Clinical, histologic and prognostic features of clinically amyopathic dermatomyositis
CONCLUSIONS: CADM patients differ in disease onset, autoantibody profiles, joint and lung involvement. While laboratory and instrumental tests have not shown muscle involvement in CADM, many muscle biopsies have shown MHC-I overexpression.PMID:38488091 | DOI:10.55563/clinexprheumatol/kgpnbq (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Marco Fornaro Francesco Girolamo Margherita Giannini Laura Coladonato Adriana Capuano Marco Capodiferro Dario D'Abbicco Maddalena Ruggieri Mariangela Mastrapasqua Florenzo Iannone Source Type: research
Nailfold capillaroscopy findings of a multicentric multi-ethnic cohort of patients with idiopathic inflammatory myopathies
CONCLUSIONS: NVC abnormalities are related to the diagnosis, clinical features, disease activity, and autoantibodies of patients with IIM.PMID:38488092 | DOI:10.55563/clinexprheumatol/l9gudh (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Jiram Torres-Ruiz Iago Pinal-Fernandez Albert Selva-O'Callaghan Bianca Campbell Sandra Mu ñoz-Braceras Nancy R Mej ía-Domínguez Carlos N úñez-Álvarez Jos é Milisenda Maria Casal-Dom ínguez Katherine Pak Alfredo Guill én-Del-Castillo Ernesto Trall Source Type: research
Clinical, histologic and prognostic features of clinically amyopathic dermatomyositis
CONCLUSIONS: CADM patients differ in disease onset, autoantibody profiles, joint and lung involvement. While laboratory and instrumental tests have not shown muscle involvement in CADM, many muscle biopsies have shown MHC-I overexpression.PMID:38488091 | DOI:10.55563/clinexprheumatol/kgpnbq (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Marco Fornaro Francesco Girolamo Margherita Giannini Laura Coladonato Adriana Capuano Marco Capodiferro Dario D'Abbicco Maddalena Ruggieri Mariangela Mastrapasqua Florenzo Iannone Source Type: research
Nailfold capillaroscopy findings of a multicentric multi-ethnic cohort of patients with idiopathic inflammatory myopathies
CONCLUSIONS: NVC abnormalities are related to the diagnosis, clinical features, disease activity, and autoantibodies of patients with IIM.PMID:38488092 | DOI:10.55563/clinexprheumatol/l9gudh (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Jiram Torres-Ruiz Iago Pinal-Fernandez Albert Selva-O'Callaghan Bianca Campbell Sandra Mu ñoz-Braceras Nancy R Mej ía-Domínguez Carlos N úñez-Álvarez Jos é Milisenda Maria Casal-Dom ínguez Katherine Pak Alfredo Guill én-Del-Castillo Ernesto Trall Source Type: research
Clinical, histologic and prognostic features of clinically amyopathic dermatomyositis
CONCLUSIONS: CADM patients differ in disease onset, autoantibody profiles, joint and lung involvement. While laboratory and instrumental tests have not shown muscle involvement in CADM, many muscle biopsies have shown MHC-I overexpression.PMID:38488091 | DOI:10.55563/clinexprheumatol/kgpnbq (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Marco Fornaro Francesco Girolamo Margherita Giannini Laura Coladonato Adriana Capuano Marco Capodiferro Dario D'Abbicco Maddalena Ruggieri Mariangela Mastrapasqua Florenzo Iannone Source Type: research
Use of inhaled treprostinil in patients with interstitial lung disease and pulmonary hypertension: to boldly go where no other pulmonary vasodilator has gone before?
Pulmonary hypertension (PH) is a feared complication in patients with any chronic lung disease,1 but those with lung fibrosis have an especially poor mortality and the morbidity burden is very high.2 3 Up to very recently, there has been an almost nihilistic attitude towards these patients, since the lack of treatment options restricted the indication of a definitive diagnosis through right heart catheterisation (RHC) to lung transplant evaluation and enrolment in a clinical trial.4 Although with sound rationale, randomised placebo-controlled trials (RCT) with pulmonary vasodilators, have been negative or at worse detrimen...
