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Inhibition of Drp1-mediated mitochondrial fission improves contrast-induced acute kidney injury by targeting the mROS-TXNIP-NLRP3 inflammasome axis
Int Immunopharmacol. 2024 Apr 11;133:112001. doi: 10.1016/j.intimp.2024.112001. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a critical complication known for their extremely high mortality rate and lack of effective clinical therapy. Disorders in mitochondrial dynamics possess a pivotal role in the occurrence and progression of contrast-induced nephropathy (CIN) by activating NLRP3 inflammasome. The activation of dynamin-related protein-1 (Drp1) can trigger mitochondrial dynamic disorders by regulating excessive mitochondrial fission. However, the precise role of Drp1 during CIN has not been clarified. In vi...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Jiong Zhang Qian Wei Shu-Kun Wu Fang Wang Tong-Ling Yuan Jia Wang Source Type: research

Predictors of augmented renal clearance based on iohexol plasma clearance in critically ill children
ConclusionsOur findings raise PICU clinician awareness about increased risk for ARC after major surgery and in patients with eGFR above age-specific thresholds. This knowledge enables identification of patients with an ARC risk profile who would potentially benefit from a dose increase at initiation of treatment to avoid underexposure.Trial registrationClinicalTrials.gov NCT05179564, registered retrospectively on January 5, 2022.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research

Photocatalytic activation of sulfite by maghemite ( γ-Fe 2 O 3 ) for iohexol degradation and alleviation effect of HCO 3 - on water acidification
This study expands the application of soil iron oxide mineral in S(IV) activation in water treatment and proposes an approach to regulate water acidification in S(IV)-based AOP.PMID:38355082 | DOI:10.1016/j.envpol.2024.123557 (Source: Environmental Pollution)
Source: Environmental Pollution - February 14, 2024 Category: Environmental Health Authors: Cheng Wang Shujing Zhou Xiaoming Wang Wenfeng Tan Xionghan Feng Source Type: research

Determination of glomerular filtration rate “en passant” after high doses of iohexol for computed tomography in intensive care medicine—a proof of concept
Accurate assessment of renal function is of great clinical and scientific importance, as it is an important pharmacokinetic covariate of pivotal drugs. The iohexol clearance is nearly identical to the glomerular filtration rate, but its determination usually requires an intravenous injection and therefore bears intrinsic risks. This motivates to showcase an “en passant” approach to quantification of renal function without additional risk or blood sampling beyond routine care using real-world data. We enrolled 37 intensive care patients who received high doses of iohexol for computed tomography imaging, and quantified s...
Source: Frontiers in Pharmacology - February 1, 2024 Category: Drugs & Pharmacology Source Type: research

Metallic artifacts-free spectral computed tomography angiography based on renal clearable bismuth chelate
Biomaterials. 2023 Dec 14;305:122422. doi: 10.1016/j.biomaterials.2023.122422. Online ahead of print.ABSTRACTComputed tomography angiography (CTA) is one of the most important diagnosis techniques for various vascular diseases in clinic. However, metallic artifacts caused by metal implants and calcified plaques in more and more patients severely hinder its wide applications. Herein, we propose an improved metallic artifacts-free spectral CTA technique based on renal clearable bismuth chelate (Bi-DTPA dimeglumine) for the first time. Bi-DTPA dimeglumine owns the merits of ultra-simple synthetic process, approximately 100% o...
Source: Biomaterials - December 21, 2023 Category: Materials Science Authors: Gang Shu Lu Zhao Fengtan Li Yingjian Jiang Xuening Zhang Chunshui Yu Jinbin Pan Shao-Kai Sun Source Type: research

Effects of Low-Osmolar Contrast Media on Long-Term Renal Impairment After Coronary Angiography: Iohexol Versus Iopromide
To investigate the long-term effects of 2 commonly used low-osmolar contrast media, iohexol and iopromide, on renal function and survival in patients who underwent coronary angiography. A total of 14,141 cardiology patients from 2006 to 2013 were recruited, of whom 1,793 patients (679 patients on iohexol and 1,114 on iopromide) were evaluated for long-term renal impairment and 5,410 patients (1,679 patients on iohexol and 3,731 on iopromide) were admitted for survival analyses spanning as long as 15 years. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 6, 2023 Category: Cardiology Authors: Ying Cui, Shuhang Zhang, Weilang Wang, Noble Chibuike Opara, Dandan Yao, Binrong Li, Wentao Yang, Shenghong Ju, Yuan-Cheng Wang Source Type: research

