Genetics by the Numbers
Even though scientists have been studying genetics since the mid-19th century, they continue to make new discoveries about genes and how they impact our health on a regular basis. NIGMS researchers study how genes are expressed and regulated, how gene variants with different “spellings” of their genetic code affect health, and much more. Get the drop on DNA and the gist of genes with these fast facts:
3.2 Billion
A marbled lungfish has a genome over 40 times larger than humans. Credit: iStock.
That’s how many base pairs—or sets of genetic “letters”—make up the human genome. If you were...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 24, 2024 Category: Research Authors: Chrissa Chverchko Tags: Genes By the Numbers DNA Genomics Source Type: blogs
Forbidden quotes in medicine
(Source: Dr.S.Venkatesan MD)
Source: Dr.S.Venkatesan MD - April 22, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized best quote on medical ethics bio ethics british journal of medical ethics ethical dysfunction future of noble profession Hippocratic oath indian journal of medical ethics Lown Institute medical education modified hippocra Source Type: blogs
Assessment of LV Diastolic Function by Echo in SR and AF
Echocardiographic assessment of left ventricular diastolic function with special reference on diastolic function assessment in atrial fibrillation.
Though there are several parameters for evaluation of left ventricular diastolic function by echocardiography, the most commonly used are the pulsed Doppler mitral E/A ratio and tissue Doppler mitral E/e’ ratio.
Some of the other useful parameters are mitral E velocity deceleration time, changes in mitral inflow with Valsalva maneuver, mitral L velocity, isovolumic relaxation time, left atrial maximum volume index, pulmonary vein systolic/diastolic velocity ratio, color M-mod...
Source: Cardiophile MD - April 15, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
ECG in LMCA Stenosis
ECG in a person with persistent anginal pain for the past several hours showing significant ST segment depression anterolateral leads along with sinus tachycardia. ST segment elevation is noted in aVR. Such a pattern is consistent with significant left main coronary artery stenosis.
Clinical evaluation and X-Ray chest showed features of pulmonary edema. Angiography done after initial stabilization showed severe stenosis of distal left main coronary artery. In addition, there were multiple lesions in all three vessels, making a standard indication for an urgent coronary artery bypass grafting.
A similar ECG pattern can also...
Source: Cardiophile MD - April 13, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Ballooning an obstructed prosthetic Aortic valve : Can be a real tense procedure!
A 76-year-old woman with a history of double valve replacement (Aortic and mitral valves) for rheumatic heart disease, presented with acute dyspnea after a switch from Warfarin to LMWH before a planned bone marrow biopsy.
The investigations revealed a stuck aortic prosthetic valve ,that showed a prohibitive gradient of more than 50 mmhg. Since, she refused further surgery, a rare and risky effort was made to balloon dilate the prosthetic valve leaflet, though it is not a standard approved modality. It was decided to dilate the supero-lateral orifice and the central orifices by simultaneous kissing balloon. The results w...
Source: Dr.S.Venkatesan MD - April 10, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Mitral prosthetic valve-Surgical tips and techniques prosthetic valve dysfunction prosthetic valves prosthetic valves -Technical issues Uncategorized balloon dilatation of prosthetic valve best review article on prosthetic valve obstruction Source Type: blogs
What Is Genetics?
This post is the first in our miniseries on genetics. Stay tuned for more!
Genetics is the study of genes and heredity—how traits are passed from parents to children through DNA. A gene is a segment of DNA that contains instructions for building one or more molecules that help the body work. Researchers estimate that humans have about 20,000 genes, which account for about 1 percent of our DNA. The remainder of the DNA plays a role in regulating genes, and scientists are researching other potential functions.
DNA Details
Credit: NIGMS.
DNA is shaped like a twisted ladder, called a double heli...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Genes Common questions DNA Genetics Miniseries Genomics Source Type: blogs
Costco Weight-Loss Program: Omission of Critical Data Puts Patients at (Financial) Risk
This week, the world learned that Costco Wholesale would start selling Novo Nordisk ' s newest, but vastly overpriced GLP-1 inhibitor medicine known generically as semaglutide (sold under the brand names Ozempic and Rybelsus for Type 2 diabetes, and under the brand name of Wegovy for weight-loss for those with obesity without Type 2 diabetes). We learned of the Costco GLP-1 initiative from a press release from Costco ' s strategic partner known as Sesamehttps://sesamecare.com/ which is the entity which will connect patients with its network of thousands of outpatient healthcare providers nationwide who are more than w...
Source: Scott's Web Log - April 3, 2024 Category: Endocrinology Tags: 2024 biosimilars Costco GLP-1 inhibitor liraglutide semaglutide Sesame Source Type: blogs
Brugada Syndrome
Transcript of the video: Brugada Syndrome was described by Brugada brothers in 1992 as right bundle branch block pattern in anterior leads with ST segment elevation and syncope or sudden cardiac death and it was later in 1998, that the genetic basis of the disease was identified, with mutations in sodium channel. Later on, several other mutations have been attributed to cause the ECG pattern in Brugada syndrome.
