An economic evaluation and incremental analysis of the cost effectiveness of three universal childhood varicella vaccination strategies for Ireland
CONCLUSION: A one-dose strategy was highly cost effective from the payer perspective, driven by a reduction in hospitalisations. Two-dose strategies were cost saving from the societal perspective. These results should be considered alongside other factors such as acceptability of a new vaccine within the overall childhood immunisation schedule, programme objectives and budget impact.PMID:38609807 | DOI:10.1016/j.vaccine.2024.04.027 (Source: Herpes)
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Susan Ahern John Browne Aileen Murphy Conor Teljeur M áirín Ryan Source Type: research
Long-term performance of show-jumping horses and relationship with severity of ataxia and complications associated with myeloencephalopathy caused by equine herpes virus-1
CONCLUSIONS AND CLINICAL IMPORTANCE: Horses affected by EHM were able to return to their previous performance levels, but certain clinical variables were negatively associated with postoutbreak performance. Ataxia grade upon admission and the development of systemic signs of vasculitis and urinary complications were potential poor prognostic indicators in sport horses. Variables linked to fatality included prior vaccination against EHV-1, ataxia grade upon admission, and the development of urinary complications.PMID:38609161 | DOI:10.1111/jvim.17070 (Source: Herpes)
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Mar ía de la Cuesta-Torrado Ana Velloso Alvarez Patricia Neira-Egea Juan Cuervo-Arango Source Type: research
Determination of HLA class II risk alleles and prediction of self/non-self-epitopes contributing Hashimoto's thyroiditis in a group of Iranian patients
This study aimed to determine the HLA-II risk alleles for developing Hashimoto's thyroiditis (HT) in order to analyze the molecular homology between candidate pathogen-derived epitopes and potentially self-antigens (thyroid peroxidase, TPO) based on the presence of HLA risk alleles. HLA-DRB1/-DQB1 genotyping was performed in 100 HT patients and 330 ethnically matched healthy controls to determine the predisposing/protective alleles for HT disease. Then, in silico analysis was conducted to examine the sequence homology between epitopes derived from autoantigens and four potentially relevant pathogens and their binding capac...
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Ata Shirizadeh Shiva Borzouei Zahra Razavi Amir Taherkhani Javad Faradmal Ghasem Solgi Source Type: research
Amenamevir for Treating Acyclovir-Resistant or Refractory Herpes Simplex Virus Infection in Allogeneic Hematopoietic Stem Cell Transplantation Recipients. Two Case Reports
Int J Antimicrob Agents. 2024 Apr 10:107169. doi: 10.1016/j.ijantimicag.2024.107169. Online ahead of print.NO ABSTRACTPMID:38608846 | DOI:10.1016/j.ijantimicag.2024.107169 (Source: Herpes)
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: L éo Sallée Laetitia Souchet David Boutolleau St éphanie Nguyen Source Type: research
Satellite Glial Cells in Human Disease
Cells. 2024 Mar 23;13(7):566. doi: 10.3390/cells13070566.ABSTRACTSatellite glial cells (SGCs) are the main type of glial cells in sensory ganglia. Animal studies have shown that these cells play essential roles in both normal and disease states. In a large number of pain models, SGCs were activated and contributed to the pain behavior. Much less is known about SGCs in humans, but there is emerging recognition that SGCs in humans are altered in a variety of clinical states. The available data show that human SGCs share some essential features with SGCs in rodents, but many differences do exist. SGCs in DRG from patients suf...
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Menachem Hanani Source Type: research
Temporary Spinal Cord Stimulation for Herpes Zoster With Myelitis: A Case Series
Conclusions: Temporary SCS alleviated pain in cases of shingles with myelitis refractory to interventional therapy. Even in cases with myelitis, tSCS for ZAP remains an effective way to prevent PHN.PMID:38606211 | PMC:PMC11006553 | DOI:10.7759/cureus.55979 (Source: Herpes)
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Reon Kobayashi Asae Taketomi Eiko Hara Hitoshi Mera Katsunori Oe Source Type: research
Neonatal Herpes Reporting in the United States: Review of Current Policies by State
J Pediatric Infect Dis Soc. 2024 Apr 12:piae031. doi: 10.1093/jpids/piae031. Online ahead of print.NO ABSTRACTPMID:38606511 | DOI:10.1093/jpids/piae031 (Source: Herpes)
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Natalie Saremi Katherine A Lewis Jeffrey D Klausner Source Type: research
A putative design for the electromagnetic activation of split proteins for molecular and cellular manipulation
Front Bioeng Biotechnol. 2024 Mar 28;12:1355915. doi: 10.3389/fbioe.2024.1355915. eCollection 2024.ABSTRACTThe ability to manipulate cellular function using an external stimulus is a powerful strategy for studying complex biological phenomena. One approach to modulate the function of the cellular environment is split proteins. In this method, a biologically active protein or an enzyme is fragmented so that it reassembles only upon a specific stimulus. Although many tools are available to induce these systems, nature has provided other mechanisms to expand the split protein toolbox. Here, we show a novel method for reconsti...
