Efficacy comparison of titrated oral solution of misoprostol and intravenous oxytocin on labour induction in women with full-term pregnancy.
Authors: Kashanian M, Eshraghi N, Rahimi M, Sheikhansari N, Javanmanesh F Abstract A double-blind randomised trial was conducted on women with gestational age of 40-42 weeks of pregnancy and Bishop score of more than 5. The first group received oxytocin infusion and the second group received a titrated oral solution of misoprostol. Then, the two groups were compared by the primary outcome (the number of deliveries in the first 24 hours of intervention). The two groups did not have any significant difference in maternal and gestational age at the time of intervention, primary Bishop score, parity and n...
Source: Journal of Obstetrics and Gynaecology - June 15, 2019 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

Misoprostol vaginal insert (Mysodelle) versus Dinoprostone intravaginal gel (Prostin) for induction of labour
Publication date: Available online 12 June 2019Source: European Journal of Obstetrics & Gynecology and Reproductive BiologyAuthor(s): A. Sharp, D. Faluyi, Z AlfirevicAbstractObjectiveThe aim of this study is the compare the effectiveness and safety of Misoprostol Vaginal Insert (Mysodelle) versus Dinoprostone intravaginal gel (Prostin) for induction of labour.Study designWe performed a prospective cohort study of the use of misoprostol vaginal inserts (Mysodelle) in the induction of pregnancy and compared it to a historical cohort of women induced with the Dinoprostone intravaginal gel (Prostin) at the Liverpool Women&...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - June 13, 2019 Category: OBGYN Source Type: research

Rising Cesarean Rates: Are Primary Sections Overused?
AbstractDoubling of C-section rates from year 2000 to 2015 globally was declared an eye-opener on October 13, 2018, in FIGO World Congress. Rapid increase in rates without clear evidence of concomitant decrease in maternal or neonatal morbidity or mortality raises significant concern that cesarean delivery is overused. This review addresses issues related to exponentially rising rates, reasons for it, and strategies to reduce. Previous cesarean delivery has main contribution to rising rates as per evidence from the literature search in last 5  years. Focus on optimizing indications of primary C-section resulted in mak...
Source: The Journal of Obstetrics and Gynecology of India - June 13, 2019 Category: OBGYN Source Type: research

Pregnancy outcomes of adolescent primigravida and risk of pregnancy-induced hypertension: a hospital-based study in Southern Thailand.
The objectives were to examine pregnancy outcomes in adolescent primigravida and to determine the effects of adolescent pregnancy on pregnancy-induced hypertension (PIH). A retrospective analysis of pregnancy outcomes was carried out in 2440 adolescent primigravida, compared with 14,259 primigravida aged 20-29 years. The adolescents had significantly higher rates of maternal death, maternal heart disease, PIH, puerperal infection, chorioamnionitis, urinary tract infection, foetal anomaly, preterm delivery, low birth weight, low Apgar scores and stillbirth. Multivariate logistic regression analysis showed that both old...
Source: Journal of Obstetrics and Gynaecology - June 12, 2019 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

Foley catheter versus cervical double balloon for labor induction: a prospective randomized study
. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - June 12, 2019 Category: Perinatology & Neonatology Authors: Ido Solt Maya Frank Wolf Shani Ben-Haroush Svetlana Kaminskyi Ella Ophir Jacob Bornstein Source Type: research

Misoprostol vaginal insert (Mysodelle) versus Dinoprostone intravaginal gel (Prostin) for induction of labour
The aim of this study is the compare the effectiveness and safety of Misoprostol Vaginal Insert (Mysodelle) versus Dinoprostone intravaginal gel (Prostin) for induction of labour. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - June 12, 2019 Category: OBGYN Authors: A. Sharp, D. Faluyi, Z Alfirevic Tags: Full length article Source Type: research

Foley catheter versus cervical double balloon for labor induction: a prospective randomized study
. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - June 12, 2019 Category: Perinatology & Neonatology Authors: Ido Solt Maya Frank Wolf Shani Ben-Haroush Svetlana Kaminskyi Ella Ophir Jacob Bornstein Source Type: research

