Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects.
Abstract Tucatinib is a potent tyrosine kinase inhibitor selective for human epidermal growth factor receptor 2 (HER2) approved by the US Food and Drug Administration for the treatment of HER2-positive metastatic breast cancer and in development for other HER2-positive solid tumors. Modest, reversible serum creatinine (SCr) elevations have been observed in tucatinib clinical trials. SCr is conveyed by the renal drug transporters organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) and 2-K (MATE2-K) and can increase in the presence of inhibitors of these transporters. In vitro, tu...
Source: The Journal of Clinical Pharmacology - September 28, 2020 Category: Drugs & Pharmacology Authors: Topletz-Erickson AR, Lee AJ, Mayor JG, Rustia EL, Abdulrasool LI, Wise AL, Dailey B, DeChenne S, Walker LN, Alley SC, Endres CJ Tags: J Clin Pharmacol Source Type: research

Evaluation of the pharmacokinetic drug-drug interaction potential of iohexol, a renal filtration marker
ConclusionsIohexol is unlikely to affect the clinical pharmacokinetics of carboplatin, paclitaxel, gemcitabine, or other agents used in combination with carboplatin treatment. Measuring GFR with iohexol to better dose carboplatin is unlikely to alter the safety or efficacy of chemotherapy through pharmacokinetic drug-drug interactions. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - September 18, 2020 Category: Cancer & Oncology Source Type: research

Simultaneous Dual-Contrast Imaging of Small Bowel With Iodine and Bismuth Using Photon-Counting-Detector Computed Tomography: A Feasibility Animal Study
Conclusions Our study demonstrated the feasibility of simultaneous imaging of iodine and bismuth in small bowel of swine using PCD-CT. (Source: Investigative Radiology)
Source: Investigative Radiology - September 9, 2020 Category: Radiology Tags: Technical Note Source Type: research

Proenkephalin Compared to Conventional Methods to Assess Kidney Function in Critically Ill Sepsis Patients
Background: The assessment of renal function in clinical practice remains challenging. Using creatinine to assess the glomerular filtration rate (GFR) is notoriously inaccurate, and determination of the true GFR, e.g., using inulin or iohexol, is laborious and not feasible in daily practice. Proenkephalin (PENK) is a novel candidate biomarker for kidney function that is filtrated in the glomerulus, has shown to represent steady-state GFR in patients with different severities of renal insufficiency. In this pilot study in non-steady-state critically ill patients, we compared plasma PENK concentrations with creatinine-base...
Source: Shock - August 14, 2020 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

Developments in X-Ray Contrast Media and the Potential Impact on Computed Tomography
Over the past 120 years, continuous developments in medical imaging has improved diagnosis and treatment for many diseases and has thereby improved treatment outcome and quality of life of many patients. The number of computed tomography (CT) examinations is today increasing by 4% per year worldwide, for a total of approximately 300 million CT scans per year. About 40% of CT scans are contrast enhanced. Intravenous iodinated contrast media are commonly used for contrast enhancement in CT scans to evaluate diseases and determine treatment response. The current gold standards for intravenous x-ray contrast media in CT or int...
Source: Investigative Radiology - August 14, 2020 Category: Radiology Tags: Review Article Source Type: research

A Machine Learning Approach to Estimate the Glomerular Filtration Rate in Intensive Care Unit Patients Based on Plasma Iohexol Concentrations and Covariates
AbstractObjectiveThis work aims to evaluate whether a machine learning approach is appropriate to estimate the glomerular filtration rate in intensive care unit patients based on sparse iohexol pharmacokinetic data and a limited number of predictors.MethodsEighty-six unstable patients received 3250  mg of iohexol intravenously and had nine blood samples collected 5, 30, 60, 180, 360, 540, 720, 1080, and 1440 min thereafter. Data splitting was performed to obtain a training (75%) and a test set (25%). To estimate the glomerular filtration rate, 37 candidate potential predictors were considere d and the best machin...
Source: Clinical Pharmacokinetics - August 14, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of dapagliflozin and gliclazide on the cardiorenal axis in people with type 2 diabetes
Conclusion: Dapagliflozin seemingly influences systemic and renal hemodynamics independently and beyond glucose lowering in people with type 2 diabetes. This clinical trial was registered at https://clinicalTrials.gov (ID: NCT02682563). (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Incidence and Risk Factors of Nausea and Vomiting after Exposure to Low-Osmolality Iodinated Contrast Media in Children: A Focus on Preparative Fasting.
CONCLUSION: Only a small proportion (2.1%) of children experienced nausea or vomiting after exposure to low-osmolality ICM. Many children underwent excessive fasting; however, fasting duration was not associated with nausea and vomiting. Moreover, ongoing chemotherapy and the use of iomeprol or iohexol were identified as potential risk factors for emetic complications in children. PMID: 32767861 [PubMed - as supplied by publisher] (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - August 13, 2020 Category: Radiology Tags: Korean J Radiol Source Type: research

