A Case of Palmoplantar Keratoderma in the Constellation of Connective Tissue Diseases
Cureus. 2024 Mar 20;16(3):e56531. doi: 10.7759/cureus.56531. eCollection 2024 Mar.ABSTRACTOverlap syndrome is a clinical challenge and brings together a wide range of treatment options for the treating physician. Addressing each and every complaint of the patient is crucial. A 50-year-old female patient presented with skin thickening, blackening, and hyperkeratosis; dysphagia; joint pain; features of myopathy; Raynaud's phenomenon; and dry mouth. Inflammatory markers were raised along with a positive antinuclear antibody (ANA) with Golgi apparatus pattern, anti-Sjögren's-syndrome-related antigen A (anti-SSA)/Ro60 3+, anti...
Source: Pain Physician - April 22, 2024 Category: Anesthesiology Authors: Ishan Verma Amol H Dube Sunita Kumbhalkar Keshao Nagpure Gitesh Sawatkar Sachin R Chuadhari Ashwini Umredkar Source Type: research
Interstitial Lung Disease
This review summarizes current evidence regarding the diagnosis and treatment of interstitial lung disease. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 22, 2024 Category: General Medicine Source Type: research
Toupet fundoplication to prevent progression of scleroderma-associated interstitial lung damage: a study protocol
ConclusionsThe expected reduction of reflux burden in SSc patients selected for Toupet fundoplication may improve GERD symptoms/complications, pulmonary function, and quality of life, and may be associated with a reduced risk for lung transplant. (Source: European Surgery)
Source: European Surgery - April 22, 2024 Category: Surgery Source Type: research
Anti-U1RNP antibodies are associated with a distinct clinical phenotype and a worse survival in patients with systemic sclerosis
CONCLUSIONS: In SSc patients, anti-U1RNP antibodies are associated with a higher incidence of overlap syndrome, a distinct clinical phenotype, and poorer survival compared to SSc-RNP- and MCTD patients. Our study suggests that SSc-RNP+ patients should be separated from MCTD patients and may constitute an enriched population for progressive lung disease.PMID:38642508 | DOI:10.1016/j.jaut.2024.103220 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - April 20, 2024 Category: Allergy & Immunology Authors: Kevin Chevalier Guillaume Chassagnon Sarah Leonard-Louis Pascal Cohen Bertrand Dunogue Alexis Regent Benjamin Thoreau Luc Mouthon Benjamin Chaigne Source Type: research
Prevalence and prognostic meaning of interstitial lung abnormalities in remote CT scans of patients with interstitial lung disease treated with antifibrotic therapy
CONCLUSIONS: Fibrotic ILAs are frequent in remote scans of patients with clinically relevant ILD, long before they require antifibrotics. Findings of traction bronchiectasis and honeycombing in the earliest scans, even in asymptomatic patients, are related to mortality and progression later on.PMID:38642956 | DOI:10.1016/j.rxeng.2023.03.006 (Source: Radiologia)
Source: Radiologia - April 20, 2024 Category: Radiology Authors: M M Garc ía Mullor J J Arenas-Jim énez A Ure ña Vacas I Gay á García-Manso J L P érez Pérez N Serra Serra R Garc ía Sevila Source Type: research
Palliative Care in Interstitial Lung Disease: With the “Who,” We Need the What, When, Where, and How.