Nondefinitive Studies of Labor Induction Methods: Enough Already!
PMID: 31188329 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 11, 2019 Category: OBGYN Authors: Ayala NK, Rouse DJ Tags: Obstet Gynecol Source Type: research

Oral or Vaginal Misoprostol for Labor Induction and Cesarean Delivery Risk.
CONCLUSION: Compared with vaginal misoprostol, oral misoprostol may be associated with increased risk of cesarean delivery and longer time to vaginal delivery. PMID: 31188317 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 11, 2019 Category: OBGYN Authors: Handal-Orefice RC, Friedman AM, Chouinard SM, Eke AC, Feinberg B, Politch J, Iverson RE, Yarrington CD Tags: Obstet Gynecol Source Type: research

Should we offer elective induction of labor to nulliparous women at 39 weeks?
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - June 10, 2019 Category: OBGYN Authors: William A. Grobman, Aaron B. Caughey Tags: Letter to the Editors Source Type: research

Cervical ripening balloon as a method of preinduction - one center study.
CERVICAL RIPENING BALLOON AS A METHOD OF PREINDUCTION - ONE CENTER STUDY. Acta Clin Croat. 2018 Dec;57(4):762-767 Authors: Košec V, Djaković I, Sabolović Rudman S Abstract - Cervical ripening can be promoted in many ways, but mechanical methods are among the oldest. Like all other methods, this one also has its pros and cons. Disadvantages compared to pharmacological methods include some maternal discomfort upon manipulation of the cervix, a theoretical increase in the risk of maternal and neonatal infection from the introduction of a foreign body, potential disruption of a low-lying placenta,...
Source: Acta Clinica Croatica - June 8, 2019 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Elective induction of labour in low risk nulliparous women at term: caution is needed
Publication date: Available online 5 June 2019Source: European Journal of Obstetrics & Gynecology and Reproductive BiologyAuthor(s): Tullio Ghi, Andrea Dall’Asta, Stefania FieniAbstractThe recently published ARRIVE trial demonstrated that “policies aimed at the avoidance of elective labour induction among low-risk nulliparous women at 39 weeks of gestation are unlikely to reduce the rate of caesarean delivery on a population level”. In this commentary we discuss some controversial aspects of the study that in our opinion may undermine its validity at wide population level. (Source: European Journal of...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - June 6, 2019 Category: OBGYN Source Type: research

IJERPH, Vol. 16, Pages 2015: Influence of Body Mass Index on Gestation and Delivery in Nulliparous Women: A Cohort Study
Conclusion: Obesity is associated with increased complications during pregnancy, an increased incidence of a cesarean section and induced birth but it has no significant effect on the delivery time. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - June 6, 2019 Category: Environmental Health Authors: Noem í Rodríguez-Mesa Paula Robles-Benayas Yolanda Rodr íguez-López Eva Mar ía Pérez-Fernández Ana Isabel Cobo-Cuenca Tags: Article Source Type: research

Toward Open-Ended Fraternal Transitions in Individuality.
Abstract The emergence of new replicating entities from the union of simpler entities characterizes some of the most profound events in natural evolutionary history. Such transitions in individuality are essential to the evolution of the most complex forms of life. Thus, understanding these transitions is critical to building artificial systems capable of open-ended evolution. Alas, these transitions are challenging to induce or detect, even with computational organisms. Here, we introduce the DISHTINY (Distributed Hierarchical Transitions in Individuality) platform, which provides simple cell-like organisms with ...
Source: Artificial Life - June 5, 2019 Category: Science Authors: Moreno MA, Ofria C Tags: Artif Life Source Type: research

Elective induction of labour in low risk nulliparous women at term: caution is needed
The recently published ARRIVE trial demonstrated that “policies aimed at the avoidance of elective labour induction among low-risk nulliparous women at 39 weeks of gestation are unlikely to reduce the rate of caesarean delivery on a population level”. In this commentary we discuss some controversial aspects of the study that in our opinion may unde rmine its validity at wide population level. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - June 5, 2019 Category: OBGYN Authors: Tullio Ghi, Andrea Dall ’Asta, Stefania Fieni Source Type: research

