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Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading
This study aims to investigate the positive effects of MSCs against ferroptosis in an ALF model and explore the underlying molecular mechanisms of their therapeutic function. Our results show that intravenously injected MSCs protect against ferroptosis in ALF mouse models. MSCs decrease iron deposition in the liver of ALF mice by downregulating hepcidin level and upregulating FPN1 level. MSCs labelled with Dil are mainly observed in the hepatic sinusoid and exhibit colocalization with the macrophage marker CD11b fluorescence. ELISA demonstrates a high level of IGF1 in the CCL 4+MSC group. Suppressing the IGF1 effect by the...
Source: Acta Biochimica et Biophysica Sinica - January 26, 2024 Category: Biochemistry Authors: Haiqin Cheng Yaqian Shi Xuewei Li Ning Jin Mengyao Zhang Zhizhen Liu Yuxiang Liang Jun Xie Source Type: research

The P124A mutation of SRP14 alters its migration on SDS-PAGE without impacting its function
In conclusion, the substitution of proline for alanine in the alanine-rich tail of SRP14 results in faster migration on SDS-PAGE, but has little effect on its function.PMID:38273782 | DOI:10.3724/abbs.2024004 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - January 26, 2024 Category: Biochemistry Authors: Yaofu Liu Jinqiu Zhou Source Type: research

lncRNA CYTOR promotes lung adenocarcinoma gemcitabine resistance and epithelial-mesenchymal transition by sponging miR-125a-5p and upregulating ANLN and RRM2
In this study, lncRNA CYTOR expression and its association with the prognosis of LUAD patients are assessed by quantitative RT-PCR and Kaplan-Meier survival analysis. In vitro and in vivo functional studies are conducted to evaluate the biological functions of CYTOR in LUAD. The underlying mechanism regarding the tumor-promoting effects of CYTOR is explored using RNA immunoprecipitation, biotin-labelled RNA pulldown, luciferase reporter assays, and western blot analysis. We identify that CYTOR is an oncogenic lncRNA and is apparently upregulated in LUAD by analysing TCGA-LUAD data. High CYTOR expression is a poor prognosti...
Source: Acta Biochimica et Biophysica Sinica - January 26, 2024 Category: Biochemistry Authors: Qijun Cao Haixia Wang Jialong Zhu Chen Qi Hairong Huang Xiaoyuan Chu Source Type: research

Valproic acid regulates the miR-155/Jarid2 axis by affecting miR-155 promoter methylation in glioma
This study demonstrates a new mechanism of VPA treatment of gliomas by affecting the miR-155/JARID2 axis, which could be regarded as a new strategy for the prevention and treatment of glioma.PMID:38273784 | DOI:10.3724/abbs.2023259 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - January 26, 2024 Category: Biochemistry Authors: Ruixuan Wang Yanhong Chen Weilu Kuang Wuzhong Jiang Wenjing Zeng Yinyun Chen Zhengzheng Liu Source Type: research

NK cell depletion promotes liver metastasis of lung cancer cells
Acta Biochim Biophys Sin (Shanghai). 2024 Jan 22. doi: 10.3724/abbs.2023266. Online ahead of print.NO ABSTRACTPMID:38247326 | DOI:10.3724/abbs.2023266 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - January 22, 2024 Category: Biochemistry Authors: Pan Yu Long Zhang Jianhui Tian Jiajun Liu Zujun Que Ge Li Yiyang Zhou Source Type: research

Arginine vasopressin induces ferroptosis to promote heart failure via activation of the V1aR/CaN/NFATC3 pathway
This study may lead to the proposal of a novel therapeutic strategy for HF.PMID:38247327 | DOI:10.3724/abbs.2023289 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - January 22, 2024 Category: Biochemistry Authors: Zhiyong Wu Hua Jiang Qiulin Yin Zhifeng Zhang Xuanlan Chen Source Type: research

