Excretable, ultrasmall hexagonal NaGdF 4 :Yb50% nanoparticles for bimodal imaging and radiosensitization
ConclusionThese biocompatible and in vivo clearable ultrasmall NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - February 5, 2021 Category: Cancer & Oncology Source Type: research

A systematic review of cost-effectiveness analyses across the acute kidney injury landscape.
Authors: Suh K, Kellum JA, Kane-Gill SL Abstract INTRODUCTION: Acute kidney injury (AKI) is a complex and common condition associated with increased morbidity, mortality, and costs. Evidence from cost-effectiveness analysis (CEA) have targeted various aspects of AKI including detection with biomarkers, treatment with renal replacement therapy, and prevention when using contrast media. However, there has not been a systematic review of these studies across the entirety of AKI. Areas covered: PubMed, Embase, and Cochrane library were used to identify CEA studies that involved AKI from 2004 onwards. These studies comp...
Source: Expert Review of Pharmacoeconomics and Outcomes Research - February 3, 2021 Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research

MRGPRX2 mediates immediate-type pseudo-allergic reactions induced by iodine-containing iohexol
Publication date: May 2021Source: Biomedicine & Pharmacotherapy, Volume 137Author(s): Feng Yuan, Chi Zhang, Maji Sun, Dongying Wu, Lin Cheng, Bin Pan, Ting Li, Delu Che (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - January 31, 2021 Category: Drugs & Pharmacology Source Type: research

A novel technique for preoperative localization of pulmonary nodules using a mixture of tissue adhesive and iohexol under computed tomography guidance: A 140 patient single ‐center study
In this study, a technique for preoperative localization of pulmonary nodules with tissue adhesive and iohexol mixture was established and proved to be safe, easy to operate and efficient in clinical practice based on our experience. It is a suitable technique for promotion in localization of pulmonary nodules including multiple pulmonary nodules. AbstractBackgroundThe increase in the incidence of pulmonary nodules has made computed tomography (CT) screening a requirement for diagnosis and treatment. Small pulmonary nodule detection during video ‐assisted thoracoscopic surgery (VATS) or thoracotomy is frequently challeng...
Source: Thoracic Cancer - January 29, 2021 Category: Cancer & Oncology Authors: Bingyu Zhang, Muyun Peng, Fenglei Yu, Xilong Mei, Jingqun Tang, Xiang Wang, Wenliang Liu, Chen Chen, Xiaofeng Chen Tags: ORIGINAL ARTICLE Source Type: research

MRGPRX2 mediates immediate-type pseudo-allergic reactions induced by iodine-containing iohexol.
CONCLUSIONS: Conclusively, inhibition of MRGPRX2-mediated mast cell degranulation and cytokine release is important to prevent iohexol-induced immediate-type pseudo-allergic reactions. PMID: 33524790 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 29, 2021 Category: Drugs & Pharmacology Authors: Yuan F, Zhang C, Sun M, Wu D, Cheng L, Pan B, Li T, Che D Tags: Biomed Pharmacother Source Type: research

Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model
Augmented renal clearance (ARC) observed in the critically ill pediatric population has received an increased attention over the last years due to its major impact on the disposition and pharmacokinetics of mainly renally excreted drugs. Apart from an important inflammatory trigger, fluid administration has been suggested to contribute to the development of ARC. Therefore, the primary objective of this study was to evaluate the effect of continuous intravenous fluid administration on renal function using a conventional piglet animal model and to quantify the impact of fluid administration on the pharmacokinetics of renally...
Source: Frontiers in Pharmacology - January 26, 2021 Category: Drugs & Pharmacology Source Type: research

Preimplantation Histological Score Associates with 6-Month GFR in Recipients of Perfused, Older Kidney Grafts: Results from a Pilot Study
Conclusions: MP safely improves graft perfusion, particularly in kidneys with severe histologic changes that would not be considered for transplantation because of high KDPI. The preimplantation histologic score associates with the functional recovery of older kidneys even in the context of a standardized program of pulsatile perfusion.Nephron (Source: Nephron)
Source: Nephron - January 22, 2021 Category: Urology & Nephrology Source Type: research