Saved by the Massive Transfusion Protocol: A Case Report of an Obstetric Patient With Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP) Syndrome and Glisson Capsule Rupture
A 31-year-old primigravid parturient with no pertinent medical history was admitted at 40 weeks and 4 days of gestation for postdate induction of labor. She was subsequently diagnosed with preeclampsia and developed hemolysis, elevated liver enzymes, and a low platelet count. An emergency cesarean delivery ensued owing to fetal bradycardia. Massive hemorrhage occurred on incision, and a diagnosis of ruptured subcapsular hepatic hematoma was made. The hemorrhage was managed using our institution’s massive transfusion protocol. Early transfusions and mobilization of necessary support stipulated in this protocol led to ...
Source: A&A Case Reports - June 3, 2019 Category: Anesthesiology Tags: Case Reports Source Type: research

The outcomes of pregnancies with reduced fetal movements: A retrospective cohort study
AbstractIntroductionTo examine the outcomes and interventions in pregnant women presenting with a perception of reduced fetal movements (RFM), and to determine if repeated episodes of RFM increase the risk of adverse outcomes.Material and methodsThis was a retrospective cohort study conducted in six NHS hospitals within the Thames Valley network region, UK and one neighbouring hospital, an area with approximately 31,000 births annually. All women with a primary presentation of perceived RFM after 24 completed weeks of gestation during the month of October 2016 were included in the study.Prospective records in all units wer...
Source: Acta Obstetricia et Gynecologica Scandinavica - May 31, 2019 Category: OBGYN Authors: Meena Bhatia, Vaia Mitsi, Lisa Court, Premila Thampi, Mohamed El ‐Nasharty, Saeed Hesham, Wendy Randall, Rachel Davies, Lawrence Impey Tags: Original Research Article Source Type: research

Labor progress determined by ultrasound is different in women requiring Cesarean delivery from those who experience a vaginal delivery following induction of labor
The diagnosis of labor dystocia is generally determined by the deviation of labor progress, which is assessed by the use of partogram. Recently, intrapartum transperineal ultrasound for the assessment of fetal head descent has been introduced to assess labor progress in the first stage of labor in a more objective and non-invasive way. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 30, 2019 Category: OBGYN Authors: Wing Ting Tse, Piya Chaemsaithong, Winnie W.Y. Chan, Angel H.W. Kwan, Junhong Huang, Kubi Appiah, Ka Chun Chong, Liona C. Poon Tags: Original Research: Obstetrics Source Type: research

Is Foley Catheter Use during a Trial of Labor after Cesarean Associated with Uterine Rupture?
Conclusion Foley catheter is a safe tool for mechanical dilation in women undergoing IOL after prior cesarean. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - May 30, 2019 Category: Perinatology & Neonatology Authors: Katz Eriksen, Jennifer L. Chandrasekaran, Suchitra Delaney, Shani S. Tags: SMFM Fellowship Series Article Source Type: research

Propofol Suppresses LPS-Induced Inflammation in Amnion Cells via Inhibition of NF- κB Activation
Conclusion:We demonstrated that propofol suppresses the expression of inflammatory substances enhanced by LPS stimulation. Furthermore, this inhibitory effect of propofol on the inflammatory substance expression is mediated by suppression of NF- κB activation. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - May 29, 2019 Category: Biotechnology Source Type: research

Labour induction with misoprostol vaginal insert compared with dinoprostone vaginal insert
AbstractIntroductionMisoprostol vaginal insert could lead to a significant reduction of the time to vaginal delivery, and an increase in the proportion of women achieving vaginal delivery, compared with dinoprostone vaginal insert. We compared delivery outcomes of misoprostol 200 μg vaginal insert and dinoprostone 10 mg vaginal insert for induction of labour in women with an unfavourable cervix.Material and methodsThis is a retrospective observational study conducted on a cohort of 220 women with a Bishop score ≤ 4 admitted for induction of labour at a single institution. Of these, 109 (49.5%) received the Misoprosto...
Source: Acta Obstetricia et Gynecologica Scandinavica - May 29, 2019 Category: OBGYN Authors: Claudia Maggi, Giorgia Mazzoni, Vera Gerosa, Nicola Fratelli, Federico Prefumo, Enrico Sartori, Andrea Lojacono Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Oxytocin and Oxytocinase in the Obese and Nonobese Parturients during Induction and Augmentation of Labor
AJP Rep 2019; 09: e177-e184 DOI: 10.1055/s-0039-1692196 Objective To investigate differences in oxytocin (OXT) biodistribution between nonobese and obese parturients during labor. Study Design Patients with body mass index (BMI) of either ≥ 18 ≤ 24.9 kg/m2 (“nonobese”) or ≥ 30 kg/m2 (“obese”) undergoing elective induction of labor were included (N = 25 each). Blood samples were collected at baseline (T0), and 20 minutes after maximal OXT augmentation or adequate uterine contractions (T1) for OXT and oxytocinase assays. ...
Source: American Journal of Perinatology Reports - May 29, 2019 Category: Perinatology & Neonatology Authors: De Tina, Annemaria Juang, Jeremy McElrath, Thomas F. Baty, Jack D. Palanisamy, Arvind Tags: Original Article Source Type: research

