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Evaluation of the protective effect of salidroside on arsenic-induced cardiac dysfunction in rats
Acta Biochim Biophys Sin (Shanghai). 2023 Oct 30. doi: 10.3724/abbs.2023252. Online ahead of print.NO ABSTRACTPMID:37905341 | DOI:10.3724/abbs.2023252 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - October 31, 2023 Category: Biochemistry Authors: Ruimeng Tian Jing Cheng Yanna Wang Chuncui Chen Lei Huang Caiyun Zhang Yifei Zhou Shanshan Dong Guilin Lu Wenjuan Qin Source Type: research

Tumor-associated microbiota in colorectal cancer with vascular tumor thrombus and neural invasion and association with clinical prognosis
In conclusion, this study is the first to comprehensively elaborate the differences in the gut microbiota of patients with CRC with different invasion statuses and to prove the relationship between some gut microbiota and clinical patient characteristics.PMID:37905339 | DOI:10.3724/abbs.2023255 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - October 31, 2023 Category: Biochemistry Authors: Mingjie Li Min Jin Lei Zhao Dandan Yu Yan Li Linli Shi Bin Zhou Li Liu Yinghao Cao Kailin Cai Jun Fan Xiu Nie Tao Zhang Hongli Liu Source Type: research

RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis
In this study, we discover that RP11-495P10.1 regulates glycometabolism reprogramming by changing the expression of pyruvate dehydrogenase kinase 1 (PDK1) and pyruvate dehydrogenase (PDH), thus contributing to the proliferation of HCC cells. Furthermore, knockdown of RP11-495P10.1 increases enrichment of H3K27Ac in the promoter of NR4A3 by promoting the activity of PDH and the production of acetyl-CoA, which leads to the increased transcription of NR4A3. Altogether, RP11-495P10.1 promotes HCC cell proliferation by regulating the reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis...
Source: Acta Biochimica et Biophysica Sinica - October 31, 2023 Category: Biochemistry Authors: Chi Liu Jie Shi Zhengyuan Jiang Shan Jiang Yuan Wu Dongqian Peng Jiebing Tang Linchi Guo Source Type: research

< em > Cryptococcus gattii < /em > strains with a high phagocytosis phenotype by macrophages display high pathogenicity at the early stage of infection < em > in vivo < /em >
In this study, a series of in vitro and in vivo experiments were conducted to investigate the interaction between macrophages and Cg. Flow cytometry was used to detect the phagocytic phenotypes of the Cg strains within macrophages. Scanning electron microscopy, transmission electron microscopy, and immunofluorescence were used to observe phagocytosis and proliferation, respectively. Survival and lung fungal burden tests were also performed. Our results show that Cg cells display different phagocytosis phenotypes, which are independent of the molecular type. Within macrophages, the high phagocytosis phenotype (HP) strains o...
Source: Acta Biochimica et Biophysica Sinica - October 27, 2023 Category: Biochemistry Authors: Chen Yang Wanjun Shen Lifeng Wang Xuelei Zang Yemei Huang Hengyu Deng Yangyu Zhou Mei Xie Xinying Xue Dingxia Shen Source Type: research

The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma
Acta Biochim Biophys Sin (Shanghai). 2023 Oct 23. doi: 10.3724/abbs.2023231. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the leading fatal malignancy worldwide. The tumor microenvironment (TME) can affect the survival, proliferation, migration, and even dormancy of cancer cells. Hypoxia is an important component of the TME, and hypoxia-inducible factor-1α (HIF-1α) is the most important transcriptional regulator. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), comprise a large part of the human transcriptome and play an important role ...
Source: Acta Biochimica et Biophysica Sinica - October 23, 2023 Category: Biochemistry Authors: Qianqian Yang Hui Tian Ziyi Guo Zhongliang Ma Guangzhi Wang Source Type: research

NF- κB downstream miR-1262 disturbs colon cancer cell malignant behaviors by targeting FGFR1
In this study, deregulated miRNAs that could play a role in colon cancer are analyzed and investigated for specific functions in vitro using cancer cells and in vivo using a subcutaneous xenograft model. miRNA downstream targets are analyzed, and predicted binding and regulation are verified. miR-1262, an antitumor miRNA, is downregulated in colon cancer tissue samples and cell lines. miR-1262 overexpression suppresses colon cancer malignant behaviors in vitro and tumor development and metastasis in a subcutaneous xenograft model and a lung metastasis mouse model in vivo. miR-1262 directly targets fibroblast growth factor ...
Source: Acta Biochimica et Biophysica Sinica - October 23, 2023 Category: Biochemistry Authors: Weilin Zhang Zhongcheng Huang Zhigang Xiao Hui Wang Qianchao Liao Zhengru Deng Deqing Wu Junjiang Wang Yong Li Source Type: research