Contrast media injection protocol for portovenous phase abdominal CT: does a fixed injection duration improve hepatic enhancement over a fixed injection rate?
ConclusionA fixed CM injection duration yields a greater magnitude in hepatic enhancement indices than a fixed injection rate. Inter-patient variability in hepatic enhancement indices do not significantly differ between the two injection protocols. (Source: Abdominal Imaging)
Source: Abdominal Imaging - January 2, 2021 Category: Radiology Source Type: research

Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy.
This study elucidated a novel mechanism in which NLRP3 inflammasome inhibition attenuated apoptosis and upregulated HIF1A and BNIP3-mediated mitophagy in CI-AKI. Additionally, this study demonstrated the potential applications of MCC950 and roxadustat in clinical CI-AKI treatment. Abbreviations: BNIP3: BCL2/adenovirus E1B interacting protein 3; Ctrl: control; DAPI: 4',6-diamidino-2-phenylindole dihydrochloride; EGLN2/PHD1: egl-9 family hypoxia-inducible factor 2; HIF1A: hypoxia inducible factor 1, alpha subunit; H-E: hematoxylin and eosin; IL18: interleukin 18; IL1B: interleukin 1 beta; LAMP1: lysosomal-associated membrane...
Source: Autophagy - December 19, 2020 Category: Cytology Authors: Lin Q, Li S, Jiang N, Jin H, Shao X, Zhu X, Wu J, Zhang M, Zhang Z, Shen J, Zhou W, Gu L, Lu R, Ni Z Tags: Autophagy Source Type: research

Probable parenteral and oral contrast-induced Steven Johnson syndrome/toxic epidermal necrolysis: A case report
We report a case of contrast-inducted Steven Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN). The patient had received parenteral iopamidol and oral iohexol five days prior. The patient's chief complaint at the Emergency Department (ED) presentation was shortness of breath and blisters throughout body. Upon arrival, the patient was awake, alert, and oriented with a blood pressure (BP) of 166/68, heart rate (HR) of 117 beats per minute, respiratory rate (RR) of 22 breaths per minute and oxygen saturation of 94% on room air. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - December 18, 2020 Category: Emergency Medicine Authors: Marianne Pop, Alice Hemenway, Faizan Shakeel Source Type: research

Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease.
Using data (2655 observations from 928 participants) from the Chronic Kidney Disease in Children Study, we developed and internally validated new glomerular filtration rate estimating equations for clinical use in children and young adults: two forms of k × [height (ht) serum creatinine (sCr)] and two forms of k × [1 cystatin C(cysC)]. For each marker, one equation used a sex-dependent k; in the other, k is sex-and age-dependent. Glomerular filtration rate (GFR) was measured directly by plasma iohexol disappearance. (Source: Kidney International)
Source: Kidney International - December 7, 2020 Category: Urology & Nephrology Authors: Christopher B. Pierce, Alvaro Mu ñoz, Derek K. Ng, Bradley A. Warady, Susan L. Furth, George J. Schwartz Tags: clinical investigation Source Type: research

Translational Studies on Biologic Fusion of a Vertebral Segment as a Novel Treatment Modality for Low Back Pain
Conclusion. LA has a sclerozing effect on the NP in pigs and patients and is therefore a candidate for further clinical studies powered to determine its potential as a treatment of chronic discogenic low back pain. Level of Evidence: 2 (Source: Spine)
Source: Spine - December 1, 2020 Category: Orthopaedics Tags: BASIC SCIENCE Source Type: research