Labour induction with misoprostol vaginal insert compared with dinoprostone vaginal insert
AbstractIntroductionMisoprostol vaginal insert could lead to a significant reduction of the time to vaginal delivery, and an increase in the proportion of women achieving vaginal delivery, compared with dinoprostone vaginal insert. We compared delivery outcomes of misoprostol 200 μg vaginal insert and dinoprostone 10 mg vaginal insert for induction of labour in women with an unfavourable cervix.Material and methodsThis is a retrospective observational study conducted on a cohort of 220 women with a Bishop score ≤ 4 admitted for induction of labour at a single institution. Of these, 109 (49.5%) received the Misoprosto...
Source: Acta Obstetricia et Gynecologica Scandinavica - May 29, 2019 Category: OBGYN Authors: Claudia Maggi, Giorgia Mazzoni, Vera Gerosa, Nicola Fratelli, Federico Prefumo, Enrico Sartori, Andrea Lojacono Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

A Serious Diagnosis Lacking Common Symptoms
​BY JENNIFER TUONG; IVAN KHARCHENKO; JEAN LUC AGARD; & AHMED RAZIUDDIN, MDA 65-year-old man who had HIV well-controlled with highly active antiretroviral therapy, hypertension, sciatica, and restless leg syndrome presented to the emergency department with left leg pain. He also had had chemotherapy and radiation for anal cancer. The patient said the pain had started 45 minutes earlier when he was sitting on the toilet.He described the pain as sore in quality and 10/10 on the pain scale. He reported that it had started in his lower back and radiated to his left leg. He said he had had no trauma or weakness to the regi...
Source: The Case Files - May 28, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Division of labor in honey bees is associated with transcriptional regulatory plasticity in the brain [RESEARCH ARTICLE]
Adam R. Hamilton, Ian M. Traniello, Allyson M. Ray, Arminius S. Caldwell, Samuel A. Wickline, and Gene E. Robinson Studies in evolutionary and developmental biology show that relationships between transcription factors (TFs) and their target genes can be altered to result in novel regulatory relationships that generate phenotypic plasticity. We hypothesized that context-dependent shifts in the nervous system associated with behavior may also be linked to changes in TF-target relationships over physiological timescales. We tested this hypothesis using honey bee (Apis mellifera) division of labor as a model system by perform...
Source: Journal of Experimental Biology - May 28, 2019 Category: Biology Authors: Hamilton, A. R., Traniello, I. M., Ray, A. M., Caldwell, A. S., Wickline, S. A., Robinson, G. E. Tags: RESEARCH ARTICLE Source Type: research

Adverse Events Associated with Ethical Kampo Formulations: Analysis of the Domestic Adverse-Event Data Reports of the Ministry of Health, Labor, and Welfare in Japan.
Conclusion: Kampo medicines may cause various adverse events. The present results provide valuable information regarding adverse events associated with Kampo medicines from the viewpoint of patient safety. PMID: 31118950 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 25, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Use of Romiplostim during pregnancy as a rescue therapy in primary immune thrombocytopenia: Literature review and case description.
We present a 34-year-old woman debuted at 13 weeks gestation, with a platelet count of 19 × 109/L and petechiae. She did not respond to initial treatment with corticosteroids and intravenous immunoglobulin. At this point, considering the limited treatment options due to toxicity and/or teratogenesis of other drugs proven to be effective against ITP like azathioprine, rituximab, cyclophosphamide, etc. and the risk of bleeding symptoms, either from mother or fetus, we decided to begin treatment with Romiplostim (thrombopoietin receptor agonist). On reviewing the literature at this matter, only eight case...
Source: Platelets - May 24, 2019 Category: Hematology Tags: Platelets Source Type: research

