Infectious Diseases: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0679. Online ahead of print.ABSTRACTIn 2023, published research on COVID-19 remains prominent. The aim of this article is to highlight important developments in infectious disease evidence unrelated to COVID-19 that were published in 2023. The literature was screened for sound new evidence relevant to internal medicine specialists and subspecialists whose focus of practice is not infectious diseases. The highlighted publications relate to various organisms and patient populations. One article provides insight into the updated guidelines for the diagnosis and management of infec...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Amena Alhammadi Rasha Alshawaf Swati Chavda Sonya Ramondino Mindy Schuster Source Type: research
Efficacy of tocilizumab in patients with moderate-to-severe corticosteroid-resistant thyroid eye disease: a prospective study
CONCLUSION: TCZ can treat active moderate-to-severe TED, showing high drug compliance and reasonable response to inflammation and extraocular motility abnormality.PMID:38622479 | DOI:10.1007/s10792-024-03117-6 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Chaeyeon Lee Ji Woong Park Yoon-Duck Kim Kyung In Woo Source Type: research
Management of Oral Manifestations of Herpes Simplex Virus, Varicella Zoster Virus, and Human Papillomavirus
Compend Contin Educ Dent. 2024 Apr;45(4):192-197; quiz 198.ABSTRACTHuman herpes virus is a family of DNA viruses that includes herpes simplex virus (HSV) and varicella zoster virus (VZV). HSV-1 and HSV-2 are fairly common and result in oral and genital lesions. Recurrent infections of herpes include lesions on the lips resulting in pain and possibly societal stigma, making adequate treatment of these conditions crucial. VZV is the cause of chicken pox and shingles. Acyclovir and other nucleoside analogues have been the gold standard of treatment for HSV and VZV, but newer, more effective treatments are being developed, whi...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Lauren Elkada Aviv Ouanounou Source Type: research
CNS Aspergillosis and Cryptococcosis with Cytomegalovirus Pneumonia in a Patient with Chronic Lymphocytic Leukemia Treated with Acalabrutinib
We describe a 68-year-old male who developed multiple bacterial, fungal and viral infections while on treatment with acalabrutinib. To our knowledge, this is the first reported case of concomitant CNS infections with Cryptococcus neoformans and Aspergillus fumigatus, along with cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1) pneumonia while on acalabrutinib. This case adds to the scarce literature of fungal and bacterial infections associated with acalabrutinib, raising the suspicion that infection risk is a medication class effect for BTKis.PMID:38621678 | DOI:10.1177/08971900241247660 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Taylor Fallin Erica Thacker Syeda Sahra Emily A Siegrist Bryan P White Katherine Summers Dena Shibib Joseph Sassine Source Type: research
Progression of herpesvirus infection remodels mitochondrial organization and metabolism
PLoS Pathog. 2024 Apr 15;20(4):e1011829. doi: 10.1371/journal.ppat.1011829. Online ahead of print.ABSTRACTViruses target mitochondria to promote their replication, and infection-induced stress during the progression of infection leads to the regulation of antiviral defenses and mitochondrial metabolism which are opposed by counteracting viral factors. The precise structural and functional changes that underlie how mitochondria react to the infection remain largely unclear. Here we show extensive transcriptional remodeling of protein-encoding host genes involved in the respiratory chain, apoptosis, and structural organizati...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Simon Leclerc Alka Gupta Visa Ruokolainen Jian-Hua Chen Kari Kunnas Axel A Ekman Henri Niskanen Ilya Belevich Helena Vihinen Paula Turkki Ana J Perez-Berna Sergey Kapishnikov Elina M äntylä Maria Harkiolaki Eric Dufour Vesa Hyt önen Eva Pereiro Tony Mc Source Type: research
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Antimicrob Agents Chemother. 2024 Apr 15:e0011024. doi: 10.1128/aac.00110-24. Online ahead of print.ABSTRACTOcular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence. Wild-type HSV-1 was grown under increasing doses of one antiviral (ACV, GCV, or TFT) or combinations thereof ...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Hanna Helena Schalkwijk Neesha Rajesh Shewakramani Kalyan Das Graciela Andrei Robert Snoeck Source Type: research
In Patients With Inflammatory Bowel Disease, Racial Disparities Exist in Burden of Vaccine-preventable Disease Hospitalizations and Outcomes
CONCLUSIONS: Significant racial disparities in VPD hospitalization and in-hospital morbidity were found among adults with IBD in the United States. With the increasing prevalence of IBD in non-white populations, targeted efforts are needed to improve health equity.PMID:38619208 | DOI:10.1097/MCG.0000000000002005 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Christian Karime Miguel Salazar Cecily N Black Freddy Caldera Philip N Okafor Muhammad B Hammami Jana G Hashash Francis A Farraye Source Type: research
Investigating the Effects of HMGB1 Overexpression on Colorectal Cancer Cell Migration via Oncolytic Herpes simplex Virus Type 1 (oHSV-1)
