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Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 21. doi: 10.3724/abbs.2024025. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin r...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Peiguang Zhang Jieqiong Cao Xujing Liang Zijian Su Bihui Zhang Zhenyu Wang Junye Xie Gengrui Chen Xue Chen Jinting Zhang Yanxian Feng Qin Xu Jianping Song An Hong Xiaojia Chen Yibo Zhang Source Type: research

Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF- κB/MAPK signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 22. doi: 10.3724/abbs.2024008. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by intestinal barrier dysfunction, inflammatory synergistic effects and excessive tissue injury. Gallic acid (GA) is renowned for its remarkable biological activity, encompassing anti-inflammatory and antioxidant properties. However, the underlying mechanisms by which GA protects against intestinal inflammation have not been fully elucidated. The aim of this study is to investigate the effect of GA on the inflammation of a lipopolysacchar...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Chu Chu Huan Ru Yuyan Chen Jinhua Xu Caihong Wang Yuanxiang Jin Source Type: research

Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer
In this study, the active ingredients of each herbal medicine composing SYF and their target proteins are obtained from the Traditional Chinese Medicine Systems Pharmacology database. Breast cancer-related genes are obtained from the GeneCards database. Major targets and pathways related to SYF treatment in breast cancer are identified by analyzing the above data. By conducting molecular docking analysis, we find that the active ingredients quercetin and luteolin bind well to the key targets KDR1, PPARG, SOD1, and VCAM1. In vitro experiments verify that SYF can reduce the proliferation, migration, and invasion ability of T...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Xiaojuan Yang Feifei Li Youyang Shi Yuanyuan Wu Rui Yang Xiaofei Liu Yang Zhang Guangtao Zhang Mei Ma Zhanyang Luo Xianghui Han Ying Xie Sheng Liu Source Type: research

Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 21. doi: 10.3724/abbs.2024025. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin r...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Peiguang Zhang Jieqiong Cao Xujing Liang Zijian Su Bihui Zhang Zhenyu Wang Junye Xie Gengrui Chen Xue Chen Jinting Zhang Yanxian Feng Qin Xu Jianping Song An Hong Xiaojia Chen Yibo Zhang Source Type: research

Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF- κB/MAPK signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 22. doi: 10.3724/abbs.2024008. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by intestinal barrier dysfunction, inflammatory synergistic effects and excessive tissue injury. Gallic acid (GA) is renowned for its remarkable biological activity, encompassing anti-inflammatory and antioxidant properties. However, the underlying mechanisms by which GA protects against intestinal inflammation have not been fully elucidated. The aim of this study is to investigate the effect of GA on the inflammation of a lipopolysacchar...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Chu Chu Huan Ru Yuyan Chen Jinhua Xu Caihong Wang Yuanxiang Jin Source Type: research

Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer
In this study, the active ingredients of each herbal medicine composing SYF and their target proteins are obtained from the Traditional Chinese Medicine Systems Pharmacology database. Breast cancer-related genes are obtained from the GeneCards database. Major targets and pathways related to SYF treatment in breast cancer are identified by analyzing the above data. By conducting molecular docking analysis, we find that the active ingredients quercetin and luteolin bind well to the key targets KDR1, PPARG, SOD1, and VCAM1. In vitro experiments verify that SYF can reduce the proliferation, migration, and invasion ability of T...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Xiaojuan Yang Feifei Li Youyang Shi Yuanyuan Wu Rui Yang Xiaofei Liu Yang Zhang Guangtao Zhang Mei Ma Zhanyang Luo Xianghui Han Ying Xie Sheng Liu Source Type: research

Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 21. doi: 10.3724/abbs.2024025. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin r...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Peiguang Zhang Jieqiong Cao Xujing Liang Zijian Su Bihui Zhang Zhenyu Wang Junye Xie Gengrui Chen Xue Chen Jinting Zhang Yanxian Feng Qin Xu Jianping Song An Hong Xiaojia Chen Yibo Zhang Source Type: research

Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF- κB/MAPK signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 22. doi: 10.3724/abbs.2024008. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by intestinal barrier dysfunction, inflammatory synergistic effects and excessive tissue injury. Gallic acid (GA) is renowned for its remarkable biological activity, encompassing anti-inflammatory and antioxidant properties. However, the underlying mechanisms by which GA protects against intestinal inflammation have not been fully elucidated. The aim of this study is to investigate the effect of GA on the inflammation of a lipopolysacchar...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Chu Chu Huan Ru Yuyan Chen Jinhua Xu Caihong Wang Yuanxiang Jin Source Type: research

Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer
In this study, the active ingredients of each herbal medicine composing SYF and their target proteins are obtained from the Traditional Chinese Medicine Systems Pharmacology database. Breast cancer-related genes are obtained from the GeneCards database. Major targets and pathways related to SYF treatment in breast cancer are identified by analyzing the above data. By conducting molecular docking analysis, we find that the active ingredients quercetin and luteolin bind well to the key targets KDR1, PPARG, SOD1, and VCAM1. In vitro experiments verify that SYF can reduce the proliferation, migration, and invasion ability of T...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Xiaojuan Yang Feifei Li Youyang Shi Yuanyuan Wu Rui Yang Xiaofei Liu Yang Zhang Guangtao Zhang Mei Ma Zhanyang Luo Xianghui Han Ying Xie Sheng Liu Source Type: research

Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 21. doi: 10.3724/abbs.2024025. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin r...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Peiguang Zhang Jieqiong Cao Xujing Liang Zijian Su Bihui Zhang Zhenyu Wang Junye Xie Gengrui Chen Xue Chen Jinting Zhang Yanxian Feng Qin Xu Jianping Song An Hong Xiaojia Chen Yibo Zhang Source Type: research

Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF- κB/MAPK signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 22. doi: 10.3724/abbs.2024008. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by intestinal barrier dysfunction, inflammatory synergistic effects and excessive tissue injury. Gallic acid (GA) is renowned for its remarkable biological activity, encompassing anti-inflammatory and antioxidant properties. However, the underlying mechanisms by which GA protects against intestinal inflammation have not been fully elucidated. The aim of this study is to investigate the effect of GA on the inflammation of a lipopolysacchar...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Chu Chu Huan Ru Yuyan Chen Jinhua Xu Caihong Wang Yuanxiang Jin Source Type: research

Baicalin ameliorates the gut barrier function and intestinal microbiota of broiler chickens
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 21. doi: 10.3724/abbs.2024029. Online ahead of print.ABSTRACTThe deoxynivalenol (DON)-contaminated feeds can impair chicken gut barrier function, disturb the balance of the intestinal microbiota, decrease chicken growth performance and cause major economic loss. With the aim of investigating the ameliorating effects of baicalin on broiler intestinal barrier damage and gut microbiota dysbiosis induced by DON, a total of 150 Arbor Acres broilers are used in the present study. The morphological damage to the duodenum, jejunum, and ileum caused by DON is reversed by treatment with ...
Source: Acta Biochimica et Biophysica Sinica - March 21, 2024 Category: Biochemistry Authors: Shuangxiu Wan Linzheng Wang Zhili Hao Lin Zhu Xiaoxia Mao Hongquan Li Panpan Sun Wei Yin Kuohai Fan Hailong Zhang Beibei Li Wansen Nie Zongjie Li Na Sun Source Type: research

Baicalin ameliorates the gut barrier function and intestinal microbiota of broiler chickens
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 21. doi: 10.3724/abbs.2024029. Online ahead of print.ABSTRACTThe deoxynivalenol (DON)-contaminated feeds can impair chicken gut barrier function, disturb the balance of the intestinal microbiota, decrease chicken growth performance and cause major economic loss. With the aim of investigating the ameliorating effects of baicalin on broiler intestinal barrier damage and gut microbiota dysbiosis induced by DON, a total of 150 Arbor Acres broilers are used in the present study. The morphological damage to the duodenum, jejunum, and ileum caused by DON is reversed by treatment with ...
Source: Acta Biochimica et Biophysica Sinica - March 21, 2024 Category: Biochemistry Authors: Shuangxiu Wan Linzheng Wang Zhili Hao Lin Zhu Xiaoxia Mao Hongquan Li Panpan Sun Wei Yin Kuohai Fan Hailong Zhang Beibei Li Wansen Nie Zongjie Li Na Sun Source Type: research

Maslinic acid alleviates intervertebral disc degeneration by inhibiting the PI3K/AKT and NF- κB signaling pathways
This study demonstrates that MA may hold promise as a therapeutic agent for alleviating ECM metabolism disorders and senescence to treat IDD.PMID:38495003 | DOI:10.3724/abbs.2024027 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - March 18, 2024 Category: Biochemistry Authors: Yichen Que Chipiu Wong Jincheng Qiu Wenjie Gao Youxi Lin Hang Zhou Bo Gao Pengfei Li Zhihuai Deng Huihong Shi Wenjun Hu Song Liu Yan Peng Peiqiang Su Caixia Xu Anjing Liang Xianjian Qiu Dongsheng Huang Source Type: research

Arsenic trioxide-induced cardiotoxicity: the protective effect of 2-aminoethoxydiphenyl-borate
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 18. doi: 10.3724/abbs.2024036. Online ahead of print.NO ABSTRACTPMID:38495004 | DOI:10.3724/abbs.2024036 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - March 18, 2024 Category: Biochemistry Authors: Jia Feng Ruimeng Tian Guilin Lu Wenjuan Qin Source Type: research