Evaluation of a dual-purpose contrast medium for radiography and ultrasonography of the small intestine in dogs.
CONCLUSIONS AND CLINICAL RELEVANCE: An MCM that combined 8.5 mL of 0.5% CMC/kg and 1.5 mL of iohexol/kg could be an alternative to barium or iohexol alone for contrast small intestinal radiography in dogs, especially when abdominal ultrasonography is to follow contrast radiography. PMID: 33251836 [PubMed - indexed for MEDLINE] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - December 1, 2020 Category: Veterinary Research Authors: Kang J, Oh D, Choi J, Kim K, Yoon J, Choi M Tags: Am J Vet Res Source Type: research

Evaluation of a recirculating hydroponic bed bioreactor for removal of contaminants of emerging concern from tertiary-treated wastewater effluent.
Abstract Tertiary-treated effluent from a municipal wastewater treatment plant in Tucson, AZ, was added to recirculating hydroponic bed bioreactors filled with light expanded clay aggregate (LECA) and recirculated for 10 days. Bioreactors were planted with high and low densities of sorghum (Sorghum bicolor), switchgrass (Panicum virgatum) and Bacillus thuringiensis cotton (Gossypium sp.). The experiment also included a non-planted bioreactor treatment and a control bioreactor with neither plants nor substrate medium. Of 46 contaminants of emerging conern assayed with liquid chromatography tandem mass spectrometry ...
Source: Chemosphere - November 28, 2020 Category: Chemistry Authors: Recsetar MS, Fitzsimmons KM, Cuello JL, Hoppe-Jones C, Snyder SA Tags: Chemosphere Source Type: research

Measured and Estimated Glomerular Filtration Rate in the ICU: A Prospective Study
Conclusions: All known estimated glomerular filtration rate equations displayed high biases and unacceptable errors when compared with measured glomerular filtration rate in a mixed ICU population, with the lowest performance related to creatinine-based equations compared with cystatin C. In the ICU, we advocate for caution when using creatinine based estimated glomerular filtration rate equations. Drifting of serum creatinine levels over time should also be taken into consideration when assessing renal function in the ICU. (Source: Critical Care Medicine)
Source: Critical Care Medicine - November 22, 2020 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Cross-Sectional and Longitudinal Performance of Creatinine- and Cystatin C-Based Estimating Equations Relative to Exogenously Measured Glomerular Filtration Rate in HIV-Positive and HIV-Negative Persons
Conclusions: Both creatinine and cystatin C have limitations as GFR indices in HIV-positive individuals. Estimated GFR based on both creatinine and cystatin C performed best in our study and may be preferred in HIV-positive persons with kidney disease or comorbidities that place them at high risk for kidney disease. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - October 31, 2020 Category: Infectious Diseases Tags: Clinical Science Source Type: research

Cross-Sectional and Longitudinal Performance of Creatinine- and Cystatin C-Based Estimating Equations Relative to Exogenously Measured Glomerular Filtration Rate in HIV-Positive and HIV-Negative Persons
Conclusions: Both creatinine and cystatin C have limitations as GFR indices in HIV-positive individuals. Estimated GFR based on both creatinine and cystatin C performed best in our study and may be preferred in HIV-positive persons with kidney disease or comorbidities that place them at high risk for kidney disease. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - October 29, 2020 Category: Infectious Diseases Tags: Clinical Science Source Type: research

Real-time glomerular filtration rate: improving sensitivity, accuracy and prognostic value in acute kidney injury
Purpose of review Acute kidney injury (AKI) is common and associated with high patient mortality, and accelerated progression to chronic kidney disease. Our ability to diagnose and stratify patients with AKI is paramount for translational progress. Unfortunately, currently available methods have major pitfalls. Serum creatinine is an insensitive functional biomarker of AKI, slow to register the event and influenced by multiple variables. Cystatin C, a proposed alternative, requires long laboratory processing and also lacks specificity. Other techniques are either very cumbersome (inuline, iohexol) or involve administrati...
Source: Current Opinion in Critical Care - October 28, 2020 Category: Nursing Tags: RENAL SYSTEM: Edited by Marlies Ostermann Source Type: research

