Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease
CONCLUSIONS: In cultured MDMs from SSc-ILD pts, nintedanib seems to downregulate the profibrotic M2 phenotype through the significant reduction of gene expression and protein synthesis of M2 cell surface markers, together with the significant reduction of TGFβ1 release, and notably MerTK, a tyrosine kinase receptor involved in lung fibrosis.PMID:38509595 | DOI:10.1186/s13075-024-03308-7 (Source: Cell Research)
Source: Cell Research - March 21, 2024 Category: Cytology Authors: Stefano Soldano Vanessa Smith Paola Montagna Emanuele Gotelli Rosanna Campitiello Carmen Pizzorni Sabrina Paolino Alberto Sulli Andrea Cere Maurizio Cutolo Source Type: research
Are immune checkpoint inhibitors safe and effective in lung cancer patients with pre-existing interstitial lung disease?
Conclusion: Generally, a pre-existing ILD history can increase the efficacy and incidence of ICIs' adverse reactions. Therefore, ICIs should be administered with caution.PMID:38511241 | DOI:10.2217/imt-2023-0147 (Source: Cancer Control)
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Lin Zhu Rong Gao Han Li Yahui Zheng Junling Yang Source Type: research
Physical activity coaching in patients with interstitial lung diseases: A randomized controlled trial
CONCLUSIONS: Twelve weeks of telecoaching did not improve physical activity, physical fitness or quality of life in patients with ILD. Future physical or behavioural interventions are needed for these patients to improve physical activity.PMID:38511242 | PMC:PMC10956148 | DOI:10.1177/14799731241235231 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - March 21, 2024 Category: Respiratory Medicine Authors: Sofie Breuls Tamara Zlamalova Katerina Raisova Astrid Blondeel Marieke Wuyts Martin Dvoracek Monika Zurkova Jonas Yserbyt Wim Janssens Wim Wuyts Thierry Troosters Heleen Demeyer Source Type: research
Physical activity coaching in patients with interstitial lung diseases: A randomized controlled trial
CONCLUSIONS: Twelve weeks of telecoaching did not improve physical activity, physical fitness or quality of life in patients with ILD. Future physical or behavioural interventions are needed for these patients to improve physical activity.PMID:38511242 | PMC:PMC10956148 | DOI:10.1177/14799731241235231 (Source: Respiratory Care)
Source: Respiratory Care - March 21, 2024 Category: Respiratory Medicine Authors: Sofie Breuls Tamara Zlamalova Katerina Raisova Astrid Blondeel Marieke Wuyts Martin Dvoracek Monika Zurkova Jonas Yserbyt Wim Janssens Wim Wuyts Thierry Troosters Heleen Demeyer Source Type: research
Are immune checkpoint inhibitors safe and effective in lung cancer patients with pre-existing interstitial lung disease?
Immunotherapy, Ahead of Print. (Source: Immunotherapy)
Source: Immunotherapy - March 21, 2024 Category: Allergy & Immunology Authors: Lin Zhu Rong Gao Han Li Yahui Zheng Junling Yang Source Type: research
Compare three diagnostic criteria of progressive pulmonary fibrosis
CONCLUSIONS: In the current situations, both the 1- and 2-year criterion are the reasonable choice to define PPF both in researches and clinical practice, and DLCO% is an independent predictor for mortality of PPF.PMID:38505056 | PMC:PMC10944769 | DOI:10.21037/jtd-23-481 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Tao Chen Chunfang Zeng Source Type: research