Catalytic ozonation of iohexol with α-Fe0.9Mn0.1OOH in water: Efficiency, degradation mechanism and toxicity evaluation
Publication date: 15 January 2021Source: Journal of Hazardous Materials, Volume 402Author(s): Pengwei Yan, Zhonglin Chen, Shuyu Wang, Yanchi Zhou, Li Li, Lei Yuan, Jimin Shen, Qianqian Jin, Xiaoxiao Zhang, Jing Kang (Source: Journal of Hazardous Materials)
Source: Journal of Hazardous Materials - August 5, 2020 Category: Environmental Health Source Type: research

Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury
Assessment of kidney function is primarily based on urine output and Creatinine (Cr)-based methods to estimate glomerular filtration rate (GFR). The latter is confounded as Cr is not exclusively filtered by the kidney and rises relatively late after the onset of acute kidney injury (AKI). This leads to delays in recognition of reduced kidney function and diagnosis of AKI, particularly in critically ill patients where kidney function can change rapidly. The gold standard methods of GFR determination, such as inulin or iohexol clearance, are labor intensive and unfeasible in acute clinical settings. Proenkephalin A 119 &ndas...
Source: Nephron - July 31, 2020 Category: Urology & Nephrology Source Type: research

Simultaneous Glomerular Filtration Rate Determination Using Inulin, Iohexol and 99mTc-DTPA Demonstrates the Need for Customized Measurement Protocols
Urinary inulin clearance is considered the gold standard of glomerular filtration rate (GFR)measurement but plasma clearance of less expensive and more accessible tracers is more commonly performed. Many plasma sampling protocols exist but little is known about their accuracy. Here, the study objectives were to compare plasma iohexol and 99mTc-DTPA GFR with varying sampling strategies to the GFR measured by urinary inulin and to identify protocols with the greatest accuracy according to clinical characteristics. (Source: Kidney International)
Source: Kidney International - July 31, 2020 Category: Urology & Nephrology Authors: Christine A. White, Ayub Akbari, Celine Allen, Andrew G. Day, Patrick A. Norman, David Holland, Michael A. Adams, Greg A. Knoll Tags: clinical investigation Source Type: research

Impact of various iodine concentrations of iohexol and iodixanol contrast media on image reconstruction techniques in a vascular-specific contrast media phantom: quantitative and qualitative image quality assessment
AbstractPurposeThe aim of our study is to investigate the impact of iodine quantification on image reconstruction when employing a vascular-specific contrast media phantom with varying iodine concentrations.Materials and methodsA 30-cm phantom simulating arterial and venous blood vessel diameters was manufactured. Small (9  mm) and medium (12 mm) cylinders contained iodine concentrations from 10 to 100% while large (21 mm) cylinders were in quartiles from 25 to 100% diluted in blood equivalent medium. Each phantom was filled with either iohexol 350 mgI/mL (Group A) or iodixanol 320 mgI/mL (Group B) and then ...
Source: La Radiologia Medica - July 15, 2020 Category: Radiology Source Type: research

