Evaluation of the effects of Artemisia Annua L. and Moringa Oleifera Lam. on CD4 count and viral load among PLWH on ART at Mbarara Regional Referral Hospital: a double-blind randomized controlled clinical trial
Initiation of ART among people living with HIV (PLWH) having a CD4 count ≤ 350cells/µl, produces poor immunological recovery, putting them at a high risk of opportunistic infections. To mitigate this, PLWH on ... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - April 16, 2024 Category: Infectious Diseases Authors: Silvano S. Twinomujuni, Esther C Atukunda, Jackson K. Mukonzo, Musinguzi Nicholas, Felicitas Roelofsen and Patrick E. Ogwang Tags: Brief Report Source Type: research
SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells
. (Source: Cell Cycle)
Source: Cell Cycle - April 16, 2024 Category: Cytology Authors: Rong MaQing-Yuan GaoZhi-Teng ChenGuang-Hong LiaoShu-Tai LiJie-Wen CaiNian-Sang LuoHao ChenHai-Feng Zhanga Department of Infectious Diseases, The First Affiliated Hospital of Chengdu Medical College, Chengdu, PRCb Department of Cardiology, Sun Yat-sen Memo Source Type: research
Near Full-Length Genome Characterization of Two Novel Unique Recombinants (CRF01_AE/CRF07_BC) in Beijing, China
AIDS Research and Human Retroviruses, Ahead of Print. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - April 16, 2024 Category: Infectious Diseases Authors: Chunlin Lan Bo Zhu Hailong Zhuo Yuting Shi Zixuan Sun Lixuan Zhang Lei Jia Hanping Li Yongjian Liu Xiaolin Wang Jingyun Li Bohan Zhang Jingwan Han Junjun Jiang Lin Li Source Type: research
Frequency of Fusion Inhibitor Resistance Mutations Among Therapy-Na ïve HIV Patients
AIDS Research and Human Retroviruses, Ahead of Print. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - April 16, 2024 Category: Infectious Diseases Authors: Farzaneh Ghassabi Ava Hashempour Behzad Dehghani Zahra Hasanshahi Nastaran Khodadad Farideh Behizadeh Mohamad Ali Davarpanah Source Type: research
COVID-19 Vaccine Hesitancy Among People Living with HIV: A Systematic Review and Meta-Analysis
AbstractVaccine hesitancy is one of the top 10 threats to global health, which affects the prevalence and fatality of vaccine-preventable diseases over the world. During the COVID-19 pandemic, people living with HIV (PLWH) may have higher risks of infection, more serious complications, and worse prognosis without the protection of the COVID-19 vaccine. A systematic review and meta-analysis aiming to evaluate the prevalence of COVID-19 vaccine hesitancy among PLWH was conducted using PubMed, Embase, and Web of Science databases for studies published between January 1, 2020, and August 31, 2022. The pooled prevalence with a ...
Source: AIDS and Behavior - April 16, 2024 Category: Infectious Diseases Source Type: research
Association of liver function and prognosis in patients with severe fever with thrombocytopenia syndrome
by Shaoqiu Zhang, Jian Wang, Qun Zhang, Yifan Pan, Zhiyi Zhang, Yu Geng, Bei Jia, Yuanyuan Li, Yali Xiong, Xiaomin Yan, Jie Li, Huali Wang, Chao Wu, Rui Huang
ObjectivesSevere fever with thrombocytopenia syndrome (SFTS) is an epidemic emerging infectious disease with high mortality rate. We investigated the association between liver injury and clinical outcomes in patients with SFTS. MethodsA total of 291 hospitalized SFTS patients were retrospectively included. Cox proportional hazards model was adopted to identify risk factors of fatal outcome and Kaplan-Meier curves were used to estimate cumulative risks. Results60.1% o...
