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Upregulation of E-cadherin by the combination of methionine restriction and HDAC2 intervention for inhibiting gastric carcinoma metastasis
In this study, we aim to explore the effect and related mechanisms of methionine restriction (MR) on gastric carcinoma metastasis. In the MR cell model, gastric carcinoma cells are cultured in the MR medium, and in the animal model, BALB/c nude rodents are administered with a methionine-free diet after receiving injections of MKN45 cells into the caudal vein. Transwell assay is used to detect cell invasion and migration. Chromatin immunoprecipitation is performed to investigate the levels of H3K9me2, H3K27Ac, and H3K27me3 in the E-cadherin promoter. The results show that MR inhibits gastric carcinoma cell migration, invasi...
Source: Acta Biochimica et Biophysica Sinica - December 25, 2023 Category: Biochemistry Authors: Yifan Li Chenxi Liu Lin Xin Chuan Liu Jiaqing Cao Zhenqi Yue Jie Sheng Yiwu Yuan Qi Zhou Zhiyang Liu Source Type: research

Corrigendum to: C-reactive protein is associated with the development of tongue squamous cell carcinoma
Acta Biochim Biophys Sin (Shanghai). 2023 Dec 20. doi: 10.3724/abbs.2023284. Online ahead of print.NO ABSTRACTPMID:38124538 | DOI:10.3724/abbs.2023284 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - December 21, 2023 Category: Biochemistry Authors: Jianxin Du Wei Hu Chengzhe Yang Yegang Wang Xiaoying Wang Pishan Yang Source Type: research

Advances in DNA damage response inhibitors in colorectal cancer therapy
Acta Biochim Biophys Sin (Shanghai). 2023 Dec 20. doi: 10.3724/abbs.2023278. Online ahead of print.ABSTRACTOne potential cause of cancer is genomic instability that arises in normal cells due to years of DNA damage in the body. The clinical application of radiotherapy and cytotoxic drugs to treat cancer is based on the principle of damaging the DNA of cancer cells. However, the benefits of these treatments also have negative effects on normal tissue. While there have been notable advancements in molecular-driven therapy and immunotherapy for colorectal cancer (CRC), a considerable portion of patients with advanced CRC do n...
Source: Acta Biochimica et Biophysica Sinica - December 20, 2023 Category: Biochemistry Authors: Yue Yu Hang Jia Tianshuai Zhang Wei Zhang Source Type: research

Endoplasmic reticulum stress caused by traumatic injury promotes cardiomyocyte apoptosis through acetylation modification of GRP78
In this study, rat models of traumatic injury are established by using the Noble-Collip trauma device. The expression of glucose-regulating protein 78 (GRP78, a molecular chaperone of the cardiomyocyte ER), acetylation modification of GRP78 and apoptosis of cardiomyocytes are determined. The results show that ERS-induced GRP78 elevation does not induce cardiomyocyte apoptosis in the early stage of trauma. However, with prolonged ERS, the GRP78 acetylation level is elevated, and the apoptosis of cardiomyocytes also increases significantly. In addition, in the early stage of trauma, the expression of histone acetyl-transfera...
Source: Acta Biochimica et Biophysica Sinica - December 18, 2023 Category: Biochemistry Authors: Zi Yan Yufeng Liu Bowen Yang Wenhui Zhao Yan Wang Deping Wang Jianguo Li Xiangying Jiao Jimin Cao Source Type: research

P53 together with ferroptosis: a promising strategy leaving cancer cells without escape
Acta Biochim Biophys Sin (Shanghai). 2023 Dec 18. doi: 10.3724/abbs.2023270. Online ahead of print.ABSTRACTTP53, functioning as the keeper of the genome, assumes a pivotal function in the inhibition of tumorigenesis. Recent studies have revealed that p53 regulates ferroptosis pathways within tumor cells and is closely related to tumorigenesis. Therefore, we summarize the pathways and mechanisms by which p53 regulates ferroptosis and identify a series of upstream and downstream molecules involved in this process. Furthermore, we construct a p53-ferroptosis network centered on p53. Finally, we present the progress of drugs t...
Source: Acta Biochimica et Biophysica Sinica - December 18, 2023 Category: Biochemistry Authors: Jianhao Zhan Jisheng Wang Yuqing Liang Xiaoping Zeng Enliang Li Hongmei Wang Source Type: research

Incretin-FGF21 fusion molecule maximizes metabolic effects in mice
Acta Biochim Biophys Sin (Shanghai). 2023 Dec 14. doi: 10.3724/abbs.2023276. Online ahead of print.NO ABSTRACTPMID:38098359 | DOI:10.3724/abbs.2023276 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - December 15, 2023 Category: Biochemistry Authors: Yulin Kong Shenglong Zhu Yong Q Chen Source Type: research

lncRNA-Gm5532 regulates osteoclast differentiation through the miR-125a-3p/TRAF6 axis
In this study, lncRNA microarray analysis was used to identify differentially expressed lncRNAs in differentiated osteoclasts. lncRNA-Gm5532 is highly expressed during osteoclast differentiation. lncRNA-Gm5532 knockdown impairs osteoclast formation and bone resorption. Mechanistic experiments show that lncRNA-Gm5532 functions as a competing endogenous RNA (ceRNA) and acts as a sponge for miR-125a-3p, which promotes TNF receptor-associated factor 6 (TRAF6) expression. miR-125a-3p mimics suppress osteoclast differentiation and TAK1/NF-κB/MAPK signaling. The miR-125a-3p inhibitor reverses the negative effects of siGm5532 on ...
Source: Acta Biochimica et Biophysica Sinica - December 15, 2023 Category: Biochemistry Authors: Jian Zhang Lingyan Zhang Gang Yao Hai Zhao Penghai Qiao Shuguang Wu Source Type: research