MicroRNA-30c attenuates contrast-induced acute kidney injury by suppressing NLRP3 inflammasome.
CONCLUSION: Our data demonstrated that the miR-30c induced by CIAKI could suppress cell apoptosis and kidney injury via targeting NLRP3. Therefore, targeting miR-30c might be a novel therapeutic candidate for CIAKI treatment and prevention. PMID: 32682254 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - July 15, 2020 Category: Allergy & Immunology Authors: Xu J, Ma L, Fu P Tags: Int Immunopharmacol Source Type: research

Quantitation of iohexol, a glomerular filtration marker, in human plasma by LC–MS/MS
Publication date: Available online 7 July 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Julianne L. Holleran, Robert A. Parise, Jianxia Guo, Brian Kiesel, Sarah E. Taylor, S. Percy Ivy, Edward Chu, Jan H. Beumer (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - July 9, 2020 Category: Drugs & Pharmacology Source Type: research

Conventional Pig as Animal Model for Human Renal Drug Excretion Processes: Unravelling the Porcine Renal Function by Use of a Cocktail of Exogenous Markers
Over recent years, pigs have been promoted as potential animal model due to their anatomical and physiological similarities with humans. However, information about the contribution of distinct renal elimination processes [glomerular filtration rate (GFR), effective renal plasma flow (ERPF), tubular secretion, and reabsorption] in pigs is currently limited. Therefore, a cocktail of renal markers, consisting of iohexol (GFR), para-aminohippuric acid (ERPF and net tubular anion secretion), pindolol (net tubular cation secretion), and fluconazole (net tubular reabsorption) was administered intravenously to 7-week-old male conv...
Source: Frontiers in Pharmacology - June 12, 2020 Category: Drugs & Pharmacology Source Type: research

Non-ionic CT Contrast Solutions Rapidly Alter Bovine Cartilage and Meniscus Mechanics
To evaluate effects of a common CT contrast agent (iohexol) on the mechanical behaviors of cartilage and meniscus. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 11, 2020 Category: Rheumatology Authors: Eva G. Baylon, Hollis A. Crowder, Garry E. Gold, Marc E. Levenston Source Type: research

Application of diffusion tensor imaging and blood oxygenation level-dependent magnetic resonance imaging to assess bilateral renal function induced by Iohexol in rabbits
Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) and diffusion tensor imaging (DTI) are useful methods for investigating the morphology and function of the kidneys, including revealing u... (Source: BMC Nephrology)
Source: BMC Nephrology - June 3, 2020 Category: Urology & Nephrology Authors: Zhiqiang Wang, Hongxu Liu, Heng Meng and Duo Zhang Tags: Research article Source Type: research

Everolimus and long-term decline in renal function after liver transplantation: real-life experience with measured GFR.
In conclusion, despite an early improvement in renal function after everolimus introduction, we found no evidence that everolimus halts the long-term mGFR decline compared to continued low-dose CNI therapy. Due to retrospective design, small sample size and heterogenous characteristics, definite conclusions require prospective studies. PMID: 32479116 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Minimizing contrast media dose in CT pulmonary angiography with high-pitch technique.
CONCLUSIONS: Diagnostic CTPA with 17 ml contrast media is possible in non-obese patients using low kVp, high pitch and carefully designed contrast media administration. ADVANCES IN KNOWLEDGE: By combining several procedures in a CTPA protocol, the contrast media dose can be minimized. PMID: 32436788 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - May 21, 2020 Category: Radiology Authors: Alobeidi H, Alshamari M, Widell J, Eriksson T, Lidén M Tags: Br J Radiol Source Type: research

Iohexol assay for direct determination of glomerular filtration rate: optimization and development of an HPLC-UV method for measurement in serum and urine
Publication date: September 2020Source: Clinica Chimica Acta, Volume 508Author(s): Soufiane El Assri, Hicham Sam, Ayoub El Assri, Yassamine Bentata, Ennouamane Saalaoui, Chaymae Rochdi, El-Houcine Sebbar, Mohammed Choukri (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - May 20, 2020 Category: Laboratory Medicine Source Type: research