Role of TLR4/MyD88/NF- κB signaling in the contrast-induced injury of renal tubular epithelial cells.
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells. Exp Ther Med. 2020 Nov;20(5):115 Authors: Wang X, Zhou J, Yang J, Wang S, Yang L Abstract The aim of the present study was to explore the role of toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor (NF)-κB signaling in the contrast-induced injury of renal tubular epithelial cells, and to investigate the potential mechanisms. HK-2 cells cultured in vitro were randomly divided into six groups as follows: i) The blank group; ii) the iohexol group; iii)...
Source: Experimental and Therapeutic Medicine - October 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects.
Abstract Tucatinib is a potent tyrosine kinase inhibitor selective for human epidermal growth factor receptor 2 (HER2) approved by the US Food and Drug Administration for the treatment of HER2-positive metastatic breast cancer and in development for other HER2-positive solid tumors. Modest, reversible serum creatinine (SCr) elevations have been observed in tucatinib clinical trials. SCr is conveyed by the renal drug transporters organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) and 2-K (MATE2-K) and can increase in the presence of inhibitors of these transporters. In vitro, tu...
Source: The Journal of Clinical Pharmacology - September 27, 2020 Category: Drugs & Pharmacology Authors: Topletz-Erickson AR, Lee AJ, Mayor JG, Rustia EL, Abdulrasool LI, Wise AL, Dailey B, DeChenne S, Walker LN, Alley SC, Endres CJ Tags: J Clin Pharmacol Source Type: research

Evaluation of the pharmacokinetic drug-drug interaction potential of iohexol, a renal filtration marker
ConclusionsIohexol is unlikely to affect the clinical pharmacokinetics of carboplatin, paclitaxel, gemcitabine, or other agents used in combination with carboplatin treatment. Measuring GFR with iohexol to better dose carboplatin is unlikely to alter the safety or efficacy of chemotherapy through pharmacokinetic drug-drug interactions. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - September 17, 2020 Category: Cancer & Oncology Source Type: research

Simultaneous Dual-Contrast Imaging of Small Bowel With Iodine and Bismuth Using Photon-Counting-Detector Computed Tomography: A Feasibility Animal Study
Conclusions Our study demonstrated the feasibility of simultaneous imaging of iodine and bismuth in small bowel of swine using PCD-CT. (Source: Investigative Radiology)
Source: Investigative Radiology - September 9, 2020 Category: Radiology Tags: Technical Note Source Type: research

Proenkephalin Compared to Conventional Methods to Assess Kidney Function in Critically Ill Sepsis Patients
Background: The assessment of renal function in clinical practice remains challenging. Using creatinine to assess the glomerular filtration rate (GFR) is notoriously inaccurate, and determination of the true GFR, e.g., using inulin or iohexol, is laborious and not feasible in daily practice. Proenkephalin (PENK) is a novel candidate biomarker for kidney function that is filtrated in the glomerulus, has shown to represent steady-state GFR in patients with different severities of renal insufficiency. In this pilot study in non-steady-state critically ill patients, we compared plasma PENK concentrations with creatinine-base...
Source: Shock - August 14, 2020 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

Developments in X-Ray Contrast Media and the Potential Impact on Computed Tomography
Over the past 120 years, continuous developments in medical imaging has improved diagnosis and treatment for many diseases and has thereby improved treatment outcome and quality of life of many patients. The number of computed tomography (CT) examinations is today increasing by 4% per year worldwide, for a total of approximately 300 million CT scans per year. About 40% of CT scans are contrast enhanced. Intravenous iodinated contrast media are commonly used for contrast enhancement in CT scans to evaluate diseases and determine treatment response. The current gold standards for intravenous x-ray contrast media in CT or int...
Source: Investigative Radiology - August 14, 2020 Category: Radiology Tags: Review Article Source Type: research

