Impacts of gait freeze on quality of life in Parkinson ’s disease, from the perspectives of patients and their carers
ConclusionsThis study shows that FoG is a significant detriment to the QoL of PwP, from the perspectives of patients and carers. This method of assessing FoG and QoL using online questionnaires has potential to enhance the reach and flexibility of this type of research. These findings will inform future studies on larger cohorts and highlight unmet clinical needs in PwP. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 19, 2024 Category: General Medicine Source Type: research
Exploring access to community neurorehabilitation for people with progressive neurological conditions: a qualitative study
CONCLUSIONS: This study adds depth to our understanding of the complexity, and the roles and needs of people with PNCs and HCPs, in accessing community neurorehabilitation. Further research is needed to determine how best to empower people to access rehabilitation.PMID:38632940 | DOI:10.1080/09638288.2024.2338198 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - April 18, 2024 Category: Rehabilitation Authors: Shona J Pryde Owen Williams Margaret P O'Hare Carolyn Murdock Katy Pedlow Source Type: research
Upper gastrointestinal training in the UK and Ireland: a Roux Group Study
CONCLUSIONS: Current CCT requirements are largely consistent with the opinions of the UGI community. Areas for improvement include flexibility in geographical working and increasing national provisions for high-quality endoscopy training.PMID:38634225 | DOI:10.1308/rcsann.2023.0104 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - April 18, 2024 Category: Surgery Authors: Dbt Robinson R Zakeri L R Brown R W Laing C Choh A Askari M Abouelazayem A Bradley A C Currie M Elmasry Rpt Evans Tmh Gall E Jerome N B Raftery M Samuel Hvm Spiers Bky Chan Source Type: research
Staff experiences of wearing the Rainbow Badge in a paediatric hospital setting: a mixed-methods survey
Conclusions
This study demonstrates that the Rainbow Badge initiative increases staff awareness of LGBTQ+ issues and helps to create a safe, inclusive environment for staff, young people and families. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: O'Dwyer, C., Kehoe, A., Shanahan, D., O'Brien, W., Hall, D. Tags: Open access Original research Source Type: research
Quality improvement project assessing the feasibility of using canister weight to estimate remaining doses in a salbutamol pressurised metered-dose inhaler
Pressurised metered-dose inhalers (pMDIs) containing salbutamol are an essential medicine for children with acute asthma. Salamol chlorofluorocarbon-free inhaler (‘Salamol’; IVAX Pharmaceuticals, Waterford, Ireland) is the most widely prescribed salbutamol pMDI in England (figure 1), costing the National Health Service £7.2 million in the 2022–23 financial year.1 In common with the other salbutamol pMDIs it lacks an integrated dose counter (IDC). Without an IDC, most children and families cannot accurately identify when a pMDI is empty.2 Thus, families may continue to use a pMDI that contains no act...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Beckett, R. S., Jagadish, A., Carroll, W., Gilchrist, F. J. Tags: PostScript Source Type: research
Accuracy of point-of-care testing for the diagnosis of respiratory pathogens in a paediatric intensive care setting
Respiratory tract infections contribute significantly to paediatric intensive care unit (PICU) admissions. Early diagnosis supports treatment, cohorting and antimicrobial stewardship. Rapid point-of-care (POC) multiplex PCR techniques show promise in improving antimicrobial and investigation stewardship across healthcare settings.1 However, debate exists regarding their role and accuracy.2 3 We sought to evaluate the feasibility and accuracy of respiratory pathogen POC testing in our PICU. All patients admitted to the regional Northern Ireland PICU undergo nasal/nasopharyngeal swab respiratory pathogen POC testing. The Bio...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Norman - Bruce, H., Wilson, K., Waheed, S., Richardson, J., Groves, H. Tags: PostScript Source Type: research
Current management of neonatal abstinence syndrome: a survey of practice in the UK and Ireland
Conclusion and relevance
Compared with the previous survey, improvements in evidence-based practices were noted, highlighting the benefits of this type of research. Nonetheless, significant variation still exists in some aspects of the management of NAS. Post-discharge follow-up varies widely, with particular deficits in ophthalmology follow-up. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Dempsey, S., O Grady, M. J. Tags: Original research Source Type: research
Correction: Hepatitis A and B vaccination in gbMSM in Ireland: findings from the European MSM internet survey 2017 (EMIS-2017)
White P, O'Donnell K, Brennan A, et al. Hepatitis A and B vaccination in gbMSM in Ireland: findings from the European MSM Internet Survey 2017 (EMIS-2017). Sex Transm Infect 2023;99:337-344.
In this article, the authors have made changes to the original manuscript to acknowledge the broad range of stakeholders who should have been included in our original acknowledgements section.
The funding section has been updated to recognise the funding given to the wider EMIS project, as opposed to this particular study.
