The role of lung biopsy for diagnosis and prognosis of interstitial lung disease in systemic sclerosis: a systematic literature review
The prognostic and theragnostic role of histopathological subsets in systemic sclerosis interstitial lung disease (SSc-ILD) have been largely neglected due to the paucity of treatment options and the risks ass... (Source: Respiratory Research)
Source: Respiratory Research - March 23, 2024 Category: Respiratory Medicine Authors: A Damiani, M Orlandi, C Bruni, G Bandini, G Lepri, C Scaletti, C Ravaglia, F Frassanito, S Guiducci, A Moggi-Pignone, M Matucci-Cerinic, V Poletti, L Tofani, TV Colby, S Bellando Randone and Sara Tomassetti Tags: Review Source Type: research

Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | DOI:10.1177/14799731241240786 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research

Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | DOI:10.1177/14799731241240786 (Source: Respiratory Care)
Source: Respiratory Care - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research

Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome
This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro. Cell death was detected by propidium iodide staining. The morphological changes of the cells were observed by transmission electron microscopy (TEM). Pyroptosis markers were detected by western blot, immunofluorescence and quantitative real-time PCR, and the related inflammatory factor IL-1β was verified by ELISA. Compared with the control group, HPMECs mortality increased after NET stimulation, and the number of pyroptosis ...
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Peipei Zhao Jiarui Zhu Ling Bai Wenlan Ma Feifei Li Cen Zhang Liangtao Zhao Liuyang Wang Sigong Zhang Source Type: research

Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | PMC:PMC10958799 | DOI:10.1177/14799731241240786 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research

Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | PMC:PMC10958799 | DOI:10.1177/14799731241240786 (Source: Respiratory Care)
Source: Respiratory Care - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research

Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome
This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro. Cell death was detected by propidium iodide staining. The morphological changes of the cells were observed by transmission electron microscopy (TEM). Pyroptosis markers were detected by western blot, immunofluorescence and quantitative real-time PCR, and the related inflammatory factor IL-1β was verified by ELISA. Compared with the control group, HPMECs mortality increased after NET stimulation, and the number of pyroptosis ...
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Peipei Zhao Jiarui Zhu Ling Bai Wenlan Ma Feifei Li Cen Zhang Liangtao Zhao Liuyang Wang Sigong Zhang Source Type: research

Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome
This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro. Cell death was detected by propidium iodide staining. The morphological changes of the cells were observed by transmission electron microscopy (TEM). Pyroptosis markers were detected by western blot, immunofluorescence and quantitative real-time PCR, and the related inflammatory factor IL-1β was verified by ELISA. Compared with the control group, HPMECs mortality increased after NET stimulation, and the number of pyroptosis ...
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Peipei Zhao Jiarui Zhu Ling Bai Wenlan Ma Feifei Li Cen Zhang Liangtao Zhao Liuyang Wang Sigong Zhang Source Type: research

Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | PMC:PMC10958799 | DOI:10.1177/14799731241240786 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research

Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome
This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro. Cell death was detected by propidium iodide staining. The morphological changes of the cells were observed by transmission electron microscopy (TEM). Pyroptosis markers were detected by western blot, immunofluorescence and quantitative real-time PCR, and the related inflammatory factor IL-1β was verified by ELISA. Compared with the control group, HPMECs mortality increased after NET stimulation, and the number of pyroptosis ...
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Peipei Zhao Jiarui Zhu Ling Bai Wenlan Ma Feifei Li Cen Zhang Liangtao Zhao Liuyang Wang Sigong Zhang Source Type: research

Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | PMC:PMC10958799 | DOI:10.1177/14799731241240786 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research

Prognosis and prognostic factors of lung cancer complications in patients with rheumatoid arthritis
ConclusionsEarly detection of lung cancer is needed, especially in patients with RA who have a history of smoking, seropositivity, or interstitial lung disease. Even after surgical resection, it should be noted that squamous cell carcinoma is prone to recurrence. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 22, 2024 Category: Rheumatology Authors: Shunichi Fujita, Kazuhisa Nakano, Akiko Nagasu, Sumie Hiramatsu ‐Asano, Takahiko Akagi, Yoshitaka Morita Tags: ORIGINAL ARTICLE Source Type: research

A case of Lomentospora prolificans endophthalmitis treated with the novel antifungal agent Olorofim
ConclusionWe report a rare case of disseminatedLomentosporosis with panophthalmitis in an immunocompromised host with prolonged survival on systemic Olorofim, voriconazole and terbinafine in conjunction with pars plana vitrectomy and intravitreal voriconazole. Early suspicion of an opportunistic fungal infection is critical, as managing disseminated disease is often unsuccessful. Despite presumed inherent resistance, intravitreal and systemic voriconazole appeared to limit disease progression in the right eye. The potential synergistic effects of combined antifungal therapy with orotomides warrant further investigation. (S...
Source: Journal of Ophthalmic Inflammation and Infection - March 22, 2024 Category: Opthalmology Source Type: research

Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease
CONCLUSIONS: In cultured MDMs from SSc-ILD pts, nintedanib seems to downregulate the profibrotic M2 phenotype through the significant reduction of gene expression and protein synthesis of M2 cell surface markers, together with the significant reduction of TGFβ1 release, and notably MerTK, a tyrosine kinase receptor involved in lung fibrosis.PMID:38509595 | DOI:10.1186/s13075-024-03308-7 (Source: Cell Research)
Source: Cell Research - March 21, 2024 Category: Cytology Authors: Stefano Soldano Vanessa Smith Paola Montagna Emanuele Gotelli Rosanna Campitiello Carmen Pizzorni Sabrina Paolino Alberto Sulli Andrea Cere Maurizio Cutolo Source Type: research

Are immune checkpoint inhibitors safe and effective in lung cancer patients with pre-existing interstitial lung disease?
Conclusion: Generally, a pre-existing ILD history can increase the efficacy and incidence of ICIs' adverse reactions. Therefore, ICIs should be administered with caution.PMID:38511241 | DOI:10.2217/imt-2023-0147 (Source: Cancer Control)
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Lin Zhu Rong Gao Han Li Yahui Zheng Junling Yang Source Type: research