A Machine Learning Approach to Estimate the Glomerular Filtration Rate in Intensive Care Unit Patients Based on Plasma Iohexol Concentrations and Covariates
AbstractObjectiveThis work aims to evaluate whether a machine learning approach is appropriate to estimate the glomerular filtration rate in intensive care unit patients based on sparse iohexol pharmacokinetic data and a limited number of predictors.MethodsEighty-six unstable patients received 3250  mg of iohexol intravenously and had nine blood samples collected 5, 30, 60, 180, 360, 540, 720, 1080, and 1440 min thereafter. Data splitting was performed to obtain a training (75%) and a test set (25%). To estimate the glomerular filtration rate, 37 candidate potential predictors were considere d and the best machin...
Source: Clinical Pharmacokinetics - August 13, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of dapagliflozin and gliclazide on the cardiorenal axis in people with type 2 diabetes
Conclusion: Dapagliflozin seemingly influences systemic and renal hemodynamics independently and beyond glucose lowering in people with type 2 diabetes. This clinical trial was registered at https://clinicalTrials.gov (ID: NCT02682563). (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Incidence and Risk Factors of Nausea and Vomiting after Exposure to Low-Osmolality Iodinated Contrast Media in Children: A Focus on Preparative Fasting.
CONCLUSION: Only a small proportion (2.1%) of children experienced nausea or vomiting after exposure to low-osmolality ICM. Many children underwent excessive fasting; however, fasting duration was not associated with nausea and vomiting. Moreover, ongoing chemotherapy and the use of iomeprol or iohexol were identified as potential risk factors for emetic complications in children. PMID: 32767861 [PubMed - as supplied by publisher] (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - August 13, 2020 Category: Radiology Tags: Korean J Radiol Source Type: research

Catalytic ozonation of iohexol with α-Fe0.9Mn0.1OOH in water: Efficiency, degradation mechanism and toxicity evaluation
Publication date: 15 January 2021Source: Journal of Hazardous Materials, Volume 402Author(s): Pengwei Yan, Zhonglin Chen, Shuyu Wang, Yanchi Zhou, Li Li, Lei Yuan, Jimin Shen, Qianqian Jin, Xiaoxiao Zhang, Jing Kang (Source: Journal of Hazardous Materials)
Source: Journal of Hazardous Materials - August 4, 2020 Category: Environmental Health Source Type: research

Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury
Assessment of kidney function is primarily based on urine output and Creatinine (Cr)-based methods to estimate glomerular filtration rate (GFR). The latter is confounded as Cr is not exclusively filtered by the kidney and rises relatively late after the onset of acute kidney injury (AKI). This leads to delays in recognition of reduced kidney function and diagnosis of AKI, particularly in critically ill patients where kidney function can change rapidly. The gold standard methods of GFR determination, such as inulin or iohexol clearance, are labor intensive and unfeasible in acute clinical settings. Proenkephalin A 119 &ndas...
Source: Nephron - July 31, 2020 Category: Urology & Nephrology Source Type: research

Simultaneous glomerular filtration rate determination using inulin, iohexol, and 99mTc-DTPA demonstrates the need for customized measurement protocols
Urinary inulin clearance is considered the gold standard of glomerular filtration rate (GFR) measurement but plasma clearance of less expensive and more accessible tracers is more commonly performed. Many plasma sampling protocols exist but little is known about their accuracy. Here, the study objectives were to compare plasma iohexol and 99mTc-DTPA GFR with varying sampling strategies to the GFR measured by urinary inulin and to identify protocols with the greatest accuracy according to clinical characteristics. (Source: Kidney International)
Source: Kidney International - July 31, 2020 Category: Urology & Nephrology Authors: Christine A. White, Ayub Akbari, Celine Allen, Andrew G. Day, Patrick A. Norman, David Holland, Michael A. Adams, Greg A. Knoll Tags: Clinical Investigation Source Type: research

