The prevalence of fibromyalgia in adults at Al-Karak Jordan: a cross-sectional study
CONCLUSION: This study sheds light on fibromyalgia's prevalence and associated factors in the Al-Karak population. The identified predictors highlight the necessity for comprehensive healthcare strategies and interventions to mitigate the disease burden. These findings aid policymakers and healthcare professionals in planning and implementing effective measures for fibromyalgia management and prevention. Further research is warranted to deepen our understanding of fibromyalgia's complexity and its implications in this region.PMID:38463111 | PMC:PMC10923264 | DOI:10.1097/MS9.0000000000001722 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Alaa Akel Mohammed Y Sarhan Majed Al Dwairy Belal Al-Zu'bi Ala Al-Qudah Omar A Alsmarat Taif Alsaraireh Mohammad Abu-Jeyyab Source Type: research
Gender-specific insights into the irritable bowel syndrome pathophysiology. Focus on gut dysbiosis and permeability
Eur J Intern Med. 2024 Mar 10:S0953-6205(24)00105-5. doi: 10.1016/j.ejim.2024.03.011. Online ahead of print.ABSTRACTIrritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder involving the brain-gut interaction. IBS is characterized by persistent abdominal pain and changes in bowel habits. IBS exerts significant impacts on quality of life and imposes huge economic costs. Global epidemiological data reveal variations in IBS prevalence, both globally and between genders, necessitating comprehensive studies to uncover potential societal and cultural influences. While the exact pathophysiology of IB...
Source: European Journal of Internal Medicine - March 11, 2024 Category: Internal Medicine Authors: Jerlin Stephy JohnBritto Agostino Di Ciaula Antonino Noto Velia Cassano Angela Sciacqua Mohamad Khalil Piero Portincasa Leonilde Bonfrate Source Type: research
Cumulative Anticholinergic Burden and its Predictors among Older Adults with Alzheimer ’s Disease Initiating Cholinesterase Inhibitors
ConclusionFour out of five older adults with AD had some level of anticholinergic burden, with over 60% having moderate –high anticholinergic burden. Several predisposing, enabling, and need factors were associated with the cumulative anticholinergic burden. The study findings suggest a critical need to minimize the cumulative anticholinergic burden to improve AD care. (Source: Drugs and Aging)
Source: Drugs and Aging - March 11, 2024 Category: Geriatrics Source Type: research
The critical role of muscularis macrophages in modulating the enteric nervous system function and gastrointestinal motility
J Smooth Muscle Res. 2024;60:1-9. doi: 10.1540/jsmr.60.1.ABSTRACTMacrophages are the originators of inflammatory compounds, phagocytic purifiers in their local environment, and wound healing protectors in oxidative environments. They are molded by the tissue milieu they inhabit, with gastrointestinal (GI) muscularis macrophages (MMs) being a prime example. MMs are located in the muscular layer of the GI tract and contribute to muscle repair and maintenance of GI motility. MMs are often in close proximity to the enteric nervous system, specifically near the enteric neurons and interstitial cells of Cajal (ICCs). Consequentl...
Source: Journal of Smooth Muscle Research - March 10, 2024 Category: Research Authors: Egan L Choi Negar Taheri Yuebo Zhang Kenjiro Matsumoto Yujiro Hayashi Source Type: research
