Chronic idiopathic urticaria: treatment with omalizumab.

Chronic idiopathic urticaria: treatment with omalizumab. Skin Therapy Lett. 2014 Dec;19(6):1-4 Authors: Naaman S, Sussman G Abstract Chronic idiopathic urticaria (CIU) is a common autoimmune skin condition characterized by spontaneously recurring hives for 6 weeks or longer. The new terminology used for CIU in most countries including Canada is chronic spontaneous urticaria (CSU). CSU is associated with significant psychosocial morbidity with a markedly negative impact on overall quality of life. Conventional approaches with antihistamines, even at high doses, is effective in about 50% of patients suffering from CSU. A new treatment option, omalizumab, a humanized monoclonal antibody against the Fc domain of IgE, has undergone the scrutiny of randomized research studies evaluating the efficacy in CSU. This editorial reviews mechanisms of action of omalizumab, efficacy, cost and potential side effect profile. Omalizumab has emerged as a very promising treatment option for patients with CSU. Future research is necessary to establish standardized protocols related to dosing as well as monitoring possible adverse effects of long-term treatment. PMID: 25807072 [PubMed - in process]
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research

Related Links:

Chronic spontaneous urticaria (CSU) is a skin disease related to autoreactive IgE in at least a subgroup of patients. However, the nature of this autoreactive IgE remains poorly characterized. This investigation had three objectives: first, to quantity CSU autoreactive IgE; second, to recognize the patterns of CSU autoreactive IgE compared with healthy control IgE; and third, to investigate the physiochemical nature of CSU autoreactive IgE.Methods: IgE autoreactivity was assessed in sera from 7 CSU and 7 healthy individuals. Autoantigen recognition patterns were assessed using principal component analysis (PCA) and heatmap...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Publication date: Available online 13 June 2019Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): D. Carvalho, P. Aguiar, P. Ferrinho, P. Mendes-Bastos, A. Palma-CarlosAbstractBackground and aimsEczema and urticaria are both inflammatory skin diseases. The prevalence of both diseases varies worldwide and the reasons are unknown. We aimed to investigate the eczema and urticaria prevalence in the Portuguese adult (≥ 16 years-old) population.Materials and methodsA telephone interview survey was performed in the last quarter of 2017. To calculate the prevalences, subjects should have been previously...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
A recent article by Dr MacGlashan1 concludes that the “true” incidence of IgE receptor antibody in patients with chronic spontaneous urticaria is less than 10%.1 Although most studies report an incidence of 25% to 45% positive basophil histamine release, constraints were added to the analysis, including dependence of basophil histamine release of S YK, Bruton tyrosine kinase, and phosphoinositide 3-kinase, which are linked to IgE receptor activation, plus successful desensitization using aggregated IgE.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
We report a case of a patient presenting with acute-onset painful hairy eruption on dorsum of the left foot near great toe. Detailed history and investigations led to appropriate diagnosis.
Source: International Journal of Trichology - Category: Dermatology Authors: Source Type: research
  Being outdoors during the warm weather season carries with it the risk of bites of all kinds – insects, animals, ticks and others. Here is some helpful advice for treating bites and itching. Check the symptoms. Most insect bites and stings are mild, causing minor symptoms like itching, redness, stinging or a small degree of swelling around the bite. In some rare cases, stings from hornets, bees, wasps, scorpions or fire ants may lead to more serious reactions, including mosquito-borne West Nile virus. The Mayo Clinic advises moving away from the area where you were stung or bitten to prevent further injur...
Source: Advanced Tissue - Category: Dermatology Authors: Tags: Wound Care Wound care products wound care treatment Source Type: news
Authors: Han JH, Je YJ, Yoon HJ, Ahn JG, Lee JS, Park JW, Park HJ Abstract Cryopyrin-associated periodic syndrome (CAPS) is a hereditary autoinflammatory syndrome caused by mutations in NLRP3 (encoding cryopyrin), which presents with fever, fatigue and arthralgia. Thus far, however there have been no reports of CAPS in Korea. Herein, we report 3 cases of CAPS for the first time in Korea. The first case, a 28-year-old man with recurrent urticaria, arthralgia and fever induced by cold, all of which were observed in his father, showed elevated erythrocyte sedimentation rate and C-reactive protein. He exhibited a p.Gly...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
CONCLUSIONS: The rate of anaphylaxis in patients with ColdU in a tropical country was lower than those reported by other studies conducted intemperate climates. On the other hand, the number of female patients, mean age at symptom onset, atopy rate, rate of concomitant chronic spontaneous urticaria and mean CTT were higher. PMID: 31172722 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
This article reviews its current status regarding pathogenesis and approach to treatment as well as therapeutic agents that are under development for the treatment of CSU. PMID: 31172716 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
We present a case of a 15-year-old male adolescent observed in the pediatric emergency department by flaccid paresis of the 4 limbs of sudden onset and progressive worsening. In the anamnesis, corticosteroid and antihistamine intake were observed on the previous day for urticaria and family history of transient episodes of flaccid paralysis in adolescence, asymptomatic after the fourth decade of life, without an established diagnosis. Diagnostic tests revealed hypokalaemia (K +
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Conclusions: Most of the Brazilian experts in this study partially agreed with the diagnostic and therapeutic recommendations of the International and US guidelines. They agreed with the use of sgAH at licensed doses. Increase in the dose to fourfold of sgAH may be suggested with restrictions, due to its non-licensed dose. Sedating anti-histamines, as suggested by the US guideline, are indicated by some of the Brazilian experts, due to its availability. Adaptations are mandatory in the treatment of CSU, due to scarce or lack of other therapeutic resources in the public health system in Brazil, such as omalizumab or cyclosporine.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
More News: Dermatology | Hives | Skin | Study | Xolair