Approach to chronic wound infections.

Approach to chronic wound infections. Br J Dermatol. 2015 Mar 15; Authors: Leaper D, Assadian O, Edmiston CE Abstract Infection is the likeliest single cause of delayed healing in healing of chronic open wounds by secondary intention. If neglected it can progress from contamination to colonization and local infection through to systemic infection, sepsis and multiple organ dysfunction syndrome, and it can be life-threatening. Infection in chronic wounds is not as easy to define as in acute wounds, and is complicated by the presence of biofilms. There is, as yet, no diagnostic for biofilm presence, but it contributes to excessive inflammation - through excessive and prolonged stimulation of nitric oxide, inflammatory cytokines and free radicals - and activation of immune complexes and complement, leading to a delay in healing. Control of biofilm is a key part of chronic wound management. Maintenance debridement and use of topical antimicrobials (antiseptics) are more effective than antibiotics, which should be reserved for treating spreading local and systemic infection. The continuing rise of antimicrobial resistance to antibiotics should lead us to reserve their use for these indications, as no new effective antibiotics are in the research pipeline. Antiseptics are effective through many mechanisms of action, unlike antibiotics, which makes the development of resistance to them unlikely. There is little evidence to support the theoretical risk that anti...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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ConclusionOverall our results show a global increase in the prevalence of HLMuRSA and HLMuRMRSA among clinical S. aureus isolates over time. However, there was only a significant increase in the prevalence of MuRMRSA compared to the other categories of strains especially MuRSA. Since for decolonization of MSSA and MRSA in both patients and healthcare personnel, mupirocin is currently still the most effective antibiotic, a reduction of its effectiveness can provide a risk for invasive infection. Monitoring of mupirocin resistance development remains critical.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsThe existing body of research fails to provide robust evidence to support sound evidential interventions supported by theoretical justifications. Furthermore, interventions to ensure long-term sustained behavior change are unclear and not addressed.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
The Pfizer Foundation announced 20 grants* to help non-governmental organizations (NGOs), non-profits and social enterprises address critical health challenges related to infectious diseases, including the increasing threat of antimicrobial resistance (AMR), in some of the world's most vulnerable communities.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Pfizer Business and Industry Source Type: news
In recent years nontyphoidal Salmonella has emerged as one of the pathogens most frequently isolated from the bloodstream in humans. Only a small group of Salmonella serovars cause this systemic infection, known as invasive nontyphoidal salmonellosis. Here, we present a focused minireview on Salmonella enterica serovar Panama, a serovar responsible for invasive salmonellosis worldwide. S. Panama has been linked with infection of extraintestinal sites in humans, causing septicemia, meningitis, and osteomyelitis. The clinical picture is often complicated by antimicrobial resistance and has been associated with a large repert...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Minireviews Source Type: research
Publication date: Available online 6 August 2019Source: Food ControlAuthor(s): Sarina Pradhan Thapa, Smriti Shrestha, Anil Kumar AnalAbstractAntibiotics are the compounds widely used to treat bacterial infections in human and variety of agricultural sectors including livestock farming, plants and crops, and aquaculture. However, rampant and uncontrolled use of antibiotics results in the emergence of resistant bacterial strains. Such resistant strains on the food chain possibly increase the risk of antibiotic resistant foodborne pathogens. Antibiotic resistant bacteria can reach human either directly via the contact with th...
Source: Food Control - Category: Food Science Source Type: research
Publication date: Available online 19 August 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Mariem Saidani, Lilia Messadi, Ela Sahmin, Sana Zouaoui, Alya Soudani, Monia Daaloul-Jedidi, Aymen Mamlouk, Faten Ben Chehida, Jean-Yves Madec, Marisa Haenni
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
This study aimed to characterize the resistance to antimicrobials, plasmids and virulence, as well as the serotypes and phylogenetic groups inE. coli isolated from sheep in Brazil. A total of 57 isolates were obtained and showed different antimicrobial resistance profiles. Nineteen isolates presented acquired antimicrobial resistance genes (ARGs) (blaCTX-M-Gp9,qnrB, qnrS, oqxB, oqxA, tetA, tetB, tetC, sul1 andsul2) and plasmid families (F, FIA, FIB, I1, K, HI1 and ColE-like). Thestx1,stx2 andehxA virulence genes were detected by PCR, being 50 isolates (87.7%) classified as STEC. A great diversity of serotypes was detected,...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
In conclusion, 3.1-PP4 is a highly promising lead towards development of a topical treatment for severely infected skin injuries.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study compared treatment failures between patients treated exclusively with IV antibiotics and those transitioned from IV to oral antibiotics for bacteraemia secondary to UTI.MethodsThis single-centre, retrospective cohort study included hospitalised, non-critically ill adult patients treated with culture-susceptible antibiotic therapy for 7–21 days. Patients were divided into two cohorts based on the route of definitive antibiotic administration. Treatment failure was a composite outcome of death and recurrence of the index micro-organism within 21 days following negative blood cultures.Results and discussionAm...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
by Jane Usher, Ken Haynes Drug resistance is a rapidly emerging concern, thus prompting the development of novel therapeutics or combinatorial therapy. Currently, combinatorial therapy targets are based on knowledge of drug mode of action and/or resistance mechanisms, constraining the number of target proteins. Unbiased ge nome-wide screens could reveal novel genetic components within interaction networks as potential targets in combination therapies. Testing this, in the context of antimicrobial resistance, we implemented an unbiased genome-wide screen, performed inSaccharomyces cerevisiae expressing aCandida glabrata PD...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
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