Fetal Long QT Syndrome - Challenges in Perinatal Management: A Review and Case Report. Induction of Labor and Vaginal Birth Under Continuous Magnesium Therapy
Z Geburtshilfe Neonatol. 2024 Feb 22. doi: 10.1055/a-2231-9348. Online ahead of print.ABSTRACTCongenital LQTS is an often undetected inherited cardiac channel dysfunction and can be a reason for intrauterine fetal demise. It can present in utero as CTG and ultrasound abnormalities, i. e., bradycardia, ventricular tachycardia, or fetal hydrops. Diagnosis is made by CTG, echocardiography, or fMCG. Intrauterine therapy with a ß blocker and i. v. magnesium should be started. Our objective was to examine the current knowledge about diagnosis and treatment of LQTS and in particular to highlight the opportunity of vaginal birth ...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - February 22, 2024 Category: Perinatology & Neonatology Authors: Linda Sarah Wegner Johannes Steinhard Thomas Frank Kai Thorsten Laser Karol Kubiak Source Type: research
Fetal Long QT Syndrome - Challenges in Perinatal Management: A Review and Case Report. Induction of Labor and Vaginal Birth Under Continuous Magnesium Therapy
Z Geburtshilfe Neonatol. 2024 Feb 22. doi: 10.1055/a-2231-9348. Online ahead of print.ABSTRACTCongenital LQTS is an often undetected inherited cardiac channel dysfunction and can be a reason for intrauterine fetal demise. It can present in utero as CTG and ultrasound abnormalities, i. e., bradycardia, ventricular tachycardia, or fetal hydrops. Diagnosis is made by CTG, echocardiography, or fMCG. Intrauterine therapy with a ß blocker and i. v. magnesium should be started. Our objective was to examine the current knowledge about diagnosis and treatment of LQTS and in particular to highlight the opportunity of vaginal birth ...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - February 22, 2024 Category: Perinatology & Neonatology Authors: Linda Sarah Wegner Johannes Steinhard Thomas Frank Kai Thorsten Laser Karol Kubiak Source Type: research
Fetal Long QT Syndrome - Challenges in Perinatal Management: A Review and Case Report. Induction of Labor and Vaginal Birth Under Continuous Magnesium Therapy
Z Geburtshilfe Neonatol. 2024 Feb 22. doi: 10.1055/a-2231-9348. Online ahead of print.ABSTRACTCongenital LQTS is an often undetected inherited cardiac channel dysfunction and can be a reason for intrauterine fetal demise. It can present in utero as CTG and ultrasound abnormalities, i. e., bradycardia, ventricular tachycardia, or fetal hydrops. Diagnosis is made by CTG, echocardiography, or fMCG. Intrauterine therapy with a ß blocker and i. v. magnesium should be started. Our objective was to examine the current knowledge about diagnosis and treatment of LQTS and in particular to highlight the opportunity of vaginal birth ...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - February 22, 2024 Category: Perinatology & Neonatology Authors: Linda Sarah Wegner Johannes Steinhard Thomas Frank Kai Thorsten Laser Karol Kubiak Source Type: research
A Case of an Obstructed Delivery by a Large, Lower Uterine Segment Fibroid Interlocked with a Fetal Mentum
We describe a case of an obstructed delivery by a large fibroid. A 37-year-old G2P1001 with a 10-cm anterior, lower uterine segment fibroid presented for labor induction. Labor was complicated by arrest of descent due to suspected obstruction of the fetal body by the fibroid after descent of the fetal head, and delivery during cesarean section was complicated by apparent interlocking of the fetal mentum with the fibroid. Large, anterior lower uterine segment fibroids have the potential to obstruct delivery of the fetal head or of the fetal body, and these patients should be counseled regarding the potential for complicatio...
