Avian ‘Bird’ Flu – undue media panic or genuine concern for pandemic potential requiring global preparedness action?
epidemics, avian influenza, H5N1, highly pathogenic avian influenza, HPAI (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 15, 2024 Category: Infectious Diseases Authors: Eskild Petersen, Ziad A Memish, David S Hui, Alessandra Scagliarini, Lone Simonsen, Edgar Simulundu, Jennifer Bloodgood, Lucille Blumberg, Shui- Shan Lee, Alimuddin Zumla Tags: Editorial Source Type: research
Comparison of prevalence estimates of pfhrp2 and pfhrp3 deletions in Plasmodium falciparum determined by conventional PCR and multiplex qPCR and implications for surveillance and monitoring
The emergence of mutant Plasmodium falciparum parasites with pfhrp2 and pfhrp3 deletions poses a major threat to the utility of histidine rich protein-2 (HRP2)-based malaria rapid diagnostic tests (RDTs), the mainstay diagnostic tool for detecting falciparum malaria in resource-limited settings. These gene-deleted parasites do not express HRP2/3 and are therefore undetectable by HRP2-based RDTs leading to false-negative results. Mutant parasites have now been reported from 40 of the 47 countries where investigations have been conducted [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 15, 2024 Category: Infectious Diseases Authors: Michelle L. Gatton, David Smith, Cielo Pasay, Karen Anderson, Selam Mihreteab, Hugo O. Valdivia, Juan F. Sanchez, Khalid B. Beshir, Jane Cunningham, Qin Cheng Source Type: research
The contribution of SARS-CoV-2 to the burden of acute respiratory infections in winter season 2022/2023: Results from the DigiHero study
At the beginning of September 2022, three years after the detection of the first SARS-CoV-2 case, the World Health Organization (WHO) globally had registered over 600 million confirmed cases and over 6.4 million deaths due to an infection with the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) [1]. By the end of the winter season in March 2023 those numbers had risen to over 761 million confirmed cases and over 6.8 million deaths [2]. Our World in Data reported an even higher number of deaths of 8.6 million [3]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 15, 2024 Category: Infectious Diseases Authors: Nadine Glaser, Sophie Diexer, Bianca Klee, Dr. Oliver Purschke, Prof. Dr. med. Mascha Binder, Prof. Dr. med. Thomas Frese, Prof. Dr. med. Matthias Girndt, PD Dr. med. Jessica H öll, Dr. Irene Moor, Prof. Dr. med. Jonas Rosendahl, Prof. Dr. med. Michael G Source Type: research
Mutations and intron polymorphisms in voltage-gated sodium channel genes of different geographic populations of Culex pipiens pallens/Culex pipiens quinquefasciatus in China
ConclusionsCx. p. pallens andCx. p. quinquefasciatus have developed resistance to insecticides in most regions of China. The neighboring downstream introns of thevgsc gene gradually decreased to one intron with the mutation of thevgsc gene. Mutations may originate from multiple mutation events rather than from a single origin, and populations lacking mutations may be genetically isolated.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 15, 2024 Category: Infectious Diseases Source Type: research
Molecular epidemiology and resistance mechanisms of tigecycline-non-susceptible Acinetobacter baumannii isolated from a tertiary care hospital in Chongqing, China
AbstractWe studied 34 isolates of Tigecycline-Non-SusceptibleA. baumannii (TNAB) obtained from clinical specimens at a large tertiary care hospital in Chongqing, China. These 34 strains belonged to 8 different clones including ST195 (35.3%) and ST208 (17.7%). EBURST analysis found that these 8 ST types belonged to the Clonal Complex 92. Tigecycline resistance-associated genesadeR, adeS, adeL, adeN, rrf, rpsJ, and trm were detected in most strains. The expression level of the resistance-nodulation-cell division (RND) efflux pumps in TNAB strains was higher than the reference strain ATCC19606. 58.8% of strains had a decrease...
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 15, 2024 Category: Microbiology Source Type: research
Performance of two immunochromatographic tests in detecting KPC variants conferring resistance to ceftazidime-avibactam
(Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 15, 2024 Category: Microbiology Source Type: research
Flagellin-modulated inflammasome pathways characterize the human alveolar macrophage response to Burkholderia pseudomallei, a lung-tropic pathogen
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Source: Infection and Immunity - April 15, 2024 Category: Infectious Diseases Authors: Lara Lovelace-MaconSarah M. BakerDeirdre DuckenSudeshna SealGuilhem RerolleDiane TomitaKelly D. SmithSandra SchwarzT. Eoin West1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington Source Type: research
Listeria monocytogenes infections in hematopoietic cell transplant recipients: clinical manifestations and risk factors: A multinational retrospective case control study of the Infectious Diseases Working Party (IDWP) of the European Society for Blood and Marrow Transplantation (EBMT).