I am always happy to see this ECG of Brugada syndrome sent to me by Professor Josep Brugada, in 2001, for the inaugural issue of the Indian Pacing and Electrophysiology Journal, which I started in 2001. And, this r...
Source: Cardiophile MD - March 28, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Endava to Acquire GalaxE Solutions to Boost Its Position in North America Healthcare With Delivery from India
Endava, a leading technology services company combining world-class engineering, industry expertise, and a people-centric mindset, has entered into a definitive agreement to acquire 100% ownership of GalaxE Group, Inc. (GalaxE), a global IT and business solutions provider headquartered in New Jersey, United States.
Founded by Tim Bryan over 30 years ago, GalaxE has been singularly focused on driving digital transformation for Fortune 500 companies in the healthcare, financial services, and retail industries.
When completed, the transaction will add approximately 1,650 employees and provide several key strategic benefits to...
Source: EMR and HIPAA - March 21, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Akin Gump Strauss Hauer & Feld LLP BofA Securities Endava GalaxE GalaxE Group Inc. Health IT Acquisitions Healthcare M&A John Cotterell JP Morgan Securities LLC Tim Bryan White & Case LLP Source Type: blogs
An Analysis of Food Security Governance in Developing Countries: A Case of Ethiopia and India
A. Rashid Zara (Sorbonne University), An Analysis of Food Security Governance in Developing Countries: A Case of Ethiopia and India (2024): The nineteenth century saw a significant expansion of agricultural yields, driven by technical changes in agriculture. The green revolution,... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - March 9, 2024 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Bringing vital medical care to St. Lucia ’ s underserved
Our mission, should we choose to accept it, is seemingly simple: we are to join forces with another non-profit group in order to deliver medical care to those that need it most on St. Lucia, a West Indian island nation variously colonized by the English and French, with Arawak and Carib roots. It will be
Read more…
Bringing vital medical care to St. Lucia’s underserved originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 29, 2024 Category: General Medicine Authors: Belen Gallarza-Wilson, MD and Lisa Sanders, MD Tags: Physician Emergency Medicine Primary Care Source Type: blogs
When conferences become an “ Edutainment Industry ” the specialty of Cardiology leads from front !
Recently , I received two e-mail invite for two major conferences one in India other in Europe.
Once upon a time, in 1990s we as fellows used to attend these conference for Rs 1000 (15 Euros/Dollors). Now it is 50-75(5000-7500%times increased) Even few years ago it was affordable. I don’t know how many of us can think to attend such conferences. Definitely not me. What prevents these guys to keep the cost nominal. Certainly, Inflation is not the reason. Air tickets and hotel room tariffs has just raised 50-100%.over the same period
if you look closely into the above menu card, Indian tariffs would te...
Source: Dr.S.Venkatesan MD - February 22, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
When medical conferences become an “ Edutainment Industry ” the specialty of Cardiology leads from front !
Recently , I received two e-mail invite for two major conferences one in India other in Europe.
Once upon a time, in 1990s we as fellows used to attend these conference for Rs 1000 (15 Euros/Dollors). Now it is 50-75(5000-7500%times increased) Even few years ago it was affordable. I don’t know how many of us can think to attend such conferences. Definitely not me. What prevents these guys to keep the cost nominal. Certainly, Inflation is not the reason. Air tickets and hotel room tariffs has just raised 50-100%.over the same period
if you look closely into the above menu card, Indian tariffs would te...
Source: Dr.S.Venkatesan MD - February 22, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
When medical conferences become an “ Edutainment Industry ” the speciality of Cardiology leads from front !
Recently , I received two e-mail invite for two major conferences one in India other in Europe.
Once upon a time, in 1990s we as fellows used to attend these conference for Rs 1000 (15 Euros/Dollors). Now it is 50-75(5000-7500%times increased) Even few years ago it was affordable. I don’t know how many of us can think to attend such conferences. Definitely not me. What prevents these guys to keep the cost nominal. Certainly, Inflation is not the reason. Air tickets and hotel room tariffs has just raised 50-100%.over the same period
if you look closely into the above menu card, Indian tariffs would te...
Source: Dr.S.Venkatesan MD - February 22, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Why ICDs are less effective in Non Ischemic DCM ?
We wish, our understanding about cardiac contractile physiology is deep and nearly complete. Heart is an irreversibly coupled electro-mechanical organ , right from the fetal days until the final heart beat. In myocardial pathology, the genesis and sustainability of ventricular arrhythmia are intricately related to the degree of LV dysfunction of any cause.
SCD is the leading cause of mortality in heart failure. Tackling SCD was in God’s domain, until the brilliance of Dr. Michel Mirowski shrunk the defibrillator and implanted it under the chest in 1980. (Dr. MM’s s a unique and inspiring story, from Poland a...
Source: Dr.S.Venkatesan MD - February 20, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized crt device crt-p vs crt-d danish trial ischemic dcm madit trial non ischemic dcm Source Type: blogs
