Spontaneous well-differentiated pancreatic islet cell carcinoma with vascular invasion in a male F344 rat
J Toxicol Pathol. 2022 Jan;35(1):99-102. doi: 10.1293/tox.2021-0037. Epub 2021 Oct 8.ABSTRACTThis case report describes a case of spontaneous pancreatic islet cell carcinoma with vascular invasion in a 110-week-old male F344 rat. Histologically, a pancreatic nodule consisting of tumor cells and many blood-rich vessels, and covered with a fibrous capsule showed local invasion in the capsule and adjacent acinar tissues, encircling a large duct-like structure (DS). The tumor was composed of well-differentiated tumor cells resembling normal pancreatic islet cells, which had small round nuclei and eosinophilic cytoplasm. Mitoti...
Source: Journal of Toxicologic Pathology - February 28, 2022 Category: Toxicology Authors: Shiori Fujiwara Yuko Yamaguchi Tsubasa Saito Tomomi Nakazawa Kazutoshi Tamura Source Type: research