Intramyocardial hydrogel delivery post myocardial infarction results in increased integrin activation and reduction in left ventricular modeling.
Conclusions: Intramyocardial delivery of hydrogel post-MI resulted increased integrin activation in MI region and decreased LV remodeling. Multimodality imaging is a feasible approach for guiding delivery and monitoring the effects of a therapeutic hydrogel in a chronic porcine MI model. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 15, 2020 Category: Nuclear Medicine Authors: Melvinsdottir, I., Lee, S.-R., Avendano, R., Midgett, D., Liu, Y.-H., Thorn, S., Hawley, C., Mamarian, M., Uman, S., Humphrey, J., Duncan, J., Burdick, J., Sinusas, A. Tags: Cardiovascular Council YIA Symposium Source Type: research

(Source: Reactions Weekly)
Source: Reactions Weekly - May 1, 2020 Category: Drugs & Pharmacology Source Type: research

HLA-DRB1*15: 02 Is Associated With Iodinated Contrast Media–Related Anaphylaxis
Background The incidence of severe reaction induced by iodinated contrast media (ICM) has increased over the years with an increasing use of imaging modalities. Although ICM anaphylaxis is rare, it can be life-threatening, but currently, there is no biomarker that can identify individuals at risk of ICM anaphylaxis. Objective The aim of this study is to investigate the genetic susceptibility of ICM anaphylaxis. Methods Patients who had ICM anaphylaxis were enrolled in the study, and their blood samples were collected for genotyping of human leukocyte antigen (HLA)-A, -B, -C, and -DR. The results were compared with ...
Source: Investigative Radiology - April 8, 2020 Category: Radiology Tags: Original Articles Source Type: research

Contrast medium-induced severe thrombocytopenia in patient on maintenance hemodialysis: a case report and literature review
AbstractA 43-year-old male patient on maintenance hemodialysis had an enhanced computed tomography scan examination with iohexol for the first time 10  min before regular hemodialysis therapy. At the start of hemodialysis, no symptoms were observed, and the platelet count was 148,000/μl. Approximately 1 h after starting hemodialysis, dyspnea and chest discomfort appeared. Since oxygen saturation of the peripheral artery decreased to 87%, oxygen administration was immediately started while continuing hemodialysis therapy. Furthermore, gingival hemorrhage was observed, and the platelet count decreased to 5000/&m...
Source: CEN Case Reports - April 8, 2020 Category: Urology & Nephrology Source Type: research

A comparison of thyroid blockade strategies in paediatric 123I-meta-iodobenzylguanidine scanning: a dual centre study
Conclusion Potassium iodate blockade is more efficacious compared with potassium perchlorate within the cohort observed. Both visual and quantitative data indicate that potassium iodate given at 30–60 min before 123I-mIBG injection provides comparable blockade effectiveness to lengthier administrations, suggesting that a single dose is well tolerated and practical. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 7, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Application of multiple injections of contrast agent in head and neck CT arteriovenous angiography in children: Study protocol clinical trial (SPIRIT Compliant)
Objective: To investigate the application value of multiple injections of contrast agent in head and neck CT arteriovenous angiography in children. Methods: A total of 100 children aged 6 to 7 years who needed head and neck CT arteriovenous angiography were prospectively selected. They were randomly divided into a control group and a research group, with 50 children in each group. The same scanning parameters and reconstruction methods were used. The right median cubital vein was injected intravenously with the contrast agent Omnipaque (350 mg I/ml). For children in the control group, a bolus of undiluted contrast a...
Source: Medicine - April 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Experimental studies on computed tomographic peritoneography. Peritoneal and residual renal function tolerance to iodinated contrast media injected into the peritoneal cavity.
This study aimed to determine whether different non-ionic ICM concentrations affect peritoneum and RRF and attempted to evaluate CT peritoneography images to identify the optimal non-ionic ICM concentrations in animals. To this end, 25 male Sprague-Dawley rats were used to establish uraemic models, after which they were injected with a 40-mL mixture of peritoneal dialysate and iohexol at varying concentrations prior to CT peritoneography. Thereafter, two experienced radiologists blinded to the rat groupings evaluated image quality, peritoneal morphology and thickness were assessed using hematoxylin and eosin and Masson sta...
Source: Seminars in Dialysis - March 12, 2020 Category: Urology & Nephrology Authors: Bai J, Dong J, Shu J, Xu Y, Ding W, Chen J Tags: Semin Dial Source Type: research