Source: American Journal of Perinatology Reports - February 21, 2024 Category: Perinatology & Neonatology Authors: Miller, Sarah E. Miller, Hayley E. Waldrop, Anne R. Karakash, Scarlett D. Shaw, Kate A. Tags: Case Report Source Type: research
Buprenorphine Induction Using Microdosing for the Management of Opioid Use Disorder in Pregnancy
Conclusion Buprenorphine microdosing was well tolerated in this patient and avoided withdrawal symptoms in the mothers, and NOWS. A microdosing study in pregnancy is indicated [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 18, 2024 Category: Perinatology & Neonatology Authors: Patel, Neil B. Parilla, Barbara V. Tags: Case Report Source Type: research
A Case of an Obstructed Delivery by a Large, Lower Uterine Segment Fibroid Interlocked with a Fetal Mentum
We describe a case of an obstructed delivery by a large fibroid. A 37-year-old G2P1001 with a 10-cm anterior, lower uterine segment fibroid presented for labor induction. Labor was complicated by arrest of descent due to suspected obstruction of the fetal body by the fibroid after descent of the fetal head, and delivery during cesarean section was complicated by apparent interlocking of the fetal mentum with the fibroid. Large, anterior lower uterine segment fibroids have the potential to obstruct delivery of the fetal head or of the fetal body, and these patients should be counseled regarding the potential for complicatio...
Source: American Journal of Perinatology Reports - February 18, 2024 Category: Perinatology & Neonatology Authors: Miller, Sarah E. Miller, Hayley E. Waldrop, Anne R. Karakash, Scarlett D. Shaw, Kate A. Tags: Case Report Source Type: research
A prospective randomized double-blind study comparing the dose-response curves of epidural ropivacaine for labor analgesia initiation between parturients with and without obesity
Conclusion: In conclusion, within the parameters of this study, our findings suggest that obesity, characterized by a mean BMI value of 30.9, does not significantly influence the EC50 and EC90 values of epidural ropivacaine for labor analgesia. Further investigations are warranted to elucidate the dose-response relationship between ropivacaine and obesity with higher BMI values.Clinical trial registration:https://www.chictr.org.cn/showproj.html?proj=190747, Identifier ChiCTR2300073273. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 16, 2024 Category: Drugs & Pharmacology Source Type: research
Methods of induction of labor in women with obesity: A secondary analysis of two multicenter randomized controlled trials
ConclusionsIn women with obesity we found a nonsignificant trend towards an increased rate of cesarean sections in the group induced with a Foley catheter compared to oral misoprostol; however, the study lacked power for this subgroup analysis. The finding of a higher risk of failed placement of a Foley catheter in women with obesity can be used in shared decision making. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 15, 2024 Category: OBGYN Authors: Doroth ée M. R. Croll,
Marieke D. T. De Vaan,
Shinta L. Moes,
Kitty W. M. Bloemenkamp,
Mieke L. G. Ten Eikelder,
Roel De Heus,
Marta Jozwiak,
Judith Kooiman,
Ben Willem Mol,
Corine J. M. Verhoeven,
Marjon A. De Boer Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Labor induction at 41+0 gestational weeks or expectant management for the nulliparous woman: The Finnish randomized controlled multicenter trial
ConclusionsOffering labor induction to nulliparous women at 41+0 gestational weeks may decrease the probability of operative delivery, postpartum hemorrhage, and neonatal weight ≥4000 g. However, this study was underpowered to affirm the trends of rising rates of CS and adverse neonatal outcomes in the expectant management group. Thus, expectant management could remain an option for some, as one in two women with expectant management had a spontaneous onset of labor. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 15, 2024 Category: OBGYN Authors: Katariina Place,
Leena Rahkonen,
Aydin Tekay,
Kirsi V äyrynen,
Maija‐Riitta Orden,
Marja Vääräsmäki,
Jukka Uotila,
Kati Tihtonen,
Kirsi Rinne,
Kaarin Mäkikallio,
Seppo Heinonen,
Heidi Kruit Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Molecules, Vol. 29, Pages 863: Effect of Adding Chestnut Inner Skin on Allergenic Protein, Antioxidant Properties, and Quality of Bread
In this study, the evaluation of hypoallergenicity was limited to instrumental analysis. In the future, we will evaluate hypoallergenicity through clinical trials in humans. (Source: Molecules)