Simultaneous Glomerular Filtration Rate Determination Using Inulin, Iohexol and 99mTc-DTPA Demonstrates the Need for Customized Measurement Protocols
Urinary inulin clearance is considered the gold standard of glomerular filtration rate (GFR)measurement but plasma clearance of less expensive and more accessible tracers is more commonly performed. Many plasma sampling protocols exist but little is known about their accuracy. Here, the study objectives were to compare plasma iohexol and 99mTc-DTPA GFR with varying sampling strategies to the GFR measured by urinary inulin and to identify protocols with the greatest accuracy according to clinical characteristics. (Source: Kidney International)
Source: Kidney International - July 30, 2020 Category: Urology & Nephrology Authors: Christine A. White, Ayub Akbari, Celine Allen, Andrew G. Day, Patrick A. Norman, David Holland, Michael A. Adams, Greg A. Knoll Tags: clinical investigation Source Type: research

Impact of various iodine concentrations of iohexol and iodixanol contrast media on image reconstruction techniques in a vascular-specific contrast media phantom: quantitative and qualitative image quality assessment
AbstractPurposeThe aim of our study is to investigate the impact of iodine quantification on image reconstruction when employing a vascular-specific contrast media phantom with varying iodine concentrations.Materials and methodsA 30-cm phantom simulating arterial and venous blood vessel diameters was manufactured. Small (9  mm) and medium (12 mm) cylinders contained iodine concentrations from 10 to 100% while large (21 mm) cylinders were in quartiles from 25 to 100% diluted in blood equivalent medium. Each phantom was filled with either iohexol 350 mgI/mL (Group A) or iodixanol 320 mgI/mL (Group B) and then ...
Source: La Radiologia Medica - July 14, 2020 Category: Radiology Source Type: research

MicroRNA-30c attenuates contrast-induced acute kidney injury by suppressing NLRP3 inflammasome.
CONCLUSION: Our data demonstrated that the miR-30c induced by CIAKI could suppress cell apoptosis and kidney injury via targeting NLRP3. Therefore, targeting miR-30c might be a novel therapeutic candidate for CIAKI treatment and prevention. PMID: 32682254 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 14, 2020 Category: Allergy & Immunology Authors: Xu J, Ma L, Fu P Tags: Int Immunopharmacol Source Type: research

Quantitation of iohexol, a glomerular filtration marker, in human plasma by LC–MS/MS
Publication date: Available online 7 July 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Julianne L. Holleran, Robert A. Parise, Jianxia Guo, Brian Kiesel, Sarah E. Taylor, S. Percy Ivy, Edward Chu, Jan H. Beumer (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - July 9, 2020 Category: Drugs & Pharmacology Source Type: research

Conventional Pig as Animal Model for Human Renal Drug Excretion Processes: Unravelling the Porcine Renal Function by Use of a Cocktail of Exogenous Markers
Over recent years, pigs have been promoted as potential animal model due to their anatomical and physiological similarities with humans. However, information about the contribution of distinct renal elimination processes [glomerular filtration rate (GFR), effective renal plasma flow (ERPF), tubular secretion, and reabsorption] in pigs is currently limited. Therefore, a cocktail of renal markers, consisting of iohexol (GFR), para-aminohippuric acid (ERPF and net tubular anion secretion), pindolol (net tubular cation secretion), and fluconazole (net tubular reabsorption) was administered intravenously to 7-week-old male conv...
Source: Frontiers in Pharmacology - June 11, 2020 Category: Drugs & Pharmacology Source Type: research

Non-ionic CT Contrast Solutions Rapidly Alter Bovine Cartilage and Meniscus Mechanics
To evaluate effects of a common CT contrast agent (iohexol) on the mechanical behaviors of cartilage and meniscus. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 10, 2020 Category: Rheumatology Authors: Eva G. Baylon, Hollis A. Crowder, Garry E. Gold, Marc E. Levenston Source Type: research

