Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices: study protocol for a randomised controlled trial
DiscussionThe BOPPP trial aims to investigate the clinical and cost-effectiveness of carvedilol in patients with cirrhosis and small oesophageal varices to determine whether this non-selective beta-blocker can prevent or reduce hepatic decompensation. There is clinical equipoise on whether intervening in cirrhosis, at an earlier stage of portal hypertension, with NSBB therapy is beneficial. Should the trial yield a positive result, we anticipate that the administration and use of carvedilol will become widespread with pathways developed to standardise the administration of the medication in primary care.Ethics and dissemin...
Source: Trials - April 16, 2024 Category: Research Source Type: clinical trials
EMERGE Mothers and Kids
Conditions: Gestational Diabetes Interventions: Other: No intervention as the study is observational. Sponsors: National University of Ireland, Galway, Ireland Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 25, 2024 Category: Research Source Type: clinical trials
Optimising Patient Experience in Head and Neck Radiotherapy
Conditions: Head and Neck Cancer Interventions: Device: Conventional 5 point closed face immobilisation mask.; Device: 5 point open face immobilization mask; Device: 3 point open face immobilization mask Sponsors: Irish Research Radiation Oncology Group Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 25, 2024 Category: Research Source Type: clinical trials
Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease
Conditions: Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Motor Neuron Disease Progressive Spinal Muscle Atrophy; Primary Lateral Sclerosis; Multiple Sclerosis; Postpoliomyelitis Syndrome Interventions: Procedure: 232 Electrode Electrophysiology (EEG-ECG-EMG-EXG) Sponsors: University of Dublin, Trinity College; Motor Neurone Disease Association, UK; Irish Research Council, IE; Health Research Board, IE; Research Motor Neurone, IE; Thierry Latran Foundation, FR; ALS Association, USA Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials
A Phase 2 Study to Investigate Efficacy and Safety of HZN-1116 in Participants With Sjogren's Syndrome
Conditions: Sjogren ' s Syndrome Interventions: Drug: HZN-1116; Drug: Placebo Sponsors: Horizon Therapeutics Ireland DAC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials
Dairy Products to Your Gut and Brain
Conditions: Healthy; Constipation Interventions: Other: Fermented dairy; Other: Non-fermented dairy Sponsors: University of Copenhagen; University of Aarhus; APC Microbiome Ireland Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials
The Impact of E-cigarettes During Pregnancy on Childhood Health Outcomes Study
Conditions: Vaping; Pregnancy Related; Pediatric Respiratory Diseases Sponsors: University College Dublin; Royal College of Surgeons, Ireland Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 6, 2024 Category: Research Source Type: clinical trials
Supporting Secondary School Student Wellbeing Through a Mobile App and Wearable Biofeedback
Conditions: No Disease or Condition is Being Studied; Stress Psychological; Overall Wellness Interventions: Device: Mobile app and wrist-worn monitor Sponsors: Royal College of Surgeons, Ireland Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 5, 2024 Category: Research Source Type: clinical trials
A Flexible Individualized ExeRcise Programme for Cancer Patients During ChEmotherapy
Conditions: Cancer Interventions: Behavioral: Exercise; Behavioral: Health Behaviour Change (Pedometer) Sponsors: University of Dublin, Trinity College; St. James ' s Hospital, Ireland Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials
Upfront Systematic Tumour BRCA Testing in Patients With High Grade Serous or Endometrioid Ovarian, Fallopian Tube or Primary Peritoneal Cancer (HGSEC): The t-BRCA Study
Conditions: Serous Ovarian Tumor; Endometrioid Carcinoma Ovary; Fallopian Tube Cancer; Primary Peritoneal Carcinoma Interventions: Genetic: Somatic and Germline BRCA1/2 Testing Sponsors: Cancer Trials Ireland Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials
Omega-3-Index Response to Eating Poultry Foods Naturally Enriched With Omega-3 Polyunsaturated Fatty Acids
Conditions: Healthy Nutrition; Healthy Adults Interventions: Other: Omega-3 polyunsaturated fatty acid, naturally enriched, poultry foods (chicken-meat and eggs); Other: Control poultry foods (chicken-meat and eggs) Sponsors: King Abdulaziz University; Royal College of Surgeons, Ireland; University College Dublin Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 14, 2024 Category: Research Source Type: clinical trials
A Safety and Efficacy Study of Dazodalibep in Participants With Sj ögren's Syndrome (SS) With Moderate-to-Severe Symptom State
Conditions: Sj ögren ' s Syndrome (SS) Interventions: Drug: Dazodalibep; Drug: Placebo Sponsors: Horizon Pharma Ireland, Ltd., Dublin Ireland Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 7, 2024 Category: Research Source Type: clinical trials
Click2Move Intervention to Reduce Home-office Workers' Sedentary Behaviour.
Conditions: Sedentary Behaviour Interventions: Behavioral: Click2Move Sponsors: University of Vic - Central University of Catalonia; National Institute for Public Health and the Environment (RIVM); Technological University of the Shannon, Athlone, Ireland; University of Ljubljana Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 7, 2024 Category: Research Source Type: clinical trials
Personalised versus standard text message prompts for increasing trial participant response to telephone follow-up: an embedded randomised controlled retention trial
ConclusionsThere is some evidence that personalised text messages could be effective at increasing response rates when data is collected via telephone and in a population of caregivers for paediatric trial participants. However, similar SWATs have shown mixed results. Given the low-cost and low risks associated with personalising text message reminders, this SWAT could be implemented easily in other RCTs scheduling telephone follow-up appointments.Trial RegistrationISRCTN 18296119, SWAT 35 (MRC Northern Ireland Network for Trials Methodology Network). (Source: Trials)
Source: Trials - February 7, 2024 Category: Research Source Type: clinical trials
The Impact of Sedation Depth Monitoring for Cognitive Functions and Early Rehabilitation After Major Joints Arthroplasty
Conditions: Total Knee Replacement Surgery Interventions: Device: Dr äger Infinity Delta series monitor (Dräger, Germany) with Covidien BIS LoC 2 channel module and BIS Quatro (4 electrodes) sensor (Covidien, Ireland); Device: Dräger Infinity Delta series monitor (Dräger, Germany) with Covidien BIS LoC 2 channel module and BIS Quatro (4 electrodes) sensor (Covidi en, Ireland) Sponsors: Lithuanian University of Health Sciences Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 5, 2024 Category: Research Source Type: clinical trials