Listeria spp. is a facultative intracellular bacillus that can infect humans following ingestion of contaminated food1. There are several species of Listeria, of which Listeria monocytogenes (LM) and (rarely) Listeria ivanovii can cause infection in humans2. Following gastrointestinal infection, Listeria can spread to the bloodstream and brain, and is one of the most common etiologies of central nervous system (CNS) infection in immunocompromised patients3. The most common manifestation of listeriosis in the immune-competent is mild gastroenteritis. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - April 15, 2024 Category: Hematology Authors: Dina Averbuch, Gloria Tridello, Lotus Wendel, Maija It älä-Remes, Ilana Oren, Michal Karas, Nicole Blijlevens, Yves Beguin, Annoek Broers, Elisabetta Calore, Chiara Cattaneo, Cecilia Isaksson, Christine Robin, Alain Gadisseur, Johan Maertens, Ann De Bec Source Type: research
Dengue hospitalizations and in-hospital mortality changes in trend in Ecuador: a nationwide study from 2015 to 2022
. (Source: Infectious Diseases)
Source: Infectious Diseases - April 15, 2024 Category: Infectious Diseases Authors: German Josuet Lapo-TalledoSchool of Medicine, Faculty of Health Sciences, Universidad T écnica de Manabí, Portoviejo, Ecuador Source Type: research
Gastrointestinal Acute Radiation Syndrome: Mechanisms, Models, Markers, and Medical Countermeasures
This report provides an overview of information that was presented during the conference, and important discussions surrounding a broad range of topics that are critical for the research, development, licensure, and use of MCMs for GI-ARS.PMID:38616048 | DOI:10.1667/RADE-23-00196.1 (Source: Radiation Research)
Source: Radiation Research - April 14, 2024 Category: Physics Authors: Thomas A Winters Libero Marzella Olivia Molinar-Inglis Paul W Price Nyun Calvin Han Jonathan E Cohen Sue-Jane Wang Anthony F Fotenos Julie M Sullivan John Esker Paula J Lapinskas Andrea L DiCarlo Source Type: research
Interaction of beauvericin in combination with antibiotics against methicillin-resistant Staphylococcus aureus and Salmonella typhimurium
Toxicon. 2024 Apr 12:107713. doi: 10.1016/j.toxicon.2024.107713. Online ahead of print.ABSTRACTMultidrug resistance in bacteria is a major challenge worldwide, increasing both mortality by infections and costs for the health systems. Therefore, it is of utmost importance to find new drugs against resistant bacteria. Beauvericin (BEA) is a mycotoxin produced by entomopathogenic and other fungi of the genus Fusarium. Our work determines the effect of BEA combined with antibiotics, which has not been previously explored. The combination analysis included different antibiotics against non-methicillin-resistant Staphylococcus a...
Source: Toxicon - April 14, 2024 Category: Toxicology Authors: V ásquez Bonilla J Norberto Barranco Florido J Esteban A Hamdan Partida Ponce Alquicira Edith Octavio Loera Source Type: research
Roles of HIF-1 α signaling in Mycobacterium tuberculosis infection: New targets for anti-TB therapeutics?
Biochem Biophys Res Commun. 2024 Apr 9;711:149920. doi: 10.1016/j.bbrc.2024.149920. Online ahead of print.ABSTRACTTuberculosis (TB), a deadly infectious disease induced by Mycobacterium tuberculosis (Mtb), continues to be a global public health issue that kill millions of patents every year. Despite significant efforts have been paid to identify effective TB treatments, the emergence of drug-resistant strains of the disease and the presence of comorbidities in TB patients urges us to explore the detailed mechanisms involved in TB immunity and develop more effective innovative anti-TB strategies. HIF-1α, a protein involved...
Source: Biochemical and Biophysical Research communications - April 14, 2024 Category: Biochemistry Authors: Chaowei Li Jiajun Wang Jun-Fa Xu Jiang Pi Biying Zheng Source Type: research
Unlocking the potential of nanocarrier-mediated mRNA delivery across diverse biomedical frontiers: A comprehensive review
Int J Biol Macromol. 2024 Apr 12:131139. doi: 10.1016/j.ijbiomac.2024.131139. Online ahead of print.ABSTRACTMessenger RNA (mRNA) has gained marvelous attention for managing and preventing various conditions like cancer, Alzheimer's, infectious diseases, etc. Due to the quick development and success of the COVID-19 mRNA-based vaccines, mRNA has recently grown in prominence. A lot of products are in clinical trials and some are already FDA-approved. However, still improvements in line of optimizing stability and delivery, reducing immunogenicity, increasing efficiency, expanding therapeutic applications, scalability and manu...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Smita Pawar Prashant Pingale Atul Garkal Riyaz Ali M Osmani Kavita Gajbhiye Madhur Kulkarni Krutika Pardeshi Tejal Mehta Amarjitsing Rajput Source Type: research
Roles of HIF-1 α signaling in Mycobacterium tuberculosis infection: New targets for anti-TB therapeutics?
Biochem Biophys Res Commun. 2024 Apr 9;711:149920. doi: 10.1016/j.bbrc.2024.149920. Online ahead of print.ABSTRACTTuberculosis (TB), a deadly infectious disease induced by Mycobacterium tuberculosis (Mtb), continues to be a global public health issue that kill millions of patents every year. Despite significant efforts have been paid to identify effective TB treatments, the emergence of drug-resistant strains of the disease and the presence of comorbidities in TB patients urges us to explore the detailed mechanisms involved in TB immunity and develop more effective innovative anti-TB strategies. HIF-1α, a protein involved...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Chaowei Li Jiajun Wang Jun-Fa Xu Jiang Pi Biying Zheng Source Type: research
Development and validation of machine learning-based models for predicting healthcare-associated bacterial/fungal infections among COVID-19 inpatients: a retrospective cohort study
ConclusionsOur machine learning models achieved strong predictive ability and may be effective clinical decision-support tools for identifying COVID-19 patients at risk for bacterial/fungal coinfection and guiding antibiotic administration. The levels of cytokines, such as IL-6, may affect the status of bacterial/fungal coinfection. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 14, 2024 Category: Infectious Diseases Source Type: research
