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Preliminary exploration of SKA1 expression in lung adenocarcinoma and its clinical significance
Acta Biochim Biophys Sin (Shanghai). 2023 Oct 9. doi: 10.3724/abbs.2023243. Online ahead of print.NO ABSTRACTPMID:37814813 | DOI:10.3724/abbs.2023243 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - October 10, 2023 Category: Biochemistry Authors: Wen Zeng Yong Chen Jun Liu Zhen An Hui Yan Tao Sun Source Type: research

Single-cell dissection, hdWGCNA and deep learning reveal the role of oxidatively stressed plasma cells in ulcerative colitis
In this study, we aim to elucidate the pathogenesis of ulcerative colitis at the single-cell level and unveil its clinical significance. Using single-cell RNA sequencing and high-dimensional weighted gene co-expression network analysis, we identify a subpopulation of plasma cells (PCs) with significantly increased infiltration in UC colonic mucosa, characterized by pronounced oxidative stress. Combining 10 machine learning approaches, we find that the PC oxidative stress genes accurately distinguish diseased mucosa from normal mucosa (independent external testing AUC=0.991, sensitivity=0.986, specificity=0.909). Using MCPc...
Source: Acta Biochimica et Biophysica Sinica - October 10, 2023 Category: Biochemistry Authors: Shaocong Mo Xin Shen Baoxiang Huang Yulin Wang Lingxi Lin Qiuming Chen Meilin Weng Takehito Sugasawa Wenchao Gu Yoshito Tsushima Takahito Nakajima Source Type: research

Alternating current stimulation promotes neurite outgrowth and plasticity in neurons through activation of the PI3K/AKT signaling pathway
In this study, immunofluorescence staining and Sholl analysis are used to assess changes in the neurite number and axon length to determine the optimal pattern and stimulation parameters of ES for neurons. Neuronal death and plasticity are detected by TUNEL staining and microelectrode array assays, respectively. mRNA sequencing and bioinformatics analysis are applied to predict the key targets of the action of ES on neurons, and the identified targets are validated by western blot analysis and qRT-PCR. The effects of alternating current stimulation (ACS) on neurons are more significant than those of direct current stimulat...
Source: Acta Biochimica et Biophysica Sinica - October 10, 2023 Category: Biochemistry Authors: Hao Zhong Cong Xing Mi Zhou Zeyu Jia Song Liu Shibo Zhu Bo Li Hongjiang Yang Hongpeng Ma Liyue Wang Rusen Zhu Zhigang Qu Guangzhi Ning Source Type: research

PHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway
Acta Biochim Biophys Sin (Shanghai). 2023 Oct 9. doi: 10.3724/abbs.2023103. Online ahead of print.ABSTRACTProlyl hydroxylase 3 (PHD3) hydroxylates HIFα in the presence of oxygen, leading to HIFα degradation. PHD3 inhibits tumorigenesis. However, the underlying mechanism is not well understood. Herein, we demonstrate that PHD3 inhibits the metastasis of colon cancer cells through the occludin-p38 MAPK pathway independent of its hydroxylase activity. We find that PHD3 inhibits colon cancer cell metastasis in the presence of the PHD inhibitor DMOG, and prolyl hydroxylase-deficient PHD3 (H196A) suppresses cell metastasis as ...
Source: Acta Biochimica et Biophysica Sinica - October 10, 2023 Category: Biochemistry Authors: Yuyao Li Tanglong Yuan Hongwei Zhang Shuting Liu Jie Lun Jing Guo Yu Wang Yuying Zhang Jing Fang Source Type: research

A novel ferroptosis-related microRNA signature with prognostic value in osteosarcoma
In conclusion, miR-635 and miR-593 exert contrasting regulatory effects on OS cell proliferation and migration.PMID:37814812 | DOI:10.3724/abbs.2023236 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - October 10, 2023 Category: Biochemistry Authors: Jie Shao Yi Zhang Zhu Chang Shiyao Du Wei Li Yushu Bai Chunwen Lu Tianming Xu Source Type: research