Nontoxic HSV vector Microbiology

The design of highly defective herpes simplex virus (HSV) vectors for transgene expression in nonneuronal cells in the absence of toxic viral-gene activity has been elusive. Here, we report that elements of the latency locus protect a nonviral promoter against silencing in primary human cells in the absence of any...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research

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Conclusion The occurrence of HSV-1 DNA in the placenta and in cord blood found suggests vertical transmission from asymptomatic pregnant women to the fetus.Resumo Objetivo Estimar a preval ência do DNA do vírus herpes humano 1 (HSV-1) em amostras de placenta, sua incidência no sangue do cordão umbilical de recém-nascidos e fatores de risco associados. Métodos Biópsias de placenta e de sangue de cordão umbilical foram analisadas, totalizando 480 amostras de parturientes assin tomáticas e seus recém-nascidos emum hospital universitário. Reaç&at...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Disseminated herpes simplex virus (HSV) is mainly seen in immunocompromised individuals. Atypical lesions can be present in both primary infection and reactivation disease. Compared with the general population, inmunocompromised hosts are at greater risk of increased persistency and severity of clinical manifestations, including severe systemic involvement such as esophagitis, meningitis, and hepatitis. Herein, we report the case of a liver transplant recipient with atypical disseminated herpes simplex virus-1 complicated by HSV-related hepatitis. Dermatological consultation and histological assessment were crucial for a c...
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
AbstractCommon infectious agents, such asToxoplasma gondii (T. gondii) and several human herpes viruses, have been linked to increased risk of self-harm. The aim of this study was to investigate the associations between self-harm and seropositivity toT. gondii, Epstein-Barr virus (EBV), Herpes Simplex virus Type 1 (HSV-1), and Cytomegalovirus (CMV). IgM and IgG antibodies to these infections were measured in the Health 2000 project nationally representative of the whole Finnish adult population, and 6250 participants, age 30 and over, were followed for 15  years via registers. In addition, lifetime suicidal ideation a...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
No abstract available
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Letters to the Editor Source Type: research
Analyst, 2020, Accepted Manuscript DOI: 10.1039/D0AN00263A, PaperCuiping Zhang, Zuojian Hu, Ke Wang, Lujie Yang, Yue Ni, Hartmut Schl üter, Pengyuan Yang, Jiaxu Hong, Hongxiu Yu Lipid mediators ( LMs) play a pivotal role in the induction and resolution of inflammation. To identify and elucidate their involvement during virus infection, Multiple Reaction Monitoring (MRM) based liquid chromatography... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Triple-negative breast cancer (TNBC) is a difficult-to-treat disease with high rates of local recurrence, distant metastasis, and poor overall survival with existing therapies. Thus, there is an unmet medical need to develop new treatment regimen(s) for TNBC patients. An oncolytic herpes simplex virus encoding a master anti-tumor cytokine, interleukin 12, (designated G47Δ-mIL12) selectively kills cancer cells while inducing anti-tumor immunity. G47Δ-mIL12 efficiently infected and killed murine (4T1 and EMT6) and human (HCC1806 and MDA-MB-468) mammary tumor cells in vitro. In vivo in the 4T1 syngeneic TNBC model...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Herpes simplex virus (HSV) typically infects oral or anogenital squamous epithelium and causes blisters and ulcerations. Here we reported an unusual case of HSV induced exuberant rectal inflammatory pseudotumo...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case report Source Type: research
Herpes simplex virus 1, an enveloped DNA virus belonging to the Herpesviridae family, spreads to neurons and causes pathological changes in the central nervous system. The purpose of this study was to investig...
Source: Virology Journal - Category: Virology Authors: Tags: Research Source Type: research
We report a case of 2½-year-old child who presented like acute necrotizing encephalopathy but on further investigations was found to be having deep cerebral vein thrombosis.
Source: Journal of Pediatric Neurosciences - Category: Neuroscience Authors: Source Type: research
Abstract Champagne, a sparkling wine produced from grapes grown in the Champagne region of France, is the requisite drink of celebration, symbolizing all things congratulatory from new years to new unions. A "champagne tap" colloquially refers to a lumbar puncture (LP) with no cerebrospinal (CSF) red blood cells (RBCs), which appears colorless (reminiscent of its clear bubbly namesake) and signifies a technically perfect procedure. PMID: 32187765 [PubMed - as supplied by publisher]
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Acad Emerg Med Source Type: research
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