Application of diffusion tensor imaging and blood oxygenation level-dependent magnetic resonance imaging to assess bilateral renal function induced by Iohexol in rabbits
Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) and diffusion tensor imaging (DTI) are useful methods for investigating the morphology and function of the kidneys, including revealing u... (Source: BMC Nephrology)
Source: BMC Nephrology - June 3, 2020 Category: Urology & Nephrology Authors: Zhiqiang Wang, Hongxu Liu, Heng Meng and Duo Zhang Tags: Research article Source Type: research

Everolimus and long-term decline in renal function after liver transplantation: real-life experience with measured GFR.
In conclusion, despite an early improvement in renal function after everolimus introduction, we found no evidence that everolimus halts the long-term mGFR decline compared to continued low-dose CNI therapy. Due to retrospective design, small sample size and heterogenous characteristics, definite conclusions require prospective studies. PMID: 32479116 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Minimizing contrast media dose in CT pulmonary angiography with high-pitch technique.
CONCLUSIONS: Diagnostic CTPA with 17 ml contrast media is possible in non-obese patients using low kVp, high pitch and carefully designed contrast media administration. ADVANCES IN KNOWLEDGE: By combining several procedures in a CTPA protocol, the contrast media dose can be minimized. PMID: 32436788 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - May 20, 2020 Category: Radiology Authors: Alobeidi H, Alshamari M, Widell J, Eriksson T, Lidén M Tags: Br J Radiol Source Type: research

Iohexol assay for direct determination of glomerular filtration rate: optimization and development of an HPLC-UV method for measurement in serum and urine
Publication date: September 2020Source: Clinica Chimica Acta, Volume 508Author(s): Soufiane El Assri, Hicham Sam, Ayoub El Assri, Yassamine Bentata, Ennouamane Saalaoui, Chaymae Rochdi, El-Houcine Sebbar, Mohammed Choukri (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 20, 2020 Category: Laboratory Medicine Source Type: research

Intramyocardial hydrogel delivery post myocardial infarction results in increased integrin activation and reduction in left ventricular modeling.
Conclusions: Intramyocardial delivery of hydrogel post-MI resulted increased integrin activation in MI region and decreased LV remodeling. Multimodality imaging is a feasible approach for guiding delivery and monitoring the effects of a therapeutic hydrogel in a chronic porcine MI model. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Melvinsdottir, I., Lee, S.-R., Avendano, R., Midgett, D., Liu, Y.-H., Thorn, S., Hawley, C., Mamarian, M., Uman, S., Humphrey, J., Duncan, J., Burdick, J., Sinusas, A. Tags: Cardiovascular Council YIA Symposium Source Type: research

Iohexol
(Source: Reactions Weekly)
Source: Reactions Weekly - April 30, 2020 Category: Drugs & Pharmacology Source Type: research

HLA-DRB1*15: 02 Is Associated With Iodinated Contrast Media–Related Anaphylaxis
Background The incidence of severe reaction induced by iodinated contrast media (ICM) has increased over the years with an increasing use of imaging modalities. Although ICM anaphylaxis is rare, it can be life-threatening, but currently, there is no biomarker that can identify individuals at risk of ICM anaphylaxis. Objective The aim of this study is to investigate the genetic susceptibility of ICM anaphylaxis. Methods Patients who had ICM anaphylaxis were enrolled in the study, and their blood samples were collected for genotyping of human leukocyte antigen (HLA)-A, -B, -C, and -DR. The results were compared with ...
Source: Investigative Radiology - April 8, 2020 Category: Radiology Tags: Original Articles Source Type: research

Contrast medium-induced severe thrombocytopenia in patient on maintenance hemodialysis: a case report and literature review
AbstractA 43-year-old male patient on maintenance hemodialysis had an enhanced computed tomography scan examination with iohexol for the first time 10  min before regular hemodialysis therapy. At the start of hemodialysis, no symptoms were observed, and the platelet count was 148,000/μl. Approximately 1 h after starting hemodialysis, dyspnea and chest discomfort appeared. Since oxygen saturation of the peripheral artery decreased to 87%, oxygen administration was immediately started while continuing hemodialysis therapy. Furthermore, gingival hemorrhage was observed, and the platelet count decreased to 5000/&m...
Source: CEN Case Reports - April 7, 2020 Category: Urology & Nephrology Source Type: research