Identification and characterization of multipotential stem cells in immortalized normal ovarian surface epithelial cells
This study aims to determine whether IOSE80 cells have the characteristics of stem cell proliferation and multilineage differentiation and their application in regenerative medicine. IOSE80 cells are sequenced by high-throughput transcriptome analysis, and 5 sets of public data are used to compare the differences between IOSE80 cells and bone marrow mesenchymal stem cells, pluripotent stem cells, and oocytes in transcriptome profiling. The IOSE80 cells present a cobblestone-like monolayer and express the epithelial cell marker KRT18; the stem cell markers IFITM3, ALDH1A1, and VIM; lowly express stem cell marker LGR5 and ge...
Source: Acta Biochimica et Biophysica Sinica - January 20, 2024 Category: Biochemistry Authors: Lin Hou Hanqing Hong Wenjiao Cao Liutong Wei Lichun Weng Shuang Yuan Chengqi Xiao Qiuwan Zhang Qian Wang Dongmei Lai Source Type: research

Suppression of pancreatic cancer proliferation through TXNIP-mediated inhibition of the MAPK signaling pathway
In conclusion, our study reveals TXNIP as a promising new predictive marker and therapeutic target for pancreatic cancer.PMID:38229544 | DOI:10.3724/abbs.2023286 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - January 17, 2024 Category: Biochemistry Authors: Qinglin Fei Kaizhou Jin Saimeng Shi Tianjiao Li Duancheng Guo Mengxiong Lin Xianjun Yu Weiding Wu Longyun Ye Source Type: research

A traditional formula of aconitum complex alleviates post-ischemic stroke by improving neural function
Acta Biochim Biophys Sin (Shanghai). 2024 Jan 16. doi: 10.3724/abbs.2023291. Online ahead of print.NO ABSTRACTPMID:38229545 | DOI:10.3724/abbs.2023291 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - January 17, 2024 Category: Biochemistry Authors: Ji Ma Ruiqi Pu Qinyang Zhou Maoru Li Jing Shang Source Type: research

Remarks from Editor-in-Chief on the celebration of the 65th anniversary of Acta Biochimica et Biophysica Sinica
Acta Biochim Biophys Sin (Shanghai). 2023 Jun 15;55(6):889-890. doi: 10.3724/abbs.2023116.NO ABSTRACTPMID:38193209 | DOI:10.3724/abbs.2023116 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - January 9, 2024 Category: Biochemistry Authors: Jianping Ding Source Type: research

Integration of scRNA and bulk RNA-sequence to construct the 5-gene molecular prognostic model based on the heterogeneity of thyroid carcinoma endothelial cell
In this study, we not only reveal that endothelial cells (ECs) are strongly associated with the progress of papillary thyroid cancer (PTC) using single-cell RNA-seq (scRNA-seq) data downloaded from Gene Expression Omnibus (GEO) and WGCNA, but also screen 5 crucial genes of ECs: CLDN5, ABCG2, NOTCH4, PLAT, and TMEM47. Furthermore, the 5-gene molecular prognostic model is constructed, which can predict how well a patient will do on PD-L1 blockade immunotherapy for TC and evaluate prognosis. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis demonstrates that PLAT is decreased in TC and the increase of PLAT c...
Source: Acta Biochimica et Biophysica Sinica - January 8, 2024 Category: Biochemistry Authors: Zhaoxian Ni Shan Cong Hongchang Li Jiazhe Liu Qing Zhang Chuanchao Wei Gaofeng Pan Hui He Weiyan Liu Anwei Mao Source Type: research

Noncanonical functions of microRNAs in the nucleus
Acta Biochim Biophys Sin (Shanghai). 2024 Jan 3. doi: 10.3724/abbs.2023268. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) that play their roles in the regulation of physiological and pathological processes. Originally, it was assumed that miRNAs only modulate gene expression posttranscriptionally in the cytoplasm by inducing target mRNA degradation. However, with further research, evidence shows that mature miRNAs also exist in the cell nucleus, where they can impact gene transcription and ncRNA maturation in several ways. This review provides an overview of novel models of nuclear miRN...
Source: Acta Biochimica et Biophysica Sinica - January 3, 2024 Category: Biochemistry Authors: Jiayi Gu Yuanan Li Youtong Tian Yehao Zhang Yongjun Cheng Yuanjia Tang Source Type: research