The methods section has also been updated to better capture the ethical considerations for this study and cite som...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Tags: Correction Source Type: research
Predicting community acquired bloodstream infection in infants using full blood count parameters and C-reactive protein; a machine learning study
Conclusion: We identified several models that can predict positive blood cultures in infants with suspected BSI aged 7 to 60 days. Application of these models could prevent administration of antimicrobial treatment and burdensome diagnostics in infants who do not need them.What is Known:• Bloodstream infection (BSI) in infants cause non-specific symptoms and may be difficult to diagnose.• Results of blood cultures can take up to 48 hours.What is New:• Machine learning models can contribute to clinical decision making on BSI in infants while blood culture results are not yet known. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - April 18, 2024 Category: Pediatrics Source Type: research
Multiple introductions of monkeypox virus to Ireland during the international mpox outbreak, May 2022 to October 2023
ConclusionWe provide insights into the international transmission dynamics supporting multiple introductions of MPXV into Ireland. Such information supported the implementation of evidence-informed public health control measures. (Source: Eurosurveillance)
Source: Eurosurveillance - April 18, 2024 Category: Infectious Diseases Authors: Gabriel Gonzalez, Michael Carr, Tom ás M Kelleher, Emer O’Byrne, Weronika Banka, Brian Keogan, Charlene Bennett, Geraldine Franzoni, Patrice Keane, Cliona Kenna, Luke W Meredith, Nicola Fletcher, Jose Maria Urtasun-Elizari, Jonathan Dean, Ciaran Browne Source Type: research
Overcoming osimertinib resistance with AKT inhibition in EGFRm-driven Non-Small-Cell-Lung-Cancer with PIK3CA/PTEN alterations
CONCLUSIONS: Together, this approach offers a potential treatment strategy for patients with EGFRm-driven NSCLC that have a sub-optimal response, or develop resistance, to osimertinib through PIK3CA/AKT/PTEN alterations.PMID:38630555 | DOI:10.1158/1078-0432.CCR-23-2540 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Ursula Grazini Aleksandra Markovets Lucy Ireland Daniel O'Neill Benjamin Phillips Man Xu Matthias Pfeifer Tereza Vaclova Matthew J Martin Ludovic Bigot Luc Friboulet Ryan Hartmaier Maria Emanuela Cuomo Simon T Barry Paul D Smith Nicolas Floc'h Source Type: research
Dissonance in the face of Alzheimer's disease breakthroughs: clinician and lay stakeholder acceptance, concerns and willingness to pay for emerging disease-modifying therapies
CONCLUSIONS: This study exposes complex attitudes toward emerging DMTs for Alzheimer's disease, challenging conventional wisdom in multiple dimensions. A surprising 25% of the public expressed aversion to these new treatments, despite society's deep-rooted fear of dementia in older age. Healthcare professionals displayed nuanced concerns, prioritising clinical effectiveness and potential brain complications. Intriguingly, younger, better-educated and privately insured individuals exhibited a greater WTP, foregrounding critical questions about healthcare equity. These multifaceted findings serve as a guidepost for healthcar...
Source: The British Journal of Psychiatry for Mental Science - April 17, 2024 Category: Psychiatry Authors: Irina Kinchin Sharon Walsh Rachel Dinh Margaret Kapuwa Sean P Kennelly Ann-Marie Miller Ann Nolan Sean O'Dowd Laura O'Philbin Suzanne Timmons Iracema Leroi Source Type: research
Overcoming osimertinib resistance with AKT inhibition in EGFRm-driven Non-Small-Cell-Lung-Cancer with PIK3CA/PTEN alterations
CONCLUSIONS: Together, this approach offers a potential treatment strategy for patients with EGFRm-driven NSCLC that have a sub-optimal response, or develop resistance, to osimertinib through PIK3CA/AKT/PTEN alterations.PMID:38630555 | DOI:10.1158/1078-0432.CCR-23-2540 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 17, 2024 Category: Cancer & Oncology Authors: Ursula Grazini Aleksandra Markovets Lucy Ireland Daniel O'Neill Benjamin Phillips Man Xu Matthias Pfeifer Tereza Vaclova Matthew J Martin Ludovic Bigot Luc Friboulet Ryan Hartmaier Maria Emanuela Cuomo Simon T Barry Paul D Smith Nicolas Floc'h Source Type: research
Overcoming osimertinib resistance with AKT inhibition in EGFRm-driven Non-Small-Cell-Lung-Cancer with PIK3CA/PTEN alterations
CONCLUSIONS: Together, this approach offers a potential treatment strategy for patients with EGFRm-driven NSCLC that have a sub-optimal response, or develop resistance, to osimertinib through PIK3CA/AKT/PTEN alterations.PMID:38630555 | DOI:10.1158/1078-0432.CCR-23-2540 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Ursula Grazini Aleksandra Markovets Lucy Ireland Daniel O'Neill Benjamin Phillips Man Xu Matthias Pfeifer Tereza Vaclova Matthew J Martin Ludovic Bigot Luc Friboulet Ryan Hartmaier Maria Emanuela Cuomo Simon T Barry Paul D Smith Nicolas Floc'h Source Type: research
Overcoming osimertinib resistance with AKT inhibition in EGFRm-driven Non-Small-Cell-Lung-Cancer with PIK3CA/PTEN alterations
CONCLUSIONS: Together, this approach offers a potential treatment strategy for patients with EGFRm-driven NSCLC that have a sub-optimal response, or develop resistance, to osimertinib through PIK3CA/AKT/PTEN alterations.PMID:38630555 | DOI:10.1158/1078-0432.CCR-23-2540 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ursula Grazini Aleksandra Markovets Lucy Ireland Daniel O'Neill Benjamin Phillips Man Xu Matthias Pfeifer Tereza Vaclova Matthew J Martin Ludovic Bigot Luc Friboulet Ryan Hartmaier Maria Emanuela Cuomo Simon T Barry Paul D Smith Nicolas Floc'h Source Type: research
