High neutrophil-lymphocyte ratio indicates poor prognosis for acute-on-chronic liver failure after liver transplantation.

High neutrophil-lymphocyte ratio indicates poor prognosis for acute-on-chronic liver failure after liver transplantation. World J Gastroenterol. 2015 Mar 21;21(11):3317-24 Authors: Lin BY, Zhou L, Geng L, Zheng ZY, Jia JJ, Zhang J, Yao J, Zheng SS Abstract AIM: To investigate the significance of pre-transplant neutrophil-lymphocyte ratio (NLR) in determining the prognosis of liver transplant (LT) recipients with acute-on-chronic liver failure (ACLF). METHODS: Data were collected from the liver transplantation data bank. The NLR values and other conventional inflammatory markers were evaluated for their ability to predict the prognosis of 153 patients with ACLF after LT. The NLR cut-off value was based on a receiver operating characteristic curve analysis. A Kaplan-Meier curve analysis and univariate and multivariate Cox regression models were used to define the independent risk factors for poor outcomes. RESULTS: The optimal NLR cut-off value was 4.6. Out of 153 patients, 83 (54.2%) had an NLR ≥ 4.6. The 1-, 3-, and 5-year overall survival rates were 94.3%, 92.5% and 92.5%, respectively, in the normal NLR group and 74.7%, 71.8% and 69.8%, respectively, in patients with high NLRs (P
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research

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We present the case of a 68 year-old man who was initially attended in emergency department with sudden onset diplopia. Neurological exploration revealed WEBINO and gait ataxia. Relevant medical history included liver transplantation and subsequent tacrolimus prescription. Complementary exams revealed ischemic lesion in mesencephalic tegmentum, involving medial longitudinal fasciculus and pretectal area. WEBINO syndrome is unfrequent. Among its etiologies, ischemic and demyelinating are the most frequent. In our case, iatrogenic etiology was also considered. Clinical recognition of this syndrome is required to perform adeq...
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Authors: Martínez Lozano H, Conthe Alonso A, Bañares R Abstract INTRODUCTION: hepatitis A virus (HAV) infection is a common cause of acute hepatitis worldwide. Since the generalization of vaccination, its incidence had markedly declined. Nevertheless, several HAV-outbreaks have been described in the last decade, mainly related to contaminated alimentary products. In recent years, a new pattern of acute HAV infection has been described with changes in the demographic profile of the infected population, which is more common in healthy young men. PATIENTS AND METHODS: a retrospective case series stud...
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Publication date: Available online 21 February 2020Source: Journal of Clinical and Experimental HepatologyAuthor(s): Kellie Young, Benny Liu, Taft Bhuket, Robert J. WongAbstractBackground &AimsDirect-acting antivirals (DAAs) are expected to improve outcomes for hepatitis C virus (HCV) patients following liver transplantation (LT). We aim to evaluate trends in post-LT outcomes with availability of DAAs.MethodsWe retrospectively evaluated U.S. adults transplanted from 1/1/2002 – 3/31/2018 using the United Network for Organ Sharing registry, stratified by pre-DAA (1/1/2002-12/31/2013) vs. post-DAA (1/1/2014-3/31/201...
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
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