1. Understand the inter-professional needs of patients with interstitial lung disease.2. Describe the implementation and impacts of palliative management in interstitial lung disease. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Gillian Love, Megan Pogue, Daniel Kramer Source Type: research
Elevated serum B-cell activator factor levels predict rapid progressive interstitial lung disease in anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis
Rapid progressive interstitial lung disease (RP-ILD) is the leading cause of anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis (anti-MDA5+DM) related death. Elevated serum B-cel... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - April 19, 2024 Category: Internal Medicine Authors: Yumeng Shi, Hanxiao You, Chang Liu, Yulu Qiu, Chengyin Lv, Yujing Zhu, Lingxiao Xu, Fang Wang, Miaojia Zhang and Wenfeng Tan Tags: Research Source Type: research
Uncovering risk factors for adverse events and infections in rheumatoid arthritis and rheumatoid arthritis with interstitial lung disease under treatment with biologics or targeted synthetic DMARDs: insights from the KOBIO Registry
CONCLUSIONS: Patients with RA-ILD exhibited a higher rate of b/tsDMARDs withdrawal due to overall AEs and infections than those with RA without ILD. In the RA-ILD group, older age was identified as a risk factor for overall AEs, whereas a current smoking status was identified as a risk factor for infections.PMID:38634363 | DOI:10.55563/clinexprheumatol/6h1euo (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Ji-Won Kim Kichul Shin Juyang Jung Chang-Hee Suh Jinhyun Kim Sun-Kyung Lee Hyoun-Ah Kim Source Type: research
Impact of obesity progression or regression on the longitudinal assessment of fibrosing interstitial lung disease
Extract
Abnormalities in lung mechanics (restriction) and pulmonary gas exchange (hypoxaemia) may jointly conspire to elicit exertional dyspnoea and decrease exercise tolerance in patients with fibrosing interstitial lung disease (f-ILD) [1]. Obesity (body mass index (BMI) ≥30 kg·m–2), a prevalent comorbidity of f-ILD [2], may negatively impact on "static" (e.g. total lung capacity (TLC)) and dynamic (forced vital capacity (FVC)) lung volumes relevant to dyspnoea genesis [3]. Arterial oxygenation decreases as obesity worsens, particularly on exertion when poorly ventilated areas are perfused with less ...
Source: European Respiratory Journal - April 18, 2024 Category: Respiratory Medicine Authors: Alqurashi, H., Marillier, M., Neder-Serafini, I., Bernard, A.-C., Moran-Mendoza, O., Neder, J. A. Tags: Research Letters Source Type: research
Author Correction: Assessing safety concerns of interstitial lung disease associated with antibody-drug conjugates: a real-world pharmacovigilance evaluation of the FDA adverse event reporting system
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 17, 2024 Category: Drugs & Pharmacology Source Type: research
Respiratory infection risk in primary Sj ögren’s syndrome complicated with interstitial lung disease: a retrospective study
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
The Oral-Lung Microbiome Axis in Connective Tissue Disease-Related Interstitial Lung Disease
Semin Respir Crit Care Med. 2024 Apr 16. doi: 10.1055/s-0044-1785673. Online ahead of print.ABSTRACTConnective tissue disease-related interstitial lung disease (CTD-ILD) is a frequent and serious complication of CTD, leading to high morbidity and mortality. Unfortunately, its pathogenesis remains poorly understood; however, one intriguing contributing factor may be the microbiome of the mouth and lungs. The oral microbiome, which is a major source of the lung microbiome through recurrent microaspiration, is altered in ILD patients. Moreover, in recent years, several lines of evidence suggest that changes in the oral and lu...
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Kale S Bongers Angeline Massett David N O'Dwyer Source Type: research
The Oral-Lung Microbiome Axis in Connective Tissue Disease-Related Interstitial Lung Disease
Semin Respir Crit Care Med. 2024 Apr 16. doi: 10.1055/s-0044-1785673. Online ahead of print.ABSTRACTConnective tissue disease-related interstitial lung disease (CTD-ILD) is a frequent and serious complication of CTD, leading to high morbidity and mortality. Unfortunately, its pathogenesis remains poorly understood; however, one intriguing contributing factor may be the microbiome of the mouth and lungs. The oral microbiome, which is a major source of the lung microbiome through recurrent microaspiration, is altered in ILD patients. Moreover, in recent years, several lines of evidence suggest that changes in the oral and lu...
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Kale S Bongers Angeline Massett David N O'Dwyer Source Type: research
GSE244062 Tissue-specific inflammation induced by constitutively active STING is mediated by enhanced TNF signaling
Contributors : Rayk Behrendt ; Hella Luksch ; Angela R ösen-WolffSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusConstitutive activation of STING by gain-of-function mutations triggers manifestation of the systemic autoinflammatory disease STING-associated vasculopathy with onset in infancy (SAVI) in humans and in mice. Murine SAVI is characterized by T cell lymphopenia, severe inflammatory interstitial lung disease, neuroinflammation and neurodegeneration with only limited contribution of type I interferon signaling. Here, we show that pharmacologic inhibition of TNF signaling in...
Source: GEO: Gene Expression Omnibus - April 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