Potential Mechanisms of the Ferroptosis Pathway in Iohexol-Induced Renal Injury
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - December 1, 2023 Category: Nanotechnology Authors: Yang, Guokai Pan, Weitao Zu, Yanping Yang, Xian Tags: research-article Source Type: research

Cystatin C as a marker of renal function in patients with chronic intestinal failure on long-term parenteral nutrition
Rationale: The estimation of renal function parameters is inaccurate in Chronic Intestinal Failure (CIF) patients on parenteral nutrition (PN). The aim of the present study is to assess the reliability of 3 CKD-EPI GFR estimating equations (eGFR) (Creatinine, Cystatin C or combined Creatinine/Cystatin C) compared to the Iohexol plasma clearance (mGFR) in patients on long-term PN (> 6 months) due to CIF. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: G. Kosmadakis, L. Derain Dubourg, M. Lauverjat, C. Bergoin, S. Lemoine, C. Chambrier Source Type: research

Effect and mechanism of phosphate enhanced sulfite activation with cobalt ion for effective iohexol abatement
This study highlights the important role of complexation of Co(II) with HPO42- in sulfite activation and provides a feasible idea for abatement of the microorganic pollutants.PMID:38032529 | DOI:10.1007/s11356-023-31222-z (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - November 30, 2023 Category: Environmental Health Authors: Yifan Song Jiesheng Hong Shujing Shao Jiayi Wen Xiaodan Zhao Source Type: research

Adipose-derived mesenchymal stem cells cultured in serum-free medium attenuate acute contrast-induced nephropathy by exerting anti-apoptotic effects
CONCLUSIONS: These findings strongly suggest that SF-MSCs improve CIN in model mice by exerting anti-apoptotic effects in a paracrine manner. Thus, SF-MSCs represent a potential novel therapy for CIN.PMID:37993965 | DOI:10.1186/s13287-023-03553-8 (Source: Cell Research)
Source: Cell Research - November 23, 2023 Category: Cytology Authors: Mitsuki Kadono Ayumu Nakashima Naoki Ishiuchi Kensuke Sasaki Yoshie Miura Satoshi Maeda Asuka Fujita Ayano Sasaki Shogo Nagamatsu Takao Masaki Source Type: research

Reduction of contrast medium for transcatheter aortic valve replacement planning using a spectral detector CT: a prospective clinical trial
ConclusionAmong TAVR candidates undergoing pre-interventional CT at a dual-layer spectral detector system, applying 40 mL CM is sufficient to maintain diagnostic image quality. VMI 40-keV reconstructions improve the vessel attenuation and are recommended for evaluation.Clinical relevance statementContrast medium reduction to 40 mL in pre-interventional transcatheter aortic valve replacement CT using dual-energy CT maintains image quality, while 40-keV virtual monoenergetic imaging reconstructions enhance vessel attenuation. These results offer valuable recommendations for interventional transcatheter aortic valve repla...
Source: European Radiology - November 18, 2023 Category: Radiology Source Type: research

Adipose Tissue Impacts Radiofrequency Ablation Lesion Size: Results of an Ex Vivo Poultry Model
CONCLUSIONS: Adipose tissue content was inversely related to lesion size in all samples. This factor should be considered when assessing methods of enhancing lesion size in human models.PMID:37976485 (Source: Pain Physician)
Source: Pain Physician - November 17, 2023 Category: Anesthesiology Authors: Leili Shahgholi Nicole Ortiz Tahereh Naeimi Raymon Dhall Mohammad Zaidi Bryce Liu Chong Kim Timothy Deer Alan D Kaye Sayed E Wahezi Source Type: research

A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta)
In this study, we aimed to determine if the Schwartz formula as used in human pediatric medicine can estimate GFR in rhesus macaques. We hypothesized that iohexol-GFR would correlate with the Schwartz formula-estimated GFR (eGFR) in irradiated and non-irradiated rhesus macaques. Twelve rhesus macaques [age 5-14 years (mean 7 years); 5 females, 7 males] with a range of BUN levels were selected for comparison to 4 non-irradiated controls (2 females, 2 males). Irradiated animals were divided by BUN into 3 groups: BUN ≤20 mg/dL (n = 4), BUN >20-24 mg/dL (n = 4), and BUN ≥25 mg/dL (n = 4). Baseline serum chemistry and ur...
Source: Radiation Research - October 30, 2023 Category: Physics Authors: Allison M Tomasino John D Olson George W Schaaf Anderson O Cox Cristina M Furdui J Mark Cline Eric P Cohen Source Type: research