Live birth after letrozole as an adjunct to follicle-stimulating hormone versus follicle-stimulating hormone alone for ovarian stimulation in in vitro fertilisation cycles —study protocol for a randomised controlled trial
DiscussionThe present study is the first multicentre randomised study to compare the live birth rate of the fresh embryo transfer following ovarian stimulation by letrozole and FSH versus FSH alone in women with anticipated high ovarian responses.Trial registrationClinicalTrials.govNCT02912988. Registered on  September 23, 2016. This trial protocol is version 2.0. (Source: Trials)
Source: Trials - April 1, 2022 Category: Research Source Type: clinical trials

Biomarkers of Endometrial Receptivity
Conditions:   IVF;   Infertility Treatment;   Fertility Disorders;   Embryo Transfer Interventions:   Diagnostic Test: Cervical mucus will be collected from patients undergoing IVF (in vitro fertilisation);   Diagnostic Test: Cervical mucus will be collected from patients undergoing transfer of cryopreserved embryos Sponsors:   The Institute of Molecular and Translational Medicine, Czech Republic;   University Hospital Olomouc;   Brno University Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 6, 2020 Category: Research Source Type: clinical trials

Study to Assess the Design of Use of REKOVELLE ® in Women Undergoing In Vitro Fertilisation or Intracytoplasmic Sperm Injection Procedures in Routine Clinical Practice
Condition:   Controlled Ovarian Stimulation Intervention:   Drug: Follitropin Delta Sponsor:   Ferring Pharmaceuticals Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 7, 2020 Category: Research Source Type: clinical trials

TILT: Time-Lapse Imaging Trial —a pragmatic, multi-centre, three-arm randomised controlled trial to assess the clinical effectiveness and safety of time-lapse imaging in in vitro fertilisation treatment
DiscussionIn the absence of high-quality evidence, there is no current national guidance, recommendation or policy for the use of TLI. The use of TLI is not consistently incorporated into standard IVF care. A large, pragmatic, multi-centre, trial will provide much needed definitive evidence regarding the effectiveness of TLI. If proven to be effective, its incorporation into standard care would translate into significant clinical and economic benefits. If not, it would allow allocation of resources to more effective interventions.Trial registrationISRCTN registryISRCTN17792989. Prospectively registered on 18 April 2018 (Source: Trials)
Source: Trials - June 30, 2020 Category: Research Source Type: clinical trials