Effects of Changes in Analytic Variables and Contrast Material on Measurement of Computed Tomography Glomerular Filtration Rates in Healthy Candidates
Conclusion Results from CT-GFR were most accurate when the kidney cortex was selected as the region of interest or when using 60-second time point for whole-kidney assessment, regardless of CM osmolarity. (Source: Journal of Computer Assisted Tomography)
Source: Journal of Computer Assisted Tomography - March 1, 2020 Category: Radiology Tags: Abdominal Imaging Source Type: research

Measuring glomerular filtration rate with iohexol plasma disappearance: blood collection duration is essential for accurate glomerular filtration rate determinations
Recently, Rowe et  al. reported the biological variation of measured glomerular filtration rate (mGFR) and estimated glomerular filtration rate (eGFR) for chronic kidney disease in 20 patients.1 An examination of their iohexol plasma disappearance mGFR protocol shows that the authors administered 5 ml of Omnipaque 2 40 (518 g/l of iohexol; GE Healthcare [Little Chalfont, Buckinghamshire, UK]) and acquired blood specimens at 3 time points with the longest collection time duration of 240 minutes. We acknowledge that there is currently no standardized protocol for an iohexol plasma disappearance procedure for the purpose...
Source: Kidney International - February 19, 2020 Category: Urology & Nephrology Authors: Jesse C. Seegmiller, Natalie Ebert Tags: Letter to the Editor Source Type: research

Enhanced specificity due to method specific limits for relative ion intensities in a high-performance liquid chromatography – tandem mass spectrometry method for iohexol in human serum
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - February 18, 2020 Category: Laboratory Medicine Source Type: research

Impact of CT injector technology and contrast media viscosity on vascular enhancement: Evaluation in a circulation phantom.
Abstract OBJECTIVES: To assess the impact of piston-based vs peristaltic injection system technology and contrast media viscosity on achievable iodine delivery rates (IDRs) and vascular enhancement in a pre-clinical study. METHODS: Four injectors were tested: MEDRAD®Centargo, MEDRAD® Stellant, CT Exprès®, and CT motion™ using five contrast media (iopromide [300 mgI ml-1 and 370 mgI ml-1], iodixanol 320 mgI ml-1, iohexol 350 mgI ml-1, iomeprol 400 mgI ml-1). Three experiments were performed evaluating achievable IDR ...
Source: The British Journal of Radiology - February 4, 2020 Category: Radiology Authors: McDermott M, Kemper C, Barone W, Jost G, Endrikat J Tags: Br J Radiol Source Type: research

A prospective controlled study of metabolic and physiologic effects of kidney donation suggests that donors retain stable kidney function over the first nine years.
While there have been numerous studies of living kidney donors, most have been retrospective without suitable controls and have yielded conflicting results. To clarify this we studied 205 living donor candidates and 203 controls having no medical conditions precluding donation. Before and at six months, one, two, three, six, and nine years after donation we measured iohexol glomerular filtration rate, clinic blood pressure, urine protein excretion and metabolic parameters reported to be affected by kidney function. (Source: Kidney International)
Source: Kidney International - February 3, 2020 Category: Urology & Nephrology Authors: Bertram L. Kasiske, Tracy L. Anderson-Haag, Daniel A. Duprez, Roberto S. Kalil, Paul L. Kimmel, Todd E. Pesavento, Jon J. Snyder, Matthew R. Weir Tags: Clinical Investigation Source Type: research

Distribution of sodium hypochlorite throughout the mesial root canal system of mandibular molars after adjunctive irrigant activation procedures: a micro-computed tomographic study
ConclusionsThe XP-endo Finisher instrument promoted better distribution of irrigant throughout the root canal system, especially in the apical canal segment, when compared to PUI. However, the tested approaches did not differ as to the ability to drive irrigants into the isthmus area.Clinical relevanceThis study highlighted that the XP-endo Finisher instrument presented a better performance to distribute irrigant throughout the root canal system, especially in the apical canal segment compared to positive pressure irrigation and PUI. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 27, 2020 Category: Dentistry Source Type: research

