The Effect of Inflammatory Bowel Disease and Irritable Bowel Syndrome on Pravastatin Oral Bioavailability: In vivo and in silico evaluation using bottom-up wbPBPK modeling
AAPS PharmSciTech. 2024 Apr 11;25(4):86. doi: 10.1208/s12249-024-02803-z.ABSTRACTThe common disorders irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) can modify the drugs' pharmacokinetics via their induced pathophysiological changes. This work aimed to investigate the impact of these two diseases on pravastatin oral bioavailability. Rat models for IBS and IBD were used to experimentally test the effects of IBS and IBD on pravastatin pharmacokinetics. Then, the observations made in rats were extrapolated to humans using a mechanistic whole-body physiologically-based pharmacokinetic (wbPBPK) model. The r...
Source: AAPS PharmSciTech - April 11, 2024 Category: Drugs & Pharmacology Authors: Motasem M Alsmadi Alla A Abudaqqa Nasir Idkaidek Nidal A Qinna Ahmad Al-Ghazawi Source Type: research
The Effect of Inflammatory Bowel Disease and Irritable Bowel Syndrome on Pravastatin Oral Bioavailability: In vivo and in silico evaluation using bottom-up wbPBPK modeling
AAPS PharmSciTech. 2024 Apr 11;25(4):86. doi: 10.1208/s12249-024-02803-z.ABSTRACTThe common disorders irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) can modify the drugs' pharmacokinetics via their induced pathophysiological changes. This work aimed to investigate the impact of these two diseases on pravastatin oral bioavailability. Rat models for IBS and IBD were used to experimentally test the effects of IBS and IBD on pravastatin pharmacokinetics. Then, the observations made in rats were extrapolated to humans using a mechanistic whole-body physiologically-based pharmacokinetic (wbPBPK) model. The r...
Source: AAPS PharmSciTech - April 11, 2024 Category: Drugs & Pharmacology Authors: Motasem M Alsmadi Alla A Abudaqqa Nasir Idkaidek Nidal A Qinna Ahmad Al-Ghazawi Source Type: research
Understanding preferences for receiving health communications and information about clinical trials: a cross-sectional study among US adults
CONCLUSION: Effective health communication may be achieved via multiple formats shared directly by healthcare providers.PMID:38595182 | DOI:10.1080/03007995.2024.2340720 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Dalia Majumdar Diane Webb Stephanie Parsons Elizabeth M Selwan-Lewis Trisha Rettig Emily Chastain Winifred Obanor Rob Birnberg Amy Kuang Source Type: research
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
CONCLUSION: Our finding that increased expression of the 5-HT2B receptor contributes to visceral hyperalgesia by inducing TRPV1 expression in IBS-D patients provides important insights into the potential mechanisms underlying IBS-D-associated visceral hyperalgesia.PMID:38596485 | PMC:PMC11000090 | DOI:10.3748/wjg.v30.i10.1431 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Source Type: research
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
CONCLUSION: Our finding that increased expression of the 5-HT2B receptor contributes to visceral hyperalgesia by inducing TRPV1 expression in IBS-D patients provides important insights into the potential mechanisms underlying IBS-D-associated visceral hyperalgesia.PMID:38596485 | PMC:PMC11000090 | DOI:10.3748/wjg.v30.i10.1431 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Source Type: research
Different Food Preferences in Patients with Gastrointestinal Disorders
Conclusions Patients with FD had a negative preference for foods, particularly fatty foods, independent of the severity of GI symptoms.PMID:38599865 | DOI:10.2169/internalmedicine.3433-24 (Source: Internal Medicine)
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Ryo Katsumata Tomoka Kaburagi Takayuki Hosokawa Noriaki Manabe Manabu Ishii Katsunori Ishii Tomohiro Tanikawa Noriyo Urata Maki Ayaki Ken Nishino Takahisa Murao Mitsuhiko Suehiro Minoru Fujita Miwa Kawanaka Ken Haruma Hirofumi Kawamoto Toshihiro Takao Tom Source Type: research
Understanding preferences for receiving health communications and information about clinical trials: a cross-sectional study among US adults