Source: Molecules - February 15, 2024 Category: Chemistry Authors: Yoko Tsurunaga Eishin Morita Tags: Article Source Type: research
Optimal Misoprostol Dosing Among Patients with a BMI Greater Than 30: A Randomized Controlled Trial
Patients with obesity experience an increased duration of labor with increased risk of perinatal morbidity. Compared to parturients without obesity, they also experience fewer uterine contractions after administration of misoprostol. It is unclear whether the same dose of misoprostol should be used for induction of labor in patients with obesity compared to non-obese patients. Therefore, we sought to investigate if a higher dose of misoprostol for patients with obesity is more effective. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 14, 2024 Category: OBGYN Authors: Alexander M. SAUCEDO, Miriam ALVAREZ, George A. MACONES, Alison G. CAHILL, Lorie M. HARPER Tags: Original Research: Obstetrics Source Type: research
Early versus delayed amniotomy following transcervical Foley balloon in the induction of labor: a randomized clinical trial
To determine if amniotomy within two hours after Foley balloon removal compared with amniotomy four hours or later reduces the duration of active labor and time taken to achieve vaginal delivery in term pregnant women undergoing labor induction. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 14, 2024 Category: OBGYN Authors: Marissa BERRY, Kelly LAMIMAN, Megan N. SLAN, Xue ZHANG, Daphne D. ARENA GONCHAROV, Yihharn P. HWANG, Jennifer A. ROGERS, Luis D. PACHECO, George R. SAADE, Antonio F. SAAD Tags: Original Research: Obstetrics Source Type: research
Early vs delayed amniotomy following transcervical Foley balloon in the induction of labor: a randomized clinical trial
The optimal timing of amniotomy during labor induction is a topic of ongoing debate due to the potential risks associated with both amniotomy and prolonged labor. As such, individuals in the field of obstetrics and gynecology must carefully evaluate the associated benefits and drawbacks of this procedure. While amniotomy can expedite the labor process, it may also lead to complications such as umbilical cord prolapse, fetal distress, and infection. Therefore, a careful and thorough examination of the risks and benefits of amniotomy during labor induction is essential in making an informed decision regarding the optimal tim...
Source: American Journal of Obstetrics and Gynecology - February 14, 2024 Category: OBGYN Authors: Marissa Berry, Kelly Lamiman, Megan N. Slan, Xue Zhang, Daphne D. Arena Goncharov, Yihharn P. Hwang, Jennifer A. Rogers, Luis D. Pacheco, George R. Saade, Antonio F. Saad Tags: Original Research Source Type: research
Optimal misoprostol dosing among patients with a body mass index greater than 30: a randomized controlled trial
Patients with obesity experience an increased duration of labor with an increased risk for perinatal morbidity. When compared with parturients without obesity, they also experience fewer uterine contractions after administration of misoprostol. It is unclear if the same dose of misoprostol should be used for induction of labor in patients with obesity compared to non-obese patients. Therefore, we sought to investigate if a higher dose of misoprostol for patients with obesity is more effective. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 14, 2024 Category: OBGYN Authors: Alexander M. Saucedo, Miriam Alvarez, George A. Macones, Alison G. Cahill, Lorie M. Harper Tags: Original Research Source Type: research
Disruption of the SP-A/SP-R210 < sub > L < /sub > (Myo18A α) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestation
We report that either lack of SP-A or disruption of SP-R210L delays parturition by 0.40 and 0.55 days compared to controls, respectively. LPS induced labor 0.60, 1.01, 0.40, 1.00, and 1.31 days earlier than PBS controls in WT, SP-A-deficient, littermate controls, heterozygous, and homozygous SP-R210L-deficient mice, respectively. Lack of SP-A reduced litter size in PBS-treated mice, whereas the total number of pups delivered was similar in all LPS-treated mice. The number of live pups, however, was significantly reduced by 50-70% in SP-A and SP-R210L-deficient mice compared to controls. Differences in gestational length we...
Source: Am J Physiol Lung Ce... - February 13, 2024 Category: Respiratory Medicine Authors: Zhiwei Guan Brandon Worth Todd M Umstead Shaili Amatya Jennifer Booth Zissis C Chroneos Source Type: research
