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Dexmedetomidine ameliorates high glucose-induced epithelial-mesenchymal transformation in HK-2 cells through the Cdk5/Drp1/ROS pathway
Acta Biochim Biophys Sin (Shanghai). 2023 Nov 27. doi: 10.3724/abbs.2023220. Online ahead of print.ABSTRACTEpithelial-mesenchymal transformation (EMT) plays an important role in the progression of diabetic nephropathy. Dexmedetomidine (DEX) has shown renoprotective effects against ischemic reperfusion injury; however, whether and how DEX prevents high glucose-induced EMT in renal tubular epithelial cells is incompletely known. Here, we conduct in vitro experiments using HK-2 cells, a human tubular epithelial cell line. Our results demonstrate that high glucose increases the expressions of EMT-related proteins, including Vi...
Source: Acta Biochimica et Biophysica Sinica - November 28, 2023 Category: Biochemistry Authors: Fei Wang Weilong Xu Xiaoge Liu Jun Zhang Source Type: research

κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway
Acta Biochim Biophys Sin (Shanghai). 2023 Nov 28. doi: 10.3724/abbs.2023223. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a prevalent and chronic joint disease that affects the aging population, causing pain and disability. Macrophages in synovium are important mediators of synovial inflammatory activity and pathological joint pain. Previous studies have demonstrated the significant involvement of κ-opioid receptor (KOR) in the regulation of pain and inflammation. Our study reveals a significant reduction in synovial KOR expression among patients and mice with OA. Here, we find that KOR activation effectively inhi...
Source: Acta Biochimica et Biophysica Sinica - November 28, 2023 Category: Biochemistry Authors: Yi Shi Huaqiang Tao Xueyan Li Liyuan Zhang Chunhui Li Wen Sun Miao Chu Kai Chen Pengfei Zhu Qiang Wang Chengyong Gu Liangliang Wang Xing Yang Yuefeng Hao Source Type: research

Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation
In this study, we first report that DHCE shows antitumor activities in vitro and in vivo and exerts stronger inhibitory effects than celastrol on BTZ-R cells. We find that DHCE inhibits BTZ-R cell viability by promoting apoptosis via extrinsic and intrinsic pathways and suppresses BTZ-R MM cell proliferation by inducing G0/G1 phase cell cycle arrest. In addition, inactivation of JAK2/STAT3 and PI3K/Akt pathways are involved in the DHCE-mediated antitumor effect. Simultaneously, DHCE acts synergistically with BTZ on BTZ-R cells. PSMB5, a molecular target of BTZ, is overexpressed in BTZ-R MM cells compared with BTZ-S MM cell...
Source: Acta Biochimica et Biophysica Sinica - November 27, 2023 Category: Biochemistry Authors: Shuhan Jin Bo Li Bibo Zhang Xuejie Gao Xinyan Jia Li Xu Shuaikang Chang Ke Hu Guanli Wang Zhijian Xu Ting Zhang Dongliang Song Guang Yang Xiaosong Wu Huabin Zhu Cheng Huang Yumeng Lu Jumei Shi Weiliang Zhu Gege Chen Source Type: research

HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8
Acta Biochim Biophys Sin (Shanghai). 2023 Nov 24. doi: 10.3724/abbs.2023274. Online ahead of print.ABSTRACTHypertrophic scar (HS) is one of the most common sequelae of patients, especially after burns and trauma. The roles of regulatory long noncoding RNAs (lncRNAs) in mediating HS remain underexplored. Human hypertrophic scar-derived fibroblasts (HSFBs) have been shown to exert more potent promoting effects on extracellular matrix (ECM) accumulation than normal skin-derived fibroblasts (NSFBs) and are associated with enhanced HS formation. The purpose of this study is to search for lncRNAs enriched in HSFBs and investigat...
Source: Acta Biochimica et Biophysica Sinica - November 25, 2023 Category: Biochemistry Authors: Fang Ma Honglin Liu Tongtong Xia Zhenghao Zhang Shengchao Ma Yinju Hao Jiangyong Shen Yideng Jiang Nan Li Source Type: research