CONCLUSION: Effective health communication may be achieved via multiple formats shared directly by healthcare providers.PMID:38595182 | DOI:10.1080/03007995.2024.2340720 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Dalia Majumdar Diane Webb Stephanie Parsons Elizabeth M Selwan-Lewis Trisha Rettig Emily Chastain Winifred Obanor Rob Birnberg Amy Kuang Source Type: research
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
CONCLUSION: Our finding that increased expression of the 5-HT2B receptor contributes to visceral hyperalgesia by inducing TRPV1 expression in IBS-D patients provides important insights into the potential mechanisms underlying IBS-D-associated visceral hyperalgesia.PMID:38596485 | PMC:PMC11000090 | DOI:10.3748/wjg.v30.i10.1431 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Source Type: research
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
CONCLUSION: Our finding that increased expression of the 5-HT2B receptor contributes to visceral hyperalgesia by inducing TRPV1 expression in IBS-D patients provides important insights into the potential mechanisms underlying IBS-D-associated visceral hyperalgesia.PMID:38596485 | PMC:PMC11000090 | DOI:10.3748/wjg.v30.i10.1431 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Source Type: research
Different Food Preferences in Patients with Gastrointestinal Disorders
Conclusions Patients with FD had a negative preference for foods, particularly fatty foods, independent of the severity of GI symptoms.PMID:38599865 | DOI:10.2169/internalmedicine.3433-24 (Source: Internal Medicine)
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Ryo Katsumata Tomoka Kaburagi Takayuki Hosokawa Noriaki Manabe Manabu Ishii Katsunori Ishii Tomohiro Tanikawa Noriyo Urata Maki Ayaki Ken Nishino Takahisa Murao Mitsuhiko Suehiro Minoru Fujita Miwa Kawanaka Ken Haruma Hirofumi Kawamoto Toshihiro Takao Tom Source Type: research
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
CONCLUSION: Our finding that increased expression of the 5-HT2B receptor contributes to visceral hyperalgesia by inducing TRPV1 expression in IBS-D patients provides important insights into the potential mechanisms underlying IBS-D-associated visceral hyperalgesia.PMID:38596485 | PMC:PMC11000090 | DOI:10.3748/wjg.v30.i10.1431 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Source Type: research
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
CONCLUSION: Our finding that increased expression of the 5-HT2B receptor contributes to visceral hyperalgesia by inducing TRPV1 expression in IBS-D patients provides important insights into the potential mechanisms underlying IBS-D-associated visceral hyperalgesia.PMID:38596485 | PMC:PMC11000090 | DOI:10.3748/wjg.v30.i10.1431 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Source Type: research
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
CONCLUSION: Our finding that increased expression of the 5-HT2B receptor contributes to visceral hyperalgesia by inducing TRPV1 expression in IBS-D patients provides important insights into the potential mechanisms underlying IBS-D-associated visceral hyperalgesia.PMID:38596485 | PMC:PMC11000090 | DOI:10.3748/wjg.v30.i10.1431 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Source Type: research
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
CONCLUSION: Our finding that increased expression of the 5-HT2B receptor contributes to visceral hyperalgesia by inducing TRPV1 expression in IBS-D patients provides important insights into the potential mechanisms underlying IBS-D-associated visceral hyperalgesia.PMID:38596485 | PMC:PMC11000090 | DOI:10.3748/wjg.v30.i10.1431 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Source Type: research
Different Food Preferences in Patients with Gastrointestinal Disorders
Conclusions Patients with FD had a negative preference for foods, particularly fatty foods, independent of the severity of GI symptoms.PMID:38599865 | DOI:10.2169/internalmedicine.3433-24 (Source: Internal Medicine)
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Ryo Katsumata Tomoka Kaburagi Takayuki Hosokawa Noriaki Manabe Manabu Ishii Katsunori Ishii Tomohiro Tanikawa Noriyo Urata Maki Ayaki Ken Nishino Takahisa Murao Mitsuhiko Suehiro Minoru Fujita Miwa Kawanaka Ken Haruma Hirofumi Kawamoto Toshihiro Takao Tom Source Type: research
