate the relationship between globus pharyngeus and laryngopharyngeal reflux, as well as between globus and thyroid volume. A two-year prospective study included 56 patients aged 18-75 with globus symptom. Anthropometric, clinical and laboratory data were collected. All patients filled-out the Glasgow Edinburgh Throat Scale (GETS) and then underwent thyroid ultrasound. Morphological changes of the larynx were detected by direct laryngoscopy and classified by the Reflux Finding Score (RFS). If RFS...
Source: Acta Clinica Croatica - September 27, 2018 Category: General Medicine Tags: Acta Clin Croat Source Type: research