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lncRNA-Gm5532 regulates osteoclast differentiation through the miR-125a-3p/TRAF6 axis
In this study, lncRNA microarray analysis was used to identify differentially expressed lncRNAs in differentiated osteoclasts. lncRNA-Gm5532 is highly expressed during osteoclast differentiation. lncRNA-Gm5532 knockdown impairs osteoclast formation and bone resorption. Mechanistic experiments show that lncRNA-Gm5532 functions as a competing endogenous RNA (ceRNA) and acts as a sponge for miR-125a-3p, which promotes TNF receptor-associated factor 6 (TRAF6) expression. miR-125a-3p mimics suppress osteoclast differentiation and TAK1/NF-κB/MAPK signaling. The miR-125a-3p inhibitor reverses the negative effects of siGm5532 on ...
Source: Acta Biochimica et Biophysica Sinica - December 15, 2023 Category: Biochemistry Authors: Jian Zhang Lingyan Zhang Gang Yao Hai Zhao Penghai Qiao Shuguang Wu Source Type: research

cGAS-STING-mediated inflammation and neurodegeneration as a strategy for the treatment of neurodegenerative diseases
Acta Biochim Biophys Sin (Shanghai). 2023 Dec 8. doi: 10.3724/abbs.2023258. Online ahead of print.NO ABSTRACTPMID:38069505 | DOI:10.3724/abbs.2023258 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - December 9, 2023 Category: Biochemistry Authors: Yongjia Luo Zhenwang Zhao Xiaobo Hu Source Type: research

Melatonin alleviates valproic acid-induced neural tube defects by modulating Src/PI3K/ERK signaling and oxidative stress
Acta Biochim Biophys Sin (Shanghai). 2023 Dec 7. doi: 10.3724/abbs.2023234. Online ahead of print.ABSTRACTNeural tube defects (NTDs) represent a developmental disorder of the nervous system that can lead to significant disability in children and impose substantial social burdens. Valproic acid (VPA), a widely prescribed first-line antiepileptic drug for epilepsy and various neurological conditions, has been associated with a 4-fold increase in the risk of NTDs when used during pregnancy. Consequently, urgent efforts are required to identify innovative prevention and treatment approaches for VPA-induced NTDs. Studies have d...
Source: Acta Biochimica et Biophysica Sinica - December 8, 2023 Category: Biochemistry Authors: Yuxiang Liang Ying Wang Xiao Zhang Shanshan Jin Yuqian Guo Zhaowei Yu Xinrui Xu Qizhi Shuai Zihan Feng Binghong Chen Ting Liang Ruifang Ao Jianting Li Juan Zhang Rui Cao Hong Zhao Zhaoyang Chen Zhizhen Liu Jun Xie Source Type: research

κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway
Acta Biochim Biophys Sin (Shanghai). 2023 Nov 28. doi: 10.3724/abbs.2023223. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a prevalent and chronic joint disease that affects the aging population, causing pain and disability. Macrophages in synovium are important mediators of synovial inflammatory activity and pathological joint pain. Previous studies have demonstrated the significant involvement of κ-opioid receptor (KOR) in the regulation of pain and inflammation. Our study reveals a significant reduction in synovial KOR expression among patients and mice with OA. Here, we find that KOR activation effectively inhi...
Source: Acta Biochimica et Biophysica Sinica - November 28, 2023 Category: Biochemistry Authors: Yi Shi Huaqiang Tao Xueyan Li Liyuan Zhang Chunhui Li Wen Sun Miao Chu Kai Chen Pengfei Zhu Qiang Wang Chengyong Gu Liangliang Wang Xing Yang Yuefeng Hao Source Type: research

Dexmedetomidine ameliorates high glucose-induced epithelial-mesenchymal transformation in HK-2 cells through the Cdk5/Drp1/ROS pathway
Acta Biochim Biophys Sin (Shanghai). 2023 Nov 27. doi: 10.3724/abbs.2023220. Online ahead of print.ABSTRACTEpithelial-mesenchymal transformation (EMT) plays an important role in the progression of diabetic nephropathy. Dexmedetomidine (DEX) has shown renoprotective effects against ischemic reperfusion injury; however, whether and how DEX prevents high glucose-induced EMT in renal tubular epithelial cells is incompletely known. Here, we conduct in vitro experiments using HK-2 cells, a human tubular epithelial cell line. Our results demonstrate that high glucose increases the expressions of EMT-related proteins, including Vi...
Source: Acta Biochimica et Biophysica Sinica - November 28, 2023 Category: Biochemistry Authors: Fei Wang Weilong Xu Xiaoge Liu Jun Zhang Source Type: research