Idiopathic Pulmonary Fibrosis Patients Exhibit Greater Levels of Senescence in Bone Marrow Stem Cells
Idiopathic pulmonary fibrosis (IPF) appears to be significantly driven by the presence of senescent cells in the lungs. Other forms of fibrosis in other organs have been similarly linked to senescent cells. Increased cellular senescence is a feature of aging, and indeed is one of the root causes of aging. These cells secrete a potent mix of signals that induce inflammation, damage tissue structures, and change the behavior of nearby cells for the worse. In this context the results presented here are intriguing; the authors of this open access paper find that IPF patients have more senescent bone marrow stem cells.
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Source: Fight Aging! - October 2, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Approach to Interstitial Lung Disease: DAMS Unplugged
Presenting a short teaching video with pulmonologist and Radiologist discussing different aspects of ILD Famous Radiology Blog http://www.sumerdoc.blogspot.com
TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - June 28, 2018 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Patterns of interstitial lung disease in the elderly
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - January 25, 2018 Category: Internal Medicine Tags: pulmonary Source Type: blogs
What the hospitalist needs to know about interstitial lung disease
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - January 15, 2018 Category: Internal Medicine Tags: pulmonary Source Type: blogs
Orbiting ORBITA
By ANISH KOKA, MD
I’m sitting amidst a number of cardiologists to go over the most recent trials presented at the interventional cardiology conference in Denver. The cardiology fellow presenting goes quickly through the hors de oeuvres until finally getting to the main course – ORBITA.
ORBITA sought to test the very foundations interventional cardiology was built on – the simple idea that opening a stenosed coronary artery was good for patients. The trial was a double blind randomized control trial of patients with tightly stenosed arteries who either had a stent placed or had a sham procedure. Before the resul...
Source: The Health Care Blog - December 4, 2017 Category: Consumer Health News Authors: anish_koka Tags: Uncategorized Anish Koka cardiology Orbita Source Type: blogs
DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis
In case you may have missed this one, Ivana Yang and colleagues from the University of Colorado have published a fascinating article in the December 1, 2014 issue of American Journal of Respiratory and Critical Care Medicine, "Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis," that explores possible epigenetic mechanisms through DNA methylation that may be involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Many of these studies are being done in various cancers, but this one suggests one or more programs that unfold with IPF.
(Source: The Daily Sign-Out)
Source: The Daily Sign-Out - February 11, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Idiopathic Pulmonary Fibrosis Interstitial Lung Disease Source Type: blogs
DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis
In case you may have missed this one, Ivana Yang and colleagues from the University of Colorado have published a fascinatingarticle in the December 1, 2014 issue of American Journal of Respiratory and Critical Care Medicine,"Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis," that explores possible epigenetic mechanisms through DNA methylation that may be involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF).Many of these studies are being done in various cancers, but this one suggests one or more programs that unfold with IPF. (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - February 11, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Idiopathic Pulmonary Fibrosis Interstitial Lung Disease Source Type: blogs
Toby Maher on his respiratory disorders research
Toby Maher has been an F1000 Faculty Member in the Respiratory Diseases Faculty since 2011. Recently, F1000 Publisher Kathleen Wets visited him at the Royal Brompton hospital in London, where Maher is a clinician-scientist. During Kathleen’s visit, she bumped into … Continue reading → (Source: Naturally Selected)
Source: Naturally Selected - January 19, 2015 Category: Biomedical Science Authors: Adie Chan Tags: Faculty Members Respiratory Disorders Video clinical trials idiopathic pulmonary fibrosis Imperial College Interstitial lung disease Prince Charles rare lung diseases Royal Brompton Toby Maher UCL Source Type: blogs
Novel cutaneous and pulmonary syndrome associated with mutations in STING
Fascinating article describing a vasculopathic cutaneous and pulmonary syndrome associated with autosomal dominant mutations in TMEM173, the gene encoding stimulator of interferon genes (STING). An incredible body of work presented with numerous clinical pictures and photomicrographs in the supplementary appendix that nicely illustrate the pathologic changes. This work sheds light on an important inflammatory pathway through the description of this "experiment of nature."
Liu Y, Jesus AA, Marrero B, et al. Activated STING in a Vascular and Pulmonary Syndrome. New England Journal of Medic...
Source: The Daily Sign-Out - August 6, 2014 Category: Pathologists Authors: Mark D. Pool, M.D. Source Type: blogs
Novel cutaneous and pulmonary syndrome associated with mutations in STING
Fascinating article describing a vasculopathic cutaneous and pulmonary syndrome associated with autosomal dominant mutations in TMEM173, the gene encoding stimulator of interferon genes (STING). An incredible body of work presented with numerous clinical pictures and photomicrographs in the supplementary appendix that nicely illustrate the pathologic changes. This work sheds light on an important inflammatory pathway through the description of this"experiment of nature."Liu Y, Jesus AA, Marrero B, et al. Activated STING in a Vascular and Pulmonary Syndrome. New England Journal of Medicine ...
Source: The Daily Sign-Out - August 6, 2014 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Source Type: blogs
Role of Bone Marrow-Derived HPCs in Pulmonary Fibrosis
Interesting article from AJRCCM just published online that adds to accumulating data implicating circulating bone marrow-derived hematopoietic progenitor cells in the development of lung fibrosis. Abstract below. Rationale: Bone marrow (BM)-derived cells have been implicated in pulmonary fibrosis, however, their... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - September 9, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Interstitial Lung Disease Source Type: blogs
Atomic force microscopy! EMT and idiopathic pulmonary fibrosis
Here is a very intesting article I recently found with some very cool technology: Abstract: Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis of idiopathic pulmonary fibrosis. Associated with this phenotypic transition is the acquisition of an elongated cell... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - March 23, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Epithelial-to-Mesenchymal Transition Interstitial Lung Disease Source Type: blogs
