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Ferroptosis: a potential target for the treatment of atherosclerosis
Acta Biochim Biophys Sin (Shanghai). 2024 Feb 7. doi: 10.3724/abbs.2024016. Online ahead of print.ABSTRACTAtherosclerosis (AS), the main contributor to acute cardiovascular events, such as myocardial infarction and ischemic stroke, is characterized by necrotic core formation and plaque instability induced by cell death. The mechanisms of cell death in AS have recently been identified and elucidated. Ferroptosis, a novel iron-dependent form of cell death, has been proven to participate in atherosclerotic progression by increasing endothelial reactive oxygen species (ROS) levels and lipid peroxidation. Furthermore, accumulat...
Source: Acta Biochimica et Biophysica Sinica - February 8, 2024 Category: Biochemistry Authors: Chengyi Li Ran Liu Zhenyu Xiong Xue Bao Sijia Liang Haotian Zeng Wei Jin Quan Gong Lian Liu Jiawei Guo Source Type: research

Mitochondrial deoxyguanosine kinase is required for female fertility in mice
In this study, we find that Dguok knockout results in female infertility. Mechanistically, DGUOK deficiency hinders ovarian development and oocyte maturation. Moreover, DGUOK deficiency in oocytes causes a significant reduction in mitochondrial DNA copy number and abnormal mitochondrial dynamics and impairs germinal vesicle breakdown. Only few DGUOK-deficient oocytes can extrude their first polar body during in vitro maturation, and these oocytes exhibit irregular chromosome arrangements and different spindle lengths. In addition, DGUOK deficiency elevates reactive oxygen species levels and accelerates oocyte apoptosis. Ou...
Source: Acta Biochimica et Biophysica Sinica - February 8, 2024 Category: Biochemistry Authors: Yake Gao Rui Dong Jiacong Yan Huicheng Chen Lei Sang Xinyi Yao Die Fan Xin Wang Xiaoyuan Zuo Xu Zhang Shengyu Yang Ze Wu Jianwei Sun Source Type: research

Melatonin protects TEGDMA-induced preodontoblast mitochondrial apoptosis via the JNK/MAPK signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Feb 2. doi: 10.3724/abbs.2023263. Online ahead of print.ABSTRACTResin monomer-induced dental pulp injury presents a pathology related to mitochondrial dysfunction. Melatonin has been regarded as a strong mitochondrial protective bioactive compound from the pineal gland. However, it remains unknown whether melatonin can prevent dental pulp from resin monomer-induced injury. The aim of this study is to investigate the effects of melatonin on apoptosis of mouse preodontoblast cells (mDPC6T) induced by triethylene glycol dimethacrylate (TEGDMA), a major component in dental resin, and t...
Source: Acta Biochimica et Biophysica Sinica - February 3, 2024 Category: Biochemistry Authors: Qihao Yu Ruize Hua Bingyang Zhao Dongchao Qiu Chengfei Zhang Shengbin Huang Yihuai Pan Source Type: research

AMPK/PGC-1 α and p53 modulate VDAC1 expression mediated by reduced ATP level and metabolic oxidative stress in neuronal cells
In this study, we find that VDAC1 protein expression is up-regulated in various neuronal cell lines in response to intracellular metabolic and oxidative stress. We further demonstrate that VDAC1 expression is modulated by intracellular ATP level. Through the use of pharmacological agonists and inhibitors and small interfering RNA (siRNA), we reveal that the AMPK/PGC-1α signaling pathway is involved in regulating VDAC1 expression. Additionally, based on bioinformatics predictions and biochemical verification, we identify p53 as a potential transcription factor that regulates VDAC1 promoter activity during metabolic oxidati...
Source: Acta Biochimica et Biophysica Sinica - February 1, 2024 Category: Biochemistry Authors: Zhitong Wang Tingting Xu Yingni Sun Xiang Zhang Xiaoliang Wang Source Type: research

UBA3 promotes the occurrence and metastasis of intrahepatic cholangiocarcinoma through MAPK signaling pathway
In conclusion, our study shows that bufalin inhibits ICC by targeting UBA3, which has emerged as a new biomarker and potential therapeutic target for ICC.PMID:38298057 | DOI:10.3724/abbs.2024014 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - February 1, 2024 Category: Biochemistry Authors: Huhu Zhang Jiahua Yang Qinghang Song Xiaoyan Ding Fulin Sun Lina Yang Source Type: research

Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats
In conclusion, our results suggest that Puerarin is an effective drug against HF and may play a protective role in the myocardium by inhibiting the activation of p38 and its downstream NHE1.PMID:38282474 | DOI:10.3724/abbs.2023269 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - January 29, 2024 Category: Biochemistry Authors: Guopin Pan Baoyue Cui Mingming Han Laibiao Lin Yinlan Li Ling Wang Shuang Guo Yaling Yin Heqin Zhan Peng Li Source Type: research

ATIP/ATIP1 regulates prostate cancer metastasis through mitochondrial dynamic-dependent signaling
In this study, we explore the biological function of ATIP1, which is a mitochondrial-located isoform of angiotensin II AT2 receptor interacting proteins (ATIPs) in prostate cancer cells. The results showed that ATIP is downregulated in prostate cancer tissues and is negatively correlated with the disease-free survival rate of prostate cancer patients. Silencing of ATIP promotes mitochondrial fission and enhances tumor cell migration and invasion. Reconstitution of ATIP1 in ATIP-deficient cells significantly attenuates mitochondrial trafficking and tumor cell movement. Therefore, ATIP1 is a negative regulator of mitochondri...
Source: Acta Biochimica et Biophysica Sinica - January 29, 2024 Category: Biochemistry Authors: Haokun Yuan Ruiqin Fang Chi Fu Shuo Wang Xiaoqin Tong Deyi Feng Xiaoqing Wei Xirong Hu Yuan Wang Source Type: research

8-Oxoguanine-DNA glycosylase (OGG1) protects cells from senescence via the p53-p21 pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Jan 29. doi: 10.3724/abbs.2023264. Online ahead of print.ABSTRACTCellular senescence is an important factor leading to pulmonary fibrosis. Deficiency of 8-oxoguanine-DNA glycosylase (OGG1) in mice leads to alleviation of bleomycin (BLM)-induced mouse pulmonary fibrosis, and inhibition of the OGG1 enzyme reduces the epithelial mesenchymal transition (EMT) in lung cells. In the present study, we find decreased expression of OGG1 in aged mice and BLM-induced cell senescence. In addition, a decrease in OGG1 expression results in cell senescence, such as increases in the percentage of S...
Source: Acta Biochimica et Biophysica Sinica - January 29, 2024 Category: Biochemistry Authors: Shenglan Gao Lujun Chen Ziying Lin Zhiliang Xu Yahong Wang Huayu Ling Zijun Wu Yu Yin Weimin Yao Keng Wu Gang Liu Source Type: research