The role of lung biopsy for diagnosis and prognosis of interstitial lung disease in systemic sclerosis: a systematic literature review
The prognostic and theragnostic role of histopathological subsets in systemic sclerosis interstitial lung disease (SSc-ILD) have been largely neglected due to the paucity of treatment options and the risks ass... (Source: Respiratory Research)
Source: Respiratory Research - March 23, 2024 Category: Respiratory Medicine Authors: A Damiani, M Orlandi, C Bruni, G Bandini, G Lepri, C Scaletti, C Ravaglia, F Frassanito, S Guiducci, A Moggi-Pignone, M Matucci-Cerinic, V Poletti, L Tofani, TV Colby, S Bellando Randone and Sara Tomassetti Tags: Review Source Type: research
Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | DOI:10.1177/14799731241240786 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research
Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | DOI:10.1177/14799731241240786 (Source: Respiratory Care)
Source: Respiratory Care - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome
This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro. Cell death was detected by propidium iodide staining. The morphological changes of the cells were observed by transmission electron microscopy (TEM). Pyroptosis markers were detected by western blot, immunofluorescence and quantitative real-time PCR, and the related inflammatory factor IL-1β was verified by ELISA. Compared with the control group, HPMECs mortality increased after NET stimulation, and the number of pyroptosis ...
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Peipei Zhao Jiarui Zhu Ling Bai Wenlan Ma Feifei Li Cen Zhang Liangtao Zhao Liuyang Wang Sigong Zhang Source Type: research
Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | PMC:PMC10958799 | DOI:10.1177/14799731241240786 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research
Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | PMC:PMC10958799 | DOI:10.1177/14799731241240786 (Source: Respiratory Care)
Source: Respiratory Care - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome
This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro. Cell death was detected by propidium iodide staining. The morphological changes of the cells were observed by transmission electron microscopy (TEM). Pyroptosis markers were detected by western blot, immunofluorescence and quantitative real-time PCR, and the related inflammatory factor IL-1β was verified by ELISA. Compared with the control group, HPMECs mortality increased after NET stimulation, and the number of pyroptosis ...
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Peipei Zhao Jiarui Zhu Ling Bai Wenlan Ma Feifei Li Cen Zhang Liangtao Zhao Liuyang Wang Sigong Zhang Source Type: research
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome
This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro. Cell death was detected by propidium iodide staining. The morphological changes of the cells were observed by transmission electron microscopy (TEM). Pyroptosis markers were detected by western blot, immunofluorescence and quantitative real-time PCR, and the related inflammatory factor IL-1β was verified by ELISA. Compared with the control group, HPMECs mortality increased after NET stimulation, and the number of pyroptosis ...
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Peipei Zhao Jiarui Zhu Ling Bai Wenlan Ma Feifei Li Cen Zhang Liangtao Zhao Liuyang Wang Sigong Zhang Source Type: research
Clinical implications of frailty assessed in hospitalized patients with acute-exacerbation of interstitial lung disease
CONCLUSIONS: Frailty was associated with reduced exercise capacity, increased comorbidities and hospital complications. Identifying frailty may highlight those requiring additional multidisciplinary support, but further study is needed to explore whether frailty is modifiable with AE-ILD.PMID:38515270 | PMC:PMC10958799 | DOI:10.1177/14799731241240786 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - March 22, 2024 Category: Respiratory Medicine Authors: Marine Van Hollebeke Karan Chohan Colin J Adams Jolene H Fisher Shane Shapera Lee Fidler Ewan C Goligher Tereza Martinu Lisa Wickerson Sunita Mathur Lianne G Singer W Darlene Reid Dmitry Rozenberg Source Type: research
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome
This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro. Cell death was detected by propidium iodide staining. The morphological changes of the cells were observed by transmission electron microscopy (TEM). Pyroptosis markers were detected by western blot, immunofluorescence and quantitative real-time PCR, and the related inflammatory factor IL-1β was verified by ELISA. Compared with the control group, HPMECs mortality increased after NET stimulation, and the number of pyroptosis ...
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Peipei Zhao Jiarui Zhu Ling Bai Wenlan Ma Feifei Li Cen Zhang Liangtao Zhao Liuyang Wang Sigong Zhang Source Type: research
