High neutrophil-lymphocyte ratio indicates poor prognosis for acute-on-chronic liver failure after liver transplantation.

High neutrophil-lymphocyte ratio indicates poor prognosis for acute-on-chronic liver failure after liver transplantation. World J Gastroenterol. 2015 Mar 21;21(11):3317-24 Authors: Lin BY, Zhou L, Geng L, Zheng ZY, Jia JJ, Zhang J, Yao J, Zheng SS Abstract AIM: To investigate the significance of pre-transplant neutrophil-lymphocyte ratio (NLR) in determining the prognosis of liver transplant (LT) recipients with acute-on-chronic liver failure (ACLF). METHODS: Data were collected from the liver transplantation data bank. The NLR values and other conventional inflammatory markers were evaluated for their ability to predict the prognosis of 153 patients with ACLF after LT. The NLR cut-off value was based on a receiver operating characteristic curve analysis. A Kaplan-Meier curve analysis and univariate and multivariate Cox regression models were used to define the independent risk factors for poor outcomes. RESULTS: The optimal NLR cut-off value was 4.6. Out of 153 patients, 83 (54.2%) had an NLR ≥ 4.6. The 1-, 3-, and 5-year overall survival rates were 94.3%, 92.5% and 92.5%, respectively, in the normal NLR group and 74.7%, 71.8% and 69.8%, respectively, in patients with high NLRs (P
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research

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During the COVID-19 pandemic, the US saw a 60% increase in people requiring a liver transplant for a disease caused by heavy drinking, University of Michigan researchers found.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Korean J Gastroenterol. 2021 Oct 25;78(4):240-244. doi: 10.4166/kjg.2021.079.ABSTRACTNiemann-Pick disease type C (NPC) is a neurovisceral lysosomal storage disorder caused by mutations in the NPC1 and NPC2 genes. These mutations cause the accumulation of unesterified cholesterol and other lipids in the lysosomes. NPC has a broad spectrum of clinical manifestations, depending on the age of onset. A 15-day-old infant presented at the Seoul National University Children's Hospital with neonatal cholestasis and hepatosplenomegaly, with the onset of jaundice at 5 days of age. Despite supportive treatment, the patient was conside...
Source: Korean J Gastroenter... - Category: Gastroenterology Authors: Source Type: research
In this study, C57BL/6 mice under a high fat diet (HFD) were treated with sodium copper chlorophyllin (CHL), a water-soluble derivative of chlorophyll, in drinking water. After 28 weeks of HFD feeding, liver steatosis was established accompanied by gut microbiota dysbiosis, intestinal impairment, endotoxemia, systemic inflammation, and insulin resistance. Administration of CHL effectively alleviated systemic and intestinal inflammation and maintained tight junction in the intestinal barrier. CHL rebalanced gut microbiota in the mice under high fat feeding and attenuated hepatic steatosis, insulin resistance, dyslipidemia, ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Tacrolimus is an essential immunosuppressant for the prevention of rejection in solid organ transplantation. Its low therapeutic index and high pharmacokinetic variability necessitates therapeutic drug monitoring (TDM) to individualise dose. However, rejection and toxicity still occur in transplant recipients with blood tacrolimus trough concentrations (C0) within the target ranges. Peripheral blood mononuclear cells (PBMC) have been investigated as surrogates for tacrolimus’s site of action (lymphocytes) and measuring allograft tacrolimus concentrations has also been explored for predicting rejection or nephrotoxici...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Biliary complications are often referred to as the Achilles ’ heel of liver transplantation (LT). The most common of these complications include strictures, and leaks. Prompt diagnosis and management is key for preservation of the transplanted organ. Unfortunately, a number of factors can lead to delays in diagnosis and make adequate treatment a challenge. Innovations in advanced endoscopic techniques have increased non-surgical options for these complications and in many cases is the preferred approach.
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
AbstractPurpose of ReviewStatic cold storage has been the gold standard for deceased donor kidney and liver graft preservation. Ex vivo organ perfusion technology has emerged as a potential alternative to static cold storage for kidney and liver graft preservation.Recent FindingsHypothermic machine perfusion of marginal deceased donor kidney grafts has become a standard clinical practice in kidney transplantation. Further studies are required to elucidate the role of normothermic machine perfusion for marginal deceased donor kidney grafts. Multicenter, prospective randomized trials have been initiated in the USA to evaluat...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx. A Profile of Michael Greve and the Segment of the Longevity Industry that He Supports https://www.fightaging.org/archives/2021/10/a-profile-of-michael-greve-and-the-segment-of-the-longevity-industry-that-he-supports/ Would that the popular media produced more popular science articles about the longevity industry like this one. It is not just a profile of someone trying to make a difference in the world by advancing the state of medici...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Br J Surg. 2021 Oct 24:znab350. doi: 10.1093/bjs/znab350. Online ahead of print.NO ABSTRACTPMID:34689205 | DOI:10.1093/bjs/znab350
Source: The British Journal of Surgery - Category: Surgery Authors: Source Type: research
CONCLUSION: Liver transplantation with individual surgical and postoperative treatment strategy for patients with Budd-Chiari syndrome provides comparable outcomes.PMID:34688524 | DOI:10.1016/j.asjsur.2021.09.007
Source: Asian Journal of Surgery - Category: Surgery Authors: Source Type: research
Gene. 2021 Oct 21:146007. doi: 10.1016/j.gene.2021.146007. Online ahead of print.ABSTRACTAIM: The purpose of this study was to investigate the effect of CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in liver transplant recipients and donors on tacrolimus concentrations in the early stages after liver transplantation.METHODS: One hundred and thirty-eight liver transplant recipients and matched donors were genotyped for CYP3A7 (rs10211 and rs2257401), CYP3A4 (rs4646437 and rs2242480), and CYP3A5*3 (rs776746) polymorphisms. The relationships between dose-adjusted trough concentrations (C0/D) of tacrolimus and corresponding...
Source: Gene - Category: Genetics & Stem Cells Authors: Source Type: research
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