A comparison of thyroid blockade strategies in paediatric 123I-meta-iodobenzylguanidine scanning: a dual centre study
Conclusion Potassium iodate blockade is more efficacious compared with potassium perchlorate within the cohort observed. Both visual and quantitative data indicate that potassium iodate given at 30–60 min before 123I-mIBG injection provides comparable blockade effectiveness to lengthier administrations, suggesting that a single dose is well tolerated and practical. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 7, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Application of multiple injections of contrast agent in head and neck CT arteriovenous angiography in children: Study protocol clinical trial (SPIRIT Compliant)
Objective: To investigate the application value of multiple injections of contrast agent in head and neck CT arteriovenous angiography in children. Methods: A total of 100 children aged 6 to 7 years who needed head and neck CT arteriovenous angiography were prospectively selected. They were randomly divided into a control group and a research group, with 50 children in each group. The same scanning parameters and reconstruction methods were used. The right median cubital vein was injected intravenously with the contrast agent Omnipaque (350 mg I/ml). For children in the control group, a bolus of undiluted contrast a...
Source: Medicine - April 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Experimental studies on computed tomographic peritoneography. Peritoneal and residual renal function tolerance to iodinated contrast media injected into the peritoneal cavity.
This study aimed to determine whether different non-ionic ICM concentrations affect peritoneum and RRF and attempted to evaluate CT peritoneography images to identify the optimal non-ionic ICM concentrations in animals. To this end, 25 male Sprague-Dawley rats were used to establish uraemic models, after which they were injected with a 40-mL mixture of peritoneal dialysate and iohexol at varying concentrations prior to CT peritoneography. Thereafter, two experienced radiologists blinded to the rat groupings evaluated image quality, peritoneal morphology and thickness were assessed using hematoxylin and eosin and Masson sta...
Source: Seminars in Dialysis - March 11, 2020 Category: Urology & Nephrology Authors: Bai J, Dong J, Shu J, Xu Y, Ding W, Chen J Tags: Semin Dial Source Type: research

Effects of Changes in Analytic Variables and Contrast Material on Measurement of Computed Tomography Glomerular Filtration Rates in Healthy Candidates
Conclusion Results from CT-GFR were most accurate when the kidney cortex was selected as the region of interest or when using 60-second time point for whole-kidney assessment, regardless of CM osmolarity. (Source: Journal of Computer Assisted Tomography)
Source: Journal of Computer Assisted Tomography - March 1, 2020 Category: Radiology Tags: Abdominal Imaging Source Type: research

Measuring glomerular filtration rate with iohexol plasma disappearance: blood collection duration is essential for accurate glomerular filtration rate determinations
Recently, Rowe et  al. reported the biological variation of measured glomerular filtration rate (mGFR) and estimated glomerular filtration rate (eGFR) for chronic kidney disease in 20 patients.1 An examination of their iohexol plasma disappearance mGFR protocol shows that the authors administered 5 ml of Omnipaque 2 40 (518 g/l of iohexol; GE Healthcare [Little Chalfont, Buckinghamshire, UK]) and acquired blood specimens at 3 time points with the longest collection time duration of 240 minutes. We acknowledge that there is currently no standardized protocol for an iohexol plasma disappearance procedure for the purpose...
Source: Kidney International - February 19, 2020 Category: Urology & Nephrology Authors: Jesse C. Seegmiller, Natalie Ebert Tags: Letter to the Editor Source Type: research

Enhanced specificity due to method specific limits for relative ion intensities in a high-performance liquid chromatography – tandem mass spectrometry method for iohexol in human serum
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - February 18, 2020 Category: Laboratory Medicine Source Type: research