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Connor J Grady E Alejandro Castellanos Franco Jory Schossau Ryan C Ashbaugh Galit Pelled Assaf A Gilad Source Type: research
Acute liver failure caused by high-dose tigecycline: A case report
We report the case of a 76-year-old female patient with cerebral hemorrhage who received high-dose tigecycline (100 mg q12h) with other drugs for ventilator-associated pneumonia. 25 days after admission, she developed acute liver failure, mainly manifested by abnormally high bilirubin, coagulation dysfunction, and gastrointestinal hemorrhage with hemorrhagic shock. According to the updated Roussel Uclaf causality assessment method, the patient's acute liver injury was most likely caused by tigecycline.PMID:38606856 | DOI:10.5414/CP204549 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 12, 2024 Category: Drugs & Pharmacology Authors: Yingpei Zhang Jiajun Wang Yibin Tan Jianhua Wu Source Type: research
Microbiome Profile of South Korean Vector Mosquitoes
This study sheds light on the complex interactions between mosquitoes and their microbiome, revealing potential implications for vector competence, disease transmission, and vector control strategies.PMID:38608996 | DOI:10.1016/j.actatropica.2024.107213 (Source: Acta Tropica)
Source: Acta Tropica - April 12, 2024 Category: Infectious Diseases Authors: Ashraf Akintayo Akintola Ui Wook Hwang Source Type: research
Evaluation of an HIV homecare program for lost-to-follow-up populations: a mixed methods study in Detroit, Michigan
CONCLUSION: Homecare offers an innovative system for successfully re-engaging and maintaining lost-to-follow-up PLWHIV in care. These findings have implications for HIV control efforts and could inform the development of future programs for difficult to reach populations.PMID:38609992 | DOI:10.1186/s12981-024-00608-5 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - April 12, 2024 Category: Infectious Diseases Authors: L V Bonadonna E Guerrero T McClendon S Union D Kabbani D Wittmann J Cohn J Veltman Source Type: research
Daptomycin and ceftaroline combination for the treatment of persistent methicillin-resistant < em > Staphylococcus aureus < /em > bloodstream infections: a case series and literature review
In this report, we present a case series of 7 patients who failed vancomycin and then were treated with daptomycin and ceftaroline for persistent MRSA BSIs. The median age (IQR) of the included patients was 59 (48-67), with 5 male and 2 female patients. Six patients (85.7%) had a clinical cure for their persistent BSIs. The median time (IQR) for sterilization of MRSA BSIs after initiation of daptomycin and ceftaroline combination was 2 days (1-3). Among the patients who had clinical cures, the median time for clinical cures (IQR) was 6 weeks (4.5-6 weeks). The combination of daptomycin and ceftaroline could be an excellent...
Source: Journal of Chemotherapy - April 12, 2024 Category: Cancer & Oncology Authors: Yazed S Alsowaida Ahmed Alsolami Thamer A Almangour Source Type: research
Functional and Multi-Omics Effects of an Optimized CRISPR-Mediated FURIN Depletion in U937 Monocytes
Cells. 2024 Mar 28;13(7):588. doi: 10.3390/cells13070588.ABSTRACTThe pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious diseases, cancer and cardiovascular diseases. Previously, we performed a systemic inhibition of FURIN in a mouse model of atherosclerosis and demonstrated significant plaque reduction and alterations in macrophage function. To understand the cellular mechanisms affected by FURIN inhibition in myeloid cells, we optimized a CRISPR-mediated gene deletion protocol for successfully deriving hemizygous (HZ) and nullizygous (NZ) F...
Source: Atherosclerosis - April 12, 2024 Category: Cardiology Authors: Ruiming Chua Lijin Wang Roshni Singaraja Sujoy Ghosh Source Type: research
Peptide Extract from Red Kidney Beans, < em > Phaseolus vulgaris < /em > (Fabaceae), Shows Promising Antimicrobial, Antibiofilm, and Quorum Sensing Inhibitory Effects
In this study, peptides were extracted from the seeds of Phaseolus vulgaris (Fabaceae), and the antimicrobial activities of the extract were evaluated using microbroth dilution against five different microorganisms. The extract showed antimicrobial activity against all tested organisms with minimum inhibitory concentrations (MIC) of 2.5 mg/mL, except for Candida albicans and Pseudomonas aeruginosa, which had MICs of 1.25 mg/mL. The extract was also bacteriostatic for all tested organisms. The crude peptide extract from Phaseolus vulgaris was further studied for its antibiofilm activity against Pseudomonas aeruginosa, a com...
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Jennifer Tetteh De-Youngster Wereko Brobbey Kofi Junior Osei Azumah Ayamah Michael Konney Laryea Godfred Darko Lawrence Sheringham Borquaye Source Type: research
Understanding the influence of the microbiome on childhood infections
Expert Rev Anti Infect Ther. 2024 Apr 12:1-17. doi: 10.1080/14787210.2024.2340664. Online ahead of print.ABSTRACTINTRODUCTION: The microbiome is known to have a substantial impact on human health and disease. However, the impacts of the microbiome on immune system development, susceptibility to infectious diseases, and vaccine-elicited immune responses are emerging areas of interest.AREAS COVERED: In this review, we provide an overview of development of the microbiome during childhood. We highlight available data suggesting that the microbiome is critical to maturation of the immune system and modifies susceptibility to a ...
Source: Expert Review of Anti-Infective Therapy - April 12, 2024 Category: Infectious Diseases Authors: Sarah M Heston Jillian H Hurst Matthew S Kelly Source Type: research