Effects of a single-bolus bupivacaine injection into the coccygeal spinal canal of rabbits.
Abstract It has been reported that drugs intended for epidural administration through the lumbosacral junction are accidentally administered into the subarachnoid space frequently in rabbits. Therefore, we evaluated the epidural single-bolus injection technique for the administration of bupivacaine into the coccygeal spinal canal of rabbits. After epidural distribution was confirmed by the injection of iohexol into the coccygeal spinal canal, 0.3 ml/kg 0.5% bupivacaine or 0.3 ml/kg normal saline was injected via the same needle. After the first attempt of iohexol injection, although the contrast was found in the e...
Source: Anal Sci - January 22, 2020 Category: Chemistry Authors: Ong BHE, Hidaka Y, Kaneko Y, Yamamoto S, Mizutani S, Sekiguchi S, Torisu S, Naganobu K Tags: J Vet Med Sci Source Type: research

Intestinal barrier dysfunction in liver cirrhosis assessed by iohexol test.
CONCLUSIONS: Increased IP is found in 23% of cirrhotic patients. Permeability alterations are significantly more pronounced in patients with advanced LC with the presence of ascites and in those with alcoholic etiology. PMID: 31957845 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The cotton test redistributes nasal airflow in patients with empty nose syndrome
BackgroundEmpty nose syndrome (ENS) remains a controversial disease primarily associated with inferior turbinate tissue loss. Cotton placement into the inferior meatus often alleviates ENS symptoms within minutes, but the physiologic explanation for this phenomenon is unknown. Computational fluid dynamics (CFD) was employed to evaluate the mechanisms of altered nasal airflow conferred by cotton testing.MethodsSix ENS patients (12 sides) with pre ‐existing sinus computed tomography (CT) imaging were enrolled after marked symptomatic improvement (decrease in score on the Empty Nose Syndrome 6‐Item Questionnaire [ENS6Q] o...
Source: International Forum of Allergy and Rhinology - January 17, 2020 Category: Allergy & Immunology Authors: Jennifer Malik, Andrew Thamboo, Sachi Dholakia, Nicole A. Borchard, Sam McGhee, Chengyu Li, Kai Zhao, Jayakar V. Nayak Tags: ORIGINAL ARTICLE Source Type: research

Assessment of the glomerular filtration rate (GFR) in kidney transplant recipients using Bayesian estimation of the iohexol clearance
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - January 13, 2020 Category: Laboratory Medicine Source Type: research

Assessment of the glomerular filtration rate (GFR) in kidney transplant recipients using Bayesian estimation of the iohexol clearance
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Volume: 58 Issue: 4 Pages: 577-587 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - January 11, 2020 Category: Laboratory Medicine Source Type: research

Comparability of Plasma Iohexol Clearance Across Population-Based Cohorts
ConclusionsAgreement between the iohexol assays and clearance protocols in the 3 investigated cohorts was substantial. Our findings indicate that plasma iohexol clearance measurements can be compared across these studies. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - December 24, 2019 Category: Urology & Nephrology Source Type: research

Measurements of echocardiographic indices and biomarkers of kidney injury in dogs with chronic kidney disease
Publication date: Available online 11 December 2019Source: The Veterinary JournalAuthor(s): M.J. Hezzell, J.D. Foster, M.A. Oyama, J. Buch, G. Farace, J.J. Quinn, M. YerramilliAbstractPathophysiological cardiac and renal interactions are termed cardiovascular-renal disorder (CvRD). Cardiovascular disease/dysfunction secondary to kidney disease (CvRDK), is a leading cause of death in human chronic kidney disease (CKD) patients. The presence and clinical impact of CvRDK in dogs with CKD is unknown. We hypothesized that echocardiographic measurements, and cardiac and renal biomarkers, will be altered in dogs with CKD and asso...
Source: The Veterinary Journal - December 11, 2019 Category: Veterinary Research Source Type: research