CONCLUSION: Our findings emphasize the complex regulation of CRC cell migration, and provides valuable insights into potential molecular mechanisms and pathways. These findings have implications for further research into cancer progression and the development of therapeutic strategies.PMID:38618508 | PMC:PMC11007377 | DOI:10.18502/ajmb.v16i2.14863 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Sara Shayan Arash Arashkia Golnaz Bahramali Kayhan Azadmanesh Source Type: research
Kaposi's Sarcoma with Primary Lymph Node Involvement in a Retroviral Infected (RVI) Patient
Int Med Case Rep J. 2024 Apr 8;17:311-319. doi: 10.2147/IMCRJ.S458320. eCollection 2024.ABSTRACTOne kind of angioproliferative disorder is Kaposi's sarcoma (KS). Growth of spindle-shaped cells, edema, inflammation, and neoangiogenesis are its defining features. Because it lacks the typical indicators of malignancy, it is classified as an intermediate neoplasm. People who are immunocompromised, receiving organ transplants, or receiving antiretroviral therapy are linked to KS. Although lymph node involvement by KS is extremely uncommon, when it does occur, it usually manifests as either the epidemic form in (Human Immuno-def...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Bizunesh Dires Fenta Alazar Berhe Aregawi Teketel Tadesse Geremew Berhanu Kelemework Fenta Source Type: research
Multiple ocular manifestations in a patient diagnosed with herpes zoster ophthalmicus: case report
Conclusions: Final visual acuity for the left eye remained 1 despite numerous manifestations of the disease. Abbreviations: VZV = Varicella-zoster virus, BCVA = best-corrected visual acuity, OU = both eyes, OD = right eye, OS = left eye, IOP = intraocular pressure, NCT = non-contact tonometer, ZVX = Zostavax vaccine.PMID:38617727 | PMC:PMC11007559 | DOI:10.22336/rjo.2024.16 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: David-Ionu ț Beuran Mioara-Laura Macovei Ioana Ruxandra Boca Source Type: research
Herpes simplex keratitis: A brief clinical overview
World J Virol. 2024 Mar 25;13(1):89934. doi: 10.5501/wjv.v13.i1.89934.ABSTRACTThe aim of our minireview is to provide a brief overview of the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type of corneal viral infection is caused by the herpes simplex virus (HSV), which can affect several tissues, including the cornea. One significant aspect of HSK is its potential to cause recurrent episodes of inflammation and damage to the cornea. After the initial infection, the HSV can establish a latent infection in the trigeminal ganglion, ...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Mutali Musa Ehimare Enaholo Gladness Aluyi-Osa George Nnamdi Atuanya Leopoldo Spadea Carlo Salati Marco Zeppieri Source Type: research
Differential protective impact of peptide vaccine formulae targeting the lung- and liver-stage of challenge Schistosoma mansoni infection in mice
Acta Trop. 2024 Apr 13:107208. doi: 10.1016/j.actatropica.2024.107208. Online ahead of print.ABSTRACTThe study aimed to elicit protective immune responses against murine schistosomiasis mansoni at the parasite lung- and liver stage. Two peptides showing amino acid sequence similarity to gut cysteine peptidases, which induce strong memory immune effectors in the liver, were combined with a peptide based on S. mansoni thioredoxin peroxidase (TPX), a prominent lung-stage schistosomula excretory-secretory product, and alum as adjuvant. Only one of the 2 cysteine peptidases-based peptides in a multiple antigenic peptide constru...
Source: Acta Tropica - April 15, 2024 Category: Infectious Diseases Authors: Hatem Tallima Menerva M Tadros Rashika El Ridi Source Type: research
Listeria monocytogenes infections in hematopoietic cell transplant recipients: clinical manifestations and risk factors: A multinational retrospective case control study of the Infectious Diseases Working Party (IDWP) of the European Society for Blood and Marrow Transplantation (EBMT)
CONCLUSIONS: HCT patients have an increased risk for listeriosis compared to general population. Listeriosis cause severe disease with septic shock and mortality. Neurolisteriosis can present with non-specific signs and normal imaging. Lymphocytopenia and non-first HCT are associated with increased risk of listeriosis; cotrimoxazole was not protective.PMID:38621480 | DOI:10.1016/j.jtct.2024.04.008 (Source: Cancer Control)
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Dina Averbuch Gloria Tridello Lotus Wendel Maija It älä-Remes Ilana Oren Michal Karas Nicole Blijlevens Yves Beguin Annoek Broers Elisabetta Calore Chiara Cattaneo Cecilia Isaksson Christine Robin Alain Gadisseur Johan Maertens Ann De Becker Catherina L Source Type: research
Respiratory pathogenic microbial infections: a narrative review
This article aims to review community-acquired respiratory illnesses covering a broad spectrum of viruses, bacteria, and atypical microorganisms and focuses on the cluster prevalence of multiple known respiratory pathogens in China, thereby providing effective prevention and control measures.PMID:38617014 | PMC:PMC11008481 | DOI:10.7150/ijms.93628 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Yiyin Long Yan Zheng Changlin Li Zhanjun Guo Peng Li Fuqing Zhang Wei Liu Yuliang Wang Source Type: research
Prevalence and genetic characteristics of Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research