Exploring Obstetrical Interventions and Stratified Cesarean Section Rates Using the Robson Classification in Tertiary Care Hospitals in the United Arab Emirates
Conclusion The CS rate in the United Arab Emirates (UAE) is higher than the global average rate and than the average rate in Asia, which highlights the need for more education of pregnant women and of their physicians in order to promote vaginal birth. A proper planning is needed to reduce the number of CSs in nulliparous women in order to prevent repeated CSs in the future. Monitoring both CS rates and outcomes is essential to ensure that policies, practices, and actions for the optimization of the utilization of CS lead to improved maternal and infant outcomes. (Source: Revista Brasileira de Ginecologia e Obstetricia)
Source: Revista Brasileira de Ginecologia e Obstetricia - May 23, 2019 Category: OBGYN Source Type: research

Increased Single-balloon Foley Catheter Volume for Induction of Labor and Time to Delivery: A Systematic Review and Meta-Analysis
(Acta Obstet Gynecol Scand. 2018;97:1051–1060) The Foley catheter is commonly used for cervical ripening in women undergoing labor induction. In an attempt to raise the Bishop score at a faster rate and decrease the time to delivery, Foley balloons are often overinflated, or balloons that accept larger volumes are used. This systematic review and meta-analysis examined randomized controlled trials to determine whether or not this practice is effective in decreasing the time between the start of labor induction and delivery. (Source: Obstetric Anesthesia Digest)
Source: Obstetric Anesthesia Digest - May 22, 2019 Category: Anesthesiology Tags: Editorials and Reviews Source Type: research

Obstetric Synthetic Oxytocin Use and Subsequent Hyperactivity/Inattention Problems in Danish Children
The objective of this population-based study was to examine the association between synthetic oxytocin use during labor and hyperactivity/inattention problems in the children. (Source: Obstetric Anesthesia Digest)
Source: Obstetric Anesthesia Digest - May 22, 2019 Category: Anesthesiology Tags: Epidemiologic Reports Surveys Source Type: research

Success of trial of labor in women with a history of previous cesarean section for failed labor induction or labor dystocia: a retrospective cohort study
The rates of cesarean section (CS) are increasing worldwide leading to an increased risk for maternal and neonatal complications in the subsequent pregnancy and labor. Previous studies have demonstrated that s... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - May 20, 2019 Category: OBGYN Authors: Katariina Place, Heidi Kruit, Aydin Tekay, Seppo Heinonen and Leena Rahkonen Tags: Research article Source Type: research

Agreement assessment of key maternal and newborn data elements between birth registry and Clinical Administrative Hospital Databases in Ontario, Canada
ConclusionsOverall, the BORN and CIHI-DAD databases had concordance on key birth and maternal data elements; however, additional work is needed to understand discrepancies identified. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - May 20, 2019 Category: OBGYN Source Type: research

Maternal Noninfectious Fever Enhances Cell Proliferation and Microglial Activation in the Neonatal Rat Dentate Gyrus.
This study was designed to test the hypothesis that induced maternal noninfectious fever alters neonatal neural progenitor cell proliferation and enhances microglial activation in the rat dentate gyrus of the hippocampus. METHODS: Systemic vehicle or IL-6 was given 3 times to near-term pregnant rats (n = 7/group) every 90 minutes, and maternal core temperature was recorded. Neonatal brains were processed and analyzed for dentate gyrus cell proliferation (using Ki-67, n = 10/group, and glial fibrillary acidic protein, n = 6/group) and resident microglia activation (using ionized calcium-binding adaptor protein-1 [Iba-1...
Source: Anesthesia and Analgesia - May 18, 2019 Category: Anesthesiology Authors: Pancaro C, Boulanger-Bertolus J, Segal S, Watson CJ, St Charles I, Mashour GA, Marchand JE Tags: Anesth Analg Source Type: research

Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanese nationwide survey
ConclusionsIN-associated AEs were identified among patients with UC, with liver dysfunction often being reversible, while surgical resection was required in a high proportion of patients who developed intussusception. Both healthcare workers and patients should adequately recognize the potential for AEs with the use of IN. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 17, 2019 Category: Gastroenterology Source Type: research

Long ‐term cognition and behavior in children born at early term gestation: a systematic review
ConclusionsChildren born early term are at increased risk of cognitive deficits, poorer school performance, and behavioral problems compared to children born full term.This article is protected by copyright. All rights reserved. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - May 15, 2019 Category: OBGYN Authors: Trine Muhs Nielsen, Mette Vesterg ård Pedersen, Ioanna Milidou, Julie Glavind, Tine Brink Henriksen Tags: Systematic review Source Type: research

Comparative analysis of myometrial and vascular smooth muscle cells to determine optimal cells for use in drug discovery
Publication date: Available online 9 May 2019Source: Pharmacological ResearchAuthor(s): Shajila Siricilla, Kelsi M. Knapp, Jackson H. Rogers, Courtney Berger, Elaine L. Shelton, Dehui Mi, Paige Vinson, Jennifer Condon, Bibhash C. Paria, Jeff Reese, Quanhu Sheng, Jennifer L. HeringtonAbstractNovel therapeutic regulators of uterine contractility are needed to manage preterm labor, induce labor and control postpartum hemorrhage. Therefore, we previously developed a high-throughput assay for large-scale screening of small molecular compounds to regulate calcium-mobilization in primary mouse uterine myometrial cells. The goal o...
Source: Pharmacological Research - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

XPG-related nucleases are hierarchically recruited for double-stranded rDNA break resection [DNA and Chromosomes]
dsDNA breaks (DSBs) are resected in a 5′→3′ direction, generating single-stranded DNA (ssDNA). This promotes DNA repair by homologous recombination and also assembly of signaling complexes that activate the DNA damage checkpoint effector kinase Chk1. In fission yeast (Schizosaccharomyces pombe), genetic screens have previously uncovered a family of three xeroderma pigmentosum G (XPG)–related nucleases (XRNs), known as Ast1, Exo1, and Rad2. Collectively, these XRNs are recruited to a euchromatic DSB and are required for ssDNA production and end resection across the genome. Here, we studied why there a...
Source: Journal of Biological Chemistry - May 10, 2019 Category: Chemistry Authors: Kevin J. Barnum, Y. Tram Nguyen, Matthew J. O'Connell Tags: DNA and Chromosomes Source Type: research

Demographic, Clinical, and Counseling Factors Associated with the Selection of Pregnancy Termination Method in the Second Trimester for Fetal and Pregnancy Anomalies
Despite women's preference for induction of labor (IOL) or dilation and evacuation (D&E) for pregnancy termination in the setting of second trimester fetal or pregnancy abnormality, many women are not given a choice between delivery methods. We investigated patient and clinical related factors associated with selecting IOL or D&E. (Source: Womens Health Issues)
Source: Womens Health Issues - May 10, 2019 Category: Primary Care Authors: Emily Maistrellis, Elizabeth Janiak, Raina Hammel, Shelley Hurwitz, Laurent Delli-Bovi, Deborah Bartz Tags: Original article Source Type: research

The cost-effectiveness of universal late-pregnancy screening for macrosomia in nulliparous women: a decision-analysis.
CONCLUSIONS: The most cost-effective policy for detection and management of fetal macrosomia is selective ultrasound scanning coupled with induction of labour for all suspected cases of macrosomia. Universal ultrasound scanning for macrosomia in late-stage pregnancy is not cost-effective. This article is protected by copyright. All rights reserved. PMID: 31066982 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 8, 2019 Category: OBGYN Authors: Wastlund D, Moraitis AA, Thornton JG, Sanders J, White IR, Brocklehurst P, Smith GCS, Wilson ECF Tags: BJOG Source Type: research

Induction of labor versus expectant management for gestational diabetes mellitus at term
ConclusionsIOL in GDM mothers at term does not reduce CS rate and may be associated with increased CS rate among nulliparous women at 38  weeks. It is also associated with increased risk for adverse composite neonatal outcome or NICU admission when done prior to 390/7 weeks. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - May 7, 2019 Category: OBGYN Source Type: research