Salt-sensitive blood pressure rise in type 1 diabetes patients is accompanied by disturbed skin macrophage influx and lymphatic dilation-a proof-of-concept study.
In conclusion, we show that salt sensitivity in type 1 diabetes patients cannot be explained by the classical concept of extracellular fluid volume expansion. Rather, we open up a potential role for macrophages and the lymphatic system. Future studies on hypertension and diabetes need to scrutinize these phenomena. PMID: 31883728 [PubMed - as supplied by publisher] (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - December 9, 2019 Category: Laboratory Medicine Authors: Wenstedt EFE, Engberink RHGO, Rorije NMG, van den Born BH, Claessen N, Aten J, Vogt L Tags: Transl Res Source Type: research

Selective bronchography (SB) to confirm bronchopleural fistula (BPF) in patients with persistent air leaks
Bronchopleural fistula(BPF)requires different diagnostic methods to know its location, number and size for a correct treatment. The aim of our study is to compare the computed tomography scan(CT)results with the selective bronchograpy(SB)information in BPF.Retrospective study including SB between 03.2014-2.2019. We analysed patients factors, pathology, CT and SB results and final treatment.SB technique requires instilling 10cc of Yodohexol Omnipaque® through a radiopaque catheter Combicath® during fluoroscopy, under deep sedation with propofol. We have included 27 SB performed under suspicion of BPF in patients wit...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Jaurrieta Largo, S., De Vega Sanchez, B., Disdier Vicente, C., Belver Blanco, M., Juarros Martinez, S. A., Roig Figueroa, V. Tags: Interventional pulmonology Source Type: research

Preparation of Injectable Egg Albumin Based Composite Implant for Photothermal Therapy of Tumor.
Abstract Polymeric hydrogels featured with three dimensional network structure have found tremendous applications in biomedicine. Herein, we report the synthesis of egg albumin (EA) based multifunctional implant as a carrier that capable of synergistically delivering photothermal transducing agent (poly dopamine, PDA) to tumor. The formation of PDA was achieved by utilizing the basicity of EA, while the formation of hydrogel implant was realized by the in vitro/in vivo near-infrared (NIR) laser induced hyperthermia of PDA. The as-prepared PDA@EA implant exhibits high photothermal conversion efficiency (38.7%). Aft...
Source: Chembiochem - October 15, 2019 Category: Biochemistry Authors: Zhang J, An X, Zheng Y, Chen Y, Wu C, Wang S Tags: Chembiochem Source Type: research

A biodegradable multifunctional porous microsphere composed of carrageenan for promoting imageable trans-arterial chemoembolization.
Abstract Trans-arterial chemoembolization (TACE) has been a mainstream treatment for hepatocellular carcinoma (HCC), accordingly there are more requirements for embolic agents' properties, mainly concentrated on biodegradability and imaging function. A new kind of biodegradable multifunctional porous microspheres (BMPMs) with internal coarse plications are ingeniously designed and manufactured, consisting of carrageenan, inhexol and superparamagnetic iron oxide nanoparticle (SPIO). BMPMs' sound roundness and excellent swelling behavior guarantee them to be smoothly transported into appointed arteries' ends and ach...
Source: International Journal of Biological Macromolecules - October 14, 2019 Category: Biochemistry Authors: Kunliang L, Zhicheng J, Xiaolong H, Dan Y, Yu Z, Haidong Z, Gaojun T, Fei X Tags: Int J Biol Macromol Source Type: research

Estimated Glomerular Filtration Rate Bias in Participants with Severe Obesity Regardless of Deindexation.
Abstract OBJECTIVE: Morbid obesity is associated with a higher independent risk of chronic kidney disease (CKD). Estimated glomerular filtration rate (eGFR) has been evaluated in a limited number of study participants with severe obesity. METHODS: A total of 706 measured GFR (mGFR) results from 598 participants with obesity (BMI ≥ 35 kg/m2 ) were retrospectively collected. The performance of the Modification of Diet in Renal Disease (MDRD) equation, Chronic Kidney Disease-Epidemiology (CKD-EPI) equation, and deindexed eGFR were compared with mGFR from the go...
Source: Obesity - October 3, 2019 Category: Eating Disorders & Weight Management Authors: Guebre-Egziabher F, Brunelle C, Thomas J, Pelletier CC, Normand G, Juillard L, Dubourg L, Lemoine S Tags: Obesity (Silver Spring) Source Type: research