Source: PLoS Neglected Tropical Diseases - April 16, 2024 Category: Tropical Medicine Authors: Shaoqiu Zhang Source Type: research
Effect of fasting plasma glucose level in severe fever and thrombocytopenia syndrome patients without diabetes
This study assessed the relationship between fasting plasma glucose (FPG) levels and in-hospital mortality, disease type, and secondary infections among individuals with SFTS without preexisting diabetes. The clinical data and laboratory results upon admission of 560 patients with SFTS without preexisting diabetes meeting the inclusion criteria at Wuhan Union Hospital were collected. FPG levels in surviving patients with SFTS subjects were significantly lower than those in patients with SFTS who had died (P (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 16, 2024 Category: Tropical Medicine Authors: Jun Pan Source Type: research
Global analysis of respiratory viral circulation and timing of epidemics in the pre-COVID-19 and COVID-19 pandemic eras, based on data from the Global Influenza Surveillance and Response System (GISRS)
The emergence of the COVID-19 pandemic, caused by SARS-CoV-2, has undeniably reshaped life on a global scale. As infection rates and fatalities surged to historic proportions, initial strategies to combat the crisis revolved around non-pharmaceutical interventions (NPIs) such as the use of facemasks, physical distancing, travel bans, and lockdowns, considering the absence of available vaccines or targeted therapeutics. Characterized by a spectrum of actions spanning individual precautions to broader societal measures, NPIs aimed to curtail the rapid dissemination of the virus [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 16, 2024 Category: Infectious Diseases Authors: Marco Del Riccio, Saverio Caini, Guglielmo Bonaccorsi, Chiara Lorini, John Paget, Koos van der Velden, Adam Meijer, Mendel Haag, Ian McGovern, Patrizio Zanobini Source Type: research
Generative Bayesian modeling to nowcast the effective reproduction number from line list data with missing symptom onset dates
by Adrian Lison, Sam Abbott, Jana Huisman, Tanja Stadler
The time-varying effective reproduction numberRt is a widely used indicator of transmission dynamics during infectious disease outbreaks. Timely estimates ofRt can be obtained from reported cases counted by their date of symptom onset, which is generally closer to the time of infection than the date of report. Case counts by date of symptom onset are typically obtained from line list data, however these data can have missing information and are subject to right truncation. Previous methods have addressed these problems independently by first imputing missing onset d...
Source: PLoS Computational Biology - April 16, 2024 Category: Biology Authors: Adrian Lison Source Type: research
Evaluation of the JF5-based Aspergillus galactomannoprotein lateral flow device for diagnosing invasive aspergillosis in cancer patients
ConclusionThe AspLFD demonstrated good performance in diagnosing IA in cancer patients, especially those with solid tumours. The AspLFD is thus an alternative POCT, particularly when GM evaluations are not readily available. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 16, 2024 Category: Microbiology Source Type: research
PIVKA-II combined with alpha-fetoprotein for the diagnostic value of hepatic tumors in children: a multicenter, prospective observational study
ConclusionsThe serum level of PIVKA-II was significantly higher in children with hepatic tumors, especially those with malignant tumors. The combination of PIVKA-II with AFP further increased the diagnostic performance.Trial registrationClinical Trials, NCT03645655. Registered 20 August 2018,https://www.clinicaltrials.gov/ct2/show/NCT03645655. (Source: Hepatology International)
Source: Hepatology International - April 16, 2024 Category: Infectious Diseases Source Type: research
Plasmodium yoelii surface-related antigen (PySRA) modulates the host pro-inflammatory responses via binding to CD68 on macrophage membrane
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Source: Infection and Immunity - April 16, 2024 Category: Infectious Diseases Authors: Xin FengJia-Li YuYi-Fan SunChen-Yan DuYao ShenLu ZhangWei-Zhong KongSu HanYang Cheng1Department of Public Health and Preventive Medicine, Laboratory of Pathogen Infection and Immunity, Wuxi School of Medicine, Jiangnan University, Wuxi, China2Department o Source Type: research
Implementation of a rapid diagnostic assay package for cryptococcosis, histoplasmosis and tuberculosis in people living with HIV in Paraguay
Opportunistic infections (OIs) are common causes of mortality among people living with HIV (PLHIV). We determined prevalence and 30-day mortality due to histoplasmosis, cryptococcosis, and TB in PLHIV with adv... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 16, 2024 Category: Infectious Diseases Authors: Gloria Aguilar, Gladys Lopez, Omar Sued, Narda Medina, Diego H. Caceres, Jose Pereira, Alexander Jordan, Virgilio Lezcano, Cristina Vicenti, Gustavo Benitez, Tania Samudio and Freddy Perez Tags: Research Source Type: research
Modelling the impact of hybrid immunity on future COVID-19 epidemic waves
Since the emergence of SARS-CoV-2 (COVID-19), there have been multiple waves of infection and multiple rounds of vaccination rollouts. Both prior infection and vaccination can prevent future infection and redu... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 16, 2024 Category: Infectious Diseases Authors: Thao P. Le, Isobel Abell, Eamon Conway, Patricia T. Campbell, Alexandra B. Hogan, Michael J. Lydeamore, Jodie McVernon, Ivo Mueller, Camelia R. Walker and Christopher M. Baker Tags: Research Source Type: research
Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology
Toxoplasma gondii (T. gondii) and Helicobacter pylori (H. pylori) are among the most prevalent foodborne parasitic and bacterial infections worldwide. However, the concurrent impact of coinfection on gastric path... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 16, 2024 Category: Infectious Diseases Authors: Marwa A. Gouda, Sara A. Saied, Ahmed Edrees, Rasha Galal Mostafa, Ashraf Elfert, Aya Abdallah seleem, Asmaa Shams and Sameh Afify Tags: Research Source Type: research