A comparison of vaginal versus buccal misoprostol for cervical ripening in women for labor induction at term (the IMPROVE trial): a triple masked randomized controlled trial
Cervical ripening is commonly needed for labor induction. Finding an optimal route of misoprostol dosing for efficacy, safety, and patient satisfaction is important and not well studied for the buccal route. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 7, 2019 Category: OBGYN Authors: David M. Haas, Joanne Daggy, Kathleen M. Flannery, Meredith L. Dorr, Carrie Bonsack, Surya S. Bhamidipalli, Rebecca C. Pierson, Anthony Lathrop, Rachel Towns, Nicole Ngo, Annette Head, Sarah Morgan, Sara K. Quinney Tags: Original Research: Obstetrics Source Type: research

Current Understanding of the Equivalence Evaluations for In Vitro Tests on Generic Dry Powder Inhaler Drug Products in Japan
This article shows the current understanding and recommendations with respect to in vitro tests, particularly for at least four groups of stages. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - May 6, 2019 Category: Drugs & Pharmacology Source Type: research

Accuracy of the Manipal Cervical Scoring System for predicting successful induction of labour.
Authors: Mohamed El Bishry G, Serag Allam I, Rasheedy R, Mahmoud A Abstract The Manipal Cervical Scoring System is an accurate and objective sonographic score that predicts the outcome of induced labour. The aim of the current study was to compare the performance of the Manipal Cervical Scoring System against the Bishop Score. A prospective study was conducted on 105 women underwent labour induction in Ain Shams University Hospital, Cairo, Egypt. Both scores were assessed pre-induction. Successful induction occurred in 78.09% of the cases. The area under the ROC curve (AUC) was of 0.940 (95% CI = 0.876 to 0.977; p ...
Source: Journal of Obstetrics and Gynaecology - May 5, 2019 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

Warfare Induces Post-Marital Residence Change
Publication date: Available online 3 May 2019Source: Journal of Theoretical BiologyAuthor(s): JiříC. Moravec, Stephen Marsland, Murray P. CoxAbstractPost-marital residence is a sex-biased dispersal defined by the place where a newly-wed couple lives after marriage. Common choices for this practice include patrilocal residence, where the couple lives with the man’s family, and matrilocal residence, where they live with the woman’s family. Deviations from accepted practice typically invoke strong sanctions, but despite this pressure to conform to post-marital residence norms, residence states are unexpect...
Source: Journal of Theoretical Biology - May 4, 2019 Category: Biology Source Type: research

Neuraxial labor analgesia: a literature review
Publication date: Available online 1 May 2019Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Fábio Farias de Aragão, Pedro Wanderley de Aragão, Carlos Alberto Martins, Karlla Fernanda Custódia Silva Leal, Alexandro Ferraz TobiasAbstractThe use of analgesia techniques for labor has become increasingly frequent, with neuraxial techniques being the most commonly used and most effective. Labor pain entails a number of physiological consequences that may be negative for the mother and fetus, and therefore must be treated. This literature review was performed through a search i...
Source: Brazilian Journal of Anesthesiology - May 3, 2019 Category: Anesthesiology Source Type: research

Sex Difference of Radiation Response in Occupational and Accidental Exposure
In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - May 3, 2019 Category: Genetics & Stem Cells Source Type: research

In silico Identification and Mechanism Exploration of Hepatotoxic Ingredients in Traditional Chinese Medicine
Conclusion: Overall, this study provides a high accurate approach to predict HILI and an in silico perspective into understanding the hepatotoxicity mechanism of TCM, which might facilitate the discovery and development of new drugs. Introduction Liver injury induced by drug, novel foods or phytotherapy, also known as hepatotoxicity, is still a major clinical and pharmaceutical concern (Amadi and Orisakwe, 2018; Hammann et al., 2018; Kyawzaw et al., 2018; Real et al., 2018). According to the data from United States National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), hepatotoxicity accounts for...
Source: Frontiers in Pharmacology - May 3, 2019 Category: Drugs & Pharmacology Source Type: research