Mass attenuation coefficients, effective atomic numbers and electron densities of some contrast agents for computed tomography
Publication date: Available online 29 September 2019Source: Radiation Physics and ChemistryAuthor(s): Mohammed Sultan Al-Buriahi, Baris T. TongucAbstractIn the clinical computed tomography (CT) examinations, a photon is attenuated as it passes a patient by tissues and contrast agents (CAs). The CAs can increase the visibility of internal structures or fluids within the patient. In this work, we have investigated the photon interaction parameters of some CT contrast agents such as iotrolan, iodixanol, iohexol, ioxilan, ioversol, and iomeprol. The mass attenuation coefficients (μ/ρ) of these contrast agents have been ...
Source: Radiation Physics and Chemistry - September 30, 2019 Category: Physics Source Type: research

Intraoperative cone-beam CT spatial priors for diffuse optical fluorescence tomography.
Abstract A hybrid system for intraoperative cone-beam CT (CBCT) imaging and continuous-wave fluorescence tomography (FT) has been developed using an image-guidance framework. Intraoperative CBCT images with sub-millimeter spatial resolution are acquired with a flat-panel C-Arm. Tetrahedral meshes are generated from CBCT for finite element method implementation of diffuse optical tomography (NIRFAST). Structural data from CBCT is incorporated directly into the optical reconstruction process using Laplacian-type regularization ("soft spatial priors"). Experiments were performed using an in-house optical sy...
Source: Physics in Medicine and Biology - September 30, 2019 Category: Physics Authors: Daly MJ, Chan H, Muhanna N, Akens MK, Wilson BC, Irish JC, Jaffray DA Tags: Phys Med Biol Source Type: research

A novel rat model of contrast-induced nephropathy based on dehydration
ConclusionsA novel CIN rat model based on dehydration and iohexol exposure was established and validated to assist in understanding and preventing CIN. (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - September 29, 2019 Category: Drugs & Pharmacology Source Type: research

Inhibition of xanthine oxidoreductase protects against contrast-induced renal tubular injury by activating adenosine monophosphate-activated protein kinase.
Abstract Reactive oxygen species (ROS) play a pivotal role in the development of contrast-induced nephropathy (CIN). The inhibition of xanthine oxidoreductase is known to reduce levels of ROS. We investigated whether febuxostat could attenuate oxidative stress via the activation of adenosine monophosphate-activated protein kinase (AMPK) against CIN. In a mouse model of CIN, renal impairment and tubular injury substantially increased, whereas febuxostat attenuated renal injury. Plasma and kidney xanthine oxidoreductase levels were decreased by febuxostat. Febuxostat administration was accompanied by the upregulatio...
Source: Free Radical Biology and Medicine - September 24, 2019 Category: Biology Authors: Yang KJ, Kim JH, Chang YK, Park CW, Kim SY, Hong YA Tags: Free Radic Biol Med Source Type: research

Nanoagents Based on Poly(ethylene glycol) ‐b‐Poly(l‐thyroxine) Block Copolypeptide for Enhanced Dual‐Modality Imaging and Targeted Tumor Radiotherapy
Polypeptide ‐based nanoagents featuring high iodine content, fascinating physicochemical properties, great simplicity, good safety, and remarkable potency, hold a tremendous potential in both diagnosis and therapy of varying diseases. AbstractFuture healthcare requires development of novel theranostic agents that are capable of not only enhancing diagnosis and monitoring therapeutic responses but also augmenting therapeutic outcomes. Here, a versatile and stable nanoagent is reported based on poly(ethylene glycol) ‐b‐poly(l‐thyroxine) (PEG‐PThy) block copolypeptide for enhanced single photon emission computed tom...
Source: Small - September 20, 2019 Category: Nanotechnology Authors: Xiaolei Gu, Zhehong Zhu, Qianyi Fan, Yaohua Wei, Guanglin Wang, Fenghua Meng, Zhiyuan Zhong, Chao Deng Tags: Full Paper Source Type: research