Acta Biochimica et Biophysica Sinica This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Agrimol B alleviates cisplatin-induced acute kidney injury by activating the Sirt1/Nrf2 signaling pathway in mice
Acta Biochim Biophys Sin (Shanghai). 2024 Feb 26. doi: 10.3724/abbs.2023285. Online ahead of print.ABSTRACTCisplatin (CDDP) is a widely used chemotherapeutic agent that has remarkable antineoplastic effects. However, CDDP can cause severe acute kidney injury (AKI), which limits its clinical application. Agrimol B is the main active ingredient found in Agrimonia pilosa Ledeb and has a variety of pharmacological activities. The effect of agrimol B on CDDP-induced renal toxicity has not been determined. To investigate whether agrimol B has a protective effect against CDDP-induced AKI, we first identify Sirtuin 1 (Sirt1) as a ...
Source: Acta Biochimica et Biophysica Sinica - February 26, 2024 Category: Biochemistry Authors: Jiarui Tang Longhui Li Zhijian Chen Cuiting Liao Kai Hu Yongqiang Yang Jiayi Huang Li Tang Li Zhang Longjiang Li Source Type: research

AHR signaling pathway mediates mitochondrial oxidative phosphorylation which leads to cytarabine resistance
In this study, RNA-Seq data from AML patients (bone marrow samples from 173 newly diagnosed AML patients) obtained from the TCGA database, and normal human RNA-Seq data (bone marrow samples from 70 healthy individuals) obtained from the GTEX database are downloaded for external validation and complementarity. The data analysis reveals that the AHR signaling pathway is activated in AML patients. Furthermore, there is a correlation between the expressions of AHR and mitochondrial oxidative phosphorylation genes. In vitro experiments show that enhancing AHR expression in AML cells increases mitochondrial oxidative phosphoryla...
Source: Acta Biochimica et Biophysica Sinica - February 26, 2024 Category: Biochemistry Authors: Yan Jia Xiyu Li Lulu Chen Ling Li Suzhen Zhang Wenhui Huang Hao Zhang Source Type: research

Molecular evolution and expression patterns of myxovirus resistance proteins in < em > Lampetra japonica < /em >
Acta Biochim Biophys Sin (Shanghai). 2024 Feb 23. doi: 10.3724/abbs.2024019. Online ahead of print.NO ABSTRACTPMID:38400631 | DOI:10.3724/abbs.2024019 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - February 24, 2024 Category: Biochemistry Authors: Jinzhao Liu Meiyao Chu Jiahui Kuang Xinran Wang Yijie Zhang Lutian Wang Yimeng Xia Yifan Sun Xinxin Liu Jing Li Jun Li Ting Zhu Source Type: research

M1 macrophage-related gene model for NSCLC immunotherapy response prediction
This study aims to develop an immunotherapy response evaluation model for NSCLC patients based on transcription. RNA sequencing profiles of 254 advanced-stage NSCLC patients treated with immunotherapy are downloaded from the POPLAR and OAK projects. Immune cell infiltration in NSCLC patients is examined, and thereafter, different coexpressed genes are identified. Next, the impact of M1 macrophage-related genes on the prognosis of NSCLC patients is investigated. Six M1 macrophage coexpressed genes, namely, NKX2-1, CD8A , SFTA3, IL2RB, IDO1, and CXCL9, exhibit a strong association with the prognosis of NSCLC and serve as eff...
Source: Acta Biochimica et Biophysica Sinica - February 21, 2024 Category: Biochemistry Authors: Sifan Wu Qiqi Sheng Pengjun Liu Zhe Jiao Jinru Lv Rong Qiao Dongkun Xie Zanhan Wang Jiamei Ge Penghui Li Tiaoxia Wei Jie Lei Jieyi Fan Liang Wang Source Type: research

< em > Xianling Lianxia < /em > formula enhances the inhibitory effects of trastuzumab on HER2-positive breast cancer
This study demonstrates that XLLXF can synergistically enhance the efficacy of trastuzumab in targeting HER2-positive BC. The mechanism may involve the modulation of inflammatory factors.PMID:38379418 | DOI:10.3724/abbs.2023281 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - February 21, 2024 Category: Biochemistry Authors: Feifei Li Yuanyuan Wu Youyang Shi Xiaofei Liu Ying Xie Sheng Liu Source Type: research

Establishment of a method for the determination of hydrogen sulfide in human serum by liquid chromatography-tandem mass spectrometry and evaluation of its clinical application
Acta Biochim Biophys Sin (Shanghai). 2024 Feb 21. doi: 10.3724/abbs.2024007. Online ahead of print.NO ABSTRACTPMID:38379419 | DOI:10.3724/abbs.2024007 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - February 21, 2024 Category: Biochemistry Authors: Chunyan Li Jia Chen Yu Su Wuzheng Liu Xiangyu Meng Ao Zhang Yitong Bai Yingzi Liu Ruichen Liu Lin Zhang Jun Wu Source Type: research

Mitochondrial deoxyguanosine kinase is required for female fertility in mice
In this study, we find that Dguok knockout results in female infertility. Mechanistically, DGUOK deficiency hinders ovarian development and oocyte maturation. Moreover, DGUOK deficiency in oocytes causes a significant reduction in mitochondrial DNA copy number and abnormal mitochondrial dynamics and impairs germinal vesicle breakdown. Only few DGUOK-deficient oocytes can extrude their first polar body during in vitro maturation, and these oocytes exhibit irregular chromosome arrangements and different spindle lengths. In addition, DGUOK deficiency elevates reactive oxygen species levels and accelerates oocyte apoptosis. Ou...
Source: Acta Biochimica et Biophysica Sinica - February 8, 2024 Category: Biochemistry Authors: Yake Gao Rui Dong Jiacong Yan Huicheng Chen Lei Sang Xinyi Yao Die Fan Xin Wang Xiaoyuan Zuo Xu Zhang Shengyu Yang Ze Wu Jianwei Sun Source Type: research