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Maslinic acid alleviates intervertebral disc degeneration by inhibiting the PI3K/AKT and NF- κB signaling pathways
This study demonstrates that MA may hold promise as a therapeutic agent for alleviating ECM metabolism disorders and senescence to treat IDD.PMID:38495003 | DOI:10.3724/abbs.2024027 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - March 18, 2024 Category: Biochemistry Authors: Yichen Que Chipiu Wong Jincheng Qiu Wenjie Gao Youxi Lin Hang Zhou Bo Gao Pengfei Li Zhihuai Deng Huihong Shi Wenjun Hu Song Liu Yan Peng Peiqiang Su Caixia Xu Anjing Liang Xianjian Qiu Dongsheng Huang Source Type: research

Arsenic trioxide-induced cardiotoxicity: the protective effect of 2-aminoethoxydiphenyl-borate
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 18. doi: 10.3724/abbs.2024036. Online ahead of print.NO ABSTRACTPMID:38495004 | DOI:10.3724/abbs.2024036 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - March 18, 2024 Category: Biochemistry Authors: Jia Feng Ruimeng Tian Guilin Lu Wenjuan Qin Source Type: research

miR-34b-3p-mediated regulation of STC2 and FN1 enhances chemosensitivity and inhibits proliferation in cervical cancer
In conclusion, our findings support the role of miR-34b-3p as a tumor suppressor in CC. This study indicates that targeting the miR-34b-3p/STC2 or FN1 axis has potential therapeutic implications for overcoming chemoresistance in CC patients.PMID:38477044 | DOI:10.3724/abbs.2024009 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - March 13, 2024 Category: Biochemistry Authors: Shanshan Jin Wenting Wang Xinrui Xu Zhaowei Yu Zihan Feng Jun Xie Huimin Lv Source Type: research

SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy
In this study, we speculate that SirT7 modulates fascin transcription and is thus involved in EndMT in hyperglycemic glomerular endothelial cells. Our data indicate that α-smooth muscle actin (α-SMA) and fascin levels are increased, while CD31 levels are decreased in the kidneys of DN rats. Consistently, our cellular experiments reveal that high glucose treatment elevates fascin levels and induces EndMT in human glomerular endothelial cells (HGECs). Moreover, silencing of fascin inhibits EndMT in hyperglycaemic HGECs. In addition, SirT7 is found to be decreased in hyperglycemic cells and in the kidneys of DN mice. Moreov...
Source: Acta Biochimica et Biophysica Sinica - March 7, 2024 Category: Biochemistry Authors: Mengchen Wu Yingxiang Hao Xinwan Wu Minmin Zhu Xiangyuan Chen Jie Qi Zhuang Yu Hongjiao Xu Source Type: research

The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 7. doi: 10.3724/abbs.2024005. Online ahead of print.ABSTRACTTriple negative breast cancer (TNBC) has a high recurrence rate, metastasis rate and mortality rate. The aim of this study is to identify new targets for the treatment of TNBC. Clinical samples are used for screening deubiquitinating enzymes (DUBs). MDA-MB-231 cells and a TNBC mouse model are used for in vitro and in vivo experiments, respectively. Western blot analysis is used to detect the protein expressions of DUBs, zinc finger E-box binding homeobox 1 (ZEB1), and epithelial-mesenchymal transition (EMT)-related mar...
Source: Acta Biochimica et Biophysica Sinica - March 7, 2024 Category: Biochemistry Authors: Qidi Huang Shurong Zheng Huayan Gu Zhi Yang Yiqiao Lu Xia Yu Guilong Guo Source Type: research