Source: Thorax - March 15, 2024 Category: Respiratory Medicine Authors: Piccari, L., Wort, S. J. Tags: Thorax Editorial Source Type: research
Survival analysis from the INCREASE study in PH-ILD: evaluating the impact of treatment crossover on overall mortality
Conclusion
Two independent modelling techniques that have been employed in the oncology literature both suggest a long-term survival benefit associated with inhaled treprostinil treatment in patients with PH-ILD. (Source: Thorax)
Source: Thorax - March 15, 2024 Category: Respiratory Medicine Authors: Nathan, S. D., Johri, S., Joly, J. M., King, C. S., Raina, A., McEvoy, C. A., Lee, D., Shen, E., Smith, P., Deng, C., Waxman, A. B. Tags: Open access, Thorax Interstitial lung disease Source Type: research
Clinical characteristics and outcome of lung cancer in patients with fibrosing interstitial lung disease
Lung cancer (LC) is an important comorbidity of interstitial lung disease (ILD) and has a poor prognosis. The clinical characteristics and outcome of each ILD subtype in LC patients have not been sufficiently ... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - March 15, 2024 Category: Respiratory Medicine Authors: Soo Jin Han, Hyeon Hwa Kim, Dong-gon Hyun, Wonjun Ji, Chang-Min Choi, Jae Cheol Lee and Ho Cheol Kim Tags: Research Source Type: research
Clinical and Genetic Spectrum of Nine Cases of NLRP3-Associated Autoinflammatory Disease (NLRP3-AID) and Identification of One Novel NLRP3 Mutation by Genetic Variation Analyses
CONCLUSIONS: Our study illuminated the distinct clinical and genetic features of Chinese NLRP3-AID patients, emphasizing the significance of early genetic screening. Despite delayed diagnosis, treatment primarily with glucocorticoids and biologic agents, led to favorable outcomes. Genetic heterogeneity, including a novel mutation, highlighted the complexity of NLRP3-AID in this population.PMID:38481988 | PMC:PMC10937081 | DOI:10.1155/2024/5722548 (Source: Cell Research)
Source: Cell Research - March 14, 2024 Category: Cytology Authors: Yaoyao Shangguan Xingru Ding Le Ma Yi-Xin Cai Shulei Xiang Xiu-Feng Huang Yunyan Shen Hai-Guo Yu Wenjie Zheng Source Type: research
Clinical and Genetic Spectrum of Nine Cases of NLRP3-Associated Autoinflammatory Disease (NLRP3-AID) and Identification of One Novel NLRP3 Mutation by Genetic Variation Analyses
CONCLUSIONS: Our study illuminated the distinct clinical and genetic features of Chinese NLRP3-AID patients, emphasizing the significance of early genetic screening. Despite delayed diagnosis, treatment primarily with glucocorticoids and biologic agents, led to favorable outcomes. Genetic heterogeneity, including a novel mutation, highlighted the complexity of NLRP3-AID in this population.PMID:38481988 | PMC:PMC10937081 | DOI:10.1155/2024/5722548 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - March 14, 2024 Category: Allergy & Immunology Authors: Yaoyao Shangguan Xingru Ding Le Ma Yi-Xin Cai Shulei Xiang Xiu-Feng Huang Yunyan Shen Hai-Guo Yu Wenjie Zheng Source Type: research
Overview of Rheumatoid Arthritis-Associated Interstitial Lung Disease and Its Treatment
Semin Respir Crit Care Med. 2024 Mar 14. doi: 10.1055/s-0044-1782218. Online ahead of print.ABSTRACTInterstitial lung disease (ILD) is a common pulmonary complication of rheumatoid arthritis (RA), causing significant morbidity and mortality. Optimal treatment for RA-ILD is not yet well defined. Reliable prognostic indicators are largely byproducts of prior ILD progression, including low or decreasing forced vital capacity and extensive or worsening fibrosis on imaging. In the absence of validated tools to predict treatment response, decisions about whether to initiate or augment treatment are instead based on clinical judg...
Source: Respiratory Care - March 14, 2024 Category: Respiratory Medicine Authors: Janelle Vu Pugashetti Joyce S Lee Source Type: research
Japanese guidelines for the treatment of idiopathic pulmonary fibrosis 2023:Revised edition
Respir Investig. 2024 Mar 13;62(3):402-418. doi: 10.1016/j.resinv.2024.02.014. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with a poor prognosis and an unknown cause that generally progresses to pulmonary fibrosis and leads to irreversible tissue alteration. The "Guidelines for the treatment of idiopathic pulmonary fibrosis 2017," specializing in the treatment of IPF for the first time in Japan and presenting evidence-based standard treatment methods suited to the state of affairs in Japan, was published in 2017, in line with the 2014 version of "Formulation procedure f...
Source: Respiratory Care - March 14, 2024 Category: Respiratory Medicine Authors: Masashi Bando Sakae Homma Hiroshi Date Kazuma Kishi Hiroyoshi Yamauchi Susumu Sakamoto Atsushi Miyamoto Yoshihito Goto Takeo Nakayama Arata Azuma Yasuhiro Kondoh Takeshi Johkoh Yasuhiko Nishioka Junya Fukuoka Yasunari Miyazaki Ichiro Yoshino Takafumi Suda Source Type: research
Clinical and Genetic Spectrum of Nine Cases of NLRP3-Associated Autoinflammatory Disease (NLRP3-AID) and Identification of One Novel NLRP3 Mutation by Genetic Variation Analyses
CONCLUSIONS: Our study illuminated the distinct clinical and genetic features of Chinese NLRP3-AID patients, emphasizing the significance of early genetic screening. Despite delayed diagnosis, treatment primarily with glucocorticoids and biologic agents, led to favorable outcomes. Genetic heterogeneity, including a novel mutation, highlighted the complexity of NLRP3-AID in this population.PMID:38481988 | PMC:PMC10937081 | DOI:10.1155/2024/5722548 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - March 14, 2024 Category: Allergy & Immunology Authors: Yaoyao Shangguan Xingru Ding Le Ma Yi-Xin Cai Shulei Xiang Xiu-Feng Huang Yunyan Shen Hai-Guo Yu Wenjie Zheng Source Type: research
Respiratory infection risk in primary Sj ögren’s syndrome complicated with interstitial lung disease: a retrospective study
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 14, 2024 Category: Rheumatology Source Type: research
Risk factors for critical COVID-19 illness during Delta- and Omicron-predominant period in Korea; using K-COV-N cohort in the National health insurance service
ConclusionWe found that the severity of COVID-19 infection was much higher for the Delta variant than for the Omicron. Although the Delta and the Omicron variant shared many risk factors for critical illness, several risk factors were found to have different effects on the development of critical COVID-19 illness between those two variants. Close monitoring of a wide range of risk factors for critical illness is warranted as new variants continue to emerge during the pandemic. (Source: PLoS One)
Source: PLoS One - March 14, 2024 Category: Biomedical Science Authors: Kyung-